36results about How to "High bactericidal activity" patented technology

The invention belongs to the field of pesticides, and relates to a 2-cyano-3-disubstituted phenyl acrylate compound as well as a preparation method and application thereof in pesticides. Carrying out alcoholysis reaction on the benzonitrile compound a and a hydrogen chloride absolute ethyl alcohol solution to obtain an intermediate b; carrying out condensation reaction on the intermediate b and ethyl cyanoacetate under the action of alkali to obtain an intermediate c; the intermediate c and a substituted compound are subjected to a substitution reaction under the action of alkali and a catalyst, and the 2-cyano-3-disubstituted phenyl acrylate compound I is obtained. The 2-cyano-3-disubstituted phenylacrylate compound provided by the invention has good bactericidal activity, and has relatively high bactericidal activity on pathogenic bacteria of chlorosclerotium, fusarium, acrocyst, colletotrichum, cercospora, verticillium and black beancurd skin; the compound can be used for preparing bactericides in the fields of agriculture, horticulture, industry and the like, and has the advantages of broad spectrum, high efficiency, low toxicity and environmental friendliness.

The invention relates to a deuterated pyrazolyl formamide compound as well as a preparation method and application thereof. Specifically, the compound has a structure as shown in a formula I, and has a more excellent bactericidal effect and an effect of increasing the yield. # imgabs0 #

The invention belongs to the field of pesticide sterilization, and discloses a pesticide composition and application thereof. Effective components of the bactericidal composition comprise an active component A and an active component B, the active component A is a compound represented by a formula I: # imgabs0, and the active component B is any one of penflufen and sedaxane; the mass ratio of the active component A to the active component B is (1: 35)-(35: 1). The pesticide composition disclosed by the invention has a broad-spectrum bactericidal effect, the use amount and use cost of effective components are effectively reduced, and generation and development of resistance are delayed.

The invention relates to the field of novel pesticide compounds, and discloses a compound containing a synene fragment and application thereof, a pesticide for preventing and controlling nematodes and / or fungi, and a method for preventing and controlling nematodes and / or fungi. The compound has a structure as shown in a formula (I). The compound containing the synene fragment, provided by the invention, has excellent biological activity on at least one plant parasitic nematode and / or fungus included in the synene fragment at a low dosage. # imgabs0 #

The present invention discloses a strain of Riemerella anatipestifer phage PT15, a phage composition thereof and its application. The phage PT15 has a deposit number of CGMCC No. 22377 and was deposited in the China General Microbiological Culture Collection Center on April 12, 2021. The present application also provides a phage composition comprising the above-mentioned phage. The above-mentioned phage and phage composition can be used as active ingredients for the preparation of therapeutic drugs and feed additives, and are used in the prevention and treatment of duck bacterial serositis. The phage composition has the advantages of safety, high efficiency and non-toxic side effects, and can be used as an active ingredient of a new type of environmental disinfectant to effectively prevent and control the pollution of breeding environment and feeding facilities, and has good application prospects.

The invention relates to the field of acupuncture and cupping disinfection, in particular to a quick disinfection device for acupuncture and cupping, which comprises a disinfection table, a processing unit is arranged on the disinfection table, and the processing unit comprises a disinfection cylinder fixed on the disinfection table, a cleaning mechanism for cleaning a cupping device and a clamping mechanism for fixing the cupping device. The cleaning mechanism comprises an inner brush part and an outer brush part, a driving shaft used for driving the inner brush part to rotate is coaxially arranged in the disinfection cylinder, and a connecting structure used for ensuring that the cupping device is clamped between the inner brush part and the outer brush part is arranged between the inner brush part and the outer brush part. The inner brush part and the outer brush part are tightly attached to the cupping device, the cleaning comprehensiveness is ensured, then the cupping device is locked by the clamping mechanism, the inner brush part and the outer brush part cooperatively work, the inner surface and the outer surface of the cupping device are deeply cleaned while the cupping device is kept relatively static, and the disinfection comprehensiveness and efficiency are improved.

The invention relates to an ultra-dispersed copper-based nano-enzyme and a preparation method and application thereof, and the copper-based nano-enzyme is formed by using a copper-containing compound and a polyphenol compound as precursors through oxidative coupling self-assembly in the presence of a polymeric dispersant and a surfactant. The preparation method comprises the following steps: uniformly mixing and stirring a copper-containing compound, a polyphenol compound, a polymeric dispersant and a surfactant in water to obtain a uniformly dispersed solution; adjusting the pH value of the solution to 5-7.4, and then carrying out a heating reaction; and cooling to obtain the copper-based nano-enzyme solution. Compared with the prior art, the ultra-dispersed copper-based nano-enzyme prepared by the method has excellent water-based solvent dispersibility, good oxidation resistance and antibacterial performance, and has wide application prospects in the fields of skin care and medical health.

The invention belongs to the technical field of biology, and particularly relates to endolysin derived from staphylococcus warneri mild bacteriophage and application of the endolysin. The endolysin has a nucleotide sequence as shown in SEQ ID NO: 1 or a nucleotide sequence obtained after further optimization of the endolysin. The endolysin gene sequence is completely and successfully obtained on the basis of the staphylococcus warneri mild bacteriophage vBG3001, the endolysin protein (endolysin 65) is successfully expressed and purified, and the endolysin protein has an inhibition effect on the growth of a gram-positive bacterium bacillus velezensis and a gram-negative bacterium burkholderia. The staphylococcus warneri mild bacteriophage perforin gene and endolysin gene are co-expressed in escherichia coli, so that the staphylococcus warneri mild bacteriophage has relatively strong bactericidal activity on host escherichia coli. The effects provide a theoretical basis for prevention and treatment of gram-negative pathogenic bacteria.

The invention discloses an antibacterial peptide and application thereof in preventing and treating dental plaque and gingival problems, and belongs to the technical field of biology. According to the invention, two cationic antibacterial peptides LR18 and LR18-2 with amphiphilic alpha-helical structures are designed from the beginning. The two antibacterial peptides have good antibacterial and bactericidal activity on oral periodontal pathogenic bacteria (including fusobacterium nucleatum, porphyromonas gingivalis and streptococcus mutans), the minimum inhibitory concentration (MIC) is 62.5-500 [mu] g / mL, and the minimum bactericidal concentration (MBC) is 62.5-2000 [mu] g / mL. The structure is simple, the chemical synthesis difficulty is low, a high-purity product can be directly synthesized, the cell hemolytic activity is low, the safety is high, the product can be used for preparing oral antibacterial drugs and / or oral care products, and oral diseases are prevented and treated by inhibiting the growth of oral periodontal pathogenic bacteria.

The invention discloses a hymexazol-containing composition with an excellent sterilization effect and a preparation method, and relates to the technical field of agricultural bactericides, the composition comprises the following raw materials: modified graphene oxide loaded hymexazol, modified graphene oxide loaded metalaxyl, beta-oligomeric acid and a surfactant; the mass ratio of the modified graphene oxide loaded hymexazol to the modified graphene oxide loaded metalaxyl to the beta-oligomeric acid to the surfactant is (3-5): (1.5-2.5): (1-1.5): (0.8-1.2). The hymexazol composition provided by the invention has the advantages of excellent bactericidal effect, high utilization rate and small damage to the environment.

The present invention discloses a strain of Bacillus Velez FS‑3 and the bacteriocin produced and its application, belonging to the field of microbial application technology. The deposit number of the Bacillus Velez FS‑3 is CGMCC NO.30514. The strain has a good antagonistic effect on Gram-negative bacteria such as multidrug-resistant Escherichia coli. The bacteriocin PFS‑3 prepared by fermentation of the strain shows good safety and bactericidal activity, and has a good therapeutic effect on mice infected with Escherichia coli resistant to polymyxins and carbapenems. The bacteriocin PFS‑3 prepared by fermentation of Bacillus Velez FS‑3 of the present invention is expected to enrich the current existing antimicrobial drug library and provide new hope for the treatment of multidrug-resistant Gram-negative bacteria infection.

The invention discloses a bactericidal composition and application thereof in preventing and treating crop diseases caused by fusarium, the active ingredients of the bactericidal composition comprise luliconazole and an ergosterol biosynthesis inhibitor, and the mass ratio of the luliconazole to the ergosterol biosynthesis inhibitor is (4: 1)-(1: 4). It is found that the luliconazole compound can significantly improve the bacteriostatic effect of ergosterol biosynthesis inhibitors such as tebuconazole, prothioconazole and prochloraz on fusarium, and can be used for preventing and treating crop diseases caused by fusarium.

The application discloses a bactericidal composition and application thereof in prevention and treatment of crop diseases, and belongs to the technical field of plant disease prevention and treatment. An active ingredient of the composition comprises a compound ZJS178 with a structure as shown in formula (I) and a methoxy acrylate bactericide, and the bactericidal composition has excellent prevention and treatment effects on crop diseases caused by fusarium. The compound ZJS178 and the methoxy acrylate bactericide have a synergistic effect under certain matching conditions, and can significantly improve bacteriostatic activity and prevention and treatment effects. The composition provided by the application is composed of effective ingredients with different action mechanisms, can overcome and delay drug resistance of pathogenic bacteria, is safe for crops, and meets the requirements of pesticide reduction and synergism.

The invention provides a polysubstituted furancarboxylic acid derivative, a bactericidal composition and application. The structural formula of the polysubstituted furoic acid derivative is as shown in (I): # imgabs0. According to the invention, a natural polysubstituted furoic acid skeleton is subjected to structural modification, and a molecular design strategy combining bioinformatics and pharmacophore hybridization is adopted; a series of polysubstituted furan formate compounds, polysubstituted furan amide compounds and furan dihydrazide compounds are designed and synthesized; results show that part of the compounds show obvious bactericidal activity on crop pathogenic bacteria such as sclerotinia rot of colza, grape gray mold, wheat glume wilt, rice sheath blight disease, pear black spot and the like, can be used as a primer for development of novel bactericides, and can also be used as a bactericide or an effective component thereof for green prevention and control of agricultural pathogenic fungal diseases.

The invention belongs to the technical field of biological medicines, and provides a ciprofloxacin derivative as well as a preparation method and application thereof. The ciprofloxacin derivative provided by the invention has a structure as shown in a formula I, an electrostatic effect sequence (amino acid part) with positive charges is connected to a lipid part, and then a series of amphiphilic ciprofloxacin derivatives are formed through conjugation of Linker and ciprofloxacin. The electrostatic effect sequence with positive charges can enhance the interaction with a bacterial cell membrane with negative charges through electrostatic interaction, then the lipid part can be inserted into a phospholipid bilayer of the bacterial cell membrane, so that the integrity of the bacterial cell membrane is damaged, the ciprofloxacin derivative enters the cell, and the ciprofloxacin derivative is degraded. Finally, bacterial cell content leakage, bacterial chromosome breakage and bacterial cell death are caused. According to the amphiphilic ciprofloxacin derivative disclosed by the invention, the amphiphilic structure and the membrane destruction mechanism of the antibacterial peptide are simulated, so that the ciprofloxacin derivative shows the unique advantage that the drug resistance is not easy to generate. # imgabs0 #

The invention discloses a bacteriophage lyase mutant and application thereof. A large number of point mutations are constructed aiming at En6-1 protein, the phage lyase mutant 18 # with improved enzyme activity and higher acinetobacter baumannii bactericidal activity is screened from the point mutations, the minimum in-vitro inhibitory concentration of the phage lyase mutant 18 # to acinetobacter baumannii is 2.0 mu g / mL, and the acinetobacter baumannii can be efficiently killed.

The application discloses a kind of implant piezoelectric nano coating and its preparation method and application.The nano coating is composed of nano-flower-shaped barium titanate and gold nanoparticles loaded on its surface.In this application, gold nanoparticles are deposited on nano-barium titanate at high temperature by using the method of sodium citrate reducing tetrachloroauric acid. The nBTO@Au prepared by this method has obvious osteogenesis and antibacterial properties. The application provides a high reactivity, catalytic and non-invasive immediate treatment mode for peri-implantitis, which has wide application potential in implant post-disinfection, peri-implantitis treatment and improving implant survival rate.

This invention relates to the field of pesticides, specifically to a fungicide composition for foliar spraying, its preparation method, and application scheme. The active ingredients of the fungicide composition include quinoline copper and phosphite A. Phosphite A is selected from at least one of phosphorous acid, alkali metal salts or alkaline earth metal salts of phosphorous acid, alkylphosphonic acids containing C1-C6 groups of phosphorous acid or alkali metal salts of alkylphosphonic acids, alkaline earth metal salts, and aluminum salts. In the fungicide composition, the weight ratio of quinoline copper to phosphite A is 99:1 to 1:99. The fungicide composition of this invention has high activity against bacterial and fungal diseases occurring in various crops, such as canker and downy mildew, and also exhibits significant synergistic effects. It not only improves the antibacterial or bacteriostatic effect but also broadens the control spectrum. Simultaneously, it can reduce the number of applications and alleviate environmental pressure, thereby achieving the effect of prevention-oriented and integrated pest management.

The invention relates to the technical field of chemical pesticides, and discloses a thiocarbamic acid seleno-trithioester derivative as well as a preparation method and application thereof, and the structural formula of the derivative is a structure I and / or a structure II; the structure I is # imgabs0 #; and the structure II is # imgabs 1 #. The seleno-trithiocarbamate derivative obtained by the preparation method disclosed by the invention has relatively good antibacterial activity.

The invention provides an antibacterial peptide mutant and application thereof. The amino acid sequence of the antibacterial peptide mutant is as shown in SEQ ID NO: 1. The nucleotide sequence codes the antibacterial peptide mutant, and the nucleotide sequence is as shown in SEQ ID NO: 2. The antibacterial peptide mutant provided by the invention can resist heat up to 120 DEG C, and can resist extreme strong acid and strong alkali environments with pH of 1-13 at normal temperature. The protein has stable physiological and biochemical properties, can tolerate hydrolysis of pepsin and trypsin with certain concentration, and has no hemolytic activity. The mutant of the Mccj25 antibacterial peptide provided by the embodiment of the invention has good bactericidal activity, can reduce the use cost of the antibacterial peptide to a certain extent, reduces the addition amount of the antibacterial peptide, and has a good application prospect.

The present invention relates to an aromatic hydrazide compound or an agronomically acceptable salt thereof as shown in formula I-1 and a preparation method thereof, as well as use thereof as a plant antibacterial agent, wherein some compounds show excellent fungicidal activity.

The invention provides an ametoctradin and oxine-copper compounded pesticide suspending agent. The active ingredients of the suspending agent comprise ametoctradin and oxine-copper, the active component accounts for 7.5 wt%-65 wt% of the suspending agent; wherein the content of ametoctradin in the suspending agent is 5wt%-30wt%, and the content of oxine-copper in the suspending agent is 2.5 wt%-35wt%; and the balance of auxiliaries and water. In addition, the invention further provides a preparation method and application of the ametoctradin and oxine-copper compounded pesticide suspending agent, the suspending agent is effective for preventing and treating cucumber downy mildew, and experiments prove that the compounded suspending agent has more obvious effect than a single component of ametoctradin and a single component of oxine-copper in the aspect of preventing and treating cucumber downy mildew.

The invention discloses application of a carbazole derivative in preventing and treating plant diseases, and relates to the technical field of medicinal chemistry. The carbazole derivative disclosed by the invention has the following structure: # imgabs0. The carbazole derivative disclosed by the invention has an excellent inhibition effect on plant pathogenic bacteria such as rice bacterial leaf blight pathogenic bacteria Xanthomonas oryzae ACCC 11602, citrus canker pathogenic bacteria Xanthomonas axonophora pv.Citri, bacterial wilt pathogenic bacteria Pseudo-monas solamacearum and soft rot pathogenic bacteria Erwinia aroideae, and the carbazole derivative disclosed by the invention is simple in structure, cheap in raw materials and easy to synthesize, and has further research and development values.

A construction method of an aerogel solid drug delivery system for treating blepharitis ciliaris belongs to the technical field of ophthalmology medical treatment, and adopts the scheme as follows: step 1, dissolving a partial polar drug in an ethanol solution to obtain a solution A, adding a metal frame carrier into the solution A, stirring, centrifuging and drying to obtain a partial polar drug-metal frame drug delivery system; step 2, fully crosslinking an aerogel material, a partial polar drug-metal framework drug delivery system and a crosslinking agent, adding a volatile oil component, and stirring until no bubble exists, so as to obtain a mixed glue solution B; or fully cross-linking the aerogel material, the volatile oil component and the cross-linking agent, stirring until no bubble exists, breaking into a thick liquid state, adding the partial polarity drug-metal framework drug delivery system, and uniformly stirring to obtain a mixed glue solution C; and step 3, freeze-drying the mixed glue solution B or the mixed glue solution B to obtain the aerogel solid-state drug delivery system for treating blepharitis ciliaris. The bactericidal effect of the dressing is obviously higher than that of traditional dressings.

The present application relates to a kind of arylamino-containing xanthine derivatives and its preparation method and application.On the basis of 1,3-disubstituted xanthine raw material, arylamino-containing xanthine derivatives obtained by series of reactions are shown as general formula I.Compounds of general formula I have higher herbicidal activity, and have obvious activity on rape, amaranthus retroflexus, barnyard grass, crabgrass, have good insecticidal activity, especially on the effect of diamondback moth is remarkable, have good fungicidal activity, and have obvious in vitro inhibitory activity on wheat scab fungus, pepper phytophthora blight fungus, sclerotinia sclerotiorum, cucumber fusarium wilt fungus, apple phialophora quercina, wheat sharp eyespot fungus, etc.Compounds of general formula I can be used as active components of herbicidal or insecticidal or fungicidal composition, for preparing agricultural herbicide or insecticide or fungicide, and can be used for the prevention and treatment of grass damage or insect damage or pathogenic damage on various crops.Also have good inhibitory effect on the activity of KARI, and can be used for KARI inhibitor.

The invention provides an isoquinoline-3-acylhydrazone aromatic cycloalkene compound and application thereof in plant disease control. The structural general formulas of the isoquinoline-3-acylhydrazone aromatic cycloalkene compound are shown as a formula 1, a formula 2 and a formula 3: imgabs0 # R1 is one of hydrogen atoms, hydroxyl groups, fluorine atoms, chlorine atoms, bromine atoms, trifluoromethyl, amino groups, sulfydryl groups, C1-12 alkyl groups, C1-6 alkoxy groups, C1-6 alkyl amino groups and C1-6 alkyl sulfydryl groups. The isoquinoline-3-acylhydrazone aromatic cycloalkane compound disclosed by the invention is applied to prevention and treatment of plant fungal diseases caused by fungal germs in agriculture. The raw materials of the isoquinoline-3-acylhydrazone aromatic ring / naphthenic compound are easy to obtain, the synthesis method is simple and practical, the cost is low, the compound has an excellent inhibition effect on plant fungal diseases, the structure is novel, and research results have positive significance on creation of new pesticides.

The present invention belongs to the technical field of pesticide sterilization, and discloses a mandipropamid-containing sterilization composition, the sterilization composition comprises an active component A and an active component B, the active component A is mandipropamid, the active component B is any one of fluoxapiprolin or flufenoxadiazam, and the mass ratio of the active component A to the active component B is 1: 50-30: 1. The bactericidal composition disclosed by the invention has a remarkable synergistic effect on diseases caused by plant oomycetes pathogenic bacteria, the application amount and the application frequency of chemical pesticides are reduced, the application efficiency is improved, the agricultural production cost is reduced, the generation and development of drug resistance of pathogenic bacteria are slowed down, and pesticide residues are reduced; the agricultural product food safety is guaranteed while the farmland ecological environment is protected.

The invention relates to the technical field of chemical pesticides, and discloses thiocarbamate selenotrithioate derivatives and preparation methods and applications thereof, wherein the structural formula of the derivatives is structure I and / or structure II; the structure I is:; the structure II is:. The thiocarbamate selenotrithioate derivatives obtained in the invention have good antibacterial activity.

The invention provides a five-membered heteroaryl compound. (In the formula, Q1 and Q2 each represent a phenyl group or the like, B1, B2 and B3 each represent an oxygen atom, a nitrogen atom, NR1, CR2, R1 represents an alkyl group or the like, R2 represents a hydrogen atom or the like, Za represents an oxygen atom or the like, T represents a partial structure (T-1) or (T-2), Z represents an oxygen atom or the like, R6 represents a hydrogen atom or the like, Zb represents an alkoxy group or the like, R7 represents RcCO-or the like, Rc represents an alkyl group or the like, R4 and R5 each represent a hydrogen atom or the like, and n represents an integer of 1-3).

The invention relates to the technical field of adhesives, in particular to a high-toughness polyacrylate adhesive, a preparation method and application of the high-toughness polyacrylate adhesive to a silicon-based negative electrode of a lithium ion battery. The polyacrylate binder is prepared by the following steps: carrying out a reaction on nano silicon dioxide and diethylenetriamine propyl trimethoxy silane, so as to prepare modified nano silicon dioxide; after polypropylene glycol reacts with excessive hexamethylene diisocyanate, polypropylene glycol reacts with modified nano silicon dioxide, and a composite toughening modifier is prepared; and adding the composite toughening modifier into the polyacrylate binder to obtain the polyacrylate binder. The prepared polyacrylate binder is high in toughness, can be applied to a silicon-based negative electrode of a lithium ion battery, and can effectively cope with stress generated by volume expansion of silicon particles as a silicon-based negative electrode binder.