Fermented lactobacillus mucus CCFM1401 for repairing skin barrier based on multiple target spots and metaplast of fermented lactobacillus mucus CCFM1401
By using the internal and external synergistic effects of Lactobacillus fermentation mucosa CCFM1401 and its epibiotic, the shortcomings of existing external products in repairing skin barrier damage have been solved, and a more comprehensive and long-term skin barrier repair effect has been achieved.
CN119709468AActive Publication Date: 2025-03-28JIANGNAN UNIV
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Patent Information
- Application Number
- CN202411502937.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-25
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2044-10-25
AI Technical Summary
Technical Problem
The existing external products have a single mechanism of action in repairing skin barrier damage, with significant short-term effects, but insufficient repair ability for chronic or long-term damage, and cannot regulate skin health from the inside.
Method used
Using Lactobacillus fermentum CCFM1401 and its epibiotics, a probiotic repair product that can be taken internally and externally is prepared through the synergistic effect of internal and external factors.
Benefits of technology
This product can significantly improve the cellular activity and barrier function of skin keratinocytes, increase the barrier function and structural protein content of skin tissue, reduce inflammatory response, and provide a more comprehensive and long-term skin barrier repair effect.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a lactobacillus mucus CCFM1401 for repairing a skin barrier based on multiple target spots and a metagen of the lactobacillus mucus CCFM1401, and belongs to the technical field of microorganisms and medicines. The thallus lysate of the fermented lactobacillus mucus CCFM1401, provided by the invention, can be used for improving the cell viability of damaged keratinocytes and the expression of FLG, LOR, IVL, ZO-1, Occludin and CLDN gene levels in the aspect of external application; and viable bacteria and metabiotics (including thallus lysate and fermentation supernatant) of the fermented lactobacillus mucus CCFM1401 are orally taken, so that TEWL can be reduced, the water content of cuticle can be up-regulated, inflammatory reactions (such as skin histamine and serum IgE) can be reduced, and the skin barrier function and expression of structural protein can be up-regulated. Therefore, the fermented lactobacillus mucilaginosus has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.
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