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Chinese medicinal gel formulation and its preparing process

A gel, traditional Chinese medicine technology, applied in pharmaceutical formulations, non-central analgesics, antipyretics, etc., can solve the problems of troublesome preparation of aerosols, short duration of drug efficacy, easy to pollute clothes, etc., and achieve non-toxicity. Side effects, fast transdermal absorption, and the effect of maintaining blood concentration

Inactive Publication Date: 2006-07-12
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aerosol preparation is troublesome and expensive
Ointment easily stains clothes
The plaster layer is thinner, and the duration of the drug effect is shorter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: Chinese medicine gel 1000 grams, its composition: 100g menthol, 70g turmeric decoction pieces, 70g Angelica decoction pieces, 40g Tianhuafen decoction pieces, 40g red peony decoction pieces, 25g carbomer-940, 4g polysorbate-80, 25g Azone, 2g triethanolamine and the rest of the distilled water.

[0010] Drug source: The traditional Chinese medicine raw materials used are prepared from authentic medicinal materials recorded in the 2005 edition of the Pharmacopoeia.

[0011] Raw material processing: Slice and crush the raw medicinal materials, pass through a 20-mesh sieve for later use.

[0012] Preparation method: Take 70g decoction pieces of turmeric, 70g decoction pieces of Angelica dahurica, 40g decoction pieces of Trichosanthum officinalis, and 40g decoction pieces of red peony root, crush them through a 20-mesh sieve and mix them. Take the mixture and add 90% ethanol, reflux for 8 hours, filter, and continue to concentrate the extract to about 50ml. M...

Embodiment 2

[0013] Embodiment 2: Chinese medicine gel 1000 grams, its composition: 75g menthol, 85g turmeric decoction pieces, 55g Baizhi decoction pieces, 44g Tianhuafen decoction pieces, 25g red peony decoction pieces, 15g carbomer-940, 3g polysorbate-80, 40g Azone, 2g triethanolamine and the rest of the distilled water.

[0014] Preparation method: with embodiment 1.

Embodiment 3

[0015] Embodiment 3: Chinese medicine gel 1000 grams, its composition: 125g menthol, 55g turmeric decoction pieces, 85g angelica decoction pieces, 25g tianhuafen decoction pieces, 44g red peony decoction pieces, 30g carbomer-940, 5g polysorbate-80, 20g Azone, 3g triethanolamine and the remaining distilled water.

[0016] Preparation method: with embodiment 1.

[0017] Pharmacological Experimental Research:

[0018] 1. Analgesic effect:

[0019] (1) The traditional Chinese medicine gel of the present invention can significantly reduce the number of writhing times in mice caused by chemical pain-inducing reagents such as acetic acid, and its analgesic effect intensity is similar to that of Voltaren. There were 30 Kunming mice, half and half for ♀♂, and 20 ±2g, randomly divided into 3 groups, 10 animals in each group, the abdomen of the animals was depilated, and the exposed skin of 2cm×2cm was the administration area. The blank group was given 0.4 g of blank gel matrix, the p...

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PUM

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Abstract

Disclosed is a Chinese medicinal gelling agent which comprises, 7.5-12.5 wt% of mentha-camphor, 5.5-8.5 wt% of curcuma longa pieces, 5.5-8.5 wt% of dahurian angelica root pieces, 2.5-4.4 wt% of pollen pieces, 2.5-4.4 wt% of red peony root pieces, 2-4 wt% of nitrogen ketone, 1.5-3 wt% of Carbomer, 0.3-0.5 wt% of polysorbate, 0.1-0.3 wt% of triethanolamine and balancing water. The invention also discloses the preparing process.

Description

technical field [0001] The invention relates to a traditional Chinese medicine gel and a preparation method thereof, in particular to a traditional Chinese medicine gel for treating diseases such as bruises, subcutaneous congestion, swelling and pain, and fractures. Background technique [0002] Traditional Chinese medicine formulations have a long history and are of various types. In Chinese medicine, traditional Chinese medicine preparations are mainly taken orally, while the pharmaceutical formulations used to treat bruises, subcutaneous congestion, swelling and pain, etc. currently mainly include decoctions, pills, powder ointments, Different dosage forms such as elixirs, wines, tablets, syrups, teas, granules, etc., are mostly tablets, and the external dosage forms are mostly emulsions, ointments, external membranes, rubber ointments, film coatings, etc. Each dosage form has its own shortcomings in terms of curative effect and method of use. Traditional Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/00A61P29/00A61P19/00
Inventor 方世平王智勇孙曼春潘振宇罗国庆吴建元曾辉
Owner WUHAN UNIV
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