A medicine for resisting rheumatism and alleviating pain is made from the materials with the following weight portions: 50 to 55 portions of gentian root, 70 to 75 portions of hemlock parsley, 70 to 75 portions of peach kernel, 65 to 70 portions of safflower, 50 to 60 portions of liquorice, 45 to 50 portions of notopterygium root, 60 to 65 portions of myrrh, 70 to 75 portions of angelica, 70 to 75 portions of boninrousette, 45 to 50 portions of nutgrass galingale rhizome, 75 to 80 portions of achyranthes root, 65 to 70 portions of earthworm, 65 to 70 portions of rhizoma atractylodis, 55 to 60 portions of corktree bark, 60 to 70 portions of milk veteh, 60 to 65 portions of salvia miltiorrhiza, 60 to 65 portions of spatholobus stem, 60 to 65 portions of pawpaw, 55 to 65 portions of paniculater swallowwort root, 60 to 65 portions of pachyma cocos, 55 to 60 portions of ground beetle, 40 to 45 portions of natural copper and 35 to 40 portions of dragon blood. The medicine can cure rheumatoid arthritis, hyperosteogeny, sciatica, cervical spondylosis, periarthritis, various arthralgia, neuralgia, kidney deficiency, lumbocrural pain, myalgia, exercise injury pain and lumbar disc protrusion, which is effective in treatment.