38 results about "Leonurus japonicus" patented technology

The invention provides a traditional Chinese medicine composition for treating chronic kidney diseases and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 16 to 24 parts of astragalus membranaceus, 24 to 36 parts of poria cocos, 24 to 36 parts of motherwort herb, 16 to 24 parts of herba pyrolae, 24 to 36 parts of hairyvein agrimony, 24 to 36 parts of herba ardisiae japonicae, 16 to 24 parts of dianthus superbus, 16 to 24 parts of cluster mallow fruit and 6.4 to 9.6 parts of tetrapanax papyriferus. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention can safely and effectively improve the renal function of patients suffering from chronic kidney diseases such as qi deficiency, blood stasis and damp turbidity accumulation, relieve clinical symptoms and delay disease progression, and a traditional Chinese medicine scheme with an exact curative effect is provided for clinically treating the diseases.

The invention belongs to the field of bone nutrition powder, and particularly relates to bone nutrition powder for assisting in relieving arthritis pain and a preparation process. In the preparation, the herba eupatorii extract and the kelp extract are matched to effectively improve the arthritis pain relieving effect of the preparation, and the lophatherum gracile, the raspberry, the motherwort and the purslane are adopted to further improve the arthritis pain relieving effect of the fermented product through the processes of fermentation and the like; the preparation is applied to preparation of the bone nutrition powder, and the bone nutrition powder for assisting in relieving arthritis pain is prepared from the bone nutrition powder, protein, fat, water-soluble dietary fibers, vitamins, mineral elements and chondroitin sulfate. The obtained bone nutrition powder can effectively provide nutrition, also has an excellent health care effect, assists in relieving arthritis pain, and is excellent in performance and relatively good in application prospect.

The invention provides a composition for promoting blackening of forehead white hair as well as a preparation method and application of the composition, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by weight: 1 to 6.5 parts of radix ginseng, 1 to 44.5 parts of radix astragali membranaci extract, 0.1 to 4 parts of rhizoma atractylodis macrocephalae rhizome extract, 0.1 to 2.2 parts of rhizoma atractylodis rhizome extract, 0.01 to 5.334 parts of cortex magnoliae officinalis extract and 0.01 to 2.565 parts of herba leonuri extract. The ginseng root, the astragalus membranaceus root extract, the rhizoma atractylodis macrocephalae rhizome extract, the rhizoma atractylodis rhizome extract, the cortex magnoliae officinalis bark extract and the herba leonuri extract are added into the ethanol solution, so that the effects of active ingredients of the plant extracts can be effectively exerted, the hair and the nutritional ingredients required by hair follicles are provided, and the prehead white hair is synergistically promoted to be black. The preparation method is simple, easy to operate and suitable for industrial production.

This invention discloses a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving postoperative visual function, belonging to the field of pharmaceutical technology. The kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is made from 10 parts of Cuscuta chinensis, 15 parts of Broussonetia papyrifera fruit, 18 parts of Lycium barbarum, 15 parts of Leonurus japonicus, 20 parts of Leonurus japonicus, 10 parts of Ligusticum chuanxiong, 9 parts of Prunus persica kernel, 6 parts of Carthamus tinctorius, 15 parts of Poria cocos, 18 parts of Albizia julibrissin bark, 12 parts of Astragalus membranaceus, and 12 parts of Pueraria lobata root. It can be standardized and adjusted according to clinical complications. This invention focuses on the critical point of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery, using the principles of tonifying the liver and kidneys and activating blood circulation to improve ocular microcirculation, enhance and stabilize vision, thereby protecting visual function, and conforming to the treatment principle of "treating the root cause when the condition is mild."

The present application relates to the field of traditional Chinese medicinal materials, in particular to a composition for resisting PRRSv and improving the reproductive performance of sows and application thereof. The present application formulates a composition composed of 10 plant extracts (Angelica sinensis extract, Atractylodes macrocephala Koidz extract, Glycyrrhiza uralensis Fisch extract, Eucommia ulmoides Oliver extract, Eucommia ulmoides leaf extract, Populus davidiana Dode extract, Perilla frutescens leaf extract, Gynostemma pentaphyllum Makino extract, Leonurus japonicus extract and Astragalus membranaceus Bge extract) for sows in late pregnancy, and collects sow blood and placenta samples at the time of delivery, studies the influence of the composition on sow reproduction, and explores the mechanism of action. The experimental results show that the composition can improve the reproductive performance of sows by increasing the total number of piglets and other indicators; meanwhile, the composition can effectively inhibit the replication of PRRSv.

The invention relates to the field of repair product preparation, in particular to a novel nano-antibacterial skin repair product for preventing hpv viruses. The formula is prepared from the following raw materials by weight: 0.80 to 4.50 g of purified water, 0.008 to 0.150 g of carbomer, 0.01 to 0.80 g of fenugreek oil, 0.01 to 0.30 g of oat beta glucan, 0.003 to 0.400 g of folium artemisiae argyi extracting solution, 0.01 to 0.40 g of herba portulacae extracting solution, 0.006 to 0.420 g of herba violae extracting solution, 0.001 to 0.200 g of herba lophatheri extracting solution, 0.007 to 0.300 g of herba taraxaci extracting solution, 0.008 to 0.220 g of rhizoma paridis chinensis extracting solution, 0.01 to 0.40 g of herba leonuri extracting solution, 0.0005 to 0.0300 g of nano silver and 0.008 to 0.150 g of borneol. The adhesive comprises the following components by weight: 0.01 to 0.30 g of sodium carboxymethyl cellulose, 0.008 to 0.220 g of lubrajel, 0.007 to 0.300 g of benzoyl peroxide, and 0.0005 to 0.0300 g of a cross-linking agent. The invention has the following beneficial effects: the ointment comprises a plurality of plant extracts, has no irritation to vagina, is safe and has no side effect; the carried antiviral and antibacterial components can rapidly permeate into the skin to protect mucous membrane cells from being damaged by viruses; skin tissues can be quickly repaired, and wound healing and regeneration capacity is improved; various plant extracts in the gel can also improve the immunity of the organism and can achieve a good antiviral effect.

The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese medicine compound for improving the egg laying performance of laying hens and a preparation method and application of the traditional Chinese medicine compound for improving the egg laying performance of the laying hens, and the traditional Chinese medicine compound comprises codonopsis pilosula, astragalus membranaceus, angelica sinensis, rhizoma atractylodis macrocephalae, herba epimedii, leonurus japonicus, fructus lycii, actinolite, rhizoma cyperi and berberine. The ratio of codonopsis pilosula to astragalus membranaceus to angelica sinensis to atractylodes macrocephala koidz to herba epimedii to leonurus japonicus to fructus lycii to actinolite to rhizoma cyperi to berberine is 2: 2: 1: 1: 3: 3: 1: 2: 1: 1. The traditional Chinese medicine compound for improving the egg laying performance of the laying hens and the preparation method and application thereof have the beneficial effects that by setting and selecting the ratio, the effectiveness and pertinence of a compound preparation can be ensured, and the effect of improving the egg laying performance of the laying hens is achieved. The method helps to improve the egg laying performance of laying hens, reduces unnecessary side effects, and can extract effective components in the traditional Chinese medicines and remove impurities by setting the extraction step. The quality and purity of the traditional Chinese medicine compound preparation can be guaranteed, and the medicine effect is improved.

This invention relates to the technical field of aquaculture feed, specifically a special nutritional feed for laying female turtles, comprising the following ingredients by weight: 45-60% Cordyceps militaris mycelium, 20-25% wheat bran, 12-15% corn flour, 5-10% tomato powder, and 3-5% oyster meat powder. The Cordyceps militaris mycelium is obtained by mixing a culture medium containing 35-50% soybean meal, 20-25% sugarcane, 15-20% Leonurus japonicus, 8-10% oyster shell powder, 5-7% soybean flour, and 2-3% silkworm pupa powder with lotus root sauce, placing it evenly in a cultivation box, sterilizing it, and then inoculating and cultivating it. The inoculum is isolated from the fruiting bodies of Cordyceps militaris and then cultivated into a liquid inoculum. This special nutritional feed for laying female turtles has a cleverly formulated ingredient ratio, achieving multiple goals such as enhancing immunity, supplementing ovulation nutrition, improving reproductive performance, preventing postpartum inflammation, and shortening the recovery period. Furthermore, this feed is highly safe and free of drug residues.

The invention discloses traditional Chinese medicine granules for treating osteoporosis. The traditional Chinese medicine granules are prepared by extracting the following traditional Chinese medicine decoction pieces in parts by weight: 10-20 parts of rhizoma cimicifugae, 15-25 parts of astragalus membranaceus, 12-18 parts of bighead atractylodes rhizome, 10-20 parts of liquorice, 15-25 parts of salvia miltiorrhiza, 10-20 parts of ligusticum wallichii, 8-12 parts of corydalis tuber, 10-20 parts of leonurus, 10-20 parts of radix ophiopogonis, 15-25 parts of adenophora stricta, 5-10 parts of fritillaria, 12-18 parts of trichosanthes kirilowii maxim, 8-12 parts of teasel root, 10-20 parts of eucommia ulmoides and the like. The traditional Chinese medicine composition can be used for treating qi deficiency and blood stasis type osteoporosis and has the effect of regulating intestinal flora.

The invention discloses a pregnancy-assisting health-care medicine and food homology formula. The invention belongs to the technical field of health care. The formula comprises the following components in parts by weight: 5-60g of wine-processed radix angelicae sinensis, 5-60g of fried radix paeoniae rubra, 5-60g of roasted cassia twig, 5-60g of processed rhizoma cyperi, 5-60g of baked ginger charcoal, 5-60g of fried polygala tenuifolia, 5-60g of roasted radix aucklandiae, 5-60g of salted fennel, 5-60g of fried eucommia ulmoides, 5-60g of deep-fried rhizoma atractylodis macrocephalae, 5-60g of fried radix dipsaci, 5-60g of salted semen cuscutae, 5-60g of processed herba epimedii, 5-60g of fried radix achyranthis bidentatae, 5-60g of herba lycopi and 5-60g of fructus corni. 5-60 g of motherwort herb; the traditional Chinese medicine adopts medicinal and edible raw materials, is safe and reliable, does not cause obvious toxic and side effects on the body after long-term taking, and is suitable for long-term body conditioning of pregnancy preparation people; the synergistic effect of multiple raw materials plays a role in regulating endocrine, improving the blood circulation of a reproductive system, enhancing the reproductive function and the like, and the pregnancy probability is effectively increased; appropriate adjustment can be carried out according to personal physique and symptoms, and high adaptability and flexibility are achieved.

The invention belongs to the technical field of liquid phase detection, and particularly relates to a wine antifebrile dichroa quality control and detection method. According to the detection method, high performance liquid chromatography is adopted to detect the content of dichroine in a solution in a test sample, and specific chromatographic conditions are as follows: a mobile phase A is acetonitrile, a mobile phase B is an acetic acid aqueous solution with the volume fraction of 0.15-0.35%, and the pH value of the mobile phase B is adjusted to 5.5-6.5 by using triethylamine; a chromatographic column takes octadecylsilane chemically bonded silica as a stationary phase, and the detection wavelength is 223 to 227 nm. The detection method disclosed by the invention has a good linear relationship when the concentration of the febrifugine is 0.67 mu g / mL to 66.64 mu g / mL; the sensitivity is high, the precision is high, and the detection limit is lt; the concentration is 0.36 mu g / mL, and the quantification limit is 1t; 0.90 [mu] g / mL; the repetitive stability is high; the sample recovery rate is high, and the average recovery rate of the dichroine hydrochloride reference substance is more than 90%.

The present invention relates to a therapeutic pharmaceutical composition for bullous epidermal necrolysis and a preparation method thereof, belonging to the technical field of pharmaceutical compositions. The pharmaceutical composition of the present invention comprises lithospermum officinale soaked oil, leonurus japonicus houtt. soaked oil, radix ampelopsis powder and paris polyphylla smith powder; through external use, it has remarkable curative effect on bullous epidermal necrolysis, can accelerate the healing and repair of wounds, is not easy to form scabs, and can avoid secondary injuries caused by the adhesion and re-uncovering of scab skin and erosion surface with the bed unit and dressing, shorten the course of disease, and improve the cure rate. In addition, the preparation method of the present invention is simple and low in cost, which can reduce the economic burden of patients.

The present application belongs to the field of biological medicine, and relates to a traditional Chinese medicine composition for treating chronic heart failure. The traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials or is prepared based on raw medicinal materials comprising the following traditional Chinese medicines: Astragalus membranaceus (Fisch.) Bunge, Acanthopanax senticosus, black ginseng, Leonurus japonicus Houtt., Ophiopogon japonicus (Thunb.) Ker-Gawl., Eutrema latifolium, Schisandra chinensis (Turcz.) Baill., Cinnamomum cassia Presl and Polygonatum sibiricum. Clinical test results show that the traditional Chinese medicine composition significantly increases the systolic pressure and diastolic pressure of heart failure patients when treating chronic heart failure patients, not only has a significant effect, but also has a rapid effect. In addition, the traditional Chinese medicine composition significantly reduces the degree of cardiac inflammation and significantly improves the cardiac function in an experimental autoimmune myocarditis mouse model. In an adriamycin-induced heart failure model SD rat, the traditional Chinese medicine composition also significantly improves the cardiac function, showing good treatment potential.

The invention relates to a traditional Chinese medicine composition for improving hypomenorrhea and application thereof, and belongs to the technical field of biological medicine. The herba leonuri, the anisodamine and the Dingkundan are combined to form the composition, efficacy complementation can be achieved, it is guaranteed that the medicine takes effect quickly, the long-acting treatment effect is maintained, meanwhile, the side effect caused by long-term single medication is avoided, the treatment safety and tolerance are improved, the menstrual volume can be remarkably increased, endometrial blood circulation can be improved, and the curative effect is improved. The hypomenorrhea is effectively improved. The medicines in the composition are all approved compliant medicines, the source is clear, the quality is controllable, the administration scheme is simple and easy to implement, the composition is suitable for clinical popularization and application, and a novel safe, efficient and reproducible treatment method is provided for hypomenorrhea.

Disclosed herein are pharmaceutical compositions and uses thereof in treating Parkinson's disease. The pharmaceutical composition comprises an ethanol extract of an herbal mixture consisting of Artemisia argyi, Morus alba L., Leonurus japonicus Houtt, Capsicum annuum L., Lophatherum gracile Brongn, Curcuma longa, and Glycyrrhiza uralensis; and a pharmaceutically acceptable excipient. The ethanol extract comprise 14 ingredients, including chlorogenic acid, leonurine, schaftoside, rutin, isochaftoside, isochlorogenic acid, 4,5-dicaffeoylquinic acid, quercetin, apigenin, glycyrrhizic acid, bisdemethoxycurcumin, demethoxycurcumin, curcumin and artemisetin.

The invention discloses a method for analyzing treatment of chronic pelvic inflammation by motherwort based on network pharmacology, and relates to the technical field of medical treatment, which comprises the following steps: firstly, screening active components of motherwort from TCMSP and BATMAN-TCM databases through multi-dimensional data mining and interaction network modeling, and then predicting potential action targets of the active components by using SwisTargetPredictions and CTD databases; the method comprises the following steps: searching a target gene related to the CPID by utilizing two databases, namely a GeneCards database and an OMIM database; the method comprises the following steps: identifying common genes of active components such as quercetin of motherwort and a CPID target gene through a motherwort-target gene-CPID interaction network, and constructing a regulatory network by using Cytoscape software; according to the method, protein interaction network analysis is carried out by adopting an STRING database, in-depth analysis is carried out on network topology characteristics by applying Cytoscape, and function enrichment analysis (GO and KEGG) is carried out on key genes by adopting a cluster Profiler packet of an R language. A research result shows that the motherwort regulates and controls a plurality of key biological pathways and molecular processes through a multi-component and multi-target synergistic effect, so that the treatment effect of the motherwort on CPID is exerted.

The invention discloses a radix sophorae flavescentis composite traditional Chinese medicine preparation for reducing soft-shell eggs and sand-preserved eggs of laying hens as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The radix sophorae flavescentis composite traditional Chinese medicine preparation is prepared by mixing radix sophorae flavescentis, radix astragali, herba epimedii, herba leonuri, pine needles, chestnut shells and licorice roots to serve as a traditional Chinese medicine composition, adopting lactobacillus plantarum, lactobacillus cellobiosus and bacillus lentus as fermentation bacteria liquid, inoculating the traditional Chinese medicine composition with the composite fermentation bacteria liquid, and conducting fermentation, drying and smashing. Through cooperation of the traditional Chinese medicine composition and the zymophyte liquid, the production of soft-shell eggs and sand-preserved eggs can be reduced. In addition, the lactobacillus plantarum, the lactobacillus cellobiosus and the bacillus lentus are combined to serve as the zymophyte liquid, and the zymophyte liquid has a synergistic effect on reducing soft-shell eggs and sand-preserved eggs laid by the laying hens.

The present invention relates to the field of medicine and food technology, and more particularly to a composition with a function of improving thrombocytopenia, a preparation method thereof, and an application thereof. The composition provided by the present invention comprises the following components in parts by weight: 20-40 parts of Chinese pine knots, 20-40 parts of herba agrimonii, 10-20 parts of raw atractylodes macrocephala, 5-20 parts of antler frost, 10-30 parts of donkey hide gelatin beads, 15-40 parts of Spatholobi vine and 5-20 parts of Leonurus japonicus; wherein, the Chinese medicine composition ... herba agrimonii; wherein, the Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of Chinese pine knots, 20-40 parts of herba agrimonii, 10-20 parts of herba agrimonii; wherein, the Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of Chinese pine knots, 20-40 parts of herba agrimonii, 10-20 parts of herba agrimonii; wherein, the Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of Chinese pine knots, 20-40 parts of herba agrimon

The invention provides application of traditional Chinese medicine polysaccharide in induction of peripheral blood mononuclear cells, and belongs to the technical field of immunotherapy. Eucommia polysaccharide, leonurus polysaccharide and cinnamon polysaccharide are preferably selected to induce peripheral blood mononuclear cells to prepare the CIK cells with efficient killing activity on tumors, the proportion of CD3 + CD56 + double positive cells and the proportion of CD3 + CD8 + double positive cells in the obtained CIK cells are greatly increased, and the killing rates of the CIK cells on various tumor cells are all 60% or above.

This invention provides a topical composition and its preparation method for reversing gray hair to black and repairing the scalp. The topical composition comprises the following raw materials in parts by weight: 10-30 parts of Polygonum multiflorum, 10-25 parts of Platycladus orientalis leaves, 8-20 parts of Artemisia argyi, 5-15 parts of ginger, 5-15 parts of Morus alba root bark, 5-12 parts of Leonurus japonicus, 5-12 parts of Lycium chinense root bark, 3-10 parts of Angelica dahurica, 5-15 parts of Morus alba leaves, 5-12 parts of Citrus reticulata peel, 3-10 parts of tea leaves, 3-10 parts of Auricularia auricula-judae, and 2-8 parts of Glycyrrhiza uralensis. The topical composition also contains a compound plant extract, which is obtained by alcohol extraction from Acer palmatum, Paederia scandens, and Areca catechu flowers in a mass ratio of (2.8-3.2):(0.9-1.1):(1.5-2.5). The composition of this invention can activate scalp tyrosinase activity and promote melanin production; improve scalp microcirculation and hair follicle nutrient supply; repair damaged hair and delay gray hair growth; achieve root-cause promotion of gray hair turning black, and also has scalp care function to restore black and shiny hair.

The invention discloses a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of products for lactating female cats. The composition is prepared from the following components in parts by weight: 45 to 75 parts of radix astragali seu hedysari, 35 to 65 parts of radix ginseng, 35 to 55 parts of radix bupleuri, 45 to 65 parts of radix curcumae, 45 to 75 parts of herba leonuri, 35 to 55 parts of semen persicae, 45 to 75 parts of radix angelicae sinensis, 20 to 40 parts of herba taraxaci, 35 to 55 parts of spica prunellae, 45 to 75 parts of radix paeoniae rubra and 45 to 75 parts of tetrapanax papyriferus. The composition provided by the invention has better palatability, is low in cost and convenient to feed, facilitates drug absorption, and can improve the feed intake of the lactating female cats, control mastitis of the female cats, relieve weight loss caused by lactation of the lactating female cats, improve the lactation yield of the lactating female cats, and further improve the weaning weight and the overall health condition of cubs.

The invention discloses a traditional Chinese medicine for treating rhinitis. The traditional Chinese medicine is prepared from herba schizonepetae, rhizoma atractylodis macrocephalae stir-fried with honey and bran, flos magnoliae (wrapped and decocted), feverfew, radix scutellariae, platycodon grandiflorum, ligusticum wallichii, pig radix scutellariae, liquorice, divaricate saposhnikovia root, astragalus membranaceus, radix angelicae, honeysuckle, leonurus, blackberry lily, rhizoma alismatis and fried semen plantaginis (wrapped and decocted). The traditional Chinese medicine composition is characterized by comprising 10-30 parts of herba schizonepetae, 10-20 parts of honey and bran fried rhizoma atractylodis macrocephalae, 10-15 parts of flos magnoliae (decocted in a wrapped manner), 10-30 parts of white chrysanthemum, 10-30 parts of radix scutellariae, 8-20 parts of platycodon grandiflorum, 10-30 parts of ligusticum wallichii, 20-40 parts of pig radix scutellariae, 10-20 parts of liquorice, 10-25 parts of radix saposhnikoviae, 25-45 parts of astragalus membranaceus, 25-45 parts of radix angelicae, 10-30 parts of honeysuckle, 25-50 parts of motherwort, 10-30 parts of rhizoma belamcandae, 20-40 parts of rhizoma alismatis and 25-40 parts of fried semen plantaginis (decocted in a wrapped manner). The traditional Chinese medicine for treating rhinitis is relatively long in treatment time, but relatively good in curative effect, and the rhinitis is not easy to relapse compared with western medicine. In the period of taking traditional Chinese medicines, patients must pay attention to inability of eating especially spicy, irritant, raw and cold food, and mostly do physical exercises to enhance the resistance.

The invention relates to the technical field of preparation of health-care products, and provides a compound foot bath tablet as well as a preparation method and application thereof. The compound foot bath tablet comprises the following components: a monarch drug, a ministerial drug, an adjuvant drug, a conductant drug and auxiliary materials. Wherein the monarch drug comprises a rhodiola rosea extract, safflower, a lucid ganoderma extract, sea-buckthorn and crocus sativus salt; the ministerial drugs comprise fructus chebulae extract, fructus terminaliae billericae extract, emblic leafflower fruit extract, fructus schizandrae extract, radix codonopsis, radix salviae miltiorrhizae, herba leonuri, radix notoginseng, juniperus formosana, rhizoma kaempferiae extract, radix astragali seu hedysari, myricaria laxiflora, rhizoma chuanxiong, sea salt, herba artemisiae annuae, lavender and mirabilis jalapa extract; the adjuvant drugs comprise gentiana macrophylla extract, gentian extract, rhizoma bolbostemmae extract, divaricate saposhnikovia root, citrus peel, sappan wood, perilla leaf, herba lycopi extract, cowherb seed extract, tribulus terrestris, rhododendron and rheum palmatum; the conductant drug comprises gastrodia elata and calamus; the auxiliary materials comprise an effervescing agent, a disintegrating agent and an adhesive. The compound foot bath tablet can clear damp and help sleep, and is convenient to use, safe and reliable.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic cerebral circulation insufficiency. The traditional Chinese medicine composition comprises the following components: gastrodia elata, desert cistanche, lucid ganoderma, fructus broussonetiae, fructus lycii, rhodiola rosea, semen cuscutae, tribulus terrestris, pseudo-ginseng and motherwort fruit. The traditional Chinese medicine composition can effectively solve the problems of large side effects and limited curative effects of existing western medicine treatment, adopts natural traditional Chinese medicine components, does not have obvious toxic or side effects, can realize consideration of both symptoms and root causes from the pathogenesis of'deficiency in root and excess in superficies', avoids the problems of gastrointestinal tract injury, liver and kidney function injury and the like caused by long-term administration of western medicine, has a more lasting curative effect and is not easy to relapse; the problems that an existing traditional Chinese medicine formula is single and poor in synergistic effect are solved, the limitation of single blood circulation promoting and blood stasis removing is broken through, a multi-target-point formula system is constructed through kidney tonifying, essence replenishing, blood circulation promoting and blood stasis removing, qi tonifying, nerve soothing, liver calming and collateral dredging, all the components achieve the synergistic effect, the disease pathogenesis is comprehensively matched, and the medicine effect is stable and remarkable.

The application discloses a Talaromyces purpureogenus and application thereof in weeding, and belongs to the technical field of bioengineering and weeding, wherein the Talaromyces purpureogenus is named as CY-1, is preserved in the China General Microbiological Culture Collection Center, and has a preservation date of May 23, 2022 and a preservation number of CGMCC No.40203. Metabolic products of the Talaromyces purpureogenus CY-1 in the application can effectively inhibit broadleaf weeds such as amaranthus retroflexus, alternanthera philoxeroides, xanthium, chenopodium album, solanum nigrum, bidens pilosa, comphre, sonchus oleraceus, pteris cretica, medicago sativa, ipomoea hederifolia, rumex patientia, galium aparine, abutilon theophrasti, portulaca oleracea, leonurus japonicus, veronica anagallis, and aster spathulifolius, and the Talaromyces purpureogenus CY-1 is green and efficient in weeding, and has a wide application prospect in weeding.

The invention provides a motherwort phenolic acid extract with a thrombolysis effect as well as a preparation method and application of the motherwort phenolic acid extract. The method provided by the invention can effectively extract the effective part with fibrinolysis effect in motherwort; the herba leonuri phenolic acid extract is mainly prepared from vanillic acid, syringic acid, trans-ferulic acid, cis-ferulic acid and 3, 4, 5-trimethyl gallic acid, and the total content of the herba leonuri phenolic acid extract is not lower than 70%. The herba leonuri phenolic acid extract has a good dissolving effect on fibrin in thrombosis, has thrombus dissolving and antithrombotic effects, and can be processed into various common preparations or sustained release preparations such as oral preparations such as tablets, capsules, granules and dropping pills according to a conventional production process of pharmaceutics; injection preparations such as injection freeze-dried powder injections and external preparations such as ointment and emulsifiable paste are used for treating thrombotic diseases (including cerebral thrombosis and subcutaneous blood stasis).

This invention belongs to the field of traditional Chinese medicine and natural product technology, specifically relating to the use of Leonurus japonicus extract in the preparation of antidepressant drugs. This invention uses 70% ethanol extraction to prepare Leonurus japonicus extract. This extraction method reduces extraction costs, shortens production time, increases extract yield, increases the extraction rate of effective components, and increases enterprise production efficiency. This invention also uses multiple depression models to verify the antidepressant activity of Leonurus japonicus extract, including a chronic unpredictable mild stress-induced depression model, a chronic corticosterone injection-induced depression model, and an ovariectomy combined with hormone withdrawal-induced depression model. The results show that Leonurus japonicus extract has a significant antidepressant effect in experimental animals. The antidepressant effect of the Leonurus japonicus extract of this invention is not obvious compared to the characteristics of traditional gynecological drugs, and it focuses on hormone-related depression, demonstrating the therapeutic value of Leonurus japonicus extract in the clinical classification of depression.

The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating ovulatory dysfunctional abnormal uterine bleeding, which is prepared from the following raw materials in parts by weight: 15-45 parts of astragalus membranaceus, 15-30 parts of leonurus japonicus, 15-30 parts of sargentodoxa cuneata, 9-18 parts of fructus aurantii, 9-30 parts of epimedium brevicornu, 9-15 parts of stir-fried scutellaria baicalensis, and 3-9 parts of panax notoginseng. The traditional Chinese medicine composition of the present invention has the advantages of definite curative effect, small toxic and side effects, low cost, and being convenient for popularization and application. In view of the large number of patients with ovulatory dysfunctional abnormal uterine bleeding and the poor clinical hormone treatment effect at present, the traditional Chinese medicine compound preparation provided by the present invention has good application prospects.

This application proposes a method for establishing a rapid propagation system for Leonurus japonicus, comprising: inoculating pretreated and sterilized Leonurus japonicus explants onto a callus induction medium for primary culture; after obtaining stable callus tissue from the primary culture, placing the callus tissue into an adventitious bud culture medium to cultivate adventitious buds; once the adventitious buds have grown, placing them into a rooting medium to root, thereby obtaining Leonurus japonicus seedlings suitable for rapid planting. Using this method, the success rate of callus induction can be improved, achieving a Leonurus japonicus callus induction rate >95%, and Leonurus japonicus callus tissue conducive to adventitious bud proliferation and rooting can be obtained, thus establishing a complete and stable rapid propagation system for Leonurus japonicus. This method can significantly shorten the growth cycle of Leonurus japonicus, enabling rapid propagation to meet market demand and providing a technological foundation for the large-scale production of Leonurus japonicus.

The application provides application of breast milk-derived stem cells combined with umbilical cord mesenchymal stem cells in preparation of a drug for treating premature ovarian failure, and belongs to the technical field of biological medicine. The application also provides a stem cell preparation for treating premature ovarian failure, which comprises breast milk-derived stem cells, umbilical cord mesenchymal stem cells, resveratrol glycoside, melatonin, Leonurus japonicus glycoside, vitamin C, human blood albumin and physiological saline. The breast milk-derived stem cells and the umbilical cord mesenchymal stem cells play a core role, promote follicle survival and regeneration, and improve the pathological state of ovarian ischemia and hypoxia; the Leonurus japonicus glycoside can assist in dredging and improving local microcirculation; the vitamin C, the melatonin and the resveratrol glycoside can remove excessive harmful free radicals in the ovary and the whole body, and curb the continuous damage of oxidative stress to the follicle. Animal experiments show that the stem cell preparation can significantly improve the serum hormone level of premature ovarian failure mice, increase the reserve and competence of follicles at all levels, and has a clear repairing effect on ovarian function.