169 results about "Skin barrier function" patented technology

The invention discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application of the anti-wrinkle composition, and belongs to the technical field of cosmetics and skin care products. The composition is prepared from the following active ingredients in percentage by mass: 0.01 percent to 20 percent of recombinant humanized I type collagen, 0.01 percent to 20 percent of recombinant humanized III type collagen, 0.01 percent to 10 percent of recombinant humanized XVII type collagen and 0.01 percent to 20 percent of space breeding desert algae extract. The three kinds of recombinant humanized collagen and the space breeding desert algae extract form a compound system, and when the total mass ratio of the three kinds of recombinant humanized collagen and the space breeding desert algae extract is within a specific range of 1.3: 1-4: 1, the three kinds of recombinant humanized collagen and the space breeding desert algae extract can achieve synergistic interaction to improve the skin barrier function. Based on the synergistic mechanism of the compound system, the composition disclosed by the invention can effectively promote and enhance the skin moisturizing and anti-wrinkle capability and repair the skin barrier, and is suitable for the development and application of anti-wrinkle, tightening and skin aging delaying skin care products.

The invention belongs to the technical field of biological medicine, and relates to a composite polypeptide composition as well as a preparation method and application thereof. According to the technical scheme, pH responsive polymer loaded oligopeptide-1, acetyl heptapeptide-4 and palmitoyl tripeptide-1 are adopted as a core, hyaluronic acid is adopted for wrapping, a hyaluronic acid layer adsorbs palmitoyl tripeptide-8, heptapeptide-6 and decapeptide-4, and the composite polypeptide with a core-shell structure is prepared and used for treating inflammatory skin diseases. In the acute stage of inflammation, the active ingredients on the outer layer quickly inhibit the activation of proinflammatory factors and immune cells and relieve red, swollen and heat pain, and the gel outer layer formed by hyaluronic acid realizes continuous release, prolongs the action time and supplements moisture to the skin; the pH-responsive polymer of the inner layer releases active ingredients at the inflammation part, so that relapse is prevented, and the skin barrier function is repaired. The composition plays a role from multiple dimensions of inflammation regulation, barrier repair, oxidation resistance and the like through a multi-layer structure design and a multi-component synergistic effect.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention relates to the field of cosmetics, in particular to an oil-controlling and acne-removing composition and application thereof. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are compounded and have a synergistic effect after being combined, a stronger oil control network is formed, and the oil control effect is greatly improved compared with that when a single component is used; a multi-channel and multi-target acne removal path is formed, and the acne removal effect is multi-dimensionally improved compared with that when a single component is used; the skin barrier function can be further enhanced, the water loss is reduced, and the acne skin damaged skin can be recovered more quickly. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are all natural plant extracts, are high in safety and are suitable for sensitive skin. After the three components are compounded, the safety is high, the oil-controlling and acne-removing effects of the oil-controlling and acne-removing composition are remarkably improved through the synergistic effect, and the acne problem can be more comprehensively solved.

The application discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application thereof, and belongs to the technical field of cosmetics and skin care products. The composition contains the following active ingredients in percentage by mass: 0.01%-20% of recombinant humanized type I collagen, 0.01%-20% of recombinant humanized type III collagen, 0.01%-10% of recombinant humanized type XVII collagen, and 0.01%-20% of space-bred desert algae extract. The three kinds of recombinant humanized collagens and the space-bred desert algae extract form a complex system, and when the total mass ratio is in a specific interval of 1.3:1-4:1, the three kinds of recombinant humanized collagens and the space-bred desert algae extract can synergistically improve the skin barrier function. Based on the synergistic mechanism of the complex system, the composition disclosed by the application can effectively promote the skin moisture retention and anti-wrinkle ability, repair the skin barrier, and is suitable for the development and application of skin care products for anti-wrinkle, skin tightening and skin aging delay.

The invention provides a composition and cream with anti-inflammatory and skin barrier injury repairing effects as well as a preparation method and application of the composition and cream, and belongs to the technical field of skin injury repairing. The invention provides a composition with anti-inflammatory and skin barrier injury repairing effects. The composition is prepared from matrine, dipotassium glycyrrhizinate, bisabolol and asiaticoside according to the weight ratio of 1: 1: 1: 1. The composition provided by the invention can play a role through a multi-target mechanism, such as up-regulation of Invoucrin, and provides a more effective prevention and treatment scheme for skin barrier dysfunction related diseases and sensitive skin.

The invention belongs to the technical field of skin care products, and discloses a quick-acting red-removing repair product which comprises the following components: water, caprylic / capric triglyceride, glycerol, sorbitol, phosphatidylcholine, 1, 3-propylene glycol, xanthan gum, eicosapentaenoic acid, docosahexaenoic acid, phytosphingosine, centella asiatica extract and tocopheryl acetate. A turmeric rhizome extract and 1, 2-hexanediol. Through mutual cooperation of the turmeric root extract and the centella asiatica extract, by taking enhancement of skin immune regulation and skin barrier functions as an action mechanism, on one hand, skin inflammatory response can be inhibited, and inflammation, microorganisms and bacteria can be effectively resisted, and on the other hand, skin barrier reconstruction can be promoted, wound healing can be promoted, and an ECM matrix can be protected; in addition, the eicosapentaenoic acid, the docosahexaenoic acid, the turmeric root extract, the phytosphingosine and the centella asiatica extract are wrapped by the nano-microcapsule liposome, so that the activity of the product can be ensured.

The invention relates to a moisturizing and anti-aging composition suitable for sensitive skin and application of the moisturizing and anti-aging composition, and belongs to the technical field of cosmetics. The composition comprises a loquat leaf extract, a camellia nitidissima flower extract, a grape fruit extract and a purslane extract as active ingredients. The folium eriobotryae extract and the grape fruit extract both have the effects of resisting oxidation, resisting inflammation and the like; the camellia nitidissima flower extract can help to relieve skin discomfort, enhance the skin barrier function and the like; the portulaca oleracea extract has the effects of moisturizing, relieving, resisting aging and the like. According to the composition disclosed by the invention, through reasonable matching and synergistic interaction of the components, the moisturizing, anti-aging, soothing and repairing effects can be remarkably improved, and the composition is mild and non-irritant, is suitable for sensitive skin, can be applied to various skin care products, and has a good market application prospect.

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

The invention discloses a novel application of bifidobacterium breve CCFM1078 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium breve CCFM1078 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mastocyte infiltration is reduced; (2) the relative expression quantity of mRNA (messenger Ribonucleic Acid) of mouse skin barrier function related genes is increased; (3) reducing the total IgE level of mouse serum; (4) reducing the levels of IL-4, IL-13 and TSLP in mouse skin tissues, improving the levels of IL-10 and IFN-gamma, recovering Th1 / Th2 immune balance, and maintaining immune homeostasis; (5) activating the expression of AHR and CYP1A1 in the skin tissue of the mouse; (6) improving IgA and sIgA secretion of mouse colon tissue; and (7) compared with a representative high-yield ILA strain, the ILA yield is higher.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The invention discloses a formula of traditional Chinese medicine acne-removing cream and a production process thereof. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 5 to 9 parts of radix arnebiae seu lithospermi, 1 to 3 parts of radix angelicae sinensis, 1 to 2 parts of bakuchiol, 20 to 25 parts of linseed oil, 10 to 15 parts of beewax, 1 to 2 parts of rosa rugosa, 1 to 3 parts of radix et rhizoma rhei, 2 to 4 parts of cortex phellodendri, 3 to 5 parts of rhizoma atractylodis-pericarpium citri reticulatae powder, 1 to 2 parts of rhizoma arisaematis powder, 1 to 3 parts of vitamin E, 0.2 to 0.6 part of adenosine, 0.5 to 1 part of Ectoine, 0.1 to 0.3 part of Pinoline and 2 to 4 parts of purified water. Alkannin contained in the radix arnebiae seu lithospermi has strong antibacterial and anti-inflammatory capacities and does not generate the problem of drug resistance, so that the growth of acnes is inhibited from the source. Angelica polysaccharide can promote proliferation of keratinocytes, enhance the skin barrier function and effectively resist external stimulation. Different from common hormones, salicylic acid and other irritant components in traditional acne-removing products, the formula integrates the double effects of safe acne removal and long-acting skin care by means of natural power.

This invention provides an anti-aging and repair dressing containing four complex active factors and its preparation method. The dressing comprises 75-90 parts of a matrix material, 5-15 parts of four complex active factors, and 3-8 parts of a moisturizing auxiliary agent. The four complex active factors are composed of recombinant human type III collagen, acetyl hexapeptide-8, ectoine, and dipotassium glycyrrhizate in a ratio of (3-6):(1-3):(2-4):(1-2). The matrix is ​​a hydrophilic nonwoven fabric or bio-cellulose membrane material that has undergone low-temperature plasma surface grafting activation treatment. The preparation process employs nitrogen combined with vacuum pulse freeze-drying technology, and enhances the activity stability through an ectoine complexation step. This dressing can promote HaCaT cell proliferation, increase collagen secretion, and inhibit inflammatory factors, significantly improving skin barrier function. It has good biocompatibility and can be used to prepare products that improve skin aging and repair.

The invention belongs to the technical field of skin care products, and discloses prebiotic enzymatic hydrolysate as well as a preparation method and application thereof. The preparation method of the prebiotic enzymatic hydrolysate comprises the following steps: (1) inoculating lactobacillus into fermentation liquor for fermentation culture, centrifuging, washing and collecting fermentation thalli, resuspending by using a phosphate buffer solution, and performing high-pressure crushing, homogenizing and cracking treatment to obtain a lactobacillus fermentation lysate product; (2) crushing dried dandelions, adding the crushed dandelions into water, uniformly dispersing, then adding the lactobacillus fermentation lysate obtained in the step (1), carrying out stirring enzymolysis extraction for 1-4 hours under the condition of normal temperature, and filtering to take filtrate, so as to obtain a dandelion enzymolysis extracting solution; and (3) adding the dandelion enzymolysis extracting solution obtained in the step (2), a moisturizing additive and a preservative into water, and uniformly mixing to obtain the prebiotic enzymolysis solution. The prebiotic enzymatic hydrolysate obtained by the invention has the effects of regulating skin micro-ecological distribution, improving skin redness and swelling / skin acne and repairing a skin barrier function.

This invention discloses the application of homoserine as a barrier repair factor in the preparation of skin repair compositions. As a multidimensional regulator of skin barrier function, homoserine systemically integrates post-sun exposure damage repair, physical barrier repair, and microecological barrier repair, providing a multi-target synergistic mechanism to effectively repair the skin barrier and alleviate skin damage. The application of homoserine in cosmetics or skin care products meets consumers' needs for precise skin repair.

The present application relates to a kind of whitening anti-aging composition suitable for sensitive skin and its application, belong to the technical field of cosmetics.The composition includes Psoralea corylifolia phenol, hydrolyzed royal jelly protein, radix notoginseng extract and camellia sinensis var. assamica flower extract as active ingredient.Psoralea corylifolia phenol has the effects of anti-aging, antioxidant and anti-inflammatory, etc.;Hydrolyzed royal jelly protein can help to relieve skin discomfort, moisturizing, enhance skin barrier function, etc.;Camellia sinensis var. assamica flower extract has the effects of anti-photoaging, whitening and anti-inflammatory soothing, while radix notoginseng extract has the effects of anti-inflammatory, antioxidant and anti-aging, etc.The composition of the present application can synergistically enhance the effects of anti-inflammatory, whitening and anti-aging by reasonable allocation of the above components, and the composition contains natural components, is mild and non-irritating, suitable for sensitive skin, and can be applied to various cosmetics.

The application relates to the technical field of biological medicines, in particular to a deer horn stem cell exosome as well as a preparation method and application thereof. The preparation method of the deer horn stem cell exosome comprises the following steps: S1, preparing P3-P5 generation deer horn stem cells; S2, preparing induced culture supernatant; S3, preparing crude extracted exosomes; and S4, preparing deer horn stem cell exosomes. The prepared deer horn stem cell exosome has high yield, high biological activity, can significantly promote fibroblast proliferation and collagen synthesis. Meanwhile, the exosome can effectively accelerate wound healing, has high 14d healing rate, can significantly increase the water content of the cutin layer of the skin, reduce the TEWL value, and improve the skin barrier function, provides high-quality raw materials for the research and development of skin repair products, and has a wide application prospect.

The object of the present invention is to provide a composition that improves skin barrier function. The problem can be solved by the composition for activating the skin barrier of the present invention, comprising β-alanine or a salt thereof.

The present invention discloses a plant cell active ingredient, comprising plant cells and an active ingredient. This invention utilizes plant cells prepared using a specific content and a specific preparation method, supplemented with a specific content of an active ingredient, and then encapsulates the active ingredient with a plant cell extract to prepare a plant cell active ingredient with improved skin absorption. This active ingredient is then mixed with a polyol to prepare a transdermal absorption enhancer composition. This composition is then added to a basic cosmetic formula, resulting in significantly improved permeability, short-term moisturizing properties, long-term moisturizing properties, skin barrier function, and in vitro anti-aging efficacy of the resulting cosmetic.

The invention belongs to the technical field of medical evaluation, and relates to a method for evaluating damage of air pollution to human skin health based on a PPO-LSTM fusion algorithm. The method comprises the following steps: acquiring multi-source data; preprocessing data, and constructing a multi-dimensional time sequence feature data set; establishing a PPO-LSTM fusion model, performing feature extraction and reinforcement learning optimization on the multi-dimensional time sequence features, and outputting skin health core indexes; performing prediction and quantitative evaluation on the functional states of the cuticle, the epidermal layer and the corium layer; generating a personalized nursing decision scheme for skin health maintenance; outputting corresponding early warning information and coping suggestions by judging the risk levels of the skin barrier function and the dermal metabolism function; and updating parameters of the skin health injury evaluation model. According to the method, multi-dimensional data are integrated in the same model at the same time, the evaluation dimension is more comprehensive, the accuracy of skin health injury evaluation is improved, and a complete closed loop from detection evaluation to nursing scheme generation and risk prompt is realized through decision making and early warning.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating psoriasis, a preparation method and application thereof. The raw material composition comprises, in mass parts, 10-30 parts of schizonepeta, 10-30 parts of moxa leaf, and 10-30 parts of rhizoma alocasia. Animal experiments show that the traditional Chinese medicine composition can promote the repair of skin barrier function and reduce the skin lesion symptoms of psoriasis-like mice, which indicates that the traditional Chinese medicine composition has a good therapeutic effect on psoriasis.

The invention relates to a small molecule water-containing composition for preparing beauty water and a preparation method thereof, and belongs to the technical field of cosmetics, the composition comprises composite plant hydrolat, plant essential oil and an emulsifier; the composite plant hydrolat comprises calendula hydrolat, pawpaw hydrolat, tulip hydrolat, fructus amomi rotundus hydrolat, torreya grandis hydrolat, linden viburnum hydrolat, lignum dalbergiae odoriferae hydrolat and peony hydrolat; the plant essential oil comprises thyme oil. Most of the selected raw materials are plant hydrolats, crude plant hydrolat liquid is subjected to small molecule treatment, so that the plant hydrolat liquid is easier to absorb, more stable and more efficient, in addition, the finally selected raw materials have the effects of moisturizing, resisting oxidation and inhibiting bacteria, a good foundation is laid for moisturizing and enhancing the skin barrier function, the effects of resisting oxidation and preventing damage are achieved, and the skin care effect is achieved. The skin micro-ecology stability is maintained through bacteriostasis, the three effects are integrated, and the improvement and beautifying of the skin quality are realized.

The present application provides a kind of oil composition, containing monounsaturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid is omega-9 fatty acid;Polyunsaturated acid is the mixture of omega-6 fatty acid and omega-3 fatty acid.The present application can repair and resist aging, all-purpose skin care, increase epidermal thickness, enhance barrier, anti-inflammatory soothing, anti-wrinkle firming, soothing repair red, nourish skin, and can be applied to sensitive skin, can inhibit LPS-induced HaCaT cell IL-6 secretion, increase the thickness of 3D skin model epidermis layer, and can promote the expression of silk aggregate protein (FLG), ceramide synthase 3 (CerS3), desmoglein core glycoprotein (DSG1) which has important role for skin barrier function, indicating that it can alleviate the inflammatory response produced by LPS stimulation HaCaT cell and has enhanced skin barrier function.

This application provides a barrier-repairing composition and its use. The composition comprises panthenol, niacinamide, folic acid, and cobalamin in a mass ratio of 3-7:1-5:0.0005-0.1:0.00005-0.01. This application also provides uses of the composition and products containing the same. The composition utilizes panthenol, niacinamide, folic acid, and cobalamin in combination, where the components complement and enhance each other, achieving a synergistic effect in upregulating BMAL2 gene expression. This enhances the DNA damage repair capacity of skin fibroblasts and potentially promotes barrier repair. Furthermore, the composition provided herein can significantly reduce the expression of capsaicin receptor 1 (TRPV1) and increase the expression of involucrin, PIEZO1, and TNXB, reducing skin discomfort and enhancing skin barrier function. Furthermore, the composition provided herein can reduce the expression of inflammatory factors, demonstrating its anti-inflammatory effect.

The present disclosure relates to a novel peptide and a composition for alleviating skin aging, a composition for caring for skin damage or alleviating skin sagging, a composition for reversing aging, an anti-glycation composition, a composition for preventing hair loss or promoting hair growth, and a composition for improving skin barrier function, wherein the compositions comprise the novel peptide.

The invention belongs to the field of daily necessities, and particularly relates to a skin care lotion containing a beautiful millettia root extract. The chrysanthemum, the alpinia oxyphylla, the clinacanthus nutans and the selaginella tamariscina are prepared into two extracts respectively, the two extracts and the beautiful millettia root extract are jointly added into the skin care lotion, and the prepared skin care lotion is fine, uniform and convenient to smear and use through two times of homogeneous grinding. According to the skin care lotion disclosed by the invention, the raw materials are reasonably combined, extracted step by step and ground by a homogenizer, so that the skin care lotion has good antioxidant and anti-aging activity, the moisture content of skin can be effectively increased, the barrier function of the skin is enhanced, and the moisturizing effect is remarkably improved.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

The invention relates to an ion-resistant liposome as well as a preparation method and application thereof, and belongs to the technical field of liposome preparation, and the ion-resistant liposome comprises a water-phase active component, an oil-phase active component and a membrane material. According to the membrane material disclosed by the invention, lecithin and polyglycerol-10 myristate are compounded, so that the interface stability of the lipidosome is synergistically enhanced, and the prepared lipidosome finished product effectively has an outstanding effect of resisting damage of metal ions to the lipidosome structure; in addition, in the water-phase active component and the oil-phase active component, key fruit oil, a caulis polygoni cuspidati seed extract and terminalia bellirica fruit water are combined for use, so that the prepared lipidosome has an excellent anti-oxidation effect through different-dimension synergistic effects of reducing lipid peroxidation, reducing the free radical level and removing various free radicals; the bunge cherry seed extract, the buckeye valeriana seed fat, the samara oil and the roselle flower extract can achieve the synergistic effect of moisturizing and locking water and improving the skin barrier function, so that the prepared liposome has excellent moisturizing and moisturizing effects.

The application discloses preparation and application of a heat-sensing repair type recombinant collagen, and relates to the technical field of bioengineering and biomedical materials.The application innovatively carries out gene fusion on a functional domain fragment of a type I humanized collagen and a functional domain fragment of a heat shock protein family through a flexible linker.The recombinant protein is used for solving problems of protein denaturation, membrane structure damage, release of inflammatory factors, impairment of skin barrier function, aggravation of water loss and sensitivity and vulnerability of skin caused by photothermal damage of skin under photothermal stress conditions (such as ultraviolet radiation, high-temperature environment or medical and beauty photoelectric treatment of thermal MAGE, etc.), and the HSP molecular chaperone function is used for guiding damaged proteins to correctly fold and maintain intracellular homeostasis, and the collagen part is used for accelerating tissue repair.Experiments prove that the recombinant protein can effectively improve skin tightness, anti-wrinkle property and barrier repair capacity after thermal damage.The application can be widely applied to the fields of cosmetics, skin repair and protection and medical and beauty postoperative care, etc.