Embodiments of the invention disclose a moisturizing and soothing colla corii asini face cream. The face cream is composed of butanediol, xanthan gum, p-hydroxyacetophenone, hexanediol, allantoin, dipotassium glycyrrhizinate, disodium EDTA, glycerin, water/glycerin/glycerol acrylate/acrylic acid copolymer/propylene glycol, arginine, N-acetylglucosamine, glyceryl stearate/PEG-100 stearate, cetearylalcohol, glyceryl stearate, beeswax, microcrystalline wax, phytosterol canola oil glycerides, stearic acid, tocopheryl acetate, polysorbate-60, sorbitan sesquioleate, octyldodecanol, jojoba seed oil,caprylic/capric triglyceride, cetyl ethyl hexanoate, decamethylcyclopentasiloxane/polydimethylsiloxane/vinyl dimethicone crosspolymer, cyclopentasiloxane, carbomer, collagen extract, placental protein, and water. The invention also discloses a preparation method of the face cream. The prepared face cream has the effects of moisturizing skin, resisting oxidation, and soothing sensitive skin.