38 results about "Chloranthus japonicus" patented technology

The invention discloses compounds with anti-tumor activity in chloranthus japonicus as well as effective parts and the purpose thereof. In the invention, three novel compounds with stronger anti-tumor activity are separated from the chloranthus japonicus which is a traditional Chinese medicine, i.e. a chloranthus japonicus element A, a chloranthus japonicus element B and a chloranthus japonicus element C. The method for separating the compounds comprises the following steps of: sequentially extracting a chloranthus japonicus extractive obtained by refluxing with 95% ethanol by using petroleum ether, ethyl acetate and n-butyl alcohol, and collecting the part obtained by ethyl acetate extraction; or degreasing the chloranthus japonicus extractive obtained by refluxing with 95% ethanol by using petroleum ether, carrying out macroporous resin column chromatograph, and eluting by using H2O, 50% alcohol and 95% alcohol sequentially; and carrying out silicagel column chromatography and ODS column chromatography on the ethyl acetate extracting part and the 50% alcohol component, and separating a prepared liquid phase to obtain the three compounds. Proved by in vitro anti-tumor activity research, the three compounds can remarkably restrain common tumor cells, have remarkable anti-tumor activity and can be used for developing novel anti-tumor harmfulless medicaments prepared from natural traditional Chinese medicines.

The invention belongs to the fields of chemical industry and medicine, and relates to an application of chloranthus japonicus alcohol M in preparation of anti-neoplastic drugs. The invention provides the application of the chloranthus japonicus alcohol M in preparation of the anti-neoplastic drugs. Cancer cells comprise hepatoma carcinoma cells, cervical cancer cells, leucocythemia cells, and pancreatic cancer cells. The chloranthus japonicus alcohol M belongs to a natural product, is low in toxic side-effect, high in bioavailability, and stable in property, and has clinical use value. A small molecule compound of the chloranthus japonicus alcohol M is used as a novel anti-neoplastic drug or an auxiliary element of the novel anti-neoplastic drug to be developed, tumor suppression effect is obvious, green environmental protection is achieved, and a novel method and a novel means are supplied for tumour treatment and cure.

The present invention discloses a fermented feed containing humic acid chelated trace elements. Bacterium strains are inoculated into a fermentation medium containing the humic acid chelated trace elements and the mixture is fermented to obtain the fermented feed containing the humic acid chelated trace elements. The fermentation medium is composed of fermentation materials and water. The raw materials of the fermentation materials consist of 10-20 parts of soybean meal, 20-45 parts of bran, 5-10 parts of humic acids, 40-50 parts of stone powder, 5-10 parts of chloranthus fortunei, 5-10 parts of chloranthus japonicus, 4-8 parts of apocynum venetum leaves, 4-8 parts of conyza blinii, 4-8 parts of folium microcotis and 0.7-1.4 parts of the humic acid chelated trace elements. The present invention also discloses a preparation method of the fermented feed. The fermented feed is prepared by the chelation of the humic acids and trace elements, helps alleviate the problems of resource wastes and environmental pollutions caused by the additions of the inorganic trace elements, and solves the problems that the amino acid trace element chelate is high in production costs and not conducive to wide uses.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a formula and a preparation method of a traditional Chinese medicine for treating chilblain. The traditional Chinese medicine is prepared from the following components in parts by weight: 10-35 parts of mongolian ammopiptanthus leaf, 10-30 parts of dried ginger, 2-8 parts of flos carthami, 5-18 parts of radix angelicae pubescentis, 10-20 parts of pepper, 15-25 parts of haws, 15-25 parts of farfugium japonicum, 3-8 parts of asarum, 10-20 parts of cinnamon, 3-8 parts of dragon blood, 5-15 parts of cortex phellodendri, 10-20 parts of licorice roots, 2-10 parts of Chinese dates, 3-8 parts of clematis chinensis and 3-8 parts of mirabilite. The preparation method comprises the following steps: adding mongolian ammopiptanthus leaf, asarum, dragon blood, radix clematidis and chloranthus japonicus into water, and decocting for the first time; adding dried ginger, flos carthami, radix angelicae pubescentis, pepper, haws, farfugium japonicum, cinnamon, cortex phellodendri, licorice roots, Chinese dates, clematis chinensis, masson pine, sambucus chinensis, solidago decurrens, akebia trifoliata, garlic, lindera glauca, stephania japonica, sargentodoxa cuneata and radix achyranthis bidentatae, and decocting for the second time; adding mirabilite into the materials in the step 2, decocting for the third time, and filtering residues to obtain decoction. The composition is prepared from natural traditional Chinese medicinal raw materials, and is simple and convenient to prepare, wide in medicinal material source and low in cost.

The invention relates to a plant protective agent as well as a preparation method and application thereof. The plant protective agent comprises active pharmaceutical ingredients and an auxiliary agentin a mass ratio of 2:3 to 3:1. The active pharmaceutical ingredients comprise, by mass, 20-45% of a Chinese pulsatilla root extract, 10-30% of a chloranthus japonicus extract, 15-25% of a Clematis armandii extract, 12-25% of an extract of Anemone tomentosa (Maxim.) Pei and 10-20% of an extract of Euphorbia lathyris. The plant protective agent provided by the invention has an insecticidal effect of 97% or above on pine caterpillars, and has the same pesticide effect as that of 2.5% deltamethrin as a pesticide; the positive protection effect is achieved on larch forest belts in Qinling Mountainforest areas; the lethality of the plant protective agent on natural enemy insects of the pine caterpillars, namely Telenomus dendrolimusi Chu, is far less than that of a pesticide; besides, the rawmaterials of the plant protective agent are all from rich plant resources in Qinling Mountain regions, the raw materials are easy to obtain, the residual effect period of the plant protective agent isshort, and damage to the Qinling Mountain ecological environment is small.

The invention discloses a feed additive composition, and particularly relates to a feed additive composition for improving Boer goat immunity. The feed additive composition comprises, by weight, 7-9 parts of neocinnamomum poilanei, 5-7 parts of cantonese speranskia, 4-6 parts of oenothera stricta roots, 4-6 parts of coriander and 2-4 parts of chloranthus japonicus sieb. The feed additive composition has the advantages that antibiotic is omitted, the composition is prepared from the traditional Chinese medicinal materials, the capacity of Boer goats for resisting cold can be improved, and the cold catching probability of the Boer goats is reduced.

The invention belongs to the fields of medicine and genetic engineering, and relates to an application of a traditional Chinese medicinal monomer, namely shizukaol D, in preparing medicines and an application method of the shizukaol D. The invention provides the application of the traditional Chinese medicinal monomer, namely the shizukaol D, in preparing the anti-tumor target medicines, in particular an application in preparing a Wnt pathway inhibitor. The invention also provides a corresponding kit for testing activity of a Wnt pathway, a method for inhibiting Wnt signal pathway of in-vitro tumor cells and a pharmaceutical composition for inhibiting the Wnt pathway. According to the application provided by the invention, a novel lead compound is provided for the Wnt pathway inhibitor, a novel method and a novel approach are offered for inhibiting the Wnt pathway of the cells and a novel application is provided for the traditional Chinese medicinal monomer, namely the shizukaol D; therefore, medicinal value of a plant source, namely chloranthus japonicus, of the shizukaol D is enhanced.

The invention relates to a traditional Chinese medicine for treating liver cirrhosis. The traditional Chinese medicine for treating liver cirrhosis is prepared by using the following medicinal materials, by weight, 12 parts of Hedyotis caudatifolia, 5 parts of Fructus Tribuli, 8 parts of Semen cassiae sopherae, 5 parts of Spine of Common Jujube, 10 parts of Balanophora involucrata Hook. F., 15 parts of Arthraxon hispidus, 14 parts of Desmos chinensis Lour, 10 parts of Chloranthus japonicus, 10 parts of Cyclosorus acuminatus, 10 parts of Herba Stellariae Saxatilis, 12 parts of Isatis oblongata DC., 14 parts of Thinleaf Mockorange, 10 parts of Mahonia bealei Carr, 8 parts of chrysanthemum sprout, 10 parts of Hypolepis punctata, 12 parts of Woolly Sterculia and 14 parts of Buddleia davidii Franch.. Clinic experiments prove that the liver cirrhosis can be safely and effectively treated by using the traditional Chinese medicine.

The invention discloses a process for preparing chloranthalactone A. The process includes the steps of purifying Chloranthus japonicus Sieb. extractives by using the high-speed counter-current chromatography, subjecting to online detection with an ultraviolet detector, collecting compositions according to maps, and preparing the chloranthalactone A once. The process has the advantages of being efficient, fast and large in preparation quantity and is applicable to preparation of the chloranthalactone A.

The invention provides a medicine for retarding breast cancer cell division. The medicine is prepared by mixing plant extracts or modified extracts. The plants comprise chloranthus japonicus, allium plants, poplar plants, garden balsam stems and mimosa pudica. Through experimental research of the inventor, the pharmaceutical composition has an extremely remarkable curative effect in the aspect of treating breast cancer, can inhibit breast cancer cell proliferation, and can avoid toxic and side effects caused by chemical drugs.

The invention discloses a linderane type sesquiterpene compound separated from a chloranthus japonicus extract, the structural formula of the linderane type sesquiterpene compound is shown in the specification, research is carried out through cell experiments such as Transwell, scratch experiments and three-dimensional culture, and the result shows that the compound can reverse epithelial cell-mesenchymal transition (EMT) of hepatoma carcinoma cells, so that invasion and metastasis of the hepatoma carcinoma cells are inhibited, and the linderane type sesquiterpene compound has a good application prospect. The obvious effect can be achieved on liver cancer treatment.

The invention discloses biomedical use of chloranthus japonicus sied lactone D serving as an indoleamine 2, 3-dioxygenase 1 inhibitor. Chloranthus japonicus sied lactone A, chloranthus japonicus siedlactone C, chloranthus japonicus sied lactone D, chloranthus japonicus sied lactone E and chloranthus japonicus sied lactone F are discovered to be effective inhibitors of indoleamine 2, 3-dioxygenase1 (IDO1). Many investigations indicate that abnormal expression of IDO1 is related to a tumor cell fleeing immune system, and therefore, IDO1 is expected to be a new tumor treatment strategy. Currently, indoximod, epacadostat and NLG 919 are IDO1 inhibitors in the clinical phase, and multiple inhibitors are at the biological activity testing stage; the IDO1 inhibitor is promising.

The invention discloses a traditional Chinese medicine for treating a liver Qi stagnation syndrome of breast cancer and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for treating the liver Qi stagnation syndrome of the breast cancer is prepared from the following medicinal raw materials: snakegourd peel, costustoot, aspongopus, beautiful sweetgum fruit, pericarpium citri reticulatae viride, rhizoma cyperi, fingered citron, citron fruit, semen aesculi, rose, semen litchi, indian lettuce, japanese ampelopsis root, fructus forsythiae, ipomoea pescaprae, edible tulip, stephania cephalantha, salvia chinensis, uraria crinita root, fiveleaf akebia fruit, chloranthus japonicus sieb, Chinese angelica and cynanchum otophyllum. The traditional Chinese medicine for treating the liver Qi stagnation syndrome of the breast cancer has the beneficial effects that the traditional Chinese medicine for treating the liver Qi stagnation syndrome of the breast cancer has the effects of soothing liver and regulating qi, eliminating carbuncle and removing stasis as well as replenishing blood and activating blood and is mainly used for treating the liver Qi stagnation syndrome of the breast cancer, theories of traditional Chinese medicine are utilized, an attention is paid to holism concept, generation and operation of qi and blood of an organism are regulated, differential treatment is carried out, treatment with emphasis on different clinical manifestations is realized, effect is taken quickly, medicinal herb resource is wide, cost is low, a preparation method is simple, an administration approach is convenient and can be easily accepted by a patient, and clinical market promotion can be carried out.

The invention discloses a traditional Chinese medicinal preparation for treating cerebral thrombosis and a preparation method thereof, and belongs to the field of traditional Chinese medicines. Effective components in the traditional Chinese medicinal preparation are prepared from the following raw materials: benzoin, Chinese azalea fruit, chloranthus japonicus, martianus dermestoides chevr, veronicastrum herb, camphor root, nude fern herb, mioga ginger, henbit, crinite pogonatherum herb, Japanese ladyslipper herb with root, divaricate saposhnikovia root, potentilla chinensis, rhizoma arisaematis, style pachysandra herb and mustard. The traditional Chinese medicinal preparation is prepared from compatible medicinal materials, accords with traditional Chinese medicine and modern medical theory, has the effects of dispelling wind and eliminating dampness, regulating qi circulation and activating blood, eliminating stasis to subdue swelling and protecting liver and bile, is convenient to use and good in absorption effect, does not have adverse or toxic or side effects. Clinical verification proves that the traditional Chinese medicinal preparation has extremely good relieving and treating effects on cerebral thrombosis and thrombus extension control, and is suitable for cerebral thrombosis clinical treatment and nursing popularization and application.