344 results about "Vitamin K2" patented technology

The present invention relates to compositions, kits and methods for the administration of various vitamin, mineral and nutrient compositions, and in a specific embodiment, the compositions, kits and methods may utilize or include vitamin D, iodine, vitamin B1, vitamin B6, vitamin B12, vitamin B2, vitamin B9, vitamin B3, vitamin E, vitamin A, vitamin C, iron, zinc, copper, magnesium, omega 3 fatty acids and one or more pharmaceutically acceptable carriers.

The invention discloses bacillus natto which is classified and named bacillus natto and has been preserved in the China Center for Type Culture Collection with the preservation number of CCTCC M 2014405. The strain is extracted from a natto product purchased in the market and is obtained through ultraviolet mutagenesis and screening. By the use of the strain, soybean protein can efficiently be utilized to synthesize vitamin K2. The invention also discloses a method for producing vitamin K2 grease by the utilization of the above bacillus natto. According to the invention, a strain fermentation technology is optimized through a novel oxygen supply strategy, and fermentation cylinder scale-up is carried out. The final output of vitamin K2 reaches 60.54 mg / L. Conversion rate relative to soybean protein is 2.018 mg / g. Production costs are low. By the above method, efficient production of vitamin K2 grease can be realized; the whole process is simple; operation is convenient; production cycle is short; content of vitamin K2 is high; and fermentation cost is reduced. The method is suitable for industrial production.

A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K3. The supplemental treatment is effective to inhibit metastases of cancer cells and inhibit tumor growth. The ratio of Vitamin C to Vitamin K3 is in the range of about 50 to 1 to about 250 to 1. A method for evaluating the effectiveness of the supplemental treatment includes monitoring the patient's serum DNase activity throughout the course of treatment.

The present invention is directed to compositions comprising a nanoparticulate vitamin K2 having improved bioavailability. The nanoparticulate vitamin K2 particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the prevention and treatment of osteoporosis. The invention also relates to a controlled release composition comprising a vitamin K2 or a nanoparticulate vitamin K2 that in operation delivers the drug in a pulsed or multi-modal manner for the prevention and treatment of osteoporosis.

The invention relates to the technical field of aquaculture feedstuff. Premix material consists of composite vitamin and composite microelement according to the mass ratio of 5 to 10:15 to 20, wherein the composite vitamin consists of vitamin A, vitamin D, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, calcium pantothenate, folic acid, biotin, inositol, vitamin C, beta-glucan, garlicin, DMPT, astaxanthin, topaz, antioxidant, mildew inhibitor and wheat middlings; and the composite microelement consists of ferric citrate, zinc sulfate, magnesium sulfate, methionine, potassium iodate, manganese sulfate, copper sulfate, sodium selenite, potassium chloride, choline chloride, betaine and zeolite. The invention has stable raw material sources and complete nutrition. A cultivated object grows rapidly with a high feedstuff conversion rate and good cultivating benefits. Compared with crabs eating other feedstuff sources such as rough fish, corn, bean pulp, and the like, the quality of Chinese mitten crab is improved. The invention relates to the feedstuff additive premix material for the Chinese mitten crab.

The invention discloses a vitamin K2 and preparation process thereof. According to the process, 1-hydroxyl-2-naphthoic acid resistant flavobacterium strain HNA12-D is fermented and cultured, and vitamin K2 efficiently metabolizes in the strain through the batch feeding of glycerin serving as the carbon source, peptone serving as the nitrogen source and precursor substances, and is extracted by using organic solvents and separated by macroporous resin, and the yield and purity of the product are improved. The total output of the vitamin K2 crude product is 200-600 mg / L after the flavobacterium strain HNA12-D of the invention is fermented and cultured for 120-144 hours, and the product purity reaches 80-99 percent after absorption chromatography; compared with the prior art, the yield output and the product purity are greatly improved, and the product can be used in industrial production.

The invention provides a multivitamin and mineral nutritional supplement composition comprising at least one polyvalent metal and at least one oxidizable vitamin with substantially improved resistance to reactions that lead to darkening and / or spotting and reactions that may reduce the potency of oxidizable vitamins. The composition is a multivitamin and mineral composition comprising at least one polyvalent metal and at least one oxidizable vitamin wherein the composition is substantially free of mobile bound water. The invention also includes methods for making such a composition and methods of preventing or reducing oxidation, improving the stability of oxidizable vitamins, and stabilizing the disintegration time of a multi-vitamin and mineral nutritional supplement composition.

The invention is concerned with compound vitamin injecting liquid and its produce method. This injecting liquid relates compound vitamin for adult and children and made of two bottles. The first bottle has vitamin C, vitamin A, vitamin D3, vitamin B1, vitamin B2, vitamin B6, niacinamide, dextrorotation panthenol, vitamin E, vitamin K and proper hydrotropic agent. The second bottle has folic acid, vitamin H and vitamin B12. The injecting liquid has same component in different dosage. The production is water-solubility injection with nice stability and safety. It can be diluted as common vitamin maintain agent. It can be used in vein for some conditions. The conditions relate to surgical, burn with large range, fracture and other trauma, serious infection illness and narcosis. Those conditions change the demand greatly and consume nutrition.

The invention aims to disclose a method for producing vitamin K2 by utilizing bacillus natto. Protoplast fusion is conducted on bacillus natto BS-53 highly yielding the vitamin K2 and bacillus natto CICC10262 having a high growth speed but a low vitamin K content, and fusants with parent advantages are screened out; obtained high-yield strains having a high growth speed are utilized to produce the vitamin K2 under an optimized fermentation condition; and isopropanol and n-hexane are utilized to extract and separate the vitamin K2. The growth speed of the strains and the yield of the vitamin K2 is increased and an effective method is provided for scale production of the vitamin K2, thereby realizing the aim of the invention.

The invention provides a vitamin orally disintegrating tablet and a preparation method thereof; the medical prescription components comprise the combination of multiplex vitamins or single vitamin, a loading agent, a disintegrant, a sacarina and a lubricant, etc. The invention aims at providing the vitamin orally disintegrating tablet with simple technique and convenient taking, and is characterized in that the technical requirements are achieved by using disintegration technology and sacarina technology to make synergic action. The vitamin orally disintegrating tablet provided by the invention are rapidly disintegrated in the oral cavity into fine particles, so as to be beneficial to the dissolving and absorption of the vitamin, thus achieving the goal of effectively supplementing the vitamin needed by the human body in time. The preparation of the invention can be taken conveniently and is especially suitable for the people such as old people, children and the patients with some diseases who have swallowing difficulty and need to supplement vitamin, or in the special environment such as having no drinkable water in a journey and out of home.

The invention discloses a method for improving output of methane produced by anaerobic digestion of inferior biomass raw materials, and belongs to the technical field of agricultural waste treatment. According to the method, various waste inferior biomass raw materials is used as a processing object, trace of electronic carrier hemin or vitamin K2 is added into an anaerobic reactor to improve the reducing force level of the whole fermentation system of biogas anaerobic fermentation so as to promote the growth and activity of hydrolytic acidification bacteria and methanogenic bacteria in the anaerobic digestion process, and the hydrolysis efficiency of the reaction system is improved, the anaerobic digestion time is shortened, and the yield of the methane and the conversion rate of the inferior biomass raw materials are improved. Due to the addition of extremely trace hemin and vitamin K2, industrial grade hemin and vitamin K2 are also applicable to the method, and the method has the advantages of simple operation and high efficiency and low cost, and is expected to be widely used in engineering practice.

The invention provides a method for detecting water-soluble vitamins in blood. The method includes the steps of detecting a mixed standard solution with at least three concentrations through a liquidchromatograph-mass spectrometer to obtain a first detecting result, wherein the mixed standard solution comprises internal standard substances and the water-soluble vitamins, and the water-soluble vitamins include the vitamin B1, the vitamin B2, the vitamin B3, the vitamin B5, pyridoxic acid, pyridoxal phosphate, the vitamin B7, the vitamin B9, 5-methyltetrahydrofolate, the vitamin B12 and the vitamin C; conducting fitting to obtain standard curve equations corresponding to the water-soluble vitamins on the basis of the first detecting result and the concentrations of the water-soluble vitamins; centrifuging a to-be-detected blood sample with a precipitate protein agent and a certain amount of internal standard substances, and taking supernate to be detected through the liquid chromatograph-mass spectrometer to obtain a second detecting result; obtaining the concentration of the water-soluble vitamins in the to-be-detected blood sample on the basis of the standard curve equations and the second detecting result. By means of the scheme, the detecting efficiency of the blood sample can be improved.

The present invention provides Natto manufactured by mixing steamed soybean, cooked barley and yam, inoculating Bacillus subtilis Natto to the mixture, and fermenting the mixture, which is almost odorless, soft, good taste, and viscous, and further, functional substances such as vitamin K2 and enzyme (Nattokinase and Protease) are remarkably increased. This product may extend the utilization as functional traditional foods relating to prevention of life-style related disease.

A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μg or less of vitamin K2 / g dry weight is obtained.

The invention discloses a method for simultaneously producing vitamin K2 and nattokinase through Bacillus natto fermentation. The method comprises the following steps: strain activation: performing streak culture on Bacillus natto in a plating culture medium, and culturing a single colony in a test tube culture medium; seed preparation: inoculating the Bacillus natto in the test tube into a seed culture medium, and culturing; production of nattokinase and vitamin K2: preparing fermentation culture medium for simultaneous production, taking the prepared seed solution after the fermentation culture medium for simultaneous production is cooled, inoculating, and producing the nattokinase and vitamin K2 under optimal culture conditions for simultaneous production; and separation and extraction of the nattokinase and vitamin K2: centrifuging the fermentation solution, separating the supernatant from the precipitate, adding inorganic high polymer flocculant into the supernatant, and taking chitosan as coagulant aid to separate the vitamin K2 and nattokinase in the supernatant. The method has the advantages of improving the raw material utilization ratio and being suitable for industrial production.

The present invention relates generally to the use of vitamin B12 (cobalamin or cyanocobalamin) alone or in combination with other photoprotective agents, including specifically other vitamins such as vitamin B9 (folic acid or folate) and vitamin B3 (niacin or niacinamide), or any chemical derivative of these vitamins and their salts, as a filter to protect cells against the damaging effects of ultraviolet (UV) light. The invention is, in one aspect, a method of reducing the rate of UV damage to cells exposed to a UV light source, by treating the cells with the vitamin composition, either alone or in combination with other photoprotective agents. Other aspects of the invention are compositions comprising effective amounts of vitamin B12 alone or in combination with other photoprotective agents including vitamin B9 and vitamin B3 and a pharmaceutically-acceptable carrier, that are useful in protecting cells, particularly skin cells, against the burning, genotoxic (mutagenic and carcinogenic), immunosuppressive and photoaging effects of UV light, especially sunlight. The invention has application as a UV light filter in oral preparations including tablets and drinks, topical creams, lotions, sprays, wipes and cosmetics. The invention also has application as a medicinal treatment for dermatological conditions caused by exposure to sunlight, such as actinic keratoses, photodermatitis, photo-induced (discoid) lupus erythematosus and the photosensitizing effects of a variety of drugs used commonly in clinical practice (e.g. certain antihistamines, ACE inhibitors, and antibiotics such as tetracycline).

The invention relates to a composition for increasing the bone mineral density and preparation and a preparation method thereof. The composition is mainly prepared from, by weight of parts, calcium carbonate, D-glucosamine hydrochloride, chondroitin sulfate, collagen protein, a casein phosphopepetides, a davallia mariesii extract and a vitamin K2. On the specific matched condition, the effect of remarkable synergistic interaction for treating osteoporosis is achieved, and the effects of blocking calcium loss and reinforcing calcium absorption are achieved; after traditional Chinese medicines of shaddock peels, chicken shells, purple bergenia herb and schisandra chinensis are added, the effect of increasing the bone density is further enhanced, and meanwhile the effects of treating the joint inflammation, tonifying the spleen and the kidney, strengthening tendons and bones, improving immunity and the like are achieved.

The invention discloses bacillus subtilis natto for high yield rate of vitamin K2 (MK-7) and application thereof, and belongs to the field of microorganisms. The bacillus subtilis natto ND-1-A27 was collected into China Center for Type Culture Collection on March 14, 2018 in Wuhan University of China, and the collection number is CCTCC NO:M 2018131. The bacillus subtilis natto has the advantages that the yield rate of the vitamin K2 (MK-7) is greatly increased and is about 70mg / L, and the maximum yield rate can be reached by about three days; the fermenting cycle is greatly shortened, the timeis shortened, and the cost is reduced; the bacillus subtilis natto can be applied to industrialized fermenting production, and the genetic stability is good; after five generations are continuously transferred, the yield rate of the vitamin K2 (MK-7) is basically stable, and is maintained at the higher level; the bacillus subtilis natto can be used as a production bacterial strain for further study and development.

Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used.

The invention belongs to the field of health care food, and especially relates to a composition used for improving skeletal system health, and applications thereof. The composition comprises skimmed milk powder, fructo-oligosaccharide, yak bone, orange fruit powder, D-glucosamine hydrochloride, bone collagen, chondroitin sulfate, herba epimedii extract, rhizoma drynariae extract, mushroom powder, magnesium carbonate, casein phosphopeptide, and vitamin K2. The composition possesses excellent prevention effects on patients with osteoporosis and skeletal system disorders such as ankylosis, arthritis, osteoproliferation, arthralgia, and myospasm, and is capable of increasing bone mineral density, and improving skeletal system health. The composition can be used for preparing health care food capable of improving skeletal system health; application range is wide; and economic benefit and social benefit are both high.

This invention discloses a method for synthesizing vitamin K2 product. The method comprises: reducing 2-methyl-1, 4-naphthoquinone into hydroquinone by using KBH4, performing Fridel-Crafts alkylation reaction with long-chain tert-terpenol in nitromethane / n-hexane system with anhydrous ZnCl2, boron trifluoride diethyl etherate and CuBr as the catalysts to introduce long-chain terpenyl to the C3 site of hydroquinone, oxidizing with isopropanol solution of FeCl3 to obtain corresponding vitamin K2. The method has such advantages as mild reaction conditions, high yield, recoverable reagents, and no environmental pollution.

The invention discloses a method for efficiently producing vitamin K2 by flavobacterium. High-producing strains are bred by means of composite mutagenesis through a low-energy ion beam and a low-temperature plasma after original strains of the flavobacterium are activated on culture media, fermentation units of the high-producing strains are increased by 50-100% through preliminary screening and shake flask fermentation secondary screening of an analog flat plate with the vitamin K2, intracellular vitamin K2 is dissolved to an extracellular environment by adding surface active agents when the flavobacterium is fermented, and the yield of the vitamin K2 is improved by 50-200%. By the aid of the method, the fermentation level of the vitamin K2 can be greatly improved, high-efficiency biosynthesis of the vitamin K2 is realized, large-scale industrialized fermentation of the vitamin K2 is possible, and the method is convenient to use.

The invention relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma.

The present invention provides a method for producing a food product containing nattokinase but containing little or none vitamin K2, comprising treating a Bacillus natto culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant (excluding chitosan). As the inorganic coagulant, calcium chloride or poly aluminum chloride is preferable, and their mixtures with a phosphorus coagulant are also preferably used. As the cationic polymer coagulant, cationic polysaccharides, hexamethylenediamine / epichlorohydrin polycondensates or dimethylamine / epichlorohydrin polycondensates are preferably used, and their mixtures with a polyacrylate are also preferably used.

The invention belongs to the field of dairy products, and particularly relates to child milk powder for promoting bone growth and a preparation method thereof. The milk powder comprises the followingcomponents in parts by weight: 3000-4000 parts of raw cow milk or raw goat milk, 100-200 parts of skim milk powder, 100-200 parts of desalted whey powder, 30-80 parts of composite vegetable oil or 1,3-dioleic acid-2-palmitic acid triglyceride, 50-150 parts of solid corn syrup, 50-150 parts of whey protein powder, 30-100 parts of crystalline fructose, 20-50 parts of fructo-oligosaccharide, 10-30 parts of anhydrous cream, 5-20 parts of galacto-oligosaccharide, 1-3 parts of compound vitamin, 1-3 parts of compound mineral and 2.2-9 parts of a calcium promoting component. By adding casein phosphopeptides, hydrolyzed yolk powder, vitamin K2 powder and other components, the calcium content is increased, and the absorption and utilization rate of calcium can be effectively increased; and by combining with probiotics, dietary fibers and other nutritional ingredients, the bone growth of children can be effectively promoted, the immunity is improved, and the growth requirements of the children are met.

The invention relates to a vitamin water aqua. The raw materials of the water aqua comprise liposome, vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin H, folic acid and solubilizer. In the invention, liposoluble vitamins are coated in a microcapsule structure of the liposome and form a homogenized and stable water aqua with water-soluble vitamins. The water aqua has stable storage character in a long time, smaller grain diameter of components and a cytoid structure and can activate the self immunologic function after entering an animal body to keep the immune level of organisms in a higher state; and meanwhile, a plurality of vitamins can be effectively stored in the organism, so that the invention avoids the problems of the loss and the insufficient utilization rate of the vitamins in the metabolic process, remarkably improves the utilization rate and the conversion rate of feed, improves the antibody level of animal organisms and enhances the disease resistant capability.

A nutritional composition for promoting musculoskeletal health in patients with inflammatory bowel disease is disclosed. The nutritional composition comprises casein protein, vitamin K in a ratio of vitamin K1:vitamin K2 being between 3:1 to 1:3 and the vitamin K providing between 3.5-20 μg / 100 kcal of the nutritional composition, vitamin D and alpha-linolenic acid. A pharmaceutical formulation, a nutritional formulation, a tube-feed formulation, a dietary supplement, a functional food, a beverage product or a combination thereof comprising the nutritional composition is also disclosed. A method for improving musculoskeletal health is also disclosed.

The invention provides a vitamin K2 compound for preventing and treating arthritis, and belongs to the field of medicine or health-care food formulae. Per 1000g of the compound comprises 0.05-0.25g of vitamin K2, 0.005-0.01g of vitamin D, 500-750g of glucosamine and 499.945-249.740g of solid or liquid matrix. The compound which is mechanically stirred and uniformly mixed under a normal temperature or heating condition is prepared to soft capsules, hard capsules or troches. The medicine or health-care food formed by the formula has remarkable preventing and treating effects on common osteoarthritis of the middle aged or the aged people, especially postmenopausal women.