181 results about "Primary dysmenorrhoea" patented technology

The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti-inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and/or conditions mediated by levels of β-amyloid are described.

The invention discloses a composition taking cycloartenyl ferulate and 24-methylene cycloartenyl ferulate as active ingredients, a preparation of the composition used as a medicine, and an application of the preparation. The total content of the cycloartenyl ferulate and the 24-methylene cycloartenyl ferulate is over 90 percent of the total active ingredients by weight percentage. As the medicine, the composition can be injection and frozen-dried powder injection and also can be an oral solid preparation, a medicine composition used for treating autonomic imbalance, climacteric syndrome, primary dysmenorrheal and premenstrual tension, periodic psychosis, vascular headache, head trauma syndrome, gastrointestinal imbalance and hyperlipemia, etc.

The feminine napkin with function of remitting dysmenorrhea is suitable for use in menstrual period and includes the skin contacting layer and bottom layer. The skin contacting layer has dysmenorrhea remitting medicine powder, which is compounded with motherwort, moxa leaf, Chuanxiong rhizome, safflower, corydalis and other three kinds of Chinese medicinal materials in certain proportion. The present invention can remit well primary dysmenorrhea and has high preventing and treating effect on secondary dysmenorrhea caused by pelvic inflammation, chronic cervicitis, etc.

The invention discloses a traditional Chinese medicinal composition for treating qi stagnation and blood stasis type primary dysmenorrheal. The traditional Chinese medicinal composition is made from the following traditional Chinese medicinal raw materials of: 9-15g of cattail pollen, 9-15g of flying squirrel feces, 9-15g of Cyperus Rotundus L, 9-15g of corydalis tuber, 9-15g of radix paeoniae rubrathe, 9-12g of dried orange peel, 15-20g of white peony root, 9-15g of Radix Saposhnikoviae, 15-20g of bighead atractylodes rhizome and 9-15g of honey-fried licorice root. The qi stagnation and blood stasis type primary dysmenorrhoea is treated by promoting blood circulation, removing blood stasis, rectifying qi, relieving pain and warming meridian. The traditional Chinese medicinal composition has advantages of reasonable compatibility, no toxic and side effect, convenient processing, low cost and obvious treatment effect.

The invention discloses a foot bath composition for treating primary dysmenorrheal. The foot bath composition comprises the following raw medicinal materials in parts by weight: 25 to 35 parts of Chinese mugwort leaf, 25 to 35 parts of motherwort herb, 25 to 35 parts of ginger, 10 to 20 parts of Chinese angelica, 10 to 20 parts of red-rooted salvia root, 10 to 20 parts of corydalis tuber, 5 to 15 parts of safflower and 5 to 15 parts of liquorice. The foot bath composition is unique in formula; the raw materials work collaboratively to achieve the effects of warming channel, expelling cold, benefiting qi, nourishing blood, regulating qi and removing stasis; the foot bath composition has an exact treatment effect on treating the primary dysmenorrheal, has a good long-term treatment effect, and has few untoward effects. The composition provided by the invention is used in the form of foot bath, is easy to operate and convenient to use, is not required to be decocted, and is suitable for a patient to treat by oneself; the patient is easy to persist; the compliance is high.

The invention relates to the field of medicine formulas, in particular to soup for treating primary dysmenorrheal. The soup is technically characterized by adopting the following raw medicines in percentage by weight: 10-13 percent of Chinese angelica, 8-10 percent of rhizoma corydalis, 8-10 percent of rhizoma cyperi, 6-9 percent of Chinese yam, 6-9 percent of radix paeoniae alba, 5-8 percent of fructus corni, 4-7 percent of liquorice, 5-7 percent of leonurus, 4-7 percent of caulis spatholobi, 3-5 percent of trogopterus dung, 3-5 percent of pericarpium zanthoxyli, 4-6 percent of ginger, 3-5 percent of ligusticum chuanxiong hort, 4-6 percent of carthamus tinctorius, 2-4 percent of peach kernel, 3-5 percent of cinnamon, and 3-5 percent of fructus aurantii, using water to soak, decocting, deslagging and obtaining filtrate. The soup has the advantages of exact curative effect, low cost and no toxic and side effect.

The invention discloses a medicinal composition for treating primary dysmenorrheal and a preparation method thereof. The medicinal composition comprises the following components according to the weight proportion: 50 to 150 portions of angelic, 30 to 90 portions of cinnamon, 30 to 90 portions of radix aucklandiae, and 75 to 225 portions of rhizoma corydalis processed with vinegar. Volatile oil is extracted from the angelica, the mixture of a water extraction of the extracted angelica is deposited in alcohol to obtain an angelica polysaccharide, and an angelica phenolic acid is obtained by an ethanol supernate which is loaded onto a macroporous absorption resin column and is eluted by ethanol; the volatile oil is extracted from the cinnamon and the radix aucklandiae, and clear paste is prepared from the ethanol supernate of a water decoction of herb residue extracted with the volatile oil which is reclaimed with the ethanol and is concentrated; a rhizoma corydalis alkaloid is extracted from the rhizoma corydalis by performing ethanol reflux extraction, loading the rhizoma corydalis alkaloid onto the macroporous absorption resin column and eluting by the ethanol; and the extracts are mixed to obtain an active component of the pharmaceutical composition. The medicinal composition maintains the analgesic effect of the prior art, reduces adverse reaction of dysmenorrhea, and has better spasmolysis at the same time. The preparation method has reasonable process and can be applied to mass production.

The invention discloses a medicament for treating dysmenorrhea and a preparation method thereof. The medicament is prepared from the following raw materials: 10 to 15 parts of nutgrass galingale rhizome, 10 to 15 parts of Indian buead, 10 to 15 parts of trogopterus dung, 10 to 15 parts of carbonized cattail pollen, 10 to 18 parts of twotooth achyranthes root, 10 to 16 parts of cortex moutan, 10 to 12 parts of salvia miltiorrhiza, 15 to 18 parts of rhizoma corydalis, 6 to 8 parts of cassia twig and 12 to 18 parts of motherwort herb. The preparation method for the medicament comprises the following steps of: weighing each raw material for later use; and soaking each raw material in water for 15 to 30 minutes, boiling with strong fire, decocting with slow fire for 15 to 20 minutes, filtering, and taking filtrate to prepare the medicament for treating the dysmenorrhea. The invention has the advantages that: the medicament has obvious effect on lower abdomen pain due to primary dysmenorrhea, membranecus dysmenorrhea, premenstrual syndrome and the like, large or small menstrual quantity, membranecus blood clots, lower abdomen sensation of chill and other symptoms.

The invention relates to the application of a breast lump-elimination preparation in preparing medicines for treating dysmenorrheal. The breast lump-elimination preparation is prepared from antler, dandelion, laminaria, Mongolian snakegourd root, suberect spatholobus stem, pseudo-ginseng, red peony root, seaweed, uniflower swisscentaury root, costustoot, figwort root, the root bark of the peony tree, prunella, weeping forsythia and red flower. Proved by pharmacodynamic experiments, breast lump-elimination granules not only have an obvious anti-inflammatory abirritation effect, but also have an obvious effect on inhibiting uterus super contraction induced by oxytocin. In clinical researches, the breast lump-elimination preparation can alleviate the clinical symptoms of primary dysmenorrheal patients when being used for treating mammary gland lobular hyperplasia, and has the characteristics of fast effect-taking, durable action and fewer adverse reactions when being used for treating the primary dysmenorrheal, and has certain effect on treating secondary dysmenorrheal.

The invention relates to a traditional Chinese medicine composition for treating primary dysmenorrheal, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition for treating primary dysmenorrheal is prepared from active components comprising the following materials in parts by weight: 10-20 parts of Chinese angelica, 5-15 parts of rhizome of chuanxiong, 1-15 parts of nutgrass galingale rhizome, 5-10 parts of roots of three-nerved spicebush, 5-15 parts of curcuma zedoary, 5-10 parts of corydalis tubers and 5-15 parts of medicinal cyathula roots. The invention has the advantage that: with setting up a project for the really selected topic of the primary dysmenorrheal with more diseased symptoms and specificity shortage of therapeutic medicaments at present and making a law on the basis of the pathogenesis of main therapeutic symptoms, the invention not only takes the formation mechanism of qi depression to blood stasis into account, but also considers pathological results caused by the qi depression to blood stasis. Prescription formulation for medicine selection accords with the theories of traditional Chinese medicine, the traditional Chinese medicine composition has definite functional main treatment and symptom types of mainly treated diseases, the theories of traditional Chinese medicine science think that Chong-Ren disharmony and uterus qi and blood stases are caused by Chong and conception channel and qi-blood disharmony and pathogenic factor interference, qi and blood stases make women feel painful, which is the pathogenesis changes of dysmenorrheal, and the traditional Chinese medicine composition achieves the functions of removing stases and stopping pains through promoting flow of qi and blood circulation and has the advantages of principal and secondary treatment of diseases, definite therapeutic effect, rapid effect, favorable clinical effect and long-term and repeated application.

The invention discloses a medicinal preparation for treating primary dysmenorrhea and a preparation method thereof. The medicinal preparation comprises the following raw materials in part by weight: 1 to 4 parts of nutgrass galingale rhizome, 0.5 to 2 parts of Chinese mugwort leaf, 3 to 9 parts of astragalus, 5 to 15 parts of Chinese angelica, 5 to 10 parts of motherwort herb, 5 to 10 parts of yanhusuo, 5 to 15 parts of prepared rehmannia root, 5 to 15 parts of red jujube and 1 to 4 parts of ginger. The preparation method comprises the following steps of: immersing the raw materials into water in an amount which is 6 to 10 times that of the raw materials for 2 hours, decocting the mixture for 1 to 3 times and 1 to 2 hours each time, filtering and merging filter liquor; concentrating the filter liquor to form thick paste with the measured relative density of between 1.20 and 1.24 at the temperature of between 80 and 85 DEG C, or concentrating the filter liquor until the filter liquor is 1/3 of the original liquid volume, adding a proper amount of brown sugar, dissolving the brown sugar through heating, concentrating the mixture to form thick paste with the measured relative density of between 1.20 and 1.24 at the temperature of between 80 and 85 DEG C, and preparing a preparation. Clinical experiments prove that the medicinal preparation has the effects of promoting blood circulation and removing blood stasis, warming channels and invigorating pulse and promoting qi circulation and relieving pain and good treatment effect, can be used for treating the primary dysmenorrhea, has unique curative effect, is safe to use and does not have any toxic or side effect.

The invention discloses a formula of a traditional Chinese medicine for treating primary dysmenorrheal. According to the formula, the traditional Chinese medicine comprises cortex moutan, amur corktree bark, szechuan lovage rhizome, peach seed, safflower, prepared nutgrass galingale rhizome, yanhusuo, rehmanniae praeparatum, red paeony root, zedoary, dahurian patrinia herb and raw coix seed. The traditional Chinese medicine is wide in medicinal sources, simple in preparation, economical and practical, is convenient to take, does not have obvious toxic or side effects, and has an obvious social benefit.

The invention belongs to the technical field of medicine and specifically relates to a pharmaceutical composition for treating primary dysmenorrheal. The pharmaceutical composition is prepared from the following components: Chinese angelica, peach kernel, nutgrass galingale rhizome, Szechuan lovage rhizome, yanhusuo, hirsute shiny bugleweed herb, safflower, combined spicebush root, cattail pollen and liquorice root. The pharmaceutical composition is completely prepared from Chinese herbs, has the effects of promoting blood circulation to remove blood stasis, and promoting qi circulation to relieve pain, and is exact in curative effect on treating the primary dysmenorrheal and in particular Qi-stagnation and blood-stasis primary dysmenorrheal and suitable for clinical popularization and application.

A method of treating primary dysmenorrhea which comprises administering to a human female suffering from the same a therapeutically effective amount of alpha-adrenergic blocker. Exemplary alpha-adrenergic blockers are phenoxybenzamine, alfuzosin, doxazosin, terazosin, prazosin, and tamsulosin, or a pharmaceutically acceptable salt or ester thereof. Tamsulosin HCl is preferred.

The invention provides a traditional Chinese medicine applying ointment capable of relieving primary dysmenorrhea of women and a preparation method thereof. The traditional Chinese medicine applying ointment comprises an active component, borneol and rice wine, wherein the active component comprises the following components in parts by weight: 15-25 parts of rhizoma corydalis, 15-25 parts of folium artemisiae argyi, 15-25 parts of cassia bark, 15-25 parts of Szechuan lovage rhizome, 1-10 parts of Manchurian wildginger herb and 10-20 parts of combined spicebush root; 30-80g of borneol and 100-200ml of rice wine are added to every 1kg of active component. The traditional Chinese medicine applying ointment and the preparation method have the beneficial effects that the traditional Chinese medicine applying ointment can effectively relieve primary dysmenorrhea of women and is fewer but better in acupoint selection; the medicines are directly accessed to lesions; the traditional Chinese medicine applying ointment is safe, has a few side effects and is simple and convenient; the preparation method is simple to operate, dispenses with special instruments and is low in preparation cost and short in preparation cycle.

A traditional Chinese medicine composition for treating primary dysmenorrhea in the type of cold-dampness coagulation is composed of stellaria monosperma, rubus lambertianus, polygonum hydropiper, rubus parkeri, lespedeza tomentosa, radix thunbergia grandiflora, berchemia kulingensis, mentha spicata, cyperus iria, cassia twigs, piper wallichii and liquorice, The traditional Chinese medicine composition can be used for clinically treating the primary dysmenorrhea in the type of cold-dampness coagulation.

The invention relates to a medicament for treating dysmenorrhea and process for preparation, wherein the medicament is prepared from the following raw materials (by weight ratio): pollen 45-65, bee honey 10-15, taurine 5-15, inositol 0.2-1.5, tea extract 6.25-18.75, vitamin B1 1-2, vitamin B2 0.5-1.5, vitamin B12 0.1-0.5, vitamin C 1-4 and cane sugar 9-14.

The invention discloses a traditional Chinese medicine composition for treating primary dysmenorrheal caused by cold coagulation and blood stasis. According to the traditional Chinese medicine, cold is one of the most common pathogenesis of dysmenorrheal, and stasis is the main pathogenesis of dysmenorrheal. The disease location of dysmenorrheal is in uterus and chongren, and the treatment principle mainly comprises regulating qi and blood of chongren. The traditional Chinese medicine composition disclosed by the invention is prepared into decoction by a drug manufacturing room of our hospital by using traditional Chinese medicines such as abies fruit, seed of ajwain, shearer phoebe bark or branchlet, south elecampane, filamental flowering crab, parker raspberry root, wild banks rose root-bark, featherleaf rodgersflower, the root of campylotropis and wolf-tail lysimachia. Clinical tests prove that the total effective rate is as high as 97.8% and no toxic and side effects are caused.

The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Chinese medicinal compound consisting of Chinese angelica, Szechuan lovage rhizome, red paeony root, cattail pollen, trogopterus dung, myrrh and corydalis tuber, removing impurity through ethanol precipitation, then injecting the extract into a macroporous absorption resin column, and purifying the extract by gradient elution of ethanol with optimized concentration. A compatible raw material formula is selected according to the Chinese medicinal theory and the gynecological disease pathogenesis; modern analysis instruments and pharmacological experiments show that the Chinese medicinal compound effective component provided by the invention has good activities of resisting uterine smooth muscle spasm, easing pain, resisting inflammation, adjusting estrogen and progestational hormone level, adjusting immunity and the like, can be used for treating multiple gynecological diseases such as primary dysmenorrhea, endometriosis, acute and chronic pelvic inflammation and the like, has clearer components and lower adverse reaction, and is expected to be developed as a new generation medicament for treating the gynecological diseases.

The invention discloses a Chinese medicine preparation for treating primary dysmenorrheal, a preparation method and an application. The Chinese medicine preparation is composed of medicines of angelica, flos rosae rugosae, fennel fruits, ligusticum wallichii, red paenoy roots and the like. On the basis of traditional Chinese medicine syndrome differentiation and treatment theory, the Chinese medicine preparation for treating primary dysmenorrheal is prepared by combining years of clinical experience. The Chinese medicine preparation for treating primary dysmenorrheal is characterized in that according to characteristics of hormonal level change at each stage of a sexual cycle, medicine intervention is performed at the luteal regression stage, two hormone peaks in the whole sexual cycle process can be avoided, relative excited signal molecues at the local position of uterus tissue can be directly confronted, interference for feedback effect on thalamus-hypophysis-ovarian axis sex hormone is weakened, and thereby the effect of treating the primary dysmenorrheal can be exerted. The Chinese medicine preparation for treating the primary dysmenorrheal has special good effects on the diseases of dysmenorrheal and abnormal menstruation and the like caused by kidney energy loss, qi stagnation and blood stasis, congealing cold blood stasis, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach and damp and hot accumulation, the Chinese medicine preparation for treating the primary dysmenorrheal is widely applied to clinic and relieves pains of patients, and the effective rate can reach to 96%.

A traditional Chinese medicine composition for treating primary dysmenorrhea consists of rhizoma cyperi, excrementum pteropi, trichosanthis palmatae, achyranthes, cortex moutan, radices salviae miltiorrhizae, rhizoma corydalis, cassia twig, purslane speedwell, akebia trifoliata koidz and railway beggarticks herb. The traditional Chinese medicine composition can be clinically used for treating theprimary dysmenorrhea.

The invention belongs to the field of biomedicines and in particular relates to a probiotic composition with a menstruation regulating function and application thereof. The probiotic composition is suitable for menstrual-period dysmenorrhea of females and is particularly suitable for primary dysmenorrhea of young females. The probiotic composition with the menstruation regulating function is prepared from lactobacillus rhamnosus, lactobacillus plantarum and bifidobacterium longum. The probiotic composition can also be compounded with traditional Chinese medicines which have the menstruation regulating function and can be used as medicines and foods, and has a synergistic effect. Probiotics are internationally recognized probiotic substances and have the advantages of safe source, remarkable effect, no toxic or side effect and the like. The probiotic composition provided by the invention can be safely eaten and also has the menstruation regulating function; the probiotic composition can be particularly used for inhibiting the primary dysmenorrhea and a novel application of the probiotics is provided. The probiotics are compounded with the traditional Chinese medicines capable of being both used as medicines and foods, and advantages are commonly expressed, so that the effect of safely and effectively treating the dysmenorrhea is realized.

The medicine for treating primary dysmenorrhea is prepared with eight Chinese medicinal materials including burreed rhizome, zeodoary, diverse wormwood herb, corydalis tuber, angelica, tree peony bark, etc. Its preparation includes crushing tree peony bark into fine pwoder, decoction for three times, collecting volatile oil, merging decoction, filtering, concentrating, mixing and other steps. Clincal application shows that the medicine has the functions of warming meridian, dispersing blood clots, regulating vital energy and stopping pain and has high curative effect on primary dysmenorrhea caused by accumulation of pathogenic cold, stagnation of the vital energy and blood stasis and no toxic side effect.

The invention discloses a traditional Chinese medicine patch for treating primary dysmenorrheal and a preparation method of the traditional Chinese medicine patch. Active ingredients of the traditional Chinese medicine patch are prepared from the following raw materials in parts by weight: 5 to 10 parts of rhizoma cyperi, 5 to 10 parts of rhizoma corydalis, 4 to 8 parts of cassia twigs, 4 to 8 parts of cortex cinnamomi, 5 to 8 parts of radix aucklandiae and 2 to 4 parts of Chinese angelica extract liquid. The preparation method comprises the following steps: stewing the Chinese angelica in water with slow fire for 40 minutes to obtain the Chinese angelica extract liquid, wherein active medicinal ingredients contained in 1 ml of the Chinese angelica extract liquid is equivalent to that contained in 1 g of Chinese angelica; weighing the rhizome cyperi, the rhizome corydalis, the cassia twigs, the cortex cinnamomi and the radix aucklandiae, and grinding into powder; mixing the powder with 2 to 4 ml of the Chinese angelica extract liquid to form paste; and uniformly smearing the prepared medicine onto a medical adhesive tape, and then covering the medicine with nonwoven fabric, thus obtaining the traditional Chinese medicine patch. The traditional Chinese medicine patch is a pure traditional Chinese medicine preparation, has no toxicity and side effect for a patient, is low in cost, can effectively treat the primary dysmenorrheal, and is fast in effectiveness and high in cure rate.

The invention relates to a traditional Chinese medicinal composition for treating primary dysmenorrhea caused by qi stagnation and blood stasis and belongs to the field of traditional Chinese medicine. The traditional Chinese medicinal composition is prepared from seven traditional Chinese medicinal raw materials as follows: rhizoma cyperi, China rose, artemisia anomala, bletilla striata, tuber fleeceflower stem, fructus aurantii and astragalus membranaceus. The traditional Chinese medicinal composition has functions of soothing liver, removing stasis, regulating qi, relieving pain, regulating menstruation, promoting blood circulation and nourishing blood and also has a remarkable curative effect on causes of primary dysmenorrhea caused by qi stagnation and blood stasis.

Disclosed is an oral administration Chinese medicament for treating primary menalgia, medicament is prepared from the following raw materials (by weight portion): burred tuber, zedoary, safflower, Chinese angelica root, root of red rooted saliva, trogopterus dung, corydalis tuber each 8-10g, banksia rose 5-6g, cinnamon 3-4g. The invention realizes easy material availability, simplified preparation, low cost, and quick effect.