107 results about "Skin barrier function" patented technology

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The application discloses an anti-wrinkle composition containing recombinant collagen as well as a preparation method and application thereof, and belongs to the technical field of cosmetics and skin care products. The composition contains the following active ingredients in percentage by mass: 0.01%-20% of recombinant humanized type I collagen, 0.01%-20% of recombinant humanized type III collagen, 0.01%-10% of recombinant humanized type XVII collagen, and 0.01%-20% of space-bred desert algae extract. The three kinds of recombinant humanized collagens and the space-bred desert algae extract form a complex system, and when the total mass ratio is in a specific interval of 1.3:1-4:1, the three kinds of recombinant humanized collagens and the space-bred desert algae extract can synergistically improve the skin barrier function. Based on the synergistic mechanism of the complex system, the composition disclosed by the application can effectively promote the skin moisture retention and anti-wrinkle ability, repair the skin barrier, and is suitable for the development and application of skin care products for anti-wrinkle, skin tightening and skin aging delay.

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

The invention discloses a novel application of bifidobacterium breve CCFM1078 in relieving atopic dermatitis, and belongs to the technical field of microorganisms. The bifidobacterium breve CCFM1078 provided by the invention can relieve atopic dermatitis, and is specifically reflected in that (1) ear swelling and back skin thickening of mice are relieved, dermatological symptoms are relieved, and mastocyte infiltration is reduced; (2) the relative expression quantity of mRNA (messenger Ribonucleic Acid) of mouse skin barrier function related genes is increased; (3) reducing the total IgE level of mouse serum; (4) reducing the levels of IL-4, IL-13 and TSLP in mouse skin tissues, improving the levels of IL-10 and IFN-gamma, recovering Th1 / Th2 immune balance, and maintaining immune homeostasis; (5) activating the expression of AHR and CYP1A1 in the skin tissue of the mouse; (6) improving IgA and sIgA secretion of mouse colon tissue; and (7) compared with a representative high-yield ILA strain, the ILA yield is higher.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

This invention provides an anti-aging and repair dressing containing four complex active factors and its preparation method. The dressing comprises 75-90 parts of a matrix material, 5-15 parts of four complex active factors, and 3-8 parts of a moisturizing auxiliary agent. The four complex active factors are composed of recombinant human type III collagen, acetyl hexapeptide-8, ectoine, and dipotassium glycyrrhizate in a ratio of (3-6):(1-3):(2-4):(1-2). The matrix is ​​a hydrophilic nonwoven fabric or bio-cellulose membrane material that has undergone low-temperature plasma surface grafting activation treatment. The preparation process employs nitrogen combined with vacuum pulse freeze-drying technology, and enhances the activity stability through an ectoine complexation step. This dressing can promote HaCaT cell proliferation, increase collagen secretion, and inhibit inflammatory factors, significantly improving skin barrier function. It has good biocompatibility and can be used to prepare products that improve skin aging and repair.

This invention discloses the application of homoserine as a barrier repair factor in the preparation of skin repair compositions. As a multidimensional regulator of skin barrier function, homoserine systemically integrates post-sun exposure damage repair, physical barrier repair, and microecological barrier repair, providing a multi-target synergistic mechanism to effectively repair the skin barrier and alleviate skin damage. The application of homoserine in cosmetics or skin care products meets consumers' needs for precise skin repair.

The application relates to the technical field of biological medicines, in particular to a deer horn stem cell exosome as well as a preparation method and application thereof. The preparation method of the deer horn stem cell exosome comprises the following steps: S1, preparing P3-P5 generation deer horn stem cells; S2, preparing induced culture supernatant; S3, preparing crude extracted exosomes; and S4, preparing deer horn stem cell exosomes. The prepared deer horn stem cell exosome has high yield, high biological activity, can significantly promote fibroblast proliferation and collagen synthesis. Meanwhile, the exosome can effectively accelerate wound healing, has high 14d healing rate, can significantly increase the water content of the cutin layer of the skin, reduce the TEWL value, and improve the skin barrier function, provides high-quality raw materials for the research and development of skin repair products, and has a wide application prospect.

The object of the present invention is to provide a composition that improves skin barrier function. The problem can be solved by the composition for activating the skin barrier of the present invention, comprising β-alanine or a salt thereof.

The invention belongs to the technical field of medical evaluation, and relates to a method for evaluating damage of air pollution to human skin health based on a PPO-LSTM fusion algorithm. The method comprises the following steps: acquiring multi-source data; preprocessing data, and constructing a multi-dimensional time sequence feature data set; establishing a PPO-LSTM fusion model, performing feature extraction and reinforcement learning optimization on the multi-dimensional time sequence features, and outputting skin health core indexes; performing prediction and quantitative evaluation on the functional states of the cuticle, the epidermal layer and the corium layer; generating a personalized nursing decision scheme for skin health maintenance; outputting corresponding early warning information and coping suggestions by judging the risk levels of the skin barrier function and the dermal metabolism function; and updating parameters of the skin health injury evaluation model. According to the method, multi-dimensional data are integrated in the same model at the same time, the evaluation dimension is more comprehensive, the accuracy of skin health injury evaluation is improved, and a complete closed loop from detection evaluation to nursing scheme generation and risk prompt is realized through decision making and early warning.

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating psoriasis, a preparation method and application thereof. The raw material composition comprises, in mass parts, 10-30 parts of schizonepeta, 10-30 parts of moxa leaf, and 10-30 parts of rhizoma alocasia. Animal experiments show that the traditional Chinese medicine composition can promote the repair of skin barrier function and reduce the skin lesion symptoms of psoriasis-like mice, which indicates that the traditional Chinese medicine composition has a good therapeutic effect on psoriasis.

The present application provides a kind of oil composition, containing monounsaturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acid is omega-9 fatty acid;Polyunsaturated acid is the mixture of omega-6 fatty acid and omega-3 fatty acid.The present application can repair and resist aging, all-purpose skin care, increase epidermal thickness, enhance barrier, anti-inflammatory soothing, anti-wrinkle firming, soothing repair red, nourish skin, and can be applied to sensitive skin, can inhibit LPS-induced HaCaT cell IL-6 secretion, increase the thickness of 3D skin model epidermis layer, and can promote the expression of silk aggregate protein (FLG), ceramide synthase 3 (CerS3), desmoglein core glycoprotein (DSG1) which has important role for skin barrier function, indicating that it can alleviate the inflammatory response produced by LPS stimulation HaCaT cell and has enhanced skin barrier function.

The present disclosure relates to a novel peptide and a composition for alleviating skin aging, a composition for caring for skin damage or alleviating skin sagging, a composition for reversing aging, an anti-glycation composition, a composition for preventing hair loss or promoting hair growth, and a composition for improving skin barrier function, wherein the compositions comprise the novel peptide.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

The application discloses preparation and application of a heat-sensing repair type recombinant collagen, and relates to the technical field of bioengineering and biomedical materials.The application innovatively carries out gene fusion on a functional domain fragment of a type I humanized collagen and a functional domain fragment of a heat shock protein family through a flexible linker.The recombinant protein is used for solving problems of protein denaturation, membrane structure damage, release of inflammatory factors, impairment of skin barrier function, aggravation of water loss and sensitivity and vulnerability of skin caused by photothermal damage of skin under photothermal stress conditions (such as ultraviolet radiation, high-temperature environment or medical and beauty photoelectric treatment of thermal MAGE, etc.), and the HSP molecular chaperone function is used for guiding damaged proteins to correctly fold and maintain intracellular homeostasis, and the collagen part is used for accelerating tissue repair.Experiments prove that the recombinant protein can effectively improve skin tightness, anti-wrinkle property and barrier repair capacity after thermal damage.The application can be widely applied to the fields of cosmetics, skin repair and protection and medical and beauty postoperative care, etc.

NEW SMALL MOLECULES AND METHODS USING THEM FOR SKIN TREATMENT. The disclosure relates to new biosynthetic gene clusters encoding type II polyketides, their products, extracts and compositions comprising the products, and methods for using the products, extracts, and compositions for skin treatment, e.g., to enhance the skin's barrier function and / or immune defenses. Figure for abstract: none

The invention relates to an astragalus membranacus root extract-containing composition for soothing, repairing and moisturizing skin, the composition comprises an astragalus membranacus root extract, glycerol, methylpropanediol, soothing and repairing components, an antioxidant, a thickening agent and water, and in the cosmetic composition, the weight percentage of the astragalus membranacus root extract is 1-2%. The composition has excellent soothing, repairing and moisturizing functions, and can improve the skin barrier function and effectively relieve the sensitive skin problem.

The invention relates to a bacteriostatic repair medical gel containing glycosylglycerol and a preparation method thereof, and belongs to the technical field of medical dressings. The gel is prepared by taking glycosylglycerol as a main active component and cooperating with chitosan, collagen, a silver ion antibacterial agent and other components through a specific process. The gel has triple synergistic effects: glycosylglycerol enhances the skin barrier function and provides lasting moisture retention by activating aquaporin; chitosan and silver ions provide broad-spectrum antibacterial activity; and collagen and glucan promote tissue repair and cell proliferation. Experiments show that the antibacterial rate of the gel on common pathogenic bacteria such as staphylococcus aureus and escherichia coli exceeds 99.9%, meanwhile, the wound healing speed can be increased by 40% or above, and the gel is good in biocompatibility and free of skin irritation. The gel can be used for repairing and nursing various skin injuries such as burn wounds, chronic ulcers and surgical wounds.

The invention provides composite gel and a preparation method thereof, and belongs to the technical field of biomedical materials. The composite gel provided by the invention takes two proteins and a variety of polysaccharides as main components or preparation raw materials, and all the components can play a very good synergistic effect, so that the composite gel can better relieve skin damage symptoms, is beneficial to moisturizing of postoperative skin, promotes wound healing and repair of damaged skin, and has a good application prospect. The skin barrier function is improved; the health condition of damaged skin is improved; meanwhile, relatively good safety, stability and biocompatibility are realized.

The invention discloses a bifidobacterium animalis subsp. Lactis BT-G9 with a growth promoting function and application of the bifidobacterium animalis subsp. Lactis BT-G9, the bifidobacterium animalis subsp. Lactis BT-G9 is preserved in China Center for Type Culture Collection, the preservation date is November 20, 2025, and the preservation number is CCTCC NO: M 20252626. The brand new bifidobacterium animalis subsp. Lactis BT-G9 provided by the invention has good tolerance to gastric juice and intestinal juice, is suitable for survival in gastrointestinal tracts, can effectively inhibit bacteria, and particularly can effectively inhibit campylobacter kirscheri, streptococcus agalactiae and / or propionibacterium acnes. Experimental results show that the strain can promote animal growth and development and improve the autism, especially when the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 are combined for use, the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 have a synergistic effect, and the improvement effect on the autism can be remarkably improved. In addition, the extracellular vesicles prepared from the strain can effectively repair the skin barrier function.

Use of a composition comprising (i) Vitamin B or a derivative thereof, (ii) saccharide isomerate; and (iii) a peptide, for improving skin barrier function.

The invention discloses an adhesion-drug release collaborative design system and method of adhesion type hydrogel, which are applied to the field of biomedical materials. A gradient cross-linking density and dynamic dual-network synergistic adhesion mechanism, a pH responsive nanopore channel of a drug sustained-release layer and a molecularly imprinted chain segment synergistic controlled-release mechanism, and a micro-breathable structure of a bionic cuticle barrier membrane and a zwitter-ion anti-adhesion surface synergistic protection mechanism are constructed; collaborative optimization of triple properties of adhesion self-enhancement in a wet environment, intelligent drug release and low skin irritation is realized; the method does not depend on traditional single function layer stacking or static parameter regulation and control, and starts from three dimensions of material microstructure design, interface coupling relation construction and dynamic response mechanism implantation to establish a set of multi-level collaborative design process capable of being implemented in an engineering mode. The finally formed hydrogel application product can maintain stable adhesive force in a complex physiological environment, at the same time releases treatment components as required, and reduces interference to a skin barrier function to the maximum extent.

The present invention relates to a composition for improving skin function, containing Lactobacillus plantarum as an active ingredient and, specifically, to a composition having the effects of activating primary cilia, improving skin barrier function, soothing skin, reducing skin wrinkles, whitening skin, and inhibiting melanin production, the composition containing a Lactobacillus plantarum beLP1 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or dead cells thereof as an active ingredient.

The present invention relates to a fermented extract of aerial parts of Anthyllis vulneraria and to the method for obtaining same. The invention also relates to the use of a fermented extract of Anthyllis vulneraria for treating / preventing skin dryness and / or for improving the barrier function of the skin.

The present invention is directed to a dietary supplement composition for enhancing gut barrier and skin health comprising a therapeutically effective amount of: (a) at least one polysaccharide chosen from a fructo-oligosaccharide, a galacto-oligosaccharide, a xylo-oligosaccharide, and mixtures thereof; (b) at least one polysaccharide mucilage having demulcent activity; (c) at least one source of insoluble dietary fiber having antioxidant activity; (d) at least one amino acid capable of supporting gut barrier integrity; (e) at least one source of resistant starch; and, optionally (f) at least one natural ingredient capable of protecting gastric function.

This invention relates to a composition containing acids, plant extracts, and enzymes, belonging to the field of cosmetics. The composition provided by this invention, by combining acids, plant extracts, and enzymes with other ingredients, can exert a synergistic effect of multiple components, and is safe and stable. It can gently yet effectively remove acne, enhance the skin barrier function, regulate the skin's microecology, and maintain the skin in a healthy state.

The application discloses a surfactant composition and application thereof, and belongs to the technical field of cosmetics.The surfactant composition provided by the application comprises sodium lauroyl glutamate, decyl glucoside, Tween-28, a betaine surfactant, a glycolipid and mucunna pruriens polysaccharide.The surfactant composition provided by the application can greatly reduce the dissolution of intercellular lipids and natural moisturizing factors and the damage to proteins on the basis of good surface activity, does not affect the skin barrier function, has a regulating effect on the skin microecosystem, balances the skin microecosystem, does not reduce the number of beneficial bacteria in the skin microecosystem, but can help reduce the number of harmful bacteria in the skin microecosystem, thereby effectively improving the skin barrier function and keeping the skin healthy.When applied to subsequent washing and protecting products, the washing and protecting products obtained are excellent in safety.

The invention discloses a composition for repairing a tough skin barrier of sensitive skin and a preparation method and application thereof, the composition for repairing the tough skin barrier of the sensitive skin comprises bisabolol, a ginger root extract and ceramide, and the mass ratio of the bisabolol to the ginger root extract to the ceramide is (0.001-5): (0.0001-1): (0.001-5). The bisabolol has anti-inflammatory and soothing effects; the ginger root extract has natural oxidation resistance and can help relieve damage of the external environment to the skin; ceramide can effectively supplement skin lipid and repair a damaged barrier structure. Under the synergistic effect of the bisabolol, the ginger root extract and the ceramide, uncomfortable symptoms such as redness and pruritus of sensitive skin can be quickly relieved, meanwhile, the skin barrier function is fundamentally enhanced, the skin tolerance and the water retention capacity are improved, and the composition can be applied to cosmetics as a composition for repairing the sensitive skin and strengthening the skin barrier.

The invention discloses a skin care composition containing an eyebright extract, which is prepared from the following raw materials: the eyebright extract, a baobab pulp extract, a rosa canina fruit extract, a safflower extract, a pomelo leaf extract, a humectant, a thickening agent, a chelating agent, a preservative, a pH regulator and deionized water. Wherein the eyebright extract is prepared by combining a high-pressure cell disruption technology and an ultrasonic extraction technology. The composition achieves the remarkable effect through the synergistic effect of multiple components, wherein the eyebright extract serves as a core active component, and experiments prove that the eyebright extract can cooperate with other plant extracts to achieve the multiple effects of preserving moisture, locking water, resisting aging, tightening skin, relieving sensitivity and the like; all the components form a stable system through optimized proportioning, and the mild and non-irritating characteristics are kept while the skin barrier function is improved.