The invention discloses TOUGUGAO. The TOUGUGAO comprises a plaster matrix, chlorpheniramine, camphor, borneol and mentholum, wherein the weight ratio of the plaster matrix to the chlorpheniramine is 2500: 1, the camphor is 30-80 g, the borneol is 15-20 g, and the mentholum is 25-65 g; the plaster matrix comprises medicinal oil and yellow lead, the weight ratio of the medicinal oil to the yellow lead is 1: (0.3-0.6), the medicinal oil comprises sesame oil and fine medicinal powder obtained by crushing traditional Chinese medicinal materials, and the weight ratio of the sesame oil to the fine medicinal powder is (1.5-4): 1; the traditional Chinese medicinal materials comprise notopterygium roots, ligusticum chuanxiong hort, caulis spatholobi, radix angelicae pubescentis, radix paeoniae rubra, radix clematidis, radix saposhnikoviae, lycopodium clavatum, garden balsam stems, radix aconiti, radix aconiti agrestis, olibanum, nux vomica, rhizoma corydalis, asarum, cinnamon, radix gentianae macrophyllae, radix achyranthis bidentatae, rhizoma dioscoreae septemlobae, radix dipsaci, rhizoma cibotii, rhizoma curcumae longae, radix stephaniae tetrandrae, radix angelicae sinensis, eucommia ulmoides, anisodus mairei, herba achilleae, sanguis draxonis, rhizoma drynariae, safflower carthamus, rhizoma atractylodis, myrrh, cassia twigs, pyrola, obscured homalomena rhizome, corydalis amabilis, mulberry twigs, agkistrodon, centipedes, leeches, ground beetles and scorpions. The invention further discloses a preparation method of the TOUGUGAO.