8results about How to "High bactericidal activity" patented technology

The invention belongs to the technical field of biology, and particularly relates to endolysin derived from staphylococcus warneri mild bacteriophage and application of the endolysin. The endolysin has a nucleotide sequence as shown in SEQ ID NO: 1 or a nucleotide sequence obtained after further optimization of the endolysin. The endolysin gene sequence is completely and successfully obtained on the basis of the staphylococcus warneri mild bacteriophage vBG3001, the endolysin protein (endolysin 65) is successfully expressed and purified, and the endolysin protein has an inhibition effect on the growth of a gram-positive bacterium bacillus velezensis and a gram-negative bacterium burkholderia. The staphylococcus warneri mild bacteriophage perforin gene and endolysin gene are co-expressed in escherichia coli, so that the staphylococcus warneri mild bacteriophage has relatively strong bactericidal activity on host escherichia coli. The effects provide a theoretical basis for prevention and treatment of gram-negative pathogenic bacteria.

The invention discloses an antibacterial peptide and application thereof in preventing and treating dental plaque and gingival problems, and belongs to the technical field of biology. According to the invention, two cationic antibacterial peptides LR18 and LR18-2 with amphiphilic alpha-helical structures are designed from the beginning. The two antibacterial peptides have good antibacterial and bactericidal activity on oral periodontal pathogenic bacteria (including fusobacterium nucleatum, porphyromonas gingivalis and streptococcus mutans), the minimum inhibitory concentration (MIC) is 62.5-500 [mu] g / mL, and the minimum bactericidal concentration (MBC) is 62.5-2000 [mu] g / mL. The structure is simple, the chemical synthesis difficulty is low, a high-purity product can be directly synthesized, the cell hemolytic activity is low, the safety is high, the product can be used for preparing oral antibacterial drugs and / or oral care products, and oral diseases are prevented and treated by inhibiting the growth of oral periodontal pathogenic bacteria.

The application discloses a bactericidal composition and application thereof in prevention and treatment of crop diseases, and belongs to the technical field of plant disease prevention and treatment. An active ingredient of the composition comprises a compound ZJS178 with a structure as shown in formula (I) and a methoxy acrylate bactericide, and the bactericidal composition has excellent prevention and treatment effects on crop diseases caused by fusarium. The compound ZJS178 and the methoxy acrylate bactericide have a synergistic effect under certain matching conditions, and can significantly improve bacteriostatic activity and prevention and treatment effects. The composition provided by the application is composed of effective ingredients with different action mechanisms, can overcome and delay drug resistance of pathogenic bacteria, is safe for crops, and meets the requirements of pesticide reduction and synergism.

The application discloses a kind of implant piezoelectric nano coating and its preparation method and application.The nano coating is composed of nano-flower-shaped barium titanate and gold nanoparticles loaded on its surface.In this application, gold nanoparticles are deposited on nano-barium titanate at high temperature by using the method of sodium citrate reducing tetrachloroauric acid. The nBTO@Au prepared by this method has obvious osteogenesis and antibacterial properties. The application provides a high reactivity, catalytic and non-invasive immediate treatment mode for peri-implantitis, which has wide application potential in implant post-disinfection, peri-implantitis treatment and improving implant survival rate.

This invention relates to the field of pesticides, specifically to a fungicide composition for foliar spraying, its preparation method, and application scheme. The active ingredients of the fungicide composition include quinoline copper and phosphite A. Phosphite A is selected from at least one of phosphorous acid, alkali metal salts or alkaline earth metal salts of phosphorous acid, alkylphosphonic acids containing C1-C6 groups of phosphorous acid or alkali metal salts of alkylphosphonic acids, alkaline earth metal salts, and aluminum salts. In the fungicide composition, the weight ratio of quinoline copper to phosphite A is 99:1 to 1:99. The fungicide composition of this invention has high activity against bacterial and fungal diseases occurring in various crops, such as canker and downy mildew, and also exhibits significant synergistic effects. It not only improves the antibacterial or bacteriostatic effect but also broadens the control spectrum. Simultaneously, it can reduce the number of applications and alleviate environmental pressure, thereby achieving the effect of prevention-oriented and integrated pest management.

The present application relates to a kind of arylamino-containing xanthine derivatives and its preparation method and application.On the basis of 1,3-disubstituted xanthine raw material, arylamino-containing xanthine derivatives obtained by series of reactions are shown as general formula I.Compounds of general formula I have higher herbicidal activity, and have obvious activity on rape, amaranthus retroflexus, barnyard grass, crabgrass, have good insecticidal activity, especially on the effect of diamondback moth is remarkable, have good fungicidal activity, and have obvious in vitro inhibitory activity on wheat scab fungus, pepper phytophthora blight fungus, sclerotinia sclerotiorum, cucumber fusarium wilt fungus, apple phialophora quercina, wheat sharp eyespot fungus, etc.Compounds of general formula I can be used as active components of herbicidal or insecticidal or fungicidal composition, for preparing agricultural herbicide or insecticide or fungicide, and can be used for the prevention and treatment of grass damage or insect damage or pathogenic damage on various crops.Also have good inhibitory effect on the activity of KARI, and can be used for KARI inhibitor.

The invention provides a five-membered heteroaryl compound. (In the formula, Q1 and Q2 each represent a phenyl group or the like, B1, B2 and B3 each represent an oxygen atom, a nitrogen atom, NR1, CR2, R1 represents an alkyl group or the like, R2 represents a hydrogen atom or the like, Za represents an oxygen atom or the like, T represents a partial structure (T-1) or (T-2), Z represents an oxygen atom or the like, R6 represents a hydrogen atom or the like, Zb represents an alkoxy group or the like, R7 represents RcCO-or the like, Rc represents an alkyl group or the like, R4 and R5 each represent a hydrogen atom or the like, and n represents an integer of 1-3).

The present application relates to a kind of fungicide composition and its application, comprising active ingredient A and active ingredient B, the active ingredient A is the compound shown in formula (I), and active ingredient B is any one of Feneptamidoquin, Fenopyramid, the mass ratio of active ingredient A and active ingredient B is 1:36~20:1.The fungicide composition or its preparation of the present application has significant synergistic effect on the disease caused by a variety of fungi, is significantly higher than the prevention and treatment effect of single component, the effective period is long, can delay the development of drug resistance simultaneously, is pollution-free to environment, is safe to natural enemy and crop.