98 results about "Medium-chain triglyceride" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a docetaxel oral self-microemulsion composition and a preparation process thereof. The docetaxel oral self-microemulsion composition is prepared from docetaxel, an oil phase, a surfactant, a cosurfactant, a stabilizer and an antioxidant, the oil phase is caprylic / capric acid mono / diglyceride, medium chain triglyceride, caprylic acid propylene glycol ester or lauric acid propylene glycol ester. The docetaxel oral self-microemulsion composition provided by the invention has relatively high drug loading capacity, good physical and chemical stability and relatively high bioavailability, and is more suitable for clinical medication.

A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and medium chain triglycerides (MCTs) or light liquid paraffin oil as liquid vehicle. The topical ophthalmological composition treats an ocular disease.

Provided herein are consumable compositions for methane reduction in ruminants comprising a haloalkane and a medium chain triglyceride (MCT). The use of MCT in the consumable compositions has been found to enhance the anti-methanogenic effect of the consumable compositions in ruminants. Also provided herein are methods of preparing the consumable composition and methods of administering the consumable compositions to ruminants.

The invention provides acanthopanax extract powder with excellent water solubility and taste and a preparation method of the acanthopanax extract powder, and belongs to the technical field of health care product or food preparation. The radix acanthopanacis senticosi extract powder is prepared from the following raw materials: radix acanthopanacis senticosi extract, medium chain triglyceride, a surfactant, a cosurfactant and cyclodextrin, and the mass ratio of the radix acanthopanacis senticosi extract to the medium chain triglyceride to the surfactant to the cosurfactant is (0.10 to 0.13) to (0.20 to 0.26) to (0.21 to 0.42) to (0.18 to 0.49). The ratio of the total mass of the acanthopanax extract, the medium chain triglyceride, the surfactant and the cosurfactant to the mass of the cyclodextrin is (1.5-2.5): 1, the preparation method of the acanthopanax extract powder is simple, the water solubility and bioavailability of the acanthopanax extract are remarkably improved, the application requirements of health care products and functional foods are met, and the acanthopanax extract powder is suitable for industrial production. And the transportation, storage and use convenience of the product is improved.

The invention relates to the technical field of functional food preparation, and discloses solid soft sweets capable of remarkably relieving asthenopia and a preparation method of the solid soft sweets, and every 100 parts by mass of the soft sweets comprise the following components: 5.8-6.2 parts of lutein ester microcapsules, the wall material of which is starch octenyl succinate with the substitution degree of 0.02-0.04; the emulsifier is lecithin of which the purity is greater than or equal to 90%, and the particle size lt of the emulsifier is 1t; the particle size is 200 nm; 75 to 85 parts of blueberry anthocyanin-VC compound freeze-dried powder; 18 to 22 parts of lycium barbarum polysaccharide; 45 to 55 parts of galactooligosaccharide; 8 to 12 parts of medium chain triglyceride; and a colloid base material. Through collaborative design of a hydrophobic modified wall material and a gradient mixing process, a multi-level protection network of active ingredients is constructed, so that the retention rate of fat-soluble nutrients in the processing and storage period is increased to 90% or above.

The present invention provides low glycemic index (GI) total nutrition formula emulsion and a preparation method therefor. The low GI total nutrition formula emulsion comprises the following raw material components in parts by weight: 10-14 parts of carbohydrates, 4-5 parts of calcium caseinate, 1.3-2 parts of dietary fiber, 0.1-0.15 part of sodium chloride, 0.1-0.12 part of sodium citrate, 0.1-0.15 part of potassium citrate, 0.15-0.2 part of magnesium chloride, 0.1-0.15 part of dipotassium hydrogen phosphate, 0.05-0.1 part of compound vitamins, 0.05-0.1 part of compound minerals, 2.5-3.6 parts of compound oil, 0.3-0.5 part of phospholipid, 0.2-0.5 part of medium chain triglyceride (MCT), 0.04-0.08 part of colloids. The preparation method comprises: preparing aqueous phases and oil phases from the raw materials step by step; mixing the aqueous phases and oil phases; and shearing, homogenizing and sterilizing the mixture to obtain the low GI total nutrition emulsion. The product features balanced and complete nutrition.

Methods improve cognitive functioning, for example, at least one of episodic memory, executive function, or language skills; supporting memory and / or recall; providing energy and / or ketones to the brain; and / or preventing and / or treating mild cognitive impairment (MCI) in an individual. A composition comprising medium chain triglycerides (MCTs) can be administered to the individual in a daily dosage providing from about 15 g to about 45 g MCTs. The MCTs can include from about 51 wt % to about 90 wt % of octanoic acid. The daily dose can be provided in at least two servings, for example, 2 or 3 servings. Each serving can provide about 15 g MCTs and can include octanoic acid and decanoic acid in a weight ratio of, for example, about 60:about 40. The individual can be 65 years or older and / or have mild cognitive impairment (MCI).

The invention discloses a W / O / W type nano-emulsion loaded with cocaine esterase as well as a preparation method and application of the W / O / W type nano-emulsion. The nano-emulsion is prepared from cocaine esterase, a phosphate buffer solution, soybean phospholipid, vitamin E polyethylene glycol succinate, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and medium chain triglyceride. The preparation method comprises the following steps: preparing the inner water phase; preparing an oil phase; slowly injecting the internal water phase into the oil phase under shearing to obtain W / O type primary emulsion; slowly adding the primary emulsion into the external water phase under shearing, and performing high-speed shearing to obtain a secondary emulsion; and performing high-pressure homogenization on the secondary emulsion to obtain the final W / O / W type nano-emulsion. The cocaine esterase is combined with the nano-emulsion for the first time, and the nano-emulsion prepared by the method has the effects of improving the temperature stability of the cocaine esterase and prolonging the in-vivo half-life period, and can be applied to rescue or prevention of cocaine acute poisoning.

The present disclosure provides compositions and methods useful for delivering and encapsulating active agents. The compositions can comprise a polymer and a medium chain triglyceride (MCT) that comprises fatty acids having 6 to 12 carbon atoms. The compositions can encapsulate active agents including an antibacterial, a color compound, a fragrance compound, an active pharmaceutical ingredient (API), an over-the-counter (OTC) ingredient, an antioxidant, a flavinoid, an essential oil, or a combination thereof. In particular, the compositions can encapsulate essential oils. These compositions provide for the gradual and controlled release of active agents, particularly essential oils and can be used in a variety of topical products including insect repellents.

A method of treating exocrine pancreatic insufficiency includes administering to an individual in need thereof (e.g., an individual with cystic fibrosis) an effective amount of an enteral composition having a total protein consisting essentially of hydrolyzed protein and a total fat containing monoacylglycerols (MAG) that are at least about 30 wt. % of the total fat, and the total fat optionally further contains medium chain triglycerides (MCT) and / or fatty acids. In one particular non-limiting embodiment, about 60 wt. % of the total fat is from MCT and about 40 wt. % of the total fat is from MAG; in another particular non-limiting embodiment, the total fat is MAG with free fatty acids (esterified and / or bound) without MCT; and in yet another particular non-limiting embodiment, the total fat is MAG alone without MCT.

The invention belongs to the technical field of biological medicines, and particularly relates to an adjuvant influenza vaccine as well as a preparation method and application thereof. The adjuvant influenza vaccine comprises an influenza virus monovalent stock solution, an adjuvant and a PBS (Phosphate Buffer Solution), the adjuvant is prepared by using mixed oil and an auxiliary agent, wherein the mixed oil comprises squalene, medium chain triglyceride and alpha-tocopherol; the auxiliary agents comprise sorbitan trioleate Span-85, Tween 80 and vitamin E succinic acid polyethylene glycol ester. The prepared adjuvant influenza vaccine is good in immune effect, and especially the overall effect of the tetravalent adjuvant influenza vaccine on four viruses can be improved.

Ready to drink coffee beverages are provided. The beverage comprises coffee; medium chain triglycerides (MCT); high acyl gellan gum; plant-based protein; and buffer wherein coffee is 0.5-2.5 w / w %, and MCT is 5-10 w / w %. The beverage can be refrigerated and shelf-stable in a homogenous state for at least six months at 4, 20 and 30° C.

The invention belongs to the technical field of veterinary treatment medicines, and relates to a compound ivermectin juglone liniment as well as a preparation method and application thereof. The compound ivermectin juglone liniment is prepared from the following components in percentage by weight: 0.2 percent to 0.7 percent of juglone, 0.3 percent to 0.7 percent of ivermectin, 0.8 percent to 1 percent of tween-80, 0.1 percent to 0.15 percent of butylated hydroxytoluene, 0.2 percent to 5 percent of azone, 0.05 percent to 5 percent of menthol, 1 percent to 12 percent of isopropyl myristate and the balance of medium chain triglyceride, the compound ivermectin juglone liniment can be used for effectively removing parasites of animals, and is non-toxic and low in toxicity.

The invention discloses a stable cyclosporine ophthalmic ultra-micro emulsion, which comprises 0.1% of cyclosporine, 1%-2% of medium chain triglyceride, 0.4%-0.8% of an emulsifier, 2%-3% of glycerol, 0.0005%-0.005% of sitaammonium chloride and sodium hydroxide with a required amount for adjusting the pH value of the emulsion to 6.1-7.9, and the emulsifier is a combination of teloxaben and poloxamer in a weight ratio of 3: 1. The cyclosporin ophthalmic ultra-micro emulsion provided by the invention is smaller in droplet particle size and higher in Zeta potential, is basically not changed after being placed for a long time, and has better stability and better expected drug effect.

Compositions and methods for providing a person with an exogenous and therapeutically effective supply of medium chain triglycerides and short chain fatty acids are disclosed. The compositions include one or more medium chain triglycerides (particularly caprylic acid) combined with one or more short chain fatty acids, such as butyric acid, butyrate salts, propionic acid, propionate salts, acetoacetate, or acetate salts. The compositions and methods are useful for inducing ketosis and weight loss, as well as supporting healthy blood sugar levels, in a person.

The invention relates to the technical field of pharmaceutical preparations, in particular to a self-nano-emulsification drug delivery system as well as a preparation method and related application thereof. The self-nano emulsifying composition comprises total glucosides of paeony, dihydroartemisinin and auxiliary materials, the auxiliary materials comprise, by mass, 10-45% of an oil phase, 20-68% of RH40 and 12-72% of ethyl alcohol, and the oil phase comprises glyceryl monooleate and medium chain triglyceride. Compared with the prior art, the self-nano-emulsion composition provided by the embodiment of the invention carries total glucosides of paeony and hydrophobic dihydroartemisinin together, realizes simultaneous administration of water-insoluble components and water-soluble components, and improves bioavailability.

The invention belongs to the technical field of functional grease preparation, and discloses a preparation method and application of medium-chain and long-chain fatty acid triglyceride. The preparation method comprises the following steps: taking mixed vegetable oil; adding water and heating to obtain an oil-water mixture; filling the immobilized lipase into a glass column with external circulating water heating for preheating; injecting the oil-water mixture from the upper part of the immobilized enzyme column to carry out enzyme hydrolysis reaction; collecting a hydrolyzed oil crude product, and separating free fatty acid; taking medium chain triglyceride, mixing, and injecting into the immobilized enzyme column for esterification reaction; and removing reaction by-products to obtain the medium and long chain fatty acid triglyceride rich in omega-3 / 6 / 9 equilibrium proportion. The product prepared by the method contains medium-chain fatty acid and long-chain fatty acid at the same time, the proportion of different fatty acids is more balanced, the health requirement of a human body on fatty acid intake is met, the immobilized enzyme column technology is used in a solvent-free system, the steps of lipase and oil separation are simplified, the service life of enzyme is remarkably prolonged, and the method is suitable for industrial production. The energy consumption and pollution emission are reduced, the production cost is reduced, and the modern industrial green development concept is met.

The present invention describes a process for preparing an aqueous mesoporous particle composition comprising a lipophilic compound, the process comprising the steps of: a. Providing an emulsifier or emulsifier blend in powder form; b. Mixing one or more oils at a temperature above 40 DEG C at which all oils have become liquid, where the melting temperatures of the oils differ and the mixture comprises at least a sufficient amount of medium chain triglycerides, such that the composition formed in step g has a partially liquid oil phase at a temperature of about 4 DEG C; c. Adding a hydrophobic compound or amphiphilic compound in any hydrophobic solvent to the oil mixture; d. Optionally cooling the mixture to room temperature; e. Adding the emulsifier powder and water to the oil mixture and emulsifying the mixture with optional stirring and heating to 30 DEG C to 40 DEG C; f, performing ultrasonic treatment on the emulsified mixture, and optionally performing mixing or fluidization treatment until the average particle size of the mixture is kept stable; g. Cooling the ultrasonically treated mixture to allow for sufficient time to crystallize; and h. Optionally, performing a second ultrasonic treatment while maintaining the mixture at a low temperature, as well as a composition produced by the above process.

Nutritional supplements and compositions for activating the GLP‑1 peptide and / or other hormones in a subject in order to regulate blood sugar, weight, and hunger of the subject are described in this application. The compositions include a first nutritional supplement containing specific amounts of hydrolyzed yeast, acacia gum powder, citrus bioflavonoids, cinnamon bark, and eggplant whole vegetable. The compositions also include a second nutritional supplement containing specific amounts of medium chain triglycerides, resistant potato starch, resistant tapioca starch, kombucha, guar gum, blueberry juice powder, cranberry fruit powder, and grape seed extract. A third composition includes the first and second nutritional supplements containing these ingredients in sufficient amounts to regulate the GLP‑1 hormone and / or other metabolic hormones. These compositions can increase the total GLP‑1 production up to about 220%. Other embodiments are also described.

A composition for oral care is provided having a medium chain triglyceride a hydrophobic anti-microbial agent, and a hydrophobic flavoring agent.

The present invention provides a composition to increase tear production to relieve irritation from dry eyes, and a method for application of the composition. The composition includes at least 5% menthol and a carrier. The carrier comprises at least one of: a triglyceride oil, a medium chain triglyceride, petroleum jelly, coconut oil, olive oil, beeswax, a wax that is semi-solid at 21 C, a vegetable wax, an animal wax, a petroleum wax, a mineral wax, a synthetic wax, vaseline, lanoline, hydrogenated rosin / glyceryl diisostearate, hydrogenated polyisobutene, polyethylene, fatty acid cholesteryl, higher fatty acid esters, aliphatic alcohols, squalene, polyethyleneglycol, higher fatty acids, animal oil, and vegetable oil. The method includes delivering the composition to a user's eye.

The invention discloses a preparation method of an oil-in-water type probiotic emulsion based on lactoferrin. The preparation method comprises the following steps: by taking a compound of lactoferrin and soybean lecithin as an emulsifier and medium chain triglyceride as an oil phase, dispersing probiotic freeze-dried powder in the oil phase, and carrying out high-speed shearing homogenization on a water phase and the oil phase, so as to obtain the oil-in-water type probiotic emulsion. The process for preparing the emulsion is simple and low in cost, the prepared emulsion can effectively embed the probiotics and has a good protection effect on the probiotics, and the gastrointestinal tolerance and environmental resistance of the probiotics in the emulsion can be improved. As a potential commercial product, the product shelf life can be prolonged, and the application range of probiotics and lactoferrin in the food field is expanded.

An extensively hydrolysed infant formula (eHF) comprising protein, carbohydrate and fat, wherein the eHF comprises about 2.4 g or less protein per 100 kcal, wherein about 30% or less by weight of the fat is medium chain triglycerides (MCTs), and wherein the eHF may further comprise 2′-fucosyllactose (2′FL) and / or lacto-N-neotetraose (LNnT).

The invention belongs to the technical field of ophthalmic gels, and discloses an ophthalmic gel for relieving eye allergy symptoms and a preparation method thereof. The preparation method comprises the following steps: S1, dissolving an active component in a phosphate buffer solution containing polysorbate 80 to prepare an active component solution; s2, mixing the obtained active ingredient solution with medium-chain triglyceride, and carrying out high-speed shearing emulsification treatment to obtain a nano emulsion; s3, mixing polyvinyl alcohol and sodium carboxymethyl cellulose, adding into deionized water, stirring and dissolving, then adding genipin, and carrying out cross-linking reaction to obtain a gel matrix; s4, mixing the obtained nano emulsion with a gel matrix, and performing dispersion treatment under ultrasonic waves; and S5, injecting the mixed system into a mold, and curing to obtain the ophthalmic gel with the pH response characteristic. Through the synergistic effect of nano emulsification and intelligent gel, the problems of sudden drug release, low bioavailability and high irritation of a traditional preparation are solved.

The invention relates to an ondansetron hydrochloride soft chewing composition for pets and a preparation method of the ondansetron hydrochloride soft chewing composition. The ondansetron hydrochloride soft chewing composition comprises the following components in percentage by mass: 3%-6% of ondansetron hydrochloride, 7.2%-8.2% of glycerol, 10.3%-14.5% of medium chain triglyceride, 19%-22% of an adhesive, 20%-30% of chicken liver powder and 25%-35% of corn starch. The preparation method comprises the following steps: uniformly mixing the raw material medicine powder with the corn starch, the chicken liver powder and the adhesive, adding the glycerol, stirring, adding the medium chain triglyceride, and stirring; the ondansetron hydrochloride soft chewing composition is good in palatability, simple in preparation process, convenient for industrial production and stable in property.

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.

The present invention the novel ointment composition based on milkfat obtained from human breast milk and combined with a synergistically beneficial ratio of medium chain triglycerides to milk fat from human breast milk.

A personal care composition having: a hydrocarbon having 4 to 6 carbons; a fatty ester, a fatty acid, a medium chain triglyceride, a silicone, vitamin E, or a combination of two or more thereof; and one or more surfactants, wherein the personal care composition is self-foaming.

The present disclosure provides compositions and methods useful for delivering and encapsulating active agents. The compositions can comprise a polymer and a medium chain triglyceride (MCT) that comprises fatty acids having 6 to 12 carbon atoms. The compositions can encapsulate active agents including an antibacterial, a color compound, a fragrance compound, an active pharmaceutical ingredient (API), an over-the-counter (OTC) ingredient, an antioxidant, a flavinoid, an essential oil, or a combination thereof. In particular, the compositions can encapsulate essential oils. These compositions provide for the gradual and controlled release of active agents, particularly essential oils and can be used in a variety of topical products including insect repellents.