52 results about "Medium-chain triglyceride" patented technology

A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and medium chain triglycerides (MCTs) or light liquid paraffin oil as liquid vehicle. The topical ophthalmological composition treats an ocular disease.

Methods improve cognitive functioning, for example, at least one of episodic memory, executive function, or language skills; supporting memory and / or recall; providing energy and / or ketones to the brain; and / or preventing and / or treating mild cognitive impairment (MCI) in an individual. A composition comprising medium chain triglycerides (MCTs) can be administered to the individual in a daily dosage providing from about 15 g to about 45 g MCTs. The MCTs can include from about 51 wt % to about 90 wt % of octanoic acid. The daily dose can be provided in at least two servings, for example, 2 or 3 servings. Each serving can provide about 15 g MCTs and can include octanoic acid and decanoic acid in a weight ratio of, for example, about 60:about 40. The individual can be 65 years or older and / or have mild cognitive impairment (MCI).

The present disclosure provides compositions and methods useful for delivering and encapsulating active agents. The compositions can comprise a polymer and a medium chain triglyceride (MCT) that comprises fatty acids having 6 to 12 carbon atoms. The compositions can encapsulate active agents including an antibacterial, a color compound, a fragrance compound, an active pharmaceutical ingredient (API), an over-the-counter (OTC) ingredient, an antioxidant, a flavinoid, an essential oil, or a combination thereof. In particular, the compositions can encapsulate essential oils. These compositions provide for the gradual and controlled release of active agents, particularly essential oils and can be used in a variety of topical products including insect repellents.

Ready to drink coffee beverages are provided. The beverage comprises coffee; medium chain triglycerides (MCT); high acyl gellan gum; plant-based protein; and buffer wherein coffee is 0.5-2.5 w / w %, and MCT is 5-10 w / w %. The beverage can be refrigerated and shelf-stable in a homogenous state for at least six months at 4, 20 and 30° C.

The invention belongs to the technical field of functional grease preparation, and discloses a preparation method and application of medium-chain and long-chain fatty acid triglyceride. The preparation method comprises the following steps: taking mixed vegetable oil; adding water and heating to obtain an oil-water mixture; filling the immobilized lipase into a glass column with external circulating water heating for preheating; injecting the oil-water mixture from the upper part of the immobilized enzyme column to carry out enzyme hydrolysis reaction; collecting a hydrolyzed oil crude product, and separating free fatty acid; taking medium chain triglyceride, mixing, and injecting into the immobilized enzyme column for esterification reaction; and removing reaction by-products to obtain the medium and long chain fatty acid triglyceride rich in omega-3 / 6 / 9 equilibrium proportion. The product prepared by the method contains medium-chain fatty acid and long-chain fatty acid at the same time, the proportion of different fatty acids is more balanced, the health requirement of a human body on fatty acid intake is met, the immobilized enzyme column technology is used in a solvent-free system, the steps of lipase and oil separation are simplified, the service life of enzyme is remarkably prolonged, and the method is suitable for industrial production. The energy consumption and pollution emission are reduced, the production cost is reduced, and the modern industrial green development concept is met.

The present invention describes a process for preparing an aqueous mesoporous particle composition comprising a lipophilic compound, the process comprising the steps of: a. Providing an emulsifier or emulsifier blend in powder form; b. Mixing one or more oils at a temperature above 40 DEG C at which all oils have become liquid, where the melting temperatures of the oils differ and the mixture comprises at least a sufficient amount of medium chain triglycerides, such that the composition formed in step g has a partially liquid oil phase at a temperature of about 4 DEG C; c. Adding a hydrophobic compound or amphiphilic compound in any hydrophobic solvent to the oil mixture; d. Optionally cooling the mixture to room temperature; e. Adding the emulsifier powder and water to the oil mixture and emulsifying the mixture with optional stirring and heating to 30 DEG C to 40 DEG C; f, performing ultrasonic treatment on the emulsified mixture, and optionally performing mixing or fluidization treatment until the average particle size of the mixture is kept stable; g. Cooling the ultrasonically treated mixture to allow for sufficient time to crystallize; and h. Optionally, performing a second ultrasonic treatment while maintaining the mixture at a low temperature, as well as a composition produced by the above process.

Nutritional supplements and compositions for activating the GLP‑1 peptide and / or other hormones in a subject in order to regulate blood sugar, weight, and hunger of the subject are described in this application. The compositions include a first nutritional supplement containing specific amounts of hydrolyzed yeast, acacia gum powder, citrus bioflavonoids, cinnamon bark, and eggplant whole vegetable. The compositions also include a second nutritional supplement containing specific amounts of medium chain triglycerides, resistant potato starch, resistant tapioca starch, kombucha, guar gum, blueberry juice powder, cranberry fruit powder, and grape seed extract. A third composition includes the first and second nutritional supplements containing these ingredients in sufficient amounts to regulate the GLP‑1 hormone and / or other metabolic hormones. These compositions can increase the total GLP‑1 production up to about 220%. Other embodiments are also described.

The invention discloses a preparation method of an oil-in-water type probiotic emulsion based on lactoferrin. The preparation method comprises the following steps: by taking a compound of lactoferrin and soybean lecithin as an emulsifier and medium chain triglyceride as an oil phase, dispersing probiotic freeze-dried powder in the oil phase, and carrying out high-speed shearing homogenization on a water phase and the oil phase, so as to obtain the oil-in-water type probiotic emulsion. The process for preparing the emulsion is simple and low in cost, the prepared emulsion can effectively embed the probiotics and has a good protection effect on the probiotics, and the gastrointestinal tolerance and environmental resistance of the probiotics in the emulsion can be improved. As a potential commercial product, the product shelf life can be prolonged, and the application range of probiotics and lactoferrin in the food field is expanded.

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.

A personal care composition having: a hydrocarbon having 4 to 6 carbons; a fatty ester, a fatty acid, a medium chain triglyceride, a silicone, vitamin E, or a combination of two or more thereof; and one or more surfactants, wherein the personal care composition is self-foaming.

The present disclosure provides compositions and methods useful for delivering and encapsulating active agents. The compositions can comprise a polymer and a medium chain triglyceride (MCT) that comprises fatty acids having 6 to 12 carbon atoms. The compositions can encapsulate active agents including an antibacterial, a color compound, a fragrance compound, an active pharmaceutical ingredient (API), an over-the-counter (OTC) ingredient, an antioxidant, a flavinoid, an essential oil, or a combination thereof. In particular, the compositions can encapsulate essential oils. These compositions provide for the gradual and controlled release of active agents, particularly essential oils and can be used in a variety of topical products including insect repellents.

The present disclosure provides compositions and methods useful for delivering and encapsulating active agents. The compositions can comprise a polymer and a medium chain triglyceride (MCT) that comprises fatty acids having 6 to 12 carbon atoms. The compositions can encapsulate active agents including an antibacterial, a color compound, a fragrance compound, an active pharmaceutical ingredient (API), an over-the-counter (OTC) ingredient, an antioxidant, a flavinoid, an essential oil, or a combination thereof. In particular, the compositions can encapsulate essential oils. These compositions provide for the gradual and controlled release of active agents, particularly essential oils and can be used in a variety of topical products including insect repellents.

This invention relates to the application of edible oils in the production of vitamin D drops, belonging to the field of pharmaceutical preparation technology. This invention uses specific types of edible oils (such as medium-chain triglycerides) as lubricants in the vitamin D drop pelleting process, which can completely solve the problem of liquid paraffin in vitamin D drops while ensuring pellet quality. Among single edible oils, medium-chain triglycerides and soybean oil produce the best pellet quality, while using a combination of medium-chain triglycerides and soybean oil can further improve pellet quality.

The invention provides a cyclosporine bulk drug and a detection method of related substances of oil-in-water emulsion thereof, the method adopts an octadecyl silane bonded silica gel chromatographic column (the front of the column is connected with a stainless steel tube), a mobile phase A is a mixed solution of acetonitrile, a water phase, tert-butyl methyl ether and phosphoric acid in a ratio of 450-480: 490-540: 25-45: 1, and the water phase contains 0.1-0.4% of an ion pair reagent; a mobile phase B is a mixed solution of acetonitrile and 0.2% phosphoric acid water in a ratio of 70: 30-80: 20, and the cyclosporine and five impurities (impurity U, impurity H, impurity dihydroA, impurity D and impurity G) thereof can be distinguished and detected at the same time through specific gradient elution. The method has the advantages of strong specificity, high sensitivity and good repeatability, and can effectively control the content of related substances in the cyclosporine oil-in-water emulsion. The method can be used for detecting the cyclosporine ophthalmic preparation containing the teloxacin and the medium chain triglyceride.

This application relates to the field of veterinary drug formulation technology, and discloses a cat anti-stress oral formulation containing pregabalin and its preparation method. The raw materials include: pregabalin-L-arginine co-ground micronized powder, isostearic acid, medium-chain triglycerides, hydrophobic fumed silica, and anhydrous yeast extract powder. The preparation method includes the following steps: weighing each raw material by mass; dissolving isostearic acid in medium-chain triglycerides by heating and stirring; starting high-speed dispersion under vacuum and constant temperature; introducing pregabalin-L-arginine co-ground micronized powder for reaction; introducing anhydrous yeast extract powder for dispersion; cooling and switching to low-speed stirring; adding hydrophobic fumed silica and running under vacuum; finally, static aging and packaging to obtain the finished product. This invention employs a technical solution of compounding pregabalin-L-arginine co-ground micronized powder, isostearic acid, and hydrophobic fumed silica in the oil phase, achieving the technical effect of thixotropic formulation and long-term static non-sedimentation.

The invention relates to a lycopene and lutein compounded eye-protecting soft capsule and a production process thereof, and discloses a lycopene and lutein compounded eye-protecting soft capsule which improves the bioavailability and stability of fat-soluble components by optimizing the component proportion and the production process and adopting a high-speed emulsification and antioxidant protection treatment technology. The eye-protecting soft capsule and the production process thereof are used for realizing more efficient retina protection and asthenopia relieving. The composition is characterized by comprising the following components in percentage by mass: 2%-10% of lutein ester, 1%-5% of lycopene, 0.5%-3% of zeaxanthin, 10%-25% of DHA algal oil, 0.5%-2% of vitamin E, 20%-40% of medium chain triglyceride, 30%-40% of gelatin, 15%-25% of glycerol and 15%-25% of purified water.

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.

The present invention discloses a topical formulation composition comprising diethylene glycol monoethyl ether and a medium chain triglyceride, and free of other pharmaceutically active ingredients. Also disclosed is the use of a topical formulation combination in the treatment of alopecia, hair growth and / or for stoma skin protection. The composition is sprayed for external use, has a good curative effect on androgenetic alopecia, and is simple in components. The composition does not contain ethanol, so that the risk of local stimulation is reduced. The composition does not contain plant extracts, and the quality is easy to control. Compared with a PRP therapy and a low-energy laser therapy, the composition is convenient to use, and a patient can use the composition by himself / herself every day without depending on special equipment.

A method reduces postprandial glucose from a meal. The method includes orally administering to an individual a composition containing medium chain triglycerides (MCT) and then subsequently orally administering the meal to the individual after the oral administration of the composition containing the MCTs and within about one hour of the oral administration of the composition containing the MCTs. For example, the meal can be administered about thirty minutes after the administration of the composition containing the MCTs. The postprandial glucose is reduced relative to postprandial glucose from (i) postprandial glucose from administration of an identically formulated composition containing MCTs at approximately the same time as the administration of the meal and (ii) postprandial glucose from administration of the meal without any MCTs within about one hour before or within about one hour afterward. The composition containing the MCTs can be a liquid oral nutritional supplement (ONS) providing incomplete nutrition.

The present application provides compositions and methods for reducing tear evaporation and for treatment of dry eye diseases. In one example, a composition is provided comprising a semi-fluorinated alkane compound such as, e.g., perfluorohexyloctane; and an additive selected from paraffin, medium chain triglycerides, propylene glycol diacetate, and combinations thereof, wherein the topical ophthalmological composition is free from any other active pharmaceutical compound useful for the treatment of dry eye disease, dry eye syndrome, meibomian gland disfunction, or keratoconjunctivitis sicca. Eye drops comprising the compositions are also provided. Methods of using the compositions are also provided and include methods for reducing one or more symptoms of dry eye disease, dry eye syndrome, meibomian gland disfunction, keratoconjunctivitis sicca, and methods for reducing or modifying tear evaporation rate, increasing tear retention time, protecting tear film, preventing tear evaporation, producing a soothing effect, or improving tear quality in an eye of a subject.

A method increases production of ketones derived from oral consumption of medium chain triglycerides (MCT) by an individual. The method includes orally administering to the individual a composition containing the MCTs and then subsequently orally administering to the individual a meal at least about ten minutes after the oral administration of the composition containing the MCTs and within about one hour of the oral administration of the composition containing the MCTs. For example, the meal can be administered about thirty minutes after the administration of the composition containing the MCTs. The ketone production is increased relative to ketone production from oral administration of the MCTs and the meal at approximately the same time. The meal can be breakfast. The composition containing the MCTs can be a liquid oral nutritional supplement (ONS) providing incomplete nutrition.

Ketogenic food formulations comprising fats, fibers, possibly carbohydrates and proteins, wherein the formulations comprise beta-hydroxybutyrate (BHB) di- and poly-esters, and medium chain triglycerides (MCTs) and the formulations for use in a ketogenic diet or for use by individuals affected by particular physiological and / or pathological conditions, on the basis of which particular dietary regimens characterized by a low carbohydrate content may be recommended and beneficial; as well as food products comprising the ketogenic food formulations.

The invention belongs to the technical field of special nutritious food, and particularly relates to vitamin D fortified aerospace yoghurt powder as well as a preparation method and application thereof. The vitamin D fortified aerospace yoghurt powder provided by the invention comprises the following components in percentage by mass: 65%-74.4% of whole milk powder, 20%-25% of white granulated sugar, 3%-5% of a leavening agent, 0.8%-1.5% of whey protein powder, 1.1%-2.0% of maltodextrin, 0.05%-0.15% of medium chain triglyceride, 0.03%-0.11% of sodium caseinate, 0.5%-1.5% of vitamin D oil and 0.1%-0.5% of sodium alginate. The vitamin D fortified spaceflight yoghurt powder provided by the invention changes the single supplement mode that vitamin D depends on tablets or capsules according to the nutritional requirements of astronauts, is high in acceptability and convenient to eat and store, meets the vitamin D intake requirements of the astronauts, and can improve the imbalance of intestinal flora in human bodies in a weightless state and enhance the intestinal health of the human bodies. The process for preparing the vitamin D fortified spaceflight yoghurt powder is simple, the embedding efficiency of the microcapsule powder is good, and the method is suitable for large-scale production.

The invention discloses an R-lipoic acid-gamma-cyclodextrin inclusion compound and a solid beverage thereof, and belongs to the technical field of solid beverages. The inclusion compound is prepared from gamma-cyclodextrin, R-lipoic acid and medium chain triglyceride (MCT) according to specific parts by weight, preferably 10 parts of gamma-cyclodextrin, 5 to 10 parts of R-lipoic acid and 0.5 to 1 part of MCT. The preparation method comprises the following steps: dissolving gamma-cyclodextrin in water, and adjusting the pH value to 3-5 by using acetic acid; dispersing R-lipoic acid in ethanol, dropwise adding into a cyclodextrin aqueous solution, and stirring; and adding MCT after high-pressure homogenization circulation, carrying out high-pressure homogenization again, and finally freeze-drying to obtain the clathrate compound. The method is mature in process, high in coating rate (greater than or equal to 94%) and suitable for industrial production. The prepared clathrate compound can be used for preparing a solid beverage, and the beverage is good in solubility, smooth in taste, free of pungent smell and good in stability and acceptability of consumers.

The present application provides compositions, methods, and dispensers for topical delivery of ophthalmological active pharmaceutical ingredients (APIs).In one example, a composition is provided comprising an active pharmaceutical ingredient soluble in MCT wherein the API is not atropine or a salt thereof, a medium chain triglyceride (MCT); and a semi-fluorinated alkane compound. In another example, a nano-emulsion is provided comprising about an active pharmaceutical ingredient soluble in MCT; a medium chain triglyceride (MCT); and a semi-fluorinated alkane compound, wherein the nano-emulsion has a droplet particle size D90 of less than about 100 nm. Dispensers containing the compositions are also provided and include glass and polyethylene terephthalate dispensers or containers. Methods of using the compositions are also provided and include a method for treating an ocular condition in a subject comprising administering the compositions or nano-emulsions to an eye of the subject.The present application also provides compositions and methods for treating ophthalmological conditions such as presbyopia and glaucoma. The compositions can comprise a muscarinic cholinergic receptor agonist and a semi-fluorinated alkane compound; or can comprise a muscarinic cholinergic receptor agonist, a semi-fluorinated alkane compound, and an organic cosolvent. The compositions can confer chemical stability of the muscarinic cholinergic receptor agonist.

The disclosure provides pharmaceutical formulations comprising d4-domperidone of the formula (I):or a pharmaceutically acceptable salt thereof. The formulations also contain (i) a glyceryl stearate, and a medium chain triglyceride; or (ii) a stearoyl polyoxyl glyceride, a nonionic poly(ethylene oxide) polymer, and a medium chain triglyceride; or (iii) a nonionic poly(ethylene oxide) polymer, and a polyethylene glycol. The disclosure also provides methods for treating a disorder that is gastroparesis, nausea apart from gastroparesis, vomiting apart from gastroparesis, nausea associated with gastroparesis, vomiting associated with gastroparesis, gastroesophageal reflux disease, insufficient lactation, or a combination thereof in a patient, comprising administering to the patient a formulation described herein. In some aspects, the disorder is gastroparesis. In other aspects, the disorder is gastroesophageal reflux disease. In further aspects, the disorder is insufficient lactation.

The invention belongs to the technical field of formula food for special medical purposes, and particularly relates to liquid special medical nutritional food containing whey protein and a preparation method of the liquid special medical nutritional food. The food is prepared from the following raw materials: maltodextrin, whey protein powder, phospholipid, citric acid fatty glyceride, stevioside, gellan gum, sodium carboxymethyl cellulose, microcrystalline cellulose, sunflower seed oil, rapeseed oil, medium chain triglyceride, macro minerals, a vitamin premix, a trace mineral premix, a functional premix, food essence and water. The pre-denatured whey protein powder accounting for 50%-100% of the total amount of protein is introduced, hydrophobic groups are exposed in advance, part of protein chains are effectively broken, a compact gel network formed by hydrophobic interaction and disulfide bonds among protein molecules in the subsequent high-temperature sterilization process is reduced, and thermal aggregation precipitation of the protein is inhibited from the source; the compounded stabilizer system and the pretreated protein have a synergistic effect to jointly construct a stable colloid system.

The invention discloses a preparation method and application of fatty acid formula powder for special medical purposes, and relates to the technical field of formula food for special medical purposes. The preparation method comprises the following steps: step 1: (1) sequentially adding wall material powder, emulsifier powder, antioxidant powder and a sweetening agent into water, and stirring and dissolving to obtain a wall material mixed solution; (2) mixing medium chain triglyceride and composite grease, and uniformly stirring to obtain a grease mixed solution; step 2, adding the grease mixed liquid into the wall material mixed liquid, uniformly stirring, homogenizing at high pressure, evaporating and concentrating, freeze-drying, crushing and sieving to obtain fatty acid formula powder; the fatty acid formula powder is prepared from the following raw materials in parts by weight: 30 to 40 parts of medium chain triglyceride, 10 to 20 parts of compound grease, 10 to 20 parts of wall material powder, 5 to 10 parts of emulsifier powder, 1 to 5 parts of antioxidant powder and 0.2 to 1 part of sweetening agent. The prepared fatty acid formula powder is high in raw material utilization rate, stable in finished product quality, high in dispersity and good in taste.

The invention discloses a micron emulsion-in-situ gel composite preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The compound preparation comprises temperature-sensitive gel and micron emulsion dispersed in the temperature-sensitive gel, the micron emulsion consists of an oil-phase raw material and a water-phase raw material. Mixing essential oil, medium chain triglyceride and an antioxidant, and stirring until the mixture is clarified to obtain an oil phase; dissolving an emulsifier, a humectant, a bactericide and a metal ion chelating agent in water to obtain a water phase; adding the oil phase into the water phase, and shearing to obtain micron emulsion; and mixing the micron emulsion with a temperature-sensitive gel matrix aqueous solution to obtain the composite preparation. The compound preparation provided by the invention can obviously prolong the residence time of the medicine in nasal mucosa; the loading capacity and the chemical stability of hydrophobic, volatile and unstable essential oil components are improved; through the structural design of the preparation, the effective regulation and control of the drug release behavior are realized, and the preparation is a dosage form with good administration compliance and storage stability.

The invention belongs to the technical field of food preservation, and relates to an active oxygen scavenging and antibacterial metal phenol composite coating and a preparation method thereof.The preparation method of the composite coating comprises the steps that a caffeic acid solution is dropwise added into a copper chloride solution, and copper-caffeic acid nanoparticles are prepared through a reaction; medium chain triglyceride and grape seed oil are adopted for carrying out melting point regulation and emulsification assistance on beewax, and composite grease is obtained; mixing copper-caffeic acid nanoparticles with a cellulose nanofiber solution, adding composite grease, and performing dispersion and ultrasonic treatment to obtain a composite coating; the copper-caffeic acid nanoparticles have the cascade catalytic activity of superoxide dismutase and catalase and have antibacterial activity and emulsifying activity, and when the composite coating is applied to fruit preservation, active oxygen generated in the fruit storage process can be removed, and growth of pathogenic bacteria is inhibited, so that the storage life of fruits is prolonged.