49 results about "Serositis" patented technology

The invention discloses an antibacterial antivirus Chinese medicinal composition for the animal, comprising the following main medicament ingredients: scutellaria extract, honeysuckle extract, isatis root extract and glycyrrhiza extract. the pharmaceutical composition of the invention can be made into premix, injection, oral liquid or granula, also can be made into feedstuff premix adding into the feedstuff. the chinese medicinal composition of the invention is a pure Chinese medicinal compound preparation which has the antibacterial, anti-inflammation, antivirus and immunity-reinforced functionsand wide application range, can effectively prevent and treat various livestock and poultry diseases caused by the virus and the bacteria, such as piggyyellow-white dysentery, swine plague, infectious pleuropneumonia, asthma, canker, circovirus, swine influenza, white diarrhea, newcastle disease, bursa of Fabricius, egg drop syndrome, duck serositis and the like, and has fast effect and remarkable curative effect.

The invention relates to a mixed yolk antibody for preventing and controlling infective oromeningitis and a preparation method thereof, and belongs to the technical field of biological agent preparation and poultry disease prevention and control. The invention takes a main epidemic serotype strain of duck plague pasteurella anatipestifer as an antigen to prepare the duck plague pasteurella anatipestifer hyperimmune yolk antibody. Infection treatment experimental results show that the prepared yolk antibody has the protection ratio for serotype I and serotype II duck plague pasteurella anatipestifer respectively reaching 80 percent and 90 percent. The product provides a new way to the prevention and control of duck infective oromeningitis and can be used for the preparation of veterinary medicines for controlling the disease or be prepared into health care products or feed additives for use. Moreover, the yolk antibody provides a material basis for improving the livestock product quality, reducing medicinal residue and promoting the human food safety.

The invention discloses a meat duck environmentally-friendly breeding feed additive. For solving the problems of medicine resistance, medicine residue and environment pollution of the conventional feed additive, the invention provides a composite feed additive which is prepared from various natural traditional Chinese medicinal herbs including houttuynia cordata, philippine violet herb, coptis chinensis, bupleurum, sweet wormwood, notopterygium root, astragalus and tangerine peel, and probiotic. According to measurement by spectrophotometry, all of the selected traditional Chinese medicine herbs including the houttuynia cordata, philippine violet herb, coptis chinensis, bupleurum, sweet wormwood, notopterygium root, astragalus and tangerine peel can promote the propagation of the lactobacillus in the probiotic to different extents and have the effects of preventing serositis of duck and improving immunity of duck and the function of a lactobacillus synergist. The feed additive has the advantages of synergetic effect, no residue and environmental friendliness.

The invention relates to a vaccine immunologic adjuvant and a vaccine, in particular to an astragalus polyose adjuvant and application thereof in an I-riemerella anatipestifer inactivated vaccine. The vaccine adjuvant is an astragalus polyose solution with the concentration of 30 milligrams per milliliter. An astragalus polyose inactivated vaccine for the I-riemerella anatipestifer is prepared from a riemerella anatipestifer RA-1 inactivated bacteria liquid as the vaccine and the astragalus polyose solution as the adjuvant through mixing. The astragalus polyose adjuvant improves the immune efficacy of the prior inactivated vaccine, effectively prevents and controls infectious serositis of duck, and provides a basis for the research of a novel immunologic adjuvant. The vaccine has good safety and immunogenicity, and can effectively prevent the infectious serositis of duck.

The invention discloses a traditional Chinese medicine composition for treating chicken and duck diseases. The traditional Chinese medicine composition aims at the aetiological agents of colibacillosis of chickens and infectious serositis of ducks so as to effect a permanent cure. The temperature inside a barn is proper, but temperature outside the barn is too low so as to cause skin surface chill and internal heat accumulation of the chickens and ducts in the process of ventilation, group expanding, and the like to cause the colibacillosis of chickens and the infectious serositis of ducks. Aiming at the aetiological agents, the invention is added with traditional Chinese medicine for inducing diaphoresis, dispelling cold and clearing internal heat on the basis of a traditional prescription for invigorating the spleen to arrest diarrhea and clearing away heat and toxic material, thereby having the advantages of treatment of both principal and secondary aspect of disease, fast effect, good treating effect and low cost without side effects.

The invention relates to a Riemerella anatipestifer bivalent inactivated vaccine and a preparation method thereof, which belongs to the technical field of preparing livestock biological preparations and controlling poultry diseases. The antigens of the vaccine are a Riemerella anatipestifer serum I strain and a serum II strain, and the proportion of the strain antigens is proper in fit. The immune period can be as long as more than 70 days through one injection of the vaccine, and the immune protection efficiency to serum I and serum II reaches more than 90 percent. The vaccine has the advantages of simplifying immunization procedures, reducing the stress reaction of inoculate animals and saving cost for production and injection. The vaccine used for commercial production can end the reality that the control on duck infectious serositis in China excessively depends on drugs, and can provide strong technical support and material guarantee for the healthy stable development of the duck breeding industry.

The invention discloses a duck infectious serositis inactivated vaccine emulsification method which comprises the following steps of: water phase preparation: loading four parts of Tween-80 into a bottle to be sterilized, adding 96 parts of germ liquid after cooling and sufficiently vibrating and shaking until the Tween-80 is completely dissolved; oil phase preparation: adopting 93 parts of white oil for injection, 5 parts of spun-80 and 2 parts of aluminum stearate, firstly taking a small amount of white oil for injection to be mixed with the aluminum stearate while preparing the oil phase, heating and dissolving the mixture, then, uniformly mixing the total amount of spun-80 with the white oil for injection, stirring the mixture until in the transparent state, and sterilizing for 30 minutes at 116 DEG C for use; and emulsifying the water phase and the oil phase according to a proportion of 1:1.5 to 1:1.3 at the rotating speed of 3200 to 4800 r / min for 8 to 12 minutes.

The invention discloses an antibacterial antivirus Chinese medicinal composition for the animal, comprising the following main medicament ingredients: scutellaria extract, honeysuckle extract, isatis root extract and glycyrrhiza extract. the pharmaceutical composition of the invention can be made into premix, injection, oral liquid or granula, also can be made into feedstuff premix adding into thefeedstuff. the chinese medicinal composition of the invention is a pure Chinese medicinal compound preparation which has the antibacterial, anti-inflammation, antivirus and immunity-reinforced functionsand wide application range, can effectively prevent and treat various livestock and poultry diseases caused by the virus and the bacteria, such as piggyyellow-white dysentery, swine plague, infectious pleuropneumonia, asthma, canker, circovirus, swine influenza, white diarrhea, newcastle disease, bursa of Fabricius, egg drop syndrome, duck serositis and the like, and has fast effect and remarkable curative effect.

The invention belongs to the technical field of biological products for veterinary uses, in particular to a method for preparing a riemerella anatipestifer and escherichia coli bigeminal inactivated vaccine and a preparation method thereof. The vaccine is prepared by inoculating riemerella anatipestifer I type, riemerella anatipestifer II type and escherichia coli O78 type which have excellent immunogenicity into a culture medium for culture, using formaldehyde solution to inactivate the bacteria and emulsifying the resulting product by an oil adjuvant. The bigeminal inactivated vaccine is used for preventing and controlling infectious serositis and colibacillosis of a duck. The preparation method of the vaccine has a simple operation; and the prepared vaccine has stable performance and can effectively prevent and control the infectious serositis and the colibacillosis of the duck.

The invention relates to duck escherichia coli with strong virulence and good immunogenicity; and the preservation number of the strain is CGMCC No.6831. The invention further provides a duplex inactivated vaccine which comprises vaccine adjuvant and antigen, wherein the antigen is the duck escherichia coli with preservation number of CGMCC No.6831 and riemerella anatipestifer with preservation number of CGMCC No.6832. The prepared duplex inactivated vaccine of the duck escherichia coli and the riemerella anatipestifer can prevent duck colibacillosis with characteristic pathological changes, such as cellulose exudative inflammation in the heart or the liver for causing duck escherichia coli septicemia, pericarditis or pleural adhesions as characteristics, and can prevent duck infectious serositis with neurological sign, fibrinous pericarditis, perihepatitis and air sacculitis as characteristics, so that excellent market promotion foreground is achieved.

The invention aims at providing a Chinese medicament for preventing and treating infectious serositis of duck, which consists of the following raw materials in parts by weight: 1 to 5 parts of musk, 1 to 5 parts of xanthiun sibiricum patrin ex wider, 1 to 5 parts of peony flower, 1 to 5 parts of plantain seed, 1 to 5 parts of myrrh, 5 to 10 parts of climbing groundsel herb, 5 to 10 parts of Japanese climbing fern spore, 5 to 10 parts of folium isatidis, 5 to 10 parts of cistanche, 5 to 10 parts of Chinese lespedeza, 10 to 15 parts of mint, 10 to 15 parts of honeysuckle, 10 to 15 parts of radix curcumae, 10 to 15 parts of asparagus, 10 to 15 parts of mulberry, 15 to 20 parts of polygonum multiflorum, 15 to 20 parts of red ginseng, 15 to 20 parts of semen boitae, 15 to 20 parts of tropaeolum majus, and 15 to 20 parts of borneol. The Chinese drugs are baked and crushed into fine powder of between 300 and 400 meshes in the proportion of the prescription, homogenized for 10 to 30 minutes with ultrasonic wave at a temperature of between 0 and 10 DEG C, and subpackaged to obtain the finished product. The Chinese medicament for preventing and treating infectious serositis of duck does not have drug resistance, and is safe and effective.

The invention relates to Chinese and western medicine powder for preventing and treating duck serositis. The Chinese and western medicine powder comprises the following components in parts by weight: 12-18 parts of cortex phellodendri, 13-20 parts of radix isatidis, 14-16 parts of dandelion, 15-22 parts of root of Chinese pulsatilla, 6-12 parts of honeysuckle, 8-12 parts of scutellaria baicalensis, 10-14 parts of fructus forsythia and 4-6 parts of ribavirin. The preparation method comprises the following steps: firstly drying, cooling, crushing and mixing various components except for ribavirin evenly according to the ratio during preparation; adding 4-6 parts of ribavirin raw powder with the mass fraction being 98%; and mixing evenly, drying, cooling, and packaging to obtain the Chinese and western medicine powder for preventing and treating duck serositis. The Chinese and western medicine powder disclosed by the invention has the advantages of being high in recovery rate, free of a toxic or side effect, significant in curative effect, free of drug tolerance, free of a drug residue, low in cost and price, and simple in preparation process, simultaneously is capable of enhancing the disease resistance of the infected duck, and can be widely applied to prevention and treatment of duck serositis; and duck serositis is not easy to recur after healing.

The invention provides a traditional Chinese medicine composition for preventing and treating duck infectious serositis and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 4-6 parts of oriental wormwood, 5-7 parts of malt, 1-2 parts of isatis root, 1-2 parts of honeysuckle, 1-2 parts of felwort, 1-2 parts of cape jasmine, 1-2 parts of root of Chinese thorowax, 1-2 parts of radices sileris and 1-2 parts of licorice root. The traditional Chinese medicine composition for preventing and treating the duck infectious serositis is prepared by grinding and mixing, is a reasonable traditional Chinese medicine prescription and an effective medicament for preventing and treating the duck infectious serositis for the duck husbandry, and is quick and curative in treatment effect, free of drug residue and toxic or side effect, difficult to generate drug tolerance, simple in preparation process, suitable for large-scale industrial production and is the first choice to treat the duck infectious serositis.

The invention provides a preparation method of a microencapsulated oral vaccine for infectious serositis of ducks, and belongs to the technical field of veterinary biological products. The method comprises the steps of preparing, enriching and purifying of a vaccine preparing bacteria solution, inactivating, microcapsule coating and the like. The microencapsulated oral vaccine for the infectious serositis of the ducks can be used for prophylactic vaccination of the ducks by water drinking or feeding, and compared with a traditional injection immunization route, the microencapsulated oral vaccine is simpler and more convenient, saves time and labor, can effectively avoid occurrence of side reactions in injection sites, is conducive to improving of quality of meat, and has a good prospect oflarge-scale application.

The invention relates to a traditional Chinese veterinary medicine for treating duck infectious serositis diseases. The traditional Chinese veterinary medicine is prepared from the following raw materials in parts by weight: 5-10 parts of florfenicol, 1-5 parts of rifampicin, 8-15 parts of PEG 6000, 5-10 parts of PVP-K30, 5-10 parts of beta-cyclodextrin, 7-12 parts of tween-80, 15-25 parts of glycerol and 25-40 parts of purified water. The traditional Chinese veterinary medicine provided by the invention is easily available in raw material and low in price, is safe and does not have toxic or side effects on livestock and poultry bodies; and a preparation method of the traditional Chinese veterinary medicine, provided by the invention, is simple, easy to operate and suitable for large-scale production and popularization.

The invention provides a traditional Chinese medicine preparation for treatment for duck infectious serositis, which is characterized in that the traditional Chinese medicine preparation is prepared by mixing Chinese herbal medicines with the following parts by weight: 32 to 48 parts of Indian buead, 48 to 72 parts of wrinkled gianthyssop herb and 48 to 72 parts of common floweringquince fruit. The preferential mix ratio of the all components is as follows: 40 parts of Indian buead, 60 parts of wrinkled gianthyssop herb and 60 parts of common floweringquince fruit. The preparation method is as follows: all the components are smashed into ultra-fine powder, and the powder is evenly mixed according to a proportion, or the heating extraction is carried out to prepare oral liquor, and medical drinking tablets are weighed according to the proportion, 5 to 10 times of water is added for soaking for 20 to 40 minutes and carrying out the decoction for 50 to 80 minutes, the mixture is concentrated to that each milliliter contains 0.5 to 1g of the raw medicine after the filtration, thus preparing the traditional Chinese medicine preparation. The traditional Chinese medicine preparation has reasonable formula and simple preparation technology; the adopted ingredients of the Chinese herbal medicines have wide range of resources, low cost and high cure rate; the pure traditional Chinese medicine preparation has no pollution, no residue, no toxicity or side effects and is easy to be absorbed by the poultry; the traditional Chinese medicine preparation can effectively improve the immune function, shorten the recovery period and have very significant efficacy.

The invention discloses a duck infectious serositis living vaccine and a preparation method thereof. The duck infectious serositis living vaccine disclosed by the invention contains a riemerella anatipestifer strain GD12 and a freeze-drying protective additive, wherein the riemerella anatipestifer strain GD12 is delivered to China Center for Type Culture Collection to be collected on April 1, 2016, and has a collection number of CCTCC NO: M 2016161. The duck infectious serositis living vaccine disclosed by the invention is high in safety and does not cause any adverse reactions to ducks; the living vaccine has an excellent immune effect, is capable of obviously improving resistance of ducklings to duck infectious serositis caused by type 1 riemerella anatipestifer, can be used for clinically preventing the duck infectious serositis caused by type 1 riemerella anatipestifer, and has significant economic and social benefits.

The invention relates to a drug composition for poultry and a preparation method thereof. An oral liquid synergistic agent for duck serositis vaccine is prepared from the following materials by weight portion: 10 to 15 portions of artemisia capillaries, 2 to 5 portions of gastrodia tuber, 15 to 20 portions of schisandra chinensis, 10 to 20 portions of lamiophlomis rotata(benth)kudo, 20 to 25 portions of hawthorn, 10 to 15 portions of atractylodes, 10 to 15 portions of gentian, 2 to 5 portions of snake gall, 10 to 20 portions of ox gall, 40 to 60 portions of aloe, 25 to 40 portions of rock candy, 10 portions of rifampicin and 15 portions of polymyxin. The oral liquid synergistic agent can be fed by being directly mixed with normal feed of the poultry or directly with water drunk by the poultry to effectively improve the immunity of an organism, disease resistant capability and anti-stress capability, lower the ratio of infecting duck serositis and improve the preventing and treating effect of the duck serositis vaccine.

The invention relates to a rifampicin nano-grade suspension and a preparation method thereof. The rifampicin nano-grade suspension provided by the invention can be taken with drinking water. The stock solution of the suspension can be uniformly dispersed in water after being diluted, and a stable suspending state is maintained. The rifampicin nano-grade suspension provided by the invention is advantaged in convenient administration, reduced wasting, ensured dosage, high medicine dissolution rate, and increased saturated solubility of the medicine. With the nano-grade suspension and the preparation method, effects of rifampicin can be fully performed in the treatments of diseases such as poultry escherichia coli, salmonella, and duck serositis.

The invention relates to a traditional Chinese medicine preparation used for preventing and treating cairna moschata infectious serositis. The traditional Chinese medicine preparation is prepared from, by weight, 1 to 50 parts of radix puerariae, 1 to 50 parts of radix scutellariae, 1 to 40 parts of herba andrographitis, 1 to 40 parts of herb of spanishneedles, 1 to 30 parts of zornia gibbosa, 1 to 40 parts of honeysuckle stem, 1 to 30 parts of herba patriniae, 1 to 40 parts of herba abri, 1 to 30 parts of indigo naturalis, 1 to 20 parts of uncaria rhynchophylla, and 1 to 20 parts of honey-fried licorice root. The traditional Chinese medicine preparation is prepared based on cairna moschata infectious serositis clinical features, Chinese veterinarian dialectic theory, and duck infectious serositis-escherichia coli mixed infection pathogenesis with pertinence; duckling immunity can be improved effectively via synergistic effects of the ingredients above; and the traditional Chinese medicine preparation possesses excellent effect in preventing cairna moschata infectious serositis, is capable of reducing morbidity of cairna moschata infectious serositis obviously, and increasing cairna moschata survival rate.

The present invention relates to a muscovy duck survival rate improving feed during the brooding period. The feed comprises the following raw materials in parts by weight: pulsatilla chinensis 1-50 parts, scutellaria baicalensis 1-50 parts, tree peony barks 1-40 parts, anemarrhena asphodeloides 1-40 parts, bidens pilosa 1-40 parts, zornia gibbosa 1-40 parts, caulis lonicerae japonicae 1-40 parts, herba abri 1-40 parts, caulis akebiae 1-30 parts, belamcanda chinensis 1-30 parts, mint 1-20 parts, platycodon grandiflorus 1-20 parts, radix glycyrrhizae preparata 1-20 parts, corn 20-50 parts, bran 30-50 parts, sunflower seed meal 5-10 parts, inulin 8-10 parts, shellfish powder 8-10 parts, cottonseed cakes 5-10 parts, and soybeans 1-30 parts. The muscovy duck survival rate improving feed can promote the absorption of minerals of ducklings, increase intestinal beneficial bacteria, and improve immunity of ducklings at the same time, has good functions of preventing muscovy duck infectious serositis, avian influenza, colibacillosis, etc., and can effectively reduce morbidity and mortality of ducklings, and improve the survival rate of ducklings.

The invention discloses a traditional Chinese medicine composition for treating multiple serositis and arthritis of pigs and a preparation method thereof. The composition is prepared from, by weight,3-9 parts of dwarf nasturtium, 7-21 parts of a partial flowering root, 4-12 parts of T.glandulosissimum var.chaotungense and 6-18 parts of trametes robiniophila. The traditional Chinese medicine composition has the advantages of both manifestation and root cause of disease treating, high overall therapeutic effect, short treatment period, difficult drug resistance, low residue and small side effects, and has important economic and social benefits for promoting the healthy development of the pig industry.

The invention discloses a medicine compound used to prevent and treat infectious serositis of ducks. The medicine compound is prepared by the following compositions that: each 100g of the medicine compound contains 5 to 10g of sodium sulfamethoxazole, 1 to 2g of trimethoprim lactate, 5 to 10g of mequindox, and the balance being pharmaceutically acceptable auxiliary materials. The invention provides the broad livestock industry with the medicine compound used to prevent and treat the infectious serositis of the ducks; the medicine compound has a simple preparation method, remarkable healing effect, simple and convenient use, and wide application range.

The invention provides traditional Chinese medicine powder for preventing and controlling infectious serositis of ducks. The traditional Chinese medicine powder comprises the following raw material medicines: red paeony root, cassia twig, platycodon grandiflorum, rhaponticum, herba epimedii, polygonum cuspidatum, houttuynia cordata, uncaria, fructus broussonetiae, Selaginella tamariscina, rhizoma acori graminei, sappanwood, sea-buckthorn, purslane, lycopodium clavatum, sedum sarmentosum, bilobate grewia, impatiens aquatilis, lawn pennywort herb and maidenhair. The traditional Chinese medicine powder is good in curative effect, safe and reliable and does not have harmful residues, and drug tolerance is difficultly generated.

The present invention relates to a vaccine composition, which contains inactivated riemerella anatipestifer antigen and live duck hepatitis virus antigen. The invention further provides application of the vaccine composition in preparation of products for concurrent prevention or treatment of breeding duck and / or young duck viral hepatitis and infectious serositis of ducks, and in preparation of products for increasing growth performances of young ducks. According to the present invention, the one-time immunization is adopted, such that the number of the vaccine injection can be reduced, the stress reaction of the young ducks can be reduced, and the impact on the young duck growth can be reduced; and the inactivated riemerella anatipestifer antigen and the live duck hepatitis virus antigen are adopted to combine so as to shorten the immunization production period of the duck hepatitis virus antigens, such that the vaccine composition is suitable for young duck immunization.

The invention aims to provide a traditional Chinese medicine composition for preventing and treating infectious serositis of duck, which is non-tolerance, safe and effective. Pericarpium granati, majoram, tongol aster herb, Chinese tuliptree bark and lindera setchuenensis gamble are used as the monarch drug for bacteriostasis, detoxicating and anti-inflammation; euonymus alatus, coriander, common wedgelet fern herb, oriental blechnum frond and centipede minima are used as the ministerial drug for detoxicating, antipyresis, antiviral and adjusting gastrointestinal motility; tree of heaven ailanthus leaf, moutan bark, menthe, anisodus luridus and eriocarpous glochidion leaf are used as the excipient for resisting stress and improving micro circulation; and folium isatidis, berchemia lineate, Peruvian groundcherry herb, ginger and shepherdspurse herb are used as the adjuvant drug. The traditional Chinese medicine composition is non-tolerance, safe and effective.

The invention relates to feed capable of improving the disease resisting property of white ducks. The feed comprises, by weight, 100-150 parts of milled broomcorn millet rice, 50-80 parts of wheat bran, 20-25 parts of kudzuvine roots, 8-10 parts of radish seeds, 10-15 parts of lard oil, 20-30 parts of salvinia natans, 10-18 parts of nymphoides peltatum, 30-33 parts of giant reed, 20-25 parts of nuphar pumila, 30-38 parts of broussonetia papyrifera leaves, 20-30 parts of pomacea canaliculata, 1-2 parts of vitamin C, 0.03-0.05 part of berberine, 3-5 parts of salt, 1-3 parts of red sugar, 1-1.5 parts of pumice powder, 2-3 parts of bentonite, 1-5 parts of vitamin D3 and 1-1.5 parts of nicotinic acid. The feed can promote the white ducks to eat more, the white ducks are fast in growth and high in disease resistance after eating the feed, and the feed can shorten the feeding period and simultaneously has the better effects of preventing bacterial diseases such as duck infectious serositis and escherichia coli.

The invention relates to a vaccine immunologic adjuvant and a vaccine, in particular to an astragalus polyose adjuvant and application thereof in an I-riemerella anatipestifer inactivated vaccine. The vaccine adjuvant is an astragalus polyose solution with the concentration of 30 milligrams per milliliter. An astragalus polyose inactivated vaccine for the I-riemerella anatipestifer is prepared from a riemerella anatipestifer RA-1 inactivated bacteria liquid as the vaccine and the astragalus polyose solution as the adjuvant through mixing. The astragalus polyose adjuvant improves the immune efficacy of the prior inactivated vaccine, effectively prevents and controls infectious serositis of duck, and provides a basis for the research of a novel immunologic adjuvant. The vaccine has good safety and immunogenicity, and can effectively prevent the infectious serositis of duck.

The invention provides a mycoplasma hyorhinis virulent strain and application thereof and relates to the technical field of microorganisms. The mycoplasma hyorhinis virulent strain disclosed by the invention is a mycoplasma hyorhinis HEF16 strain, and a preservation number is CCTCC NO:M2017462. The invention further provides application of the mycoplasma hyorhinis in establishing a mycoplasma hyorhinis toxin challenge pathogenesis model. When pure culture of the virulent strain is applied to toxin challenge, varieties of mycoplasma hyorhinis infected typical symptoms including polyserositis and arthritis can be induced; thus, virulence is strong, pathogenesis is quick, typical clinical manifestations can be shown within 7 days, morbidity situation is serious, pathogenesis can be achieved on different background pigs, and the mycoplasma hyorhinis virulent strain can be used for establishing the mycoplasma hyorhinis pathogenesis model with the typical symptoms and has representativeness.The invention further provides the application of the mycoplasma hyorhinis in preparing inactivated vaccines. The strain has good immunogenicity, and the prepared activated vaccines have a good toxinchallenge protection effect.