A moxibustion stick for treating primary dysmenorrhea caused by cold stagnation and blood stasis.

Abstract

An analgesic moxibustion stick for treating primary dysmenorrhea caused by cold stagnation and blood stasis effectively solves the problem of preparing medication for this type of dysmenorrhea. The analgesic moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a compound powder of traditional Chinese medicine with moxa wool and stirring thoroughly. The compound powder of traditional Chinese medicine is composed of warming and dispersing cold herbs, blood-activating and stasis-removing herbs, meridian-guiding herbs, and transdermal adjuvants. The warming and dispersing cold herbs are made by mixing cinnamon, dried ginger, and evodia rutaecarpa powder; the blood-activating and stasis-removing herbs are made by mixing angelica sinensis, chuanxiong rhizome, red peony root, and peach kernel powder; the meridian-guiding herbs are made by mixing asarum and cyperus rhizome powder; and the transdermal adjuvant is borneol. The paper roll is made of double-layered mulberry bark paper rolled using conventional methods. The medicinal core is then placed inside the paper roll. This invention uses abundant raw materials, has a simple preparation method, is easy to produce, and has a scientifically sound drug formulation. It has the effects of warming yang and dispersing cold, activating blood and unblocking collaterals, and has good efficacy, making it valuable for practical application.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine and acupuncture technology, and in particular to analgesic moxibustion sticks for treating primary dysmenorrhea caused by cold stagnation and blood stasis. Background Technology

[0002] Primary dysmenorrhea is a common functional disorder in gynecological clinics, mainly manifested as lower abdominal pain and distension before, during, or after menstruation, accompanied by backache or other discomfort. Severe symptoms can significantly impact daily life and work quality. Traditional Chinese medicine believes that this condition is often caused by poor circulation of Qi and blood in the Chong and Ren meridians, leading to pain due to obstruction. Cold-induced blood stasis is one of the most common clinical patterns. Moxibustion, as an important external treatment method in traditional Chinese medicine, utilizes the warmth generated by burning moxa to stimulate acupoints, achieving the purpose of warming the meridians, dispelling cold, and promoting blood circulation. It is widely used in the prevention and treatment of dysmenorrhea. Existing medicated moxa sticks are usually made by mixing a certain proportion of Chinese herbal powder into moxa wool, or by using a specific rolling process to form sticks. They are then ignited and used to fumigate specific acupoints (i.e., moxibustion), utilizing heat conduction and the penetration of volatile medicinal components to exert therapeutic effects.

[0003] However, the therapeutic effect of existing technologies on primary dysmenorrhea of ​​the cold-induced blood stasis type still needs improvement. Current general-purpose or ordinary moxa sticks often lack a systematic formulation design targeting the combined pathogenesis of cold-induced blood stasis, resulting in a low match between the release rate of the active ingredients during combustion and the thermotherapy process. This makes it difficult to continuously and stably release active substances that dilate microvessels, inhibit uterine smooth muscle spasms, and regulate prostaglandin metabolism within a suitable temperature range. Furthermore, existing products have shortcomings in structural design and adaptability to clinical moxibustion needs, often exhibiting problems such as uneven combustion, short effective intervention time, and low transdermal absorption of the active ingredients. This makes it difficult to achieve the organic unity of warming, removing blood stasis, regulating qi, and relieving pain, affecting the stability and sustainability of clinical efficacy and leading to unsatisfactory results. Summary of the Invention

[0004] In view of the above situation and to overcome the shortcomings of the existing technology, the purpose of this invention is to provide analgesic moxibustion sticks for treating primary dysmenorrhea of ​​cold stagnation and blood stasis type, which can effectively solve the problem of medication in preparing moxibustion sticks for treating primary dysmenorrhea of ​​cold stagnation and blood stasis type.

[0005] The technical solution of this invention is an analgesic moxibustion stick for treating primary dysmenorrhea of ​​the cold-induced blood stasis type. This analgesic moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 0.9–1.1:5–7, and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 38-43% warming and dispersing cold herbs, 45-50% blood-activating and stasis-removing herbs, 5-8% guiding herbs, and 2-4% transdermal adjuvants. The warming and dispersing cold herbs are composed of cinnamon in a weight ratio of 2:3:4. The formula consists of a mixture of dried ginger and Evodia rutaecarpa powder, a blood-activating and stasis-removing medicine made from a mixture of Angelica sinensis, Ligusticum chuanxiong, Paeonia lactiflora and Prunus persica powder in a weight ratio of 4:3:2:2, a guiding medicine made from a mixture of Asarum heterotropoides and Cyperus rotundus powder in a weight ratio of 1:3, and a transdermal adjuvant made from borneol. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled in a conventional manner with a diameter of 6–8 mm and a length of 180–220 mm, with an inner layer thickness of 0.1 mm and an outer layer thickness of 0.15 mm. The medicine core is placed inside the paper roll, with a core density of 0.65–0.75 g / cm³.

[0006] This invention utilizes abundant raw materials, a simple preparation method, and is easy to produce. The drug formulation is scientifically and rationally matched. It contains volatile components with the effects of warming yang and dispelling cold, promoting blood circulation and unblocking collaterals. With the help of heat, these active substances penetrate through the skin, thereby directly acting on the Chong and Ren meridians and the uterus area, achieving multi-target intervention on the pathogenesis of cold coagulation and blood stasis. It has good effects and has practical application value. Detailed Implementation

[0007] The specific implementation of the present invention will be described in detail below with reference to examples and specific circumstances. Example

[0008] This invention discloses an analgesic moxibustion stick for treating primary dysmenorrhea caused by cold stagnation and blood stasis. The moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 1:5 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 40% warming and dispersing cold herbs, 50% blood-activating and stasis-removing herbs, 6% guiding herbs, and 4% transdermal adjuvants. The warming and dispersing cold herbs are cinnamon, dried ginger, and evodia fruit in a weight ratio of 2:3:4. The mixture is made by pulverizing and mixing the following ingredients: the blood-activating and stasis-removing medicine is made by pulverizing and mixing Angelica sinensis, Ligusticum chuanxiong, Paeonia lactiflora and Prunus persica in a weight ratio of 4:3:2:2; the guiding medicine is made by pulverizing and mixing Asarum heterotropoides and Cyperus rotundus in a weight ratio of 1:3; the transdermal adjuvant is borneol; the paper roll is a hollow circle with a diameter of 7mm and a length of 190mm made by conventional methods from double-layer mulberry bark paper, with an inner layer thickness of 0.1mm and an outer layer thickness of 0.15mm; the medicine core is put into the paper roll, and the medicine core density is 0.7g / cm³. Example

[0009] This invention relates to an analgesic moxibustion stick for treating primary dysmenorrhea caused by cold stagnation and blood stasis. The analgesic moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool at a weight ratio of 0.9:7 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 43% warming and dispersing cold herbs, 45% blood-activating and stasis-removing herbs, 8% guiding herbs, and 4% transdermal adjuvants. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled using conventional methods, with a diameter of 6mm and a length of 180mm. The inner layer is 0.1mm thick and the outer layer is 0.15mm thick. The medicinal core is placed inside the paper roll, and the density of the medicinal core is 0.65g / cm³. Example

[0010] This invention relates to an analgesic moxibustion stick for treating primary dysmenorrhea of ​​the cold-induced blood stasis type. The analgesic moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 1.1:6 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 43% warming and dispersing cold herbs, 50% blood-activating and stasis-removing herbs, 5% guiding herbs, and 2% transdermal adjuvants. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled using conventional methods, with a diameter of 8mm and a length of 220mm. The inner layer is 0.1mm thick and the outer layer is 0.15mm thick. The medicinal core is placed inside the paper roll, and the density of the medicinal core is 0.75g / cm³.

[0011] The compositions given in the above embodiments can be used to prepare any amount of traditional Chinese medicine compound powder, moxa wool, and moxa sticks as needed. The given embodiments are only used to illustrate specific implementation methods of the present invention and are not intended to limit the scope of protection of the present invention. All technical means that are essentially the same as those made by equivalent substitution (transformation) means are within the scope of protection of the present invention.

[0012] In the drug combinations given above, among which: Artemisia floss (processed from Artemisia leaves): pungent, bitter, and warm; slightly toxic. It enters the liver, spleen, and kidney meridians. It dispels cold, relieves pain, warms the meridians, and stops bleeding.

[0013] Cinnamon: pungent, sweet, and hot. It enters the spleen, kidney, heart, and liver meridians. It tonifies fire and assists yang, dispels cold and relieves pain, and warms the meridians and promotes blood circulation.

[0014] Dried ginger: Pungent and hot. It enters the spleen, stomach, heart, and lung meridians. It warms the middle jiao (spleen and stomach), dispels cold, restores yang, unblocks the meridians, and warms the lungs to resolve phlegm.

[0015] Evodia rutaecarpa: pungent, bitter, and hot. Slightly toxic. Enters the liver, spleen, stomach, and kidney meridians. Dispels cold and relieves pain, warms the middle jiao and stops vomiting, and tonifies yang and stops diarrhea.

[0016] Angelica sinensis: sweet, pungent, and warm. It enters the liver, heart, and spleen meridians. It nourishes and invigorates blood, regulates menstruation and relieves pain, and moistens the intestines to promote bowel movements.

[0017] Chuanxiong (Ligusticum striatum): pungent, warm. It enters the liver, gallbladder, and pericardium meridians. It invigorates blood circulation, promotes qi flow, dispels wind, and relieves pain.

[0018] Red peony root: Bitter, slightly cold. Enters the liver meridian. Clears heat and cools the blood, disperses blood stasis and relieves pain.

[0019] Peach kernel: bitter, sweet, neutral. It enters the heart, liver, and large intestine meridians. It invigorates blood circulation, removes blood stasis, and moistens the intestines to relieve constipation.

[0020] Asarum: Pungent, warm. Enters the lung and kidney meridians. Dispels wind, disperses cold and relieves pain, warms the lungs and resolves phlegm, and clears the nasal passages.

[0021] Cyperus rotundus: pungent, slightly bitter, slightly sweet, neutral. It enters the liver and triple burner meridians. It soothes the liver, regulates qi, regulates menstruation, and relieves pain.

[0022] Borneol: Pungent, bitter, and slightly cold. It enters the heart, spleen, and lung meridians. It opens the orifices, refreshes the mind, clears heat, and relieves pain.

[0023] This invention utilizes abundant raw materials, a simple preparation method, and is easy to produce. The drug formulation is scientifically sound and possesses the effects of warming yang and dispelling cold, promoting blood circulation and unblocking collaterals. Through heat-driven transdermal penetration of these volatile components, they directly act on the Chong and Ren meridians and the uterus region, achieving multi-target intervention in the pathogenesis of cold-induced blood stasis. This effectively treats the pathogenesis of cold-induced blood stasis with good efficacy, high efficiency, and no toxic side effects. Experiments have yielded very good and beneficial technical results. The relevant experimental materials are as follows (taking Example 1 as an example): I. Performance Verification Experiment: The moxa sticks prepared in Example 1 were tested. Under standard conditions, when lit and held 4 cm away from the skin for moxibustion, the surface temperature remained stable in the range of 45±1℃, and the effective burning time was 46 minutes. GC-MS analysis showed that characteristic active ingredients such as cinnamaldehyde, tetramethylpyrazine, and asarone were detected in the combustion smoke, and the release curves remained stable within 10–45 minutes.

[0024] This indicates that it has a stable structure, excellent combustion performance, and can achieve simultaneous release of "drug-heat", providing a standard sample for subsequent efficacy verification.

[0025] II. Experiment on the effect of the lower limit of the core density parameter on the combustion performance and drug release of moxa sticks: With all other preparation conditions the same as in Example 1, only the rolling pressure was adjusted to change the core density from 0.70 g / cm³ to the lower limit of 0.65 g / cm³ as defined in the claims, thus obtaining product moxa stick A.

[0026] Tests showed that the effective burning time of moxa stick A was 42 minutes, and the surface temperature fluctuation range was 42-46℃ when the moxibustion distance was 3-5cm. Although the burning rate was slightly faster than that of Example 1, it was still within the effective range of 40-50 minutes, and the temperature did not exceed the safety threshold.

[0027] The results show that even under the condition of a core density lower limit of 0.65 g / cm³, the technical solution of the present invention can still achieve stable combustion control and effective drug release, proving that the parameter range has good feasibility.

[0028] III. Experiment on the effect of the upper limit of the core density parameter on the combustion performance and drug release of moxa sticks: With all other preparation conditions the same as in Example 1, only the rolling pressure was adjusted to change the core density from 0.70 g / cm³ to the upper limit of 0.75 g / cm³ as defined in the claims, thus obtaining product moxa stick B.

[0029] Tests showed that the effective burning time of medicated moxa stick B was 49 minutes, and the surface temperature remained stable at 44-48℃ when suspended at a distance of 3-5cm. The burning process was more prolonged, and the peak temperature was slightly higher but still within a safe range.

[0030] The results show that, under the condition of the upper limit of core density of 0.75 g / cm³, the technical solution of the present invention can still maintain excellent combustion stability and temperature controllability, further confirming the rationality of the density parameter range in the claims.

[0031] IV. Experiment on the effect of the boundary of the ratio of warming and dispersing cold medicinal materials on efficacy: Referring to the method of Example 1, the difference lies in adjusting the total proportion of warming and dispersing cold herbs. The total proportion of cinnamon, dried ginger, and evodia is adjusted from 40% to the lower limit of its range, 38% (the proportion of moxa wool is adjusted accordingly to maintain the total balance), while the proportion of the remaining components remains unchanged, and the product moxa stick C is obtained.

[0032] In a rat dysmenorrhea model experiment, the writhing inhibition rate of the moxa stick C group was 78%, slightly lower than 85% in Example 1, but still significantly better than the ordinary moxa stick group (52%).

[0033] The results showed that even when the proportion of warming and dispersing herbs was at the lower limit of 35%, the moxa stick of this invention could still exert a significant warming, dispersing, and pain-relieving effect, proving the effectiveness of this proportion range.

[0034] V. Experiment on the effect of the boundary of borneol content in transdermal adjuvant on transdermal absorption rate: The method of Example 1 is used, except that the amount of borneol added is adjusted from 4% to the lower limit of its range of 2% to obtain the product moxa stick D.

[0035] Tests showed that the cumulative permeation of ligustrazine in the moxa stick D group was 38% higher than that in the group without borneol. Although this was slightly lower than the 52% in Example 1, the improvement was still significant.

[0036] The results show that even with a borneol content of 2%, the present invention can still effectively improve the transdermal absorption of the active ingredient, confirming the feasibility of this content range.

[0037] VI. Pharmacodynamic advantages and safety experiments: 1. Experimental grouping: Sixty rats with primary dysmenorrhea of ​​the cold-blood stasis type were randomly divided into 6 groups: blank control group (no treatment), model group (no drug administration), ordinary moxa stick group (commercially available pure moxa sticks), comparative example 1 group (the formulation of Example 1 without borneol), comparative example 2 group (the formulation of Example 1 wrapped in a single layer of mulberry paper), Example 1 group and experimental groups 1-4 (using the medicated moxa sticks prepared in Experiments 2-5 respectively).

[0038] 2. Administration regimen: After modeling, apply moxibustion to Guanyuan acupoint and bilateral Sanyinjiao acupoint for 10 minutes each day for 5 consecutive days.

[0039] 3. Detection indicators: Record the number of acetic acid-induced writhing episodes; determine the content of PGE2 and PGF2α in uterine tissue; observe for burns and redness on the skin; detailed test results are shown in Table 1: Table 1 Comparison of writhing frequency and uterine prostaglandin levels in rats of different groups

[0040] As shown in Table 1, compared with the ordinary moxa stick group and the comparative examples, the number of writhing movements in Example 1 group and Experiments 1-4 groups was significantly reduced, and the PGE2 / PGF2α ratio was closer to the normal level, indicating that the moxa stick of the present invention has excellent analgesic and prostaglandin metabolism regulating effects. Among them, although Comparative Example 1 (without borneol) had a certain therapeutic effect, some animals showed agitation similar to "internal heat", and the analgesic effect was weaker than that of the borneol-containing group, confirming the key role of borneol in enhancing efficacy and reducing toxicity; the shorter burning time of Comparative Example 2 (single-layer paper) led to insufficient drug release, and the therapeutic effect was slightly inferior to that of the Example 1 group with double-layer paper structure.

[0041] Based on the above data and graph analysis, the moxa sticks provided by this invention, through their disease-specific formulation design, double-layer mulberry bark paper structure, and the synergistic effect of transdermal adjuvants, exhibit unexpected technical advantages in terms of analgesic effect, duration of efficacy, and safety, and can effectively treat primary dysmenorrhea of ​​the cold-induced blood stasis type.

[0042] VII. Clinical Trials: Based on the performance and safety of animal experiments, 58 confirmed patients aged 18-45 years were treated with the moxibustion sticks of this invention. The treatment started 7 days before menstruation, once a day, using Guanyuan + bilateral Sanyinjiao acupoints for 10 minutes each, for 5 consecutive days as one course of treatment. The efficacy was statistically analyzed over three menstrual periods. The results showed that 48 patients (82.8%) had completely eliminated menstrual pain, 8 patients (13.8%) had significantly reduced or alleviated menstrual pain, and 2 patients (3.4%) had no improvement or even a tendency for menstrual pain to stop. The total effective rate was 96.6%, and no toxic side effects were found, indicating that the medication is safe and effective.

[0043] In summary, this invention utilizes abundant raw materials, employs a simple preparation method, is convenient to use, and offers safe, long-lasting, and highly targeted medication. The method involves combining warming and dispersing herbs, blood-activating and stasis-removing herbs, meridian-guiding herbs, and transdermal adjuvants with moxa wool in a specific ratio to form the core. This core is then wrapped in a double layer of mulberry bark paper for shaping, creating a specialized drug carrier for specific diseases. Based on the systematic integration of four functional herbs in the core, the moxa stick simultaneously releases volatile components with warming, dispersing, blood-activating, and meridian-clearing effects during combustion. These active substances are driven by heat to penetrate the skin, directly acting on the Chong and Ren meridians and the uterus region, achieving multi-target intervention in the pathogenesis of cold-induced blood stasis. Building upon this foundation, by limiting the diameter, length, and core density of the moxa stick, the physical stability and heat distribution uniformity during combustion were optimized. This ensures that, under standard operating conditions with the moxa stick positioned 3-5 cm away from the skin, the surface temperature can be stably maintained within a safe and effective range of 42-48℃. This activates the skin's temperature-sensitive receptors to produce an endogenous analgesic effect while avoiding the risk of burns from high temperatures. Simultaneously, the double-layered mulberry paper wrapping structure regulates oxygen supply and combustion rate through the difference in thickness between the inner and outer layers, extending the effective burning time to 40-50 minutes and ensuring a continuous and stable output of medicinal and thermal effects during a single moxibustion session. This effectively solves the problems of existing moxa stick formulations lacking specificity, having a short therapeutic window, low heat-medicine matching, and insufficient transdermal absorption. Therefore, it avoids interruptions in therapeutic efficacy due to excessively rapid combustion or skin damage caused by temperature runaway, significantly improving the clinical efficacy, safety, and patient compliance in treating primary dysmenorrhea caused by cold stagnation and blood stasis. This represents a technological leap from a single product to a synergistic system of medicine, heat, and acupoint enhancement. In summary, this invention, through the organic combination of component compounding, structural optimization, and parameter control, forms a logically rigorous and functionally complete technical solution. It not only ensures the precise release and efficient absorption of the active ingredients at suitable temperatures, but also guarantees the controllability and consistency of clinical operations through standardized physical parameters. It provides technical support for primary dysmenorrhea of ​​the cold-induced blood stasis type and has great practical clinical application value.

Claims

1. A moxa stick for treating primary dysmenorrhea of ​​the cold-induced blood stasis type, comprising a medicinal core and a paper roll. The medicinal core is prepared by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 0.9–1.1:5–7, and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 38-43% warming and dispersing cold herbs, 45-50% blood-activating and stasis-removing herbs, 5-8% guiding herbs, and 2-4% transdermal adjuvants. The warming and dispersing cold medicine is made by mixing cinnamon, dried ginger, and evodia in a weight ratio of 2:3:

4. The blood-activating and stasis-removing medicine is made by mixing angelica, chuanxiong, red peony root, and peach kernel in a weight ratio of 4:3:2:

2. The guiding medicine is made by mixing asarum and cyperus in a weight ratio of 1:

3. The transdermal adjuvant is borneol. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled in a conventional method with a diameter of 6-8 mm and a length of 180-220 mm, with an inner layer thickness of 0.1 mm and an outer layer thickness of 0.15 mm. The medicine core is placed inside the paper roll, and the density of the medicine core is 0.65-0.75 g / cm³.

2. The moxibustion stick for treating primary dysmenorrhea of ​​cold-induced blood stasis type according to claim 1, characterized in that, This pain-relieving moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 1:5 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 40% warming and dispersing cold herbs, 50% blood-activating and stasis-removing herbs, 6% guiding herbs, and 4% transdermal adjuvants. Among them, the warming and dispersing cold herbs are made by mixing cinnamon, dried ginger, and evodia in a weight ratio of 2:3:4; the blood-activating and stasis-removing herbs are made by mixing angelica, chuanxiong, red peony root, and peach kernel in a weight ratio of 4:3:2:2; the guiding herbs are made by mixing asarum and cyperus in a weight ratio of 1:3; and the transdermal adjuvant is borneol. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled in a conventional method with a diameter of 7mm and a length of 190mm. The inner layer is 0.1mm thick and the outer layer is 0.15mm thick. The medicinal core is placed inside the paper roll, and the density of the medicinal core is 0.7g / cm³.

3. The moxibustion stick for treating primary dysmenorrhea of ​​cold-induced blood stasis type according to claim 1, characterized in that, This pain-relieving moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 0.9:7 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 43% warming and dispersing cold herbs, 45% blood-activating and stasis-removing herbs, 8% guiding herbs, and 4% transdermal adjuvants. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled in a conventional way, with a diameter of 6mm and a length of 180mm. The inner layer is 0.1mm thick and the outer layer is 0.15mm thick. The medicinal core is placed inside the paper roll, and the density of the medicinal core is 0.65g / cm³.

4. The moxibustion stick for treating primary dysmenorrhea of ​​cold-induced blood stasis type according to claim 1, characterized in that, This pain-relieving moxibustion stick consists of a medicinal core and a paper roll. The medicinal core is made by mixing a traditional Chinese medicine compound powder with moxa wool in a weight ratio of 1.1:6 and stirring evenly at room temperature. The traditional Chinese medicine compound powder consists of 43% warming and dispersing cold herbs, 50% blood-activating and stasis-removing herbs, 5% guiding herbs, and 2% transdermal adjuvants. The paper roll is a hollow circle made of double-layered mulberry bark paper rolled in a conventional way, with a diameter of 8mm and a length of 220mm. The inner layer is 0.1mm thick and the outer layer is 0.15mm thick. The medicinal core is placed inside the paper roll, and the density of the medicinal core is 0.75g / cm³.

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