100 results about "Elemene" patented technology

The invention discloses an essence with moss faint scent and applications thereof. The essence with moss faint scent comprises following ingredients: orcinol monomethyl ether, divarinol monomethyl ether, ethyl everninate, methyl divaricatinate, beta-orcinol carboxylic acid methyl ester, orcinol carboxylic acid ethyl ester, ethyl divaricatinate, pinocarveol, bata-elemene, propylene glycol, and the like. Inherent aroma compounds of natural plant essences with moss faint scent are applied in the preparation of the essence of the invention, and the essence with moss faint scent is prepared by such steps: dissolving the ingredients, and allowing the mixture to stand. Technologies are simple and are easy to operate; ingredients are easy to obtain; cost is low; operability is high; scent lasting time is long; scent quality is high; the moss faint scent is true to nature; the essence of the invention can be used as a substitute of natural moss faint scent essences so as to reduce the demand for natural essences, and possesses promising application prospect in the fields of daily use essences and cigarette essences.

This invention discloses beta-elemene nitrogen contained derivant. Nitrogen contain hetero atomic ring is brought in beta-elemene nitrogen structure to synthesize new structure beta-elemene nitrogen contained derivant. Its molecular structure formula is (I), R represents C1-C20 fatty amine group and aromatic amine group, C1-C20 contains hetero atomic ring amido group, cyclohexane backbone has three chirality centers. The derivent has some biological activities like alkaloid, it can increase polar at the same time, and make the synthesized derivent display certain alkalinity, so the goal of improve water-solubility by it with mineral acid or organic acid salt.

The present invention provides injectable water-in-oil emulsions that comprise elemenes (preferably, bete-elemene), liquid oil, an emulsifier (optionally) and a pharmaceutically acceptable aqueous phase. The present invention also provides methods for making and using such emulsions.

A beta-elemene pyrimidine derivative series is disclosd, which is prepared through reaction of beta-elemene on hypochlorite or NBS to obtain intermediate, and reacting on the pyrimidine's cyclic derivative in DMF or DMSO solvent.

The present invention discloses a kind of high-purity elemene medicine, which features the beta-elemene content as high as 98-99.9 wt%. One of its preparation process includes twice precise fractionation of elemene material containing beta-elemene of 80-92 wt% inside one heating reactor in precise fractionating tower with stainless steel cylinders as stuffing at vacuum degree of 200-500 Pa, flow rate ratio of 5 to 1 to collect the fraction at temperature of 82-83 deg.c. One other preparation process includes twice precise fractionation, and column chromatographic separation to eliminate impurity with the chromatographic column stuffed with silica gel after activation at 115-125 deg.c for 1.5 hr, and has even high beta-elemene content.

The invention discloses a A-elemene amino acid or carboxylic acid derivants, Process for preparing, usage and preparation; the structural formula of derivant is III. Wherein R represent C2-C20 every kinds of alpha-, beta-, gamma- amino acids; Every kinds of amino acids of C1-C20; wherein cyclohexane skeleton has three chirality center. This derivant is used to improve water-solubility and anticancer active of A-elemene amino acid, introducing amino acid which contains synthetic compounds of amidol or carboxy group, this derivant has stronger physiologically active and larger polarity, reaching the purpose of improving water-solubility.

A novel elemene lipid in the form of oral liquid, injection, perfusion, aerosol, or solid is prepared from the plant extract containing element isomer, phosphoride and cholesterol by alcohol injection method, reverse-phase distilling method, extruding method, or mechanical method. Its advantages are high distribution in liver, low distribution in kidney, high biologic utilization rate, and high target effect.

The invention relates to the field of organic synthesis and medicinal chemistry, and in particular relates to a beta-elemene 13-site derivative (I) or (II), and R1 and R2 are as defined in specification. The invention also discloses a preparation method of the beta-elemene 13-site derivative and use thereof in anti atherosclerosis.

The invention discloses a phthorimaea operculella zell attractant comprising the following components in parts by volume: 8-10 parts of alcohol compound, 0.5-1.5 parts of ester compound, 2-3 parts of aldehyde compound, 1-3 parts of terpene compound and 0.1-0.5 part of other compound, wherein the alcohol compound is any one of 1,8-eucalyptol and palustrol; the ester compound is any one of methyl jasmonate, anti-4, cis-7-C13 diene acetate and anti-4, cis-7, 10-C13 triene acetate; the aldehyde compound is any one of heptaldehyde, octyl aldehyde and nonaldehyde; the terpene compound is any one of limonene, phellandrene, terpinene, caryophyllene, pinene, elemene, ocimene, germacrene, farnesene and isolongifolene; and the other compound is any one of nicotine, solanone, norsolandione and para-cymene. The attractant is environment-friendly, does not injure natural enemies of pests and has remarkable attracting effect on phthorimaea operculella zell adults.

The invention relates to a method for extracting and separating beta-elemene, a device thereof and a method for preparing a filling thereof. The method for extracting and separating the beta-elemene provided by the embodiment of the invention comprises the steps as follows: the raw material of the beta-elemene is added to the upper end of a chromatography column, wherein, the chromatography column is provided with silver nitrate surface modification filling; eluent is added into the chromatography column to elute the mixed raw material of the beta-elemene and the filling; solution after the elution is collected at times; and silver ion in the solution which is collected at times after the elution is removed. In addition, the embodiment of the invention also provides the device used for extracting and separating the beta-elemene and the method for preparing the silver nitrate surface modification filling which is used in the method for extracting and separating the beta-elemene.

The invention discloses an engineering strain for producing beta-elemene and an application of the engineering strain. The engineering strain for producing beta-elemene is obtained by simultaneously converting a recombinant plasmid containing a sesquiterpene synthase coding gene XsGAS derived from xanthium sibiricum and a recombinant plasmid containing a phosphate synthase coding gene ERG20 derived from saccharomyces cerevisiae into an E.coli BL21 competent cell for construction. According to the invention, the constructed recombinant engineering bacteria is utilized for fermentation in a terrific broth (TB) culture medium to synthesize beta-elemene, and after carbon source, carbon source concentration, inducer concentration, induction time and induction OD600 are optimized, the yield of beta-elemene reaches 1.17mg / L. Compared with a chemical synthesis method, the application has the advantages that the engineering bacteria provided by invention can efficiently produce beta-elemene without pollution, and is suitable for industrial production.

The invention provides a beta-elemene halide, a preparation method therefor and an application of the beta-elemene halide. Specifically, the invention provides a preparation method for a compound witha structure represented by a formula I shown in the description, wherein each group is as defined in the description. The invention further provides a compound with a structure represented by a formula II shown in the description (each group is as defined in the description), a pharmaceutical composition containing the compound represented by the formula II, the compounds and isotope derivatives,chiral isomers, allosteric isomers, different salts, prodrug, preparations and the like of these compounds. The compounds can serve as intermediates and be used for preparing derivatives of elemene and treating various diseases capable of being treated by the elemene, including lung cancer, mammary cancer, liver cancer, and the like.

The invention discloses a preparation method and applications for a polydopamine coated mesoporous silica / elemene composite nanoparticle preparation. The preparation method includes dropwise adding anelemene and ethanol mixed solution into a mixed solution of mesoporous silica and deionized water under room temperature, performing centrifugation for 3 min after performing stirring for 4 h, and removing supernatant to obtain mesoporous silica / elemene composite nanoparticles; dropwise adding a mixed solution of the composite nanoparticles and the deionized water into a Tris buffer solution containing dopamine salt, performing stirring for 12 h at the room temperature, performing centrifugation for 3 min, and performing washing for 3 times with the deionized water; and obtaining polydopaminecoated mesoporous silica / elemene composite nanoparticles. The method can prepare polydopamine coated mesoporous silica / elemene nano-composite materials with different mass fractions. Through the showing of solid ultraviolet test results, good ultraviolet absorption can be achieved after polydopamine coats mesoporous silica / elemene nanoparticles, so that the nano preparation cannot be easily swallowed by a reticuloendothelial system and has good sustained release effects.

The invention discloses Beta-elemene amino acid derivatives as shown in the formula I and the salt accepted pharmaceutically, the synthesis method of the Beta-elemene amino acid derivatives and the usage in preparing anticancer drugs; wherein, in the formula I, R[1], R[2] are independently H or amino acid with one hydrogen atom substituted on amino; the condition is H when R[1] and R[2] are different. The synthesis method of the Beta-elemene amino acid derivatives in the formula I and the salt accepted pharmaceutically has the advantages of having good water soluble and biocompatibility and higher anticancer activity compared with Beta-elemene and an important reaction intermediate. The synthesis method can be used as synthesizing other Beta-elemene derivatives.

The invention relates to the field of natural medicines, and particularly relates to use of beta-elemene and derivatives thereof in preventing atherosclerosis, and in particular relates to an application in preparation of medicines for treating atherosclerosis. Test results show that beta-elemene and derivatives can remarkably reduce the atherosclerotic plaque area in the coronary artery of an animal model, and meanwhile has remarkable improving effect on two key links in development process of atherosclerosis: adhesion of leukocyte and endothelial cells and peroxidation of lipids. Expression of adherence factors closely related to atherosclerosis can be reduced, so that peroxidation damage of endothelial cells in vitro and in vivo caused by high fat and H2O2 is avoided.

The invention relates to a combined drug, in particular to a combined drug with anti-tumor activity. The drug comprises elemene substances with anti-tumor effect, nonsteroidal substances with anti-inflammatory effect and one or more medicinal carriers. Such synergic combination ensures the combined drug to have better anti-tumor activity.

The invention discloses an elemene injection. One liter of the injection consists of the following raw materials: 5 to 20 grams of elemene, 15 to 60 grams of soybean lecithin for injection, 5 to 99.9 grams of oil for injection, 12 to 30 grams of glycerol for injection, and the balance of phosphate buffer solution. The invention also discloses a method for preparing the elemene injection. By controlling the content of lysophosphatide in an auxiliary material, namely soybean lecithin, and key preparation process conditions, an anti-cancer medicament, namely the elemene injection, is prepared, which has no hemoclasis, no vascular irritation and no risk of the survival of microorganisms after the sterilization, is suitable for intravenous injection or arterial intervention, has a dosage form of medicament-loaded emulsions, and is safe and effective.

The invention relates to an isopropanolamine substituted beta-elemene derivative and a preparation method and an application of the isopropanolamine substituted beta-elemene derivative. Particularly, the invention relates the novel isopropanolamine substituted beta-elemene derivative shown in the general formula (I) or (II), the preparation method of the isopropanolamine substituted beta-elemene derivative, and the application of the isopropanolamine substituted beta-elemene derivative to preparation of antitumor drugs.

The invention discloses a molecularly compatible pharmaceutical composition of docetaxel and elemene and application thereof. The docetaxel and elemene are in a mass ratio of 20-1000. The compositioncan be applied to treatment of breast cancer, lung adenocarcinoma, colon cancer, gastric cancer and prostate cancer, and especially has very good treatment effect on taxane drug-resistant breast cancer, taxane drug-resistant lung adenocarcinoma and taxane drug-resistant colon cancer. During application to preparation of drugs treating taxane drug-resistant tumors, the molecularly compatible pharmaceutical composition has significant anti-paclitaxel resistance effect, also can remarkably reduce the toxicity and greatly alleviate the pain of tumor patients. The pharmaceutical composition provided by the invention provides a new strategy for drug-resistant tumor treatment, and has important significance and broad application prospects for drug-resistant tumor treatment.

The invention belongs to the technical field of medicines and provides a pharmaceutical composition. The pharmaceutical composition comprises germacrone, furanodiene, curdione, beta-elemene, curcumol, curzerene and borneol. The components of the pharmaceutical composition are definite, and the quality can be controlled. The pharmaceutical composition can be used for preparing vaginal or rectal preparations and has a good effect of treating HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) infection and cervical diseases and can be used widely clinically.

The invention provides a method for extracting delta-elemene. The method comprises the following steps of: (1) carrying out ordinary rectification by using zedoary turmeric oil of which the delta-elemene content is more than 1.5% as the raw material, wherein the vacuum degree inside a rectifying column is 150-300Pa and the rectification ratio is 2:1, and collecting distillate with a temperature of 128-135 DEG C; (2) carrying out primary fine rectification by using the distillate obtained in the step (1) as the raw material, subsequently carrying out the secondary fine rectification by using the obtained distillate as the raw material, wherein the rectification ratios are different (4:1 in the primary fine rectification, and 6:1 in the secondary fine rectification) and the vacuum degrees in precise rectifying columns are both set as 50-150Pa, and collecting distillate with a temperature of 120-125 DEG C; and (3) carrying out axial compression high pressure column separation by using the obtained distillate in the step (2) as the raw material. According to the method, a method of primary ordinary rectification, secondary precise rectification and axial compression high pressure column separation is utilized, delta-elemene with high purity is obtained, and the difficult problem that no reference substances of the delta-elemene are available for years is solved.

The invention provides recombinant yarrowia lipolytica as well as a construction method and application thereof, and relates to the field of bioengineering. The recombinant yarrowia lipolytica is a yarrowia lipolytica XJ-8 strain collected in CGMCC, with the collection number of CGMCC No.19064. The construction method of the yarrowia lipolytica is simple and efficient to operate, and can efficiently synthesize beta-elemene and / or germacrene A.

The invention discloses beta-elemene macrocyclic derivatives as well as a preparation method and application thereof in preparation of antitumor drugs. The structure of the beta-elemene macrocyclic derivative is as shown in any one of formulas (I)-(III).

The invention belongs to the technical field of medicines, and provides a medical compound containing borneol. The medical compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medical compound containing borneol is definite in ingredients and controllable in quality; the content of camphol in the borneol is controlled, so that the blood concentration and the mucosa absorbing rate of the medical compound are improved; the medical compound provided by the invention can be used for preparing suppository, ointment, capsules, effervescent tablets, gels, lotions, film agents or foaming agents; and the medical compound provided by the invention can well treat HR-HPV (high-risk human papilloma virus) and / or LR-HPV (low-risk human papilloma virus), cervical disease and the like, and is suitable for wide clinical application.

An exterior-applied elemene medicine with slow release and low irritation is proportionally prepared from elemene, organic solvent, medicinal matrix, and the additive chosen from hyaluronic acid, sodium hyaluronate gel, hyaluronidase, carbomer, and chitin. Its preparing process is also disclosed.

The invention provides a method for detecting beta-elemene and related substances thereof, which comprises the following steps of: performing isocratic elution by taking a polysaccharide derivative ofwhich the surface material is amylose-tris (3-chloro-5-methylphenyl carbamate) as a filler and acetonitrile water as a mobile phase. According to the method, beta-elemene can be effectively separatedfrom adjacent impurities and all the impurities, the reproducibility is good, beta-elemene and related substances thereof can be accurately detected, the problem that beta-elemene and related substances thereof are difficult to separate is effectively solved, and therefore it is guaranteed that the quality of beta elemene is controllable.

The invention relates to a histone deacetylase inhibitor and preparation and an application thereof, in particular to a novel histone deacetylase inhibitor based on a beta-elemene structure and a preparation method thereof, and further relates to an intermediate for synthesizing the histone deacetylase inhibitor and a preparation method thereof. The invention also relates to an application of the histone deacetylase inhibitor in preparation of antitumor drugs, and belongs to the technical field of chemical synthesis of drugs. The zinc ion combined compound and the salt or solvate thereof are shown as a general formula (I) or (II), wherein R, X, n and i are described in the claims and the specification.

The invention relates to a detection reagent kit and method of heat-resistant microorganisms in elemene lipidosome injection semi-finished products and belongs to the technical field of medical instruments and detection means. The detection reagent kit contains sterile elemene standard injection and heat-resistant microorganism biological indicator. The detection steps include S1 screening heat-resistant microorganisms in the elemene lipidosome injection semi-finished products by the boiling water bath; S2, separating, identifying and storing heat-resistant bacteria of bacillus; S3, preparing spore liquid of the heat-resistant bacteria prepared in the step S2, and calibrating concentration of spore liquid; S4, preparing biological indicator by products obtained in the step S3, and calibrating concentration of the biological indicator; S5, boiling quantitatively. The detection reagent kit fills the blank of the related technology and forms the detection technology of a complete closed loop from inspection, evaluation and treatment of heat-resistant microorganisms. The detection reagent kit helps detectors detect the pollution state of elemene, labor is saved, and detection efficiency is improved.