297 results about "Skin barrier function" patented technology

The invention discloses pediococcus pentosaceus CCFM1402 capable of effectively repairing a skin barrier and a self-fermentation metabolite of the pediococcus pentosaceus CCFM1402, and belongs to the technical field of microorganisms and medicines. The pediococcus pentosaceus CCFM1402 provided by the invention has the effect of improving the skin barrier function in both external use and oral administration; the cell activity of damaged HaCaT cells and the expression of the gene level of skin barrier function protein and tight junction protein can be improved by virtue of a thallus lysate and a fermented supernatant (metagen) of the external pediococcus pentosaceus CCFM1402; and the DNFB-induced mouse skin barrier injury can be relieved in the aspects of appearance, skin barrier protein expression and the like by orally taking viable bacteria and postbiotics of the pediococcus pentosaceus CCFM1402. Therefore, the pediococcus pentosaceus CCFM1402 has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention discloses application and an extraction method of prinsepia utilis royle polysaccharide, which comprises the following steps: extracting prinsepia utilis royle residues with 95% ethanol at 85 DEG C, filtering, extracting the residues with deionized water at 85-95 DEG C for 2-3 times, merging extracts, performing alcohol precipitation with 90%-95% ethanol at 2-6 DEG C, removing protein through a Sevage method, centrifugally collecting supernate, and freeze-drying to obtain the prinsepia utilis royle polysaccharide. And finally determining the content of the prinsepia utilis royle polysaccharide by using an anthrone-sulfuric acid colorimetric method, wherein the obtained prinsepia utilis royle polysaccharide is used for treating and improving skin lesion of psoriasis. Tests prove that prinsepia utilis royle polysaccharide can significantly improve psoriasis skin lesion, reduce inflammatory factor expression, enhance skin barrier function and increase expression of epidermal related protein, and is helpful for relieving symptoms of psoriasis patients and improving skin conditions.

The invention relates to a whitening and anti-aging composition suitable for sensitive skin and application of the whitening and anti-aging composition, and belongs to the technical field of cosmetics. The composition comprises bakuchiol, hydrolyzed royal jelly protein, a radix pseudostellariae extract and a golden camellia flower extract as active ingredients. The bakuchiol has the effects of resisting aging, resisting oxidation, resisting inflammation and the like; the hydrolyzed royal jelly protein can help to relieve skin discomfort, preserve moisture, enhance the skin barrier function and the like; the golden camellia flower extract has the effects of resisting light aging, whitening skin, fading spots, resisting inflammation and relieving allergy, and the radix pseudostellariae extract has the effects of resisting inflammation, resisting oxidation, resisting aging and the like. According to the composition disclosed by the invention, through reasonable blending of the components, synergistic interaction can be realized, the effects of resisting inflammation, whitening and delaying senescence are remarkably improved, and the composition contains natural components, is mild and non-irritant, is suitable for sensitive skin and can be applied to various cosmetics.

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The invention discloses an application of core proteoglycan or a coding gene thereof as a target spot in preparation of psoriasis treatment drugs, and a series of experiments prove that DCN can effectively protect mouse psoriasis-like dermatitis induced by imiquimod, improve skin scale, erythema, thickening and epidermal abnormal differentiation, enhance the barrier function of skin, improve the curative effect of psoriasis, and improve the curative effect of psoriasis. A large amount of infiltration of inflammatory cells is reduced, and a certain anti-inflammatory effect is achieved. Experimental research shows that the DCN has an obvious drug effect on a psoriasis model, is safe and efficient, has no side effect, is simple in production process and has the potential of realizing medical transformation. And the potential application value of the DCN on other various skin inflammatory diseases can be expanded.

The invention discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application of the anti-wrinkle composition, and belongs to the technical field of cosmetics and skin care products. The composition is prepared from the following active ingredients in percentage by mass: 0.01 percent to 20 percent of recombinant humanized I type collagen, 0.01 percent to 20 percent of recombinant humanized III type collagen, 0.01 percent to 10 percent of recombinant humanized XVII type collagen and 0.01 percent to 20 percent of space breeding desert algae extract. The three kinds of recombinant humanized collagen and the space breeding desert algae extract form a compound system, and when the total mass ratio of the three kinds of recombinant humanized collagen and the space breeding desert algae extract is within a specific range of 1.3: 1-4: 1, the three kinds of recombinant humanized collagen and the space breeding desert algae extract can achieve synergistic interaction to improve the skin barrier function. Based on the synergistic mechanism of the compound system, the composition disclosed by the invention can effectively promote and enhance the skin moisturizing and anti-wrinkle capability and repair the skin barrier, and is suitable for the development and application of anti-wrinkle, tightening and skin aging delaying skin care products.

The invention belongs to the technical field of biological medicine, and relates to a composite polypeptide composition as well as a preparation method and application thereof. According to the technical scheme, pH responsive polymer loaded oligopeptide-1, acetyl heptapeptide-4 and palmitoyl tripeptide-1 are adopted as a core, hyaluronic acid is adopted for wrapping, a hyaluronic acid layer adsorbs palmitoyl tripeptide-8, heptapeptide-6 and decapeptide-4, and the composite polypeptide with a core-shell structure is prepared and used for treating inflammatory skin diseases. In the acute stage of inflammation, the active ingredients on the outer layer quickly inhibit the activation of proinflammatory factors and immune cells and relieve red, swollen and heat pain, and the gel outer layer formed by hyaluronic acid realizes continuous release, prolongs the action time and supplements moisture to the skin; the pH-responsive polymer of the inner layer releases active ingredients at the inflammation part, so that relapse is prevented, and the skin barrier function is repaired. The composition plays a role from multiple dimensions of inflammation regulation, barrier repair, oxidation resistance and the like through a multi-layer structure design and a multi-component synergistic effect.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention relates to an intelligent response skin care composition as well as a preparation method and application thereof. The composition comprises freeze-dried phytoestrogen powder, poly (N-isopropylacrylamide), chitosan, a humectant and vitamin C, and the water dispersibility and skin absorbability of the composition are remarkably improved. Poly (N-isopropylacrylamide) and chitosan respectively endow the composition with temperature and pH response characteristics, and can intelligently slowly release and regulate and control release of active ingredients according to skin environment changes (such as high temperature and sweat pH rise), thereby achieving the effects of long-acting moisturizing, oil resistance, aging resistance and the like. Experiments show that the moisturizing rate of the composition in a high-temperature environment within 3 hours exceeds 65%, the wrinkle reduction rate within 3 months reaches 41.2%, the composition is suitable for facial masks, essence and other dosage forms, the problem that the skin barrier function is reduced due to high temperature in summer is solved, and the composition has safety and precise skin care effects.

The invention relates to an acne-removing composition for fading acne marks and preventing relapse and application thereof. The acne-removing composition comprises a first functional component, an olive leaf extract and a lactobacillus / rye fine powder fermentation product, the first functional component comprises centella asiatica extract, madecassoside and glucose. The centella asiatica extract, madecassoside and the lactobacillus / rye fine powder fermentation product in the composition disclosed by the invention contain various active chemical substances, so that the composition can help to support a skin barrier function, reduce skin sensitivity, improve skin moisture retention capacity, inhibit various inflammatory factors and play a soothing role; the olive leaf extract is rich in natural antioxidants and natural antibacterial components, free radicals can be removed, and the inflammation problem caused by lipid peroxidation is inhibited. The components can be mutually matched and synergistically interacted, so that the acne cream has excellent effects of relieving, resisting oxidation, improving the sensitive and red phenomenon of the acne skin, improving the skin barrier capability of the acne skin and lightening acne marks, has a lasting effect and can prevent relapse.

The invention relates to the field of cosmetics, in particular to an oil-controlling and acne-removing composition and application thereof. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are compounded and have a synergistic effect after being combined, a stronger oil control network is formed, and the oil control effect is greatly improved compared with that when a single component is used; a multi-channel and multi-target acne removal path is formed, and the acne removal effect is multi-dimensionally improved compared with that when a single component is used; the skin barrier function can be further enhanced, the water loss is reduced, and the acne skin damaged skin can be recovered more quickly. The black tea fermentation liquor, the olive leaf extract and the silybum marianum extract are all natural plant extracts, are high in safety and are suitable for sensitive skin. After the three components are compounded, the safety is high, the oil-controlling and acne-removing effects of the oil-controlling and acne-removing composition are remarkably improved through the synergistic effect, and the acne problem can be more comprehensively solved.

The invention relates to an anti-aging composition and application thereof. The anti-aging composition is prepared from the following raw materials: dendrobium officinale, camellia japonica and polygonatum kingianum. Dendrobium officinale, camellia japonica and polygonatum kingianum cooperate with one another to achieve a synergistic effect, secretion of type I collagen (COL-1) can be promoted, secretion of matrix metalloproteinase-1 (MMP-1) can be inhibited, and decomposition of collagen in extracellular matrixes can be slowed down. The anti-aging composition can increase skin elasticity, improve the skin barrier function, reduce the percutaneous water loss rate and delay skin aging.

The application discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application thereof, and belongs to the technical field of cosmetics and skin care products. The composition contains the following active ingredients in percentage by mass: 0.01%-20% of recombinant humanized type I collagen, 0.01%-20% of recombinant humanized type III collagen, 0.01%-10% of recombinant humanized type XVII collagen, and 0.01%-20% of space-bred desert algae extract. The three kinds of recombinant humanized collagens and the space-bred desert algae extract form a complex system, and when the total mass ratio is in a specific interval of 1.3:1-4:1, the three kinds of recombinant humanized collagens and the space-bred desert algae extract can synergistically improve the skin barrier function. Based on the synergistic mechanism of the complex system, the composition disclosed by the application can effectively promote the skin moisture retention and anti-wrinkle ability, repair the skin barrier, and is suitable for the development and application of skin care products for anti-wrinkle, skin tightening and skin aging delay.

The invention provides a composition and cream with anti-inflammatory and skin barrier injury repairing effects as well as a preparation method and application of the composition and cream, and belongs to the technical field of skin injury repairing. The invention provides a composition with anti-inflammatory and skin barrier injury repairing effects. The composition is prepared from matrine, dipotassium glycyrrhizinate, bisabolol and asiaticoside according to the weight ratio of 1: 1: 1: 1. The composition provided by the invention can play a role through a multi-target mechanism, such as up-regulation of Invoucrin, and provides a more effective prevention and treatment scheme for skin barrier dysfunction related diseases and sensitive skin.

The invention discloses a liquid crystal cream with an ice cream appearance. The liquid crystal cream is prepared from the following raw materials in percentage by weight: 5-10% of a humectant, 0.1-1% of a preservative, 0.1-3% of an emulsifier, 15-25% of an emollient, 0.3-1% of a thickener, 1-5% of a skin conditioner and the balance of water. According to the invention, the water-soluble polymer combination of the sodium carbomer and the sodium polyacrylate grafted starch is added, so that the liquid crystal cream with the appearance and texture of ice cream can be formed, the liquid crystal cream has the skin feeling experience of being light, not greasy and ice-cold water, the heavy and depressed feeling of the traditional cream is improved, and the sensory experience is better. According to the invention, the stability and transmission efficiency of active ingredients are enhanced by means of microparticle gel formed by a lamellar liquid crystal technology and a polymer, meanwhile, a lipoid structure between cuticle cells is simulated, the skin barrier function is enhanced, and the moisturizing, soothing, tightening and anti-wrinkle effects of a cream product on the skin are effectively improved.

The invention belongs to the technical field of skin care products, and discloses a quick-acting red-removing repair product which comprises the following components: water, caprylic / capric triglyceride, glycerol, sorbitol, phosphatidylcholine, 1, 3-propylene glycol, xanthan gum, eicosapentaenoic acid, docosahexaenoic acid, phytosphingosine, centella asiatica extract and tocopheryl acetate. A turmeric rhizome extract and 1, 2-hexanediol. Through mutual cooperation of the turmeric root extract and the centella asiatica extract, by taking enhancement of skin immune regulation and skin barrier functions as an action mechanism, on one hand, skin inflammatory response can be inhibited, and inflammation, microorganisms and bacteria can be effectively resisted, and on the other hand, skin barrier reconstruction can be promoted, wound healing can be promoted, and an ECM matrix can be protected; in addition, the eicosapentaenoic acid, the docosahexaenoic acid, the turmeric root extract, the phytosphingosine and the centella asiatica extract are wrapped by the nano-microcapsule liposome, so that the activity of the product can be ensured.

The invention relates to a moisturizing and anti-aging composition suitable for sensitive skin and application of the moisturizing and anti-aging composition, and belongs to the technical field of cosmetics. The composition comprises a loquat leaf extract, a camellia nitidissima flower extract, a grape fruit extract and a purslane extract as active ingredients. The folium eriobotryae extract and the grape fruit extract both have the effects of resisting oxidation, resisting inflammation and the like; the camellia nitidissima flower extract can help to relieve skin discomfort, enhance the skin barrier function and the like; the portulaca oleracea extract has the effects of moisturizing, relieving, resisting aging and the like. According to the composition disclosed by the invention, through reasonable matching and synergistic interaction of the components, the moisturizing, anti-aging, soothing and repairing effects can be remarkably improved, and the composition is mild and non-irritant, is suitable for sensitive skin, can be applied to various skin care products, and has a good market application prospect.

The invention provides an anti-sugar and anti-aging cod collagen peptide as well as a preparation method and application thereof, according to the method, the yield and functional characteristics of active peptide are remarkably improved by combining ultrasonic wave with nanometer grinding pretreatment and combining step-by-step directional enzymolysis and a three-stage ultrafiltration membrane precise separation technology. The method specifically comprises the following steps: carrying out ultrasonic pretreatment on dry cod skin, and then soaking and activating in warm water containing natural anti-sugar components; grinding and dissociating collagenous fibers by adopting high-pressure homogenization and nanoscale zirconium oxide beads; the high-purity peptide fragment with the molecular weight of 500-3000Da is obtained through step-by-step enzymolysis of a compound enzyme I and an enzyme II in combination with gradient interception of a three-stage polyethersulfone ultrafiltration membrane. The total nitrogen content of the obtained product is larger than or equal to 14.5%, the proportion of the target peptide fragment is larger than or equal to 96.7%, the yield is larger than or equal to 18.1%, and the product has remarkable anti-saccharification and anti-aging activity and can be applied to skin care products such as essence and masks to achieve collagen repair and skin barrier function improvement.

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

The invention discloses an application of glucopyranose sulfate galactooligosacharide in preparation of a medicine for treating atopic dermatitis. The glucopyranose galactooligosaccharide can significantly improve the skin condition of a DNCB-induced atopic dermatitis mouse model, including reducing the skin inflammatory factor level, improving the skin barrier function, and reducing the lymph node quality and the number of lymphocytes, and has no abnormal influence on blood routine. The composition has the advantages of small drug application dosage, low pharmaceutical cost, safety, no side effect, strong drug effect and the like, and has a wide application prospect.

To provide an external composition that promotes production of KPRP protein, which is important for horny layer formation, leading to KPRP protein-involved horny layer normalization and repair, which in turn contributes to preventing or improving a decrease in skin moisture content or a deterioration of skin barrier function.SOLUTION: The present invention provides an external composition for preventing and / or improving a decrease in skin moisture content and / or a deterioration of skin barrier function, comprising a KPRP protein production promoting component as an active ingredient.SELECTED DRAWING: Figure 4

The invention belongs to the field of biological medicines or health care products, and particularly discloses a culture method and application of an anti-aging stem cell exosome. According to the method, low-oxygen (5%-8% O) pre-culture is combined with rotary three-dimensional dynamic culture, so that the yield of the exosome is remarkably increased to 2.1 * 10 < 11 > parts / mL; tGF-beta1, IFN-gamma and NMN are added in stages to synergistically activate an immunomodulatory pathway, so that the content of TGF-beta1 reaches 8.5 ng / [mu] g. The exosome and active components (vitamin C ethyl ether, Q10 and astaxanthin) are jointly embedded in liposome (HSPC: cholesterol = 7: 3), the gastric juice stability reaches 92.3% after oral administration, and the intestinal absorption rate is increased to 80%. Experiments show that the composition can improve the Treg ratio of the spleen of an old mouse by 35%, reduce the IL-6 level by 48% and improve the skin barrier function (TEWL is reduced by 40%). Long-term toxicity experiments prove that the compound is safe (ALT has no abnormality). The invention has remarkable technical progress and clinical application potential in the anti-aging field.

The invention provides weak acid wet toilet paper special for women and a preparation process thereof, and belongs to the technical field of wet toilet paper preparation. The preparation process comprises the following steps: preparing the plant source weak acidity adjusting compound; preparing a bacteriostatic microcapsule compound; and preparing the weakly acidic wet toilet paper. The weakly acidic wet toilet paper prepared by the invention can relieve redness and pruritus of private skin caused by friction and secretion stimulation and enhance the skin barrier function, and an'instant bacteriostasis-long-acting regulation 'dual path is formed by the bacteriostatic component released by the microcapsule, the cranberry proanthocyanidin and the lactic acid bacteria metabolite, so that the recurrence rate of vaginitis is reduced.

The invention discloses lactobacillus reuteri CCFM1403 with a skin repairing effect and a metagen of the lactobacillus reuteri CCFM1403, and belongs to the technical field of microorganisms and medicines. The lactobacillus reuteri CCFM1403 provided by the invention has the effect of improving the barrier function of the skin in two aspects of external use and oral administration, and is specifically shown in that when the thallus lysate of the lactobacillus reuteri CCFM1403 is externally used, the cell viability and the related barrier function of keratinocytes after injury and the expression of a structural protein gene level can be improved; and the DNFB-induced mouse skin barrier injury can be relieved in the aspects of TEWL in apparent aspect, water content of cuticle, skin barrier protein expression and the like by orally taking viable bacteria and postbiotics of the lactobacillus reuteri CCFM1403. Therefore, the lactobacillus reuteri has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention discloses a novel application of bifidobacterium breve CCFM1078 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium breve CCFM1078 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mastocyte infiltration is reduced; (2) the relative expression quantity of mRNA (messenger Ribonucleic Acid) of mouse skin barrier function related genes is increased; (3) reducing the total IgE level of mouse serum; (4) reducing the levels of IL-4, IL-13 and TSLP in mouse skin tissues, improving the levels of IL-10 and IFN-gamma, recovering Th1 / Th2 immune balance, and maintaining immune homeostasis; (5) activating the expression of AHR and CYP1A1 in the skin tissue of the mouse; (6) improving IgA and sIgA secretion of mouse colon tissue; and (7) compared with a representative high-yield ILA strain, the ILA yield is higher.

The invention discloses a lactobacillus mucus CCFM1401 for repairing a skin barrier based on multiple target spots and a metagen of the lactobacillus mucus CCFM1401, and belongs to the technical field of microorganisms and medicines. The thallus lysate of the fermented lactobacillus mucus CCFM1401, provided by the invention, can be used for improving the cell viability of damaged keratinocytes and the expression of FLG, LOR, IVL, ZO-1, Occludin and CLDN gene levels in the aspect of external application; and viable bacteria and metabiotics (including thallus lysate and fermentation supernatant) of the fermented lactobacillus mucus CCFM1401 are orally taken, so that TEWL can be reduced, the water content of cuticle can be up-regulated, inflammatory reactions (such as skin histamine and serum IgE) can be reduced, and the skin barrier function and expression of structural protein can be up-regulated. Therefore, the fermented lactobacillus mucilaginosus has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The invention relates to the technical field of cosmetics, in particular to an oil-controlling and acne-removing composition specially researched for teenagers and application of the oil-controlling and acne-removing composition. The fig fruit extract in the composition has oil-controlling, soothing and anti-inflammatory effects, the European fairweed bud extract can effectively reduce sebum secretion and inhibit expression of inflammatory factors, and the ganoderma lucidum extract is rich in triterpenoids and polysaccharide compounds and can effectively regulate skin health and enhance the barrier function of the skin, so that the skin can be effectively nourished, and the skin can be effectively nourished. The three substances are combined for use, so that the obvious oil-controlling and acne-removing effects are achieved.

The invention relates to a tightening and lifting mask and a preparation method thereof. The mask liquid comprises the following functional components: saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin, the mass ratio of the saccharomycetes / rice fermentation product filtrate to the palmitoyl tripeptide-5 to the fibronectin is (0.1-30): (0.01-6): (0.01-2). Compared with the prior art, through the synergistic effects of the saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin on the aspects of enhancing the skin barrier function, promoting collagen generation, slowing down collagen decomposition, regulating adhesion, migration and proliferation of cells, removing reactive oxygen free radicals and the like, collagen generation of the corium layer is promoted, and the skin care effect is achieved. Skin wrinkles are reduced, and a long-term tightening and lifting effect is achieved.

To provide a novel agent capable of reinforcing tight junctions to improve the barrier function of the skin.SOLUTION: The inventors have paid attention to short-chain fatty acids, which had been considered unsuitable for use in cosmetics and the like, and conducted extensive research and discovered that acetic acid, propionic acid, and lactic acid, which are short-chain fatty acids, lower transepidermal water loss (TEWL) in a three-dimensional skin model. This invention provides a skin barrier function improver containing short-chain fatty acids as an active ingredient.SELECTED DRAWING: Figure 1