104results about How to "Improve preparation quality" patented technology

The invention relates to a halloysite nanotube drug sustained-release material and a preparation method thereof. The drug sustained-release material is prepared by the following steps: performing acid corrosion to a halloysite nanotube to obtain a dilated nanotube, loading the drug into an inner cavity of the halloysite nanotube, and coating an organosilane polymerized hydrophobic layer onto the surface of the drug-carried halloysite nanotube, wherein the during the coating of the organosilane polymerized hydrophobic layer, organosilane I is firstly used for modifying the outer surface of the halloysite nanotube, and then organosilane II is added to form the organosilane polymerized hydrophobic layer on the surface of the nanotube. Compared with the prior art, the sustained release material has universality on a hydrophobic drug and a hydrophile drug, the drug release time can be effectively prolonged, the encapsulation efficiency is high, and the administration safety of the drug can be improved.

The invention provides a new preparation method and a quality control method of a pill containing cassia twig and tuckahoe, The preparation method have the advantages of few production steps, short production cycle, high production mechanization, stable preparation quality, high content of effective ingredients, fast disintegration, high bioavailability, small dose, convenient administration and the like. The invention also provides the quality control method of cinnamyl aldehyde, cinnamic acid, paeonol, peoniflorin and amygdalin in the pill containing cassia twig and tuckahoe.

The present invention relates to a novel purpose of hederagenin and a derivative of the hederagenin. An anti-depression test of the hederagenin and the derivative of the hederagenin shows obvious anti-depression activity, wherein, the salt derivative of the hederagenin has stronger anti-depression activity than the hederagenin; the hederagenin has stronger anti-depression activity than hederangenoside; the activities of the hederagenin and a hypericum extract are equivalent; sodium hederagenin has higher activity than the hypericum extract. The present invention has obvious pharmacological effect and stable quality; the raw material of the present invention has abundant source and cheap price and is safe with low toxin; the present invention has simple preparation technology and high yield, which provides novel medicine source for preventing, diagnosing, examining, protecting, remedying and researching on the depression and diseases directly related to the depression, is fit for the industrialization production, is easy for popularizing and applying and has very important value for developing and using Chinese officinal plant resource. Affective mental disorder is listed at top in Chinese disease general burden, and the research and manufacture of the drug for preventing and remedying the depression has obvious social benefit and economic benefit.

The invention provides a preparation process and a quality control method of a cassia twig poria cocos preparation. The preparation method has the advantages of less production steps, short production period, high production mechanical degree, stable quality of the preparation, high content of effective components, rapid disintegration, high bioavailability, small dose oral administration, convenience in oral administration and the like. The invention also provides a quality control method of cinnamaldehyde, cinnamic acid, paeonol, paeoniflorin and amygdalin in a cassia twig poria cocos pill.

The invention provides a drug combination containing etoricoxib and a preparation method thereof, wherein the drug combination disclosed by the invention contains 10 to 60 percent by weight of etoricoxib, 24 to 80 percent by weight of filler, 2 to 12 percent by weight of disintegrating agents, 1 to 8 percent by weight of lubricating agent and other pharmaceutically acceptable excipients, wherein the disintegrating agents are sodium carboxymethyl starch and croscarmellose sodium. The invention solves the problem that the dissolution rate of etoricoxib preparations is low, and by a specific technical solution, the etoricoxib drug combination with a high dissolution rate is obtained.

The invention belongs to the field of a medicinal preparation and specifically relates to a posaconazole solid dispersion and a preparation method of the solid dispersion and drug use. The invention provides a posaconazole solid dispersion and its drug use. The posaconazole solid dispersion contains posaconazole, a cyclodextrin derivative and a water-soluble or enteric carrier material, wherein mass ratio of posaconazole to the cyclodextrin derivative is 1:1-4 or mass ratio of posaconazole to the cyclodextrin derivative to the water-soluble or enteric carrier material is 1:1-4:0.001-3. The posaconazole solid dispersion can remarkably raise dissolution rate of the difficultly-soluble antifungal agent posaconazole in the small intestine and also can significantly enhance bioavailability of posaconazole. By the use of a dosage form prepared from the solid dispersion, the preparation technology is simple, and quality of the dosage form is stable.

The invention belongs to the technical field of a nuclear power plant control system and specifically relates to a nuclear power plant control system temporary control change online management system.The system comprises a data server, a network server and user terminals. The data server is used for analyzing DCS configuration data and DCS function drawings, generating risk rule data and storingrelated data real-time states. The network server is used for users to access interfaces, realizing a temporary control change process and carrying out data operation and call functions. All user terminals are used for accessing the network server through a company inner network, realizing functions of initiating, checking, approving and querying the temporary control change and displaying risks existing in the change within right display areas of pages of initiating, checking and approving links. According to the system, a temporary control change management process is electronized, and influences of control system configuration data module states on the operation of sets are displayed in a visual mode.

A Chinese medicine for treating hyperlipemia and fatty liver is prepared from haw, white atractylodes rhizome, alismatis rhizome and red koji. Its advantages are high curative effect and low toxic by-effect.

The invention discloses a preparation method of cassia twig and poria cocos pills and belongs to the technical field of traditional Chinese medicines. By adopting the technical scheme, the preparation method comprises the following steps: crushing poria cocos into fine powder respectively; then carrying out alcohol extraction and water extraction on peach kernels and red paeony roots in sequence; or crushing cassia twigs and coxtex moutan into fine powder or extracting and concentrating to prepare concentrated water-paste pills or water-honeyed pills by adopting different blending technologies; carrying out a subsequent pill preparation technology to prepare the cassia twig and poria cocos pills. According to the preparation method of the cassia twig and poria cocos pills, a complete technical scheme is formed by powdering, concentration, blending and pelleting, so that the extract yield is improved, effective components are sufficiently extracted, the bioavailability is improved and the dissolution time limit is effectively controlled; the preparation method has the advantages of short production period, stable preparation quality, high effective component content, rapidness in disintegration, high bioavailability, small oral administration dosage, convenience for oral administration and the like, and can be applied to preparation of cassia twig and poria cocos water-paste pill and water-honeyed pill dosage forms.

The invention discloses a temozolomide intravenous injection fat emulsion which comprises the following components in percentage by weight: 0.01-5% of temozolomide, 5-30% of oil for injection, 0.2-5% of emulgator, 0.2-3% of stabilizer, 1-5% of isoosmotic adjusting agent and the balance of water for injection. The prepared temozolomide intravenous injection fat emulsion is uniform in appearance, narrower in distribution, high in drug loading capacity (1 mg / ml), stable in quality, used for intravenous injection, simple and practical in production process, high in controllability, and liable to large-scale industrial production; the average grain diameter is about 200 nm, the Zeta electric potential is about -40 mV, and the pH is 5.0-9.0; the temozolomide intravenous injection fat emulsion has excellent biocompatibility, can provide energy for an organism, and can realize therapeutic action to various tumours.

The invention discloses a device for rapidly mixing and preparing cutting fluid for a milling machine. The device comprises a box body, a pedestal, a driven gear, a No. one stirring rod, a liquid spraying barrel, a rotational disk and a swinging sleeve, wherein the rotational disk is fixedly arranged at the bottom end of a main rotational shaft, a guide pillar is fixedly arranged at the bottom of an outer ring of the rotational disk, the swinging sleeve sleeves the guide pillar in a sliding manner, two sides of the swinging sleeve are symmetrically and fixedly provided with compression bars, the liquid spraying barrel is fixedly arranged on an inner wall of an inner cavity at the bottom of the box body, an inner barrel is fixedly arranged in an inner cavity of the liquid spraying barrel, a ring-shaped cavity is formed between an inner wall of the inner cavity of the liquid spraying barrel and an outer ring surface of the inner barrel, a piston is arranged inside the inner barrel in a sliding manner, and the piston is fixedly arranged at one ends of the compression bars. The device is simple in structure, convenient to use and good in damping effect, the mixing efficiency of the raw materials is high and the effect is good, the preparation quality of the cutting fluid is improved, so that the device is suitable for promotion and application.

The invention discloses a real-time intestinal tract cleanliness scoring system and method based on artificial intelligence. By adopting the system and method, bowel preparation quality examined by aclinical colonoscope is monitored in real time, and scoring display is carried out at a client; and the constituent ratio of each score and the cleanliness of an examined intestinal segment within each 30 s are represented. On one hand, the bowel preparation quality condition of a patient operated by a physician can be more objectively and directly expressed in a quantitative manner, and the workload and scoring errors of endoscopic physicians are reduced, so that the error evaluation of endoscopic examination quality is reduced and the interval of reexamination of colonoscope examination isrecommended; on the other hand, medical institutions can more objectively and directly know about the bowel preparation quality, so that the quality control work can be done effectively, the intestinal tract cleaning quality is rapidly improved, the adenoma detection rate is reduced, and early detection and early treatment of precancerous lesions of intestinal tracts are realized; and more importantly, the development of the system facilitates scientific inquiry for subsequent influences on bowel preparation schemes by different intestinal tract preparations.

The present invention relates to purposes of giant knotweed extract. The in vitro anti-HIV experiment shows that resveratrol 3-O-Beta-D- glucoside 2íÕ-sulfate sodium or potash salt and resveratrol 3-O-Beta-D- glucoside 4íÕ-sulfate sodium or potash salt show significant activity of resisting hepatitis B virus; resveratrol 3-O-Beta-D- glucoside 2íÕ-sulfate sodium or potash salt also has significant HIV inhibited effect. The virus infectious diseases such as AIDS and hepatitis B poses a serious threat to human's health and life and hepatitis B is one of the major diseases affecting human's health. The present invention provides a lead compound for doing R&D of novel anti-HIV and hepatitis B virus medicines and also a novel medicine source for clinic application, thus having a significant value to develop and utilize the medical plant resources of our country.

Disclosed is a Chinese medicinal gelling agent which comprises, 7.5-12.5 wt% of mentha-camphor, 5.5-8.5 wt% of curcuma longa pieces, 5.5-8.5 wt% of dahurian angelica root pieces, 2.5-4.4 wt% of pollen pieces, 2.5-4.4 wt% of red peony root pieces, 2-4 wt% of nitrogen ketone, 1.5-3 wt% of Carbomer, 0.3-0.5 wt% of polysorbate, 0.1-0.3 wt% of triethanolamine and balancing water. The invention also discloses the preparing process.

The invention discloses a cutting fluid preparation device for the maintenance of a film laminating machine. The cutting fluid preparation device comprises a mixing box, a gas cylinder, a liquid cylinder, a driving wheel, a driven wheel No. 1, a driven wheel No. 2, a movable sleeve plate No. 1, a movable sleeve plate No. 2, a liquid spray pipe and gas ejector pipes, wherein the gas cylinder is internally provided with a piston No. 1; a gas filling pipe and a gas inlet pipe are separately arranged at the left part of the gas cylinder in a communicating way; a right side plate of the gas cylinder is in slip connection with a pull-push rod No. 1 in a sealing way; the left end of the pull-push rod No. 1 is fixedly connected with the piston No. 1; an inner cavity of the liquid cylinder is internally provided with a piston No. 2; a liquid filling pipe is arranged at the left part of the liquid cylinder in a communicating way; a right side plate of the liquid cylinder is in slip connection with a pull-push rod No. 2 in a sealing way; the left end of the pull-push rod No. 2 is fixedly connected with the piston No. 2; the other end of the liquid filling pipe is communicated with the liquidspray pipe, and the other end of the gas filling pipe is separately connected with the two gas ejector pipes. The cutting fluid preparation device is simple in structure and reasonable in design, andcan enable raw material liquid to be fully mixed so as to greatly improve the preparation quality of cutting fluid.

The invention relates to the technical fields of medicine, food and health products, and discloses a highly efficient preparation method of antitumor drug sodium cantharidinate. Add cantharidin essence into sodium hydroxide aqueous solution, heat to dissolve, add activated carbon to reflux for decolorization for 0.5-1 hour, heat filter, wash with water, concentrate under reduced pressure, add ethanol, cool to room temperature, precipitate solid and dry to obtain white powder. Wherein the equivalent ratio of cantharidin fines and sodium hydroxide is 1:2-3, and the weight ratio of cantharidin and ethanol is 1:3-10. The synthesis of sodium cantharidinate and the decolorization and refining of activated carbon are completed simultaneously, and the crystallization is carried out with ethanol-water system. The invention provides a synchronous method for synthesizing sodium cantharidate and decolorizing and refining activated carbon, the preparation process is simpler, the reaction cycle is shortened, the application of a large amount of acetone and isopropanol is omitted in the reaction process, the production cost is reduced, and The pollution to the environment is small, the quality control is simpler, the production efficiency is improved, and the industrial production is convenient.

The objective of the present invention is to provide an antioxidation method and antioxidant-functioning water that can anticipate high benchmarks of safety on the antioxidation subject such as the human body and reduced environmental burden. An antioxidation method and antioxidant-functioning water that can transform or maintain an antioxidation subject, which is in an oxidation state due to a deficiency of electrons or needs to be protected from oxidation, into a reduced state where electrons are filled by promoting the breaking reaction of molecular hydrogen used as a substrate included in the hydrogen-dissolved water into a product of active hydrogen through a process employing a catalyst, which is a precious metal colloid or a hydrogen oxidation / reduction enzyme (except for those already existing in a living organism), on the hydrogen-dissolved water.

The invention discloses an antiviral drug which can be taken orally or molten - a ribavirin tablet and a manufacturing method thereof. The compositions of the preparation by weight percent are 3.8 to 20 percent of ribavirin, 71 to 83.25 percent of sugar and 9 to 12.95 percent of other pharmaceutic adjuvant. The manufacturing method comprises the following steps: 80 meshes of the ribavirin, 80 meshes of the sugar and other filler and disintegrating agent between 80 meshes and 100 meshes are taken and mixed; an adequate bonding agent is added into the mixture and particles are prepared, boiled, dried and integrated and added with lubricant; after uniform mixture, the weight of a stator plate is tested, and tabletting is performed; and after test qualification, packaging and full inspection are performed. The preparation lightens the passivity of patients in taking medicine and particularly solves the problem of medicine taking of infants, old patients, dental patients, upper respiratory tract virus infection patients and so on; and as shown by production for a plurality of years and sampling stability study, the quality of the preparation is stable.

The invention relates to a medicine treating carcinoma of colon and the method for preparing the same, which in detail is aglycone extract from root of Patrinia scabra Bge and the preparation method. The effective component is iridoid glycosides aglycone, the content is above 40%. The invention also provides the medicine agent and preparation. It is proved by pharmacologia test that the medicine is characterized by safe utilization, function of preventing the weight of tumor in transplanted carcinoma of colon. The extract can be produced into preparations of tablet, capsule, drop pill, granular or oral.

The invention relates to olanzapine gastric soluble tablets and a preparation method thereof. Particularly, the olanzapine gastric soluble tablets comprise the following components in percentage by weight: 2 to 15 percent of olanzapine, 40 to 82 percent of mannitol, 5 to 30 percent of microcrystalline cellulose, 0.5 to 2 percent of silicon dioxide, and 0.5 to 3 percent of magnesium stearate. The olanzapine gastric soluble tablets have the overall effects of quick dissolubility and stable preparation quality, and do not have the remarkable moisture absorption phenomenon when being placed in the air for a long time. The preparation method is simple in process steps, low in cost and energy consumption and short in production cycle, and thus is suitable for wide popularization and application.

A Chinese medicine in the form of injection for treating infectious disease, the diseases in hepatobiliary system, and cardiovascular and cerebrovascular diseases is prepared from bear gall powder through extracting general cholalic acid and mixing it with additives. Its preparing process is also disclosed.

Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast / spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may be obtained from plant or plant matter comprising plant-derived VLPs by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived VLPs are recovered from the filtered fraction.

The invention relates to an application of xanthostrumarin extractive, wherein said xanthostrumarin extractive comprises diterpene compound, phenolic acid compound and other extractives while their contents are 0.5%-99%, 0.5%-99%, and 0.5%. And the production uses general extraction, separation and purification. The extraction is solvent extraction method; the separation and purification uses solvent extraction method and porous adsorption resin method. The inventive extractive can treat coryza, nasal sinusitis, etc. It has simple production and stable property.

The invention provides a medicinal composition for treating common cold. The medicinal composition comprises the following raw material medicine components in parts by weight: 3-15 parts of honeysuckle, 3-15 parts of fructus forsythiae, 3-15 parts of heartleaf houttuynia herb, 7-25 parts of reed rhizome, 3-15 parts of boat-fruited sterculia seed, 3-15 parts of bulbus fritillariae cirrhosae, 3-15 parts of Chinese olive, 3-15 parts of dwarf lilyturf root and 1-10 parts of almond. The medicament has the effects of dispelling wind and relieving exterior syndrome, clearing heat and relieving exterior syndrome, nourishing yin and moistening lung, relieving cough and reducing sputum. The preparation has the advantages of stable quality, definite therapeutic effect and low toxic or side effect and can be used for safely and effectively treating wind heat type common cold and concurrent acute tonsillitis, acute pharyngitis, acute laryngitis, acute tracheitis and acute pneumonia of the wind heat type common cold.

The invention discloses a compound oral preparation and a preparation method thereof. The compound oral preparation is used for treatment of high blood pressure and has significant effect. The preparation includes three anti-hypertensive drugs hydrochlorothiazide, amlodipine besylate, valsartan and pharmaceutical excipients. The three components all belong to hydrophobic drugs, so that the dissolution rate is one of the key indicators measuring the intrinsic quality of the preparation. A specific ratio of the raw materials to the excipients is adopted by the invention, especially a polyoxyethylene-polyoxypropylene copolymer is used, for instance poloxamer serves as a solubilizing agent, so that compared with the anti-hypertensive compound preparation EXFORGE HCT produced by American Novartis pharmaceutical company, the compound preparation has good similarity in terms of dissolution behavior. According to the invention, wet granulation or dry granulation is employed to effectively solve the problems of low bulk density, poor liquidity, strong moisture absorption, and sticking and picking of Valsartan. The preparation method of the compound preparation is simple and practical, and the product has stable quality, and good dissolution rate and content uniformity of each effective component, thus being suitable for large-scale industrial production.

The invention discloses a traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and a product thereof. The traditional Chinese medicine substance standard preparation method is based on autonomic effects of a supramolecular imprinting template of traditional Chinese medicine and diversity regulation of medical materials; and molecular topological indexes, feeding quantity at a time, precise processing and preparation and an evaluation technology are adopted, the quality control in the whole process is carried out from the part and entirety, the static state and dynamic state, the measurement and calculation, the design and experiment, the fixation and transmission, and the method has universality and integrity. The preparation and the quality control are carried out on the basis that the traditional Chinese medicine substance standard and the dynamism and the transitivity in the whole preparation process of the product of the traditional Chinese medicine substance standard are mastered, and the substance standard and the product are high in security and stability; comprehensive technological information which is of great concern to the quality control over the preparation, and the quality has credibility; the traditional Chinese medicine substance standard preparation method is suitable for all traditional Chinese medicine substance standards and the preparation of the products, and is especially suitable for research of compound preparations of ancient classic famous prescriptions; and the product can beflexibly distributed, is suitable for a whole pharmaceuticals industry, and has wide market prospects.

An application of the xanthinoside, which is prepared from xanthium fruit through extracting, separating and purifying, in preparing the medicine for relieving inflammation, relaxing pain and treating rhinitis and nasosinusitis is disclosed.

The invention discloses a lipid microballoon injection solution for a progestational hormone drug and a preparation method thereof. The lipid microballoon injection solution for the progestational hormone drug comprises progestational hormone drug progesterone as a primary drug and pharmaceutically acceptable drug excipient, wherein the drug excipient comprises oil phase, emulsifier, osmotic pressure adjusting agent, stabilizer, pH value modifier and injection water. The lipid microballoon injection solution for the progestational hormone drug is stable in quality, free from injection irritation, high in safety, applicable to local intramuscular injection and intravenous injection, and beneficial to promotion of compliance of clinical medication of patient and enriches clinical medication selection.

The invention discloses a preparation for degrading Verticilium dahliae in continuous cropping soil of eggplant, and a preparation method thereof. The method is characterized by comprising the following steps: grinding the following raw material components in part by weight: 1 part of asarum, 2 parts of radix sophorae flavescentis, and 2 parts of fructus cnidii with the grinder to the fineness of 40 meshes; fully mixing the three raw materials powder into a mixture, adding 10 parts of water, and pouring the mixture into a sealed plastic bag for decaying at 26 DEG C for 15 days; taking the decayed materials, adding 25 parts of 80 percent ethanol into the decayed materials, fully and uniformly mixing the mixture, keeping the mixture for 36 hours and then fully extracting the mixture; filtering the extract and storing the filtrate in a container; and taking the filtrate, adding 34 parts of water into the filtrate, and diluting and uniformly mixing the mixture to obtain the preparation. The method is characterized by environmental protection, no residue, no pollution to environment and farm products, and capacity of keeping high quality of farm products. The method has the advantages of no requirement of expensive instruments, easily controlled process, stable quality of preparation, low production cost, convenient use, and simple and easily controlled operation. Natural active ingredients in the product can promote growth of vegetables roots, make the plants keep good growth vigor, and is favor of the healthy growth of organs of products.