3results about How to "Reduce obesity" patented technology

The present application provides a novel phenyl derivative, 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole or a pharmaceutically acceptable salt thereof, which is useful for regulating mitochondria activity, reducing adiposity, treating diseases including diabetes and diabetes-associated complications.

This invention discloses the application of the HERP gene knockout mouse model in obesity and metabolic disorders. The invention found that, compared to the wild-type high-fat diet group, HERP gene knockout leads to earlier and more severe obesity in mice fed a high-fat diet, with increased fat percentage, aggravated adipose tissue inflammation, and phenotypes such as dyslipidemia and glucose metabolism disorders. Furthermore, HERP gene knockout results in increased adipocyte differentiation. This indicates that HERP gene knockout mice are more sensitive to nutrition, develop obesity more quickly on a high-fat diet, and exhibit more severe symptoms such as adipose amplification, adipose tissue inflammation, and glucose and lipid metabolism disorders. This model can be used for molecular mechanism research and drug screening of obesity, adipose tissue disorders, and glucose and lipid metabolism disorders. The invention further found that cilostazol can significantly alleviate obesity and lipid metabolism disorders caused by HERP gene deficiency in mice, but has no significant weight loss effect in mice with normal genotypes, providing a new strategy for precision treatment.