The invention discloses screening and application of salt-resistant
lactobacillus plantarum with multiple
uric acid reducing functions. Samples are screened and collected in soil, sauced beans, fermented flour paste,
fresh milk,
pickled vegetables and the like, a strain obtained through screening is identified as
Lactobacillus plantarum WQ47 and is named as
Lactobacillus plantarum WQ47, the strain has high
inosine and
guanosine degradation capacity, the degradation rate is 99.9% or above, the degradation rate is 99.0% or above, and therefore the
serum uric acid level can be effectively reduced. Besides, the strain WQ47 is cultured in an MRS
lactic acid bacteria culture medium to a
fermentation supernatant, a bacterial suspension and a
cell-free extract in the middle and later periods of
logarithmic growth, the
xanthine oxidase inhibition rates are 44.9%, 33.4% and 62.8% respectively,
uric acid generation can be effectively inhibited,
purine generation can be reduced by degrading
inosine and
guanosine and inhibiting the activity of
xanthine oxidase, and the strain WQ47 can be used for preparing a new strain for preventing and treating
uric acid generation. The traditional Chinese medicines jointly achieve the effects of relieving and treating the
hyperuricemia. Moreover, the strain WQ47 screened by the invention can well survive in an environment with high content of salt (NaCl) of 20% (
mass fraction), can be widely applied to fermented food,
pickled food,
functional food and the like, and has a better application effect on preventing, relieving and treating
hyperuricemia,
gout and complications of the
hyperuricemia and the
gout.