25 results about "Post-pregnancy depression" patented technology

The present disclosure relates to methods of treating major depressive disorder (MDD) or postpartum depression (PPD) in a subject in need thereof with a combination of Compound (1) and an additional antidepressant, followed by continued administration of the additional antidepressant.

The invention provides a traditional Chinese medicine preparation for treating postpartum depression and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Chinese rose flowers, hypericum perforatum, caulis polygoni multiflori, tortoise shells, radix hedysari, aleppo avens, perilla stems, officinal magnolia flowers, fructus podophylli, loofah sponge, fructus choerospondiatis, entada phaseoloides, rhizoma polygonati and other traditional Chinese medicine raw materials. The traditional Chinese medicine preparation integrates the methods of soothing liver-qi stagnation, nourishing blood for tranquilization, tonifying qi and nourishing yin, promoting blood circulation to remove meridian obstruction and promoting qi circulation to relieve middle energizer, gives consideration to both symptoms and root causes, not only relieves the symptom of postpartum liver depression, but also tonifies the root cause of deficiency of qi and blood, so that liver qi is smooth, qi and blood are full and mind is nourished, and the traditional Chinese medicine preparation has the effect of preventing and treating postpartum depression. The traditional Chinese medicine preparation provided by the invention can improve nervous system functions by influencing expression of hippocampus 5-HT and DA so as to realize the effect of regulating depression-like behaviors; the traditional Chinese medicine composition has a remarkable curative effect on postpartum depression and has a remarkable effect of improving and relieving depressive clinical symptoms of patients.

To provide a compound useful for the treatment of mental disorders, such as a depressive condition including unipolar and bipolar depressive conditions, for example, but not limited to, depression, depression from generalized anxiety, major depression, treatment resistant depression, and postpartum depression.SOLUTION: The present invention provides a tryptamine prodrug compound represented by the following formula.SELECTED DRAWING: Figure 1

The application relates to application of BDNF as a biomarker in prenatal prediction of postpartum depression morbidity risk. The mBDNF and proBDNF levels in cerebrospinal fluid and plasma can be used as independent markers for prediction of postpartum depression morbidity risk, and the plasma mBDNF or cerebrospinal fluid proBDNF level can be used for prediction of postpartum depression morbidity risk through prenatal detection, which is helpful for prediction, early identification and timely intervention of postpartum depression and reduction of harm.

The application is suitable for the technical field of artificial intelligence and medical health, and provides a postpartum depression intelligent screening and early intervention system and method, which comprises a whole life cycle management module for managing continuous data flow and state transition; a physical entity layer for collecting physiological data of puerpera, mother-infant behavior interaction data and environmental semantic data; a digital twin layer for constructing a dynamic virtual mapping model, the model comprising a causal graph model based on a structural causal model and a time sequence evolution mechanism; an application service layer for generating and pushing a risk early warning, an attribution analysis and a self-adaptive intervention scheme based on causal reasoning in stages; through causal reasoning instead of correlation analysis, the early warning accuracy is improved, the digital twin layer constructs a puerpera-baby binary group dynamic mapping based on a structural causal model, and through a directed acyclic graph to quantify the causal relationship between variables and combine Monte Carlo tree search to deduce the future risk probability, compared with a traditional scale, high-risk events such as self-harm thoughts can be early warned.

The present application relates to the field of compounds, discloses a kind of steroid compound with general formula I structure and its purposes, preparation method and the pharmaceutical composition comprising the steroid compound, to GABA A Receptor has strong positive regulation, can be used for preparing oral anti-severe depression and postpartum depression drug, with the characteristics of high efficiency.

The application belongs to the field of biochemical detection, and particularly relates to application of FBL gene expression level detection substance in postpartum depression detection and a detection system. The application of the FBL gene expression level detection substance in the preparation of a postpartum depression detection product, wherein the FBL gene expression level detection substance comprises primers or a gene detection chip. The sequence of the forward primer is 5'-TCTGGCAACCAGGTATTCAAGGC-3', and the sequence of the reverse primer is 5'-CATCGGCATTGCAACGTTTGGACT-3'. The postpartum depression detection reagent provided by the application is applied to a postpartum depression detection system, and the FBL detection precision of the test system is more than 0.85, which is high precision and is very suitable for being used as a postpartum depression early diagnosis reagent.

The invention discloses a postpartum depression risk prediction system and method based on multi-source and multi-scale fusion, and relates to the technical field of data analysis and prediction. The system generates multi-source data records useful for analysis by acquiring short-term dynamic physiological data, long-term stable physiological data, and data related to environmental or behavioral factors at different temporal resolutions. The system performs modeling and scale alignment on the multi-scale features, constructs a potential spatial representation reflecting a multi-modal association relationship, and constructs a cross-modal association structure based on the representation. The system generates a plurality of preliminary risk prediction results through a multi-path or multi-expert model, and fuses the plurality of prediction results according to prediction differences, modal availability and scale buffer features to obtain a unified risk prediction value. And determining a postpartum depression risk level based on the predicted value, and outputting risk assessment information for decision support. According to the invention, fusion processing of multi-source health data can be realized, and prediction support for postpartum depression risk is provided.

5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) or a pharmaceutically acceptable salt thereof is used for treating a patient suffering from postpartum depression (PPD), and the 5-MeO-DMT is administered via the intravenous, intramuscular or subcutaneous route.

The invention relates to the technical field of data processing, in particular to a postpartum depression risk AI dynamic screening method and system. The method comprises the following steps: firstly, analyzing intensity values of different muscles in a user image, and dividing behaviors of a user at different moments into autonomic behaviors and non-autonomic behaviors; the smiling duration and the energy ratio of the autonomic behavior to the non-autonomic behavior are analyzed, an emotion contradiction index is determined, and then a contradictory smiling window is divided; determining a physiological comprehensive value by combining the stress delay angle and the recovery delay angle; analyzing forward control and reverse feedback from emotion to physiology to obtain a bidirectional path coordination ratio; screening out an imbalance event from a contradictory smile window through a bidirectional path coordination ratio; and for the unbalance event, determining the total unbalance risk of the postpartum user in combination with the bidirectional path coordination ratio and the physiological comprehensive value. According to the invention, the accuracy of postpartum depression risk screening is improved.

The application belongs to the field of biochemical detection, and particularly relates to application of HNRNPA2B1 gene expression level detection substance in postpartum depression detection and a detection system. The application of the HNRNPA2B1 gene expression level detection substance in the preparation of a postpartum depression detection product, wherein the HNRNPA2B1 gene expression level detection substance comprises primers or a gene detection chip. The sequence of the primers is as follows: a forward primer: 5'-TAGAGCACTGAGTGCAGTAACG-3', and a reverse primer: 5'-CAGTAAGCTAGATCCACTGACGT-3'. The postpartum depression detection reagent provided by the application is applied to a postpartum depression detection system, and the detection system shows that the HNRNPA2B1 detection precision is more than 0.9, which is high precision, and is very suitable for being used as a postpartum depression early diagnosis reagent.

This invention relates to the field of microbial pharmaceutical technology, specifically disclosing the application of *Blautia Obeum* in the preparation of drugs for the prevention and treatment of depression, representing a novel use of probiotics for antidepressant purposes. This invention is the first to apply *Blautia Obeum* to the prevention and treatment of depression. This strain can be prepared in various forms, including live bacterial preparations, inactivated bacterial cells, bacterial lysates, metabolites, or bacterial extracts, combined with pharmaceutically acceptable excipients to formulate various oral microecological preparations, including conventional dosage forms such as tablets, capsules, enteric-coated preparations, and oral liquids. The drugs can effectively improve core clinical symptoms of depression, such as low mood, loss of interest, sleep disorders, anxiety, and irritability, by regulating intestinal flora homeostasis, repairing intestinal barrier function, and modulating the brain-gut axis signaling pathway. It is suitable for the prevention and treatment of various types of depression, including major depressive disorder, postpartum depression, geriatric depression, and chronic stress-induced depression. The strain used in this invention is safe and highly compatible, and the preparation is convenient to administer, providing a novel microecological intervention scheme for the clinical prevention and treatment of depression, overcoming some limitations of existing antidepressant methods, and possessing good prospects for pharmaceutical development.

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) or a pharmaceutically acceptable salt thereof is used in the treatment of patients suffering from postpartum depression (PPD).

The present disclosure relates to methods of treating major depressive disorder (MDD) with elevated anxiety in a subject in need thereof, by administering a therapeutically effective amount of Compound (1), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of treating postpartum depression (PPD) with elevated anxiety in a subject in need thereof, by administering a therapeutically effective amount of Compound (1), or a pharmaceutically acceptable salt thereof.

The application provides a traditional Chinese medicine preparation for treating postpartum depression and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from traditional Chinese medicine raw materials such as Chinese weigela, St. John's wort, radix polygoni multiflori, turtle shell, red sage root, blue cloth, perilla stem, magnolia flower, small leaf lotus, loofah, Chinese olive, rattan, and rhizoma polygonati. The traditional Chinese medicine preparation integrates the methods of soothing liver and relieving depression, nourishing blood and tranquilizing the mind, tonifying qi and nourishing yin, promoting blood circulation to remove meridian obstruction, and promoting qi circulation to relieve food retention, and takes both the symptoms and the root cause into account. The traditional Chinese medicine preparation can not only relieve the symptoms of postpartum liver depression, but also tonify qi and blood deficiency, so that liver qi is unobstructed, qi and blood are sufficient, and the heart spirit is nourished, thereby achieving the effect of preventing and treating postpartum depression. The traditional Chinese medicine preparation can affect the expression of hippocampus 5-HT and DA, improve the function of the nervous system, and further realize the effect of regulating depressive behavior. The traditional Chinese medicine preparation has a significant curative effect on postpartum depression, and can significantly improve and relieve the depressive clinical symptoms of patients.

A method for computing predisposition risk for postpartum depression of an individual female human based at least on methylation is provided. The method comprises receiving, by a computing device, methylation data for an individual female human, the methylation data describing at least DNA methylation markers in the human. The method also comprises receiving, by the device, wearables data for the female, and receiving survey data provided by the female. The method also comprises applying, by the computing device, at least a risk predictor model builder and a risk predisposition assessment prediction algorithm to at least the received data to predict a risk predisposition to postpartum depression of the individual female. The method also comprises the computer identifying methylation markers causal to postpartum depression in the methylation data. The computer generates a personalized report describing methylation markers causal to postpartum depression, the markers identified at least in the received data.

The invention provides application of a chalcone compound as well as a stereoisomer, a pharmaceutically acceptable salt or a solvate thereof in preparation of a medicament for treating depression. The depression is selected from mild depression, moderate depression, severe depression, persistent depressive disorder, depression associated with bipolar disorder, seasonal affective disorder, psychotic depression, postpartum depression, premenstrual anxiety disorder, encountering depression, pleasant sensation deficiency, melancholia, middle-year depression and late-year depression; depression caused by identifiable pressure factors, refractory depression, or a combination thereof. The compounds can treat mental symptoms of depression, such as depressive mood and loss of interest or fun in almost all activities.

The invention relates to application of BDNF as a biomarker in prenatal prediction of postnatal depression risk. The mBDNF and proBDNF levels in cerebrospinal fluid and plasma can be used as independent markers for predicting the risk of postpartum depression, the mBDNF level of the plasma or the proBDNF level of the cerebrospinal fluid can be detected in advance to predict the risk of postpartum depression, prediction, early recognition and timely intervention of postpartum depression are facilitated, and harm of the postpartum depression is relieved.

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) or a pharmaceutically acceptable salt thereof is used to treat patients suffering from postpartum depression (PPD), where 5-MeO-DMT is administered via intravenous, intramuscular, or subcutaneous routes.

5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), or a pharmaceutically acceptable salt thereof, is useful in the treatment of a patient suffering from postpartum depression (PPD).

The invention relates to the technical field of functional food, and particularly discloses medicinal and edible formula powder for regulating postpartum depression and physiological disorder and a preparation method thereof, and the medicinal and edible formula powder comprises the following components in parts by mass: 115-125 parts of black sesame, 8-15 parts of an active extract, 55-65 parts of a tartary buckwheat compound, 55-65 parts of radix puerariae, 46-50 parts of radix rehmanniae, 5-9 parts of Chinese wolfberry and hawthorn polysaccharide, 32-38 parts of chrysanthemum and 45-50 parts of rock candy. The black sesame provides a nutrition basis, and the black sesame, the radix puerariae and the radix rehmanniae regulate postpartum estrogen fluctuation; the active extract and active ingredients in the tartary buckwheat compound form a synergistic effect, oxidative stress products are removed in a linkage manner, the serum MDA level is reduced, and cortisol is regulated; polysaccharide components of the Chinese wolfberry fruits and the hawthorn fruits synergistically improve immunity; the prepared formula powder can effectively improve the physiological function of postpartum people and improve postpartum depression.

The invention relates to an essential oil composition for relieving postpartum melancholia and application thereof. The composition comprises lavender essential oil, sweet orange essential oil, frankincense essential oil, sandalwood essential oil, rosemary essential oil, base oil and auxiliary components. Through the composite effect of various essential oils, the symptoms of the postpartum depression, including anxiety, emotional fluctuation, body pain, inattention and the like, can be comprehensively relieved. The essential oil composition has the advantages of being high in safety, good in comfort, convenient to use and the like, is suitable for lying-in women to use, and can effectively improve the physical and psychological health of the lying-in women and improve the family life quality.

Provided herein are methods for treating depression, such as postpartum depression or major depressive disorder, in a subject in need thereof, comprising administering to the subject an effective amount of Compound 1 or a pharmaceutically acceptable salt thereof:

Compounds that selectively inhibit GluN2B-containing N-methyl-D-aspartic acid receptors (NM / DARs) are disclosed. In some cases, the compounds selectively target GluN2B over GluN2A, GluN2C, and / or GluN2D. Generally, the compounds possess an enhanced potency to GluN2B at a pH that is more acidic compared to the physiological pH. Pharmaceutical formulations containing one or more of the compounds are also disclosed. Additionally, methods of treating a condition, disorder or disease using the compounds or their pharmaceutical formulations thereof are disclosed. Exemplary conditions, disorders, and diseases relevant to this disclosure include stroke, subarachnoid hemorrhage, cerebral ischemia, cerebral vasospasm, hypoxia, acute CNS injury, spinal cord injury, traumatic brain injury, coronary artery bypass graft, persistent or chronic cough, substance abuse disorder, opiate withdrawal, opiate tolerance, bipolar disorder, suicidal ideation, pain, fibromyalgia, depression, postpartum depression, resting tremor, dementia, epilepsy, seizure disorder, movement disorder, and neurodegenerative disease.

The invention relates to the technical field of medical monitoring, in particular to a postpartum depression monitoring method and system, and the method comprises the steps: obtaining the evaluation data of a puerpera for an online questionnaire; integrating the personal information of the online questionnaire to a database system, and establishing a personal information file; performing preliminary evaluation on the puerpera according to the evaluation data to obtain a questionnaire evaluation result; grading the health state of the puerpera based on the personal information file and the questionnaire evaluation result; for the target puerpera classified as the critical patient, generating a clinical intervention scheme, pushing the clinical intervention scheme to a responsible doctor, and recording inspection and examination reports in the treatment process; providing videos and article propaganda and education contents related to postpartum depression for a target puerpera to access; performing postpartum follow-up on the treated target puerpera to obtain a follow-up result fed back by the intervention effect, performing association analysis on the follow-up result, the questionnaire evaluation data and the clinical intervention scheme, and outputting an optimized intervention strategy; according to the invention, the comprehensiveness and accuracy of postpartum depression monitoring can be improved.