26 results about "Proanthocyanidin" patented technology

This invention relates to a method for preparing ginkgo leaf extract, the ginkgo leaf extract obtained by the method, and pharmaceutical or food supplements containing the extract.

This invention relates to the field of feed additive technology, specifically to a Bacillus subtilis composition for improving animal intestinal health and its preparation method. It comprises the following raw materials: Bacillus subtilis engineered bacterial powder, cinnamaldehyde microcapsules, proanthocyanidins B2, selenium-enriched yeast culture, glycoterpenes, trehalose, and a carrier. The core of this invention lies in using Bacillus subtilis EhrBS-9 (CGMCC No. 24947) as the strain, constructing a dual-function engineered bacterium with tolerance and transformation through gradient cinnamaldehyde domestication and cad gene integration. This, combined with the intestinal-targeted delivery of cinnamaldehyde microcapsules, barrier strengthening of proanthocyanidins B2, and the construction of a multidimensional anti-stress network of selenium-enriched yeast, glycoterpenes, and trehalose, forms a synergistic mechanism of gut microbiota regulation, immune enhancement, and stress buffering. This addresses the industry pain point of insufficient synergistic effects of existing feed additives in terms of high-efficiency antibacterial activity, safe immune regulation, root-cause anti-stress, and ecological safety.

The application belongs to the technical field of anti-inflammatory and specifically relates to a pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system, a preparation method and application thereof. The pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system provided by the application comprises a hydrogel matrix and PACs@ZIF-8 nanoparticles wrapped in the hydrogel matrix; the PACs@ZIF-8 nanoparticles comprise ZIF-8 nanoparticles and procyanidins loaded on the ZIF-8 nanoparticles. The application not only can exert the response release of ZIF-8 in an acidic microenvironment, improve the stability of PACs and solve the problem of poor bioavailability, but also realizes local forming and long-acting slow release by using the hydrogel matrix, thereby synergistically enhancing the treatment advantages of PACs. The system provided by the application plays a role in anti-inflammatory and antioxidant and provides a new treatment method for the treatment of periodontitis.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

To provide a simple procyanidin analysis method that can be performed at a low cost, and in the form of preliminary analysis for selecting a sample for precision analysis in HPLC, that is, screening.SOLUTION: Cell size liposomes 10, 10' are composed of a lipid component system in which one or more phospholipids 2, 3 and one or more sterol-based lipids 5 are used in a constant composition, and procyanidin 8, where different phase separation domain generation patterns are generated depending on the concentration of procyanidin 8, which can be used for estimating the procyanidin concentration from the phase separation domain generation pattern. The phospholipids 2, 3 are unsaturated phospholipid or saturated phospholipid.SELECTED DRAWING: Figure 1

The present application relates to a kind of grape seed extract preparation system, including shell and inside from top to bottom arrangement of tipping bucket assembly, transmission assembly and sorting assembly.Tipping bucket assembly uses the tipping bucket container of eccentric arrangement to cooperate elastic energy storage piece, it is realized based on the sudden jump of liquid weight threshold value and is overturned, and through the rigid collision of trigger lever and limit stopper inertia vibration is generated to shake off residual liquid film, solve the cross contamination caused by high adhesion of proanthocyanidin.Transmission assembly is stepped by driving arm impact to drive ratchet disc, and it is realized physical hard lock by unidirectional transmission structure and positioning pawl, solve the alignment deviation caused by signal drift of electric control system.Sorting assembly includes distribution disc with collection bottle installation slot and distribution pipe assembly.The present application realizes precision sorting, with zero cumulative error and nondestructive emptying etc.Advantages, suitable for the automatic preparation of natural products in high volatile solvent environment.

A method for preparing an extract from the leaves of Ginkgo biloba, an extract from Ginkgo biloba obtainable by this method, and a pharmaceutical or dietary supplement containing this extract.

This invention belongs to the fields of food biotechnology and food processing, and discloses a method, product, and application for regulating the allergenicity of soybean protein based on heat-induced proanthocyanidin covalent modification. This invention aims to solve the problem of unstable regulation of soybean protein allergenicity during heat processing, and provides a stable and differentiated method for reducing allergenicity. The core of the method lies in: under heat treatment conditions, proanthocyanidins simultaneously covalently modify soybean 7S and 11S globulins, achieving differentiated regulation of their allergenicity. Products using this method exhibit the following specific pattern of allergenicity: 7S globulin products are significantly lower than heat-treated products; 11S globulin products are lower than heat-treated products and natural proteins. This low-allergenicity pattern remains stable after in vitro simulation of adult gastrointestinal digestion. This invention provides a targeted, mild, and efficient allergen regulation strategy, and the resulting products can be used to develop low-allergenic foods, special medical purpose formula foods, and dietary supplements.

This invention discloses a starch-plant polyphenol cocrystal, its preparation method, and its application in functional foods, relating to the field of functional food technology. The preparation method includes: S1, mixing starch and plant polyphenols uniformly to obtain a mixture; S2, adding the mixture to a low-temperature impact mill, adding grinding media, and introducing an inert gas into the low-temperature impact mill to subject the mixture to impact treatment, obtaining a cocrystal complex; S3, purifying and freeze-drying the cocrystal complex to obtain the starch-plant polyphenol cocrystal. This invention innovatively uses wheat starch and proanthocyanidins to form a cocrystal structure, resulting in a simpler and more efficient preparation process, eliminating the need for complex physical field treatments or multiple freeze-drying steps, and maximizing the preservation of polyphenol activity. The cocrystal structure endows the carrier with excellent sustained-release performance, enabling long-term release of polyphenols in functional food applications, solving the problems of unstable loading rates and poor sustained-release effects in existing technologies.

This invention discloses a targeted anti-aging microemulsion skincare formulation containing proanthocyanidin C1 and its preparation method, comprising the following components by weight percentage: oil phase: 12%–22%; nonionic surfactant: 18%–28%; co-surfactant: 6%–12%; proanthocyanidin C1: 0.8%–4.5%; marine collagen oligopeptides: 2%–7%; targeted modification component: 0.2%–0.8%; deionized water: balance; the formulation is an oil-in-water microemulsion with a particle size of 10–50 nm and a polydispersity index ≤0.2; the purity of the proanthocyanidin C1 is ≥95%; this invention relates to the field of anti-aging technology. This targeted anti-aging microemulsion skincare formulation containing proanthocyanidin C1 and its preparation method involve compounding an oil phase, nonionic surfactant, and co-surfactant in a specific ratio, combined with a two-stage high-pressure microfluidic homogenization process, to prepare an oil-in-water nanoscale microemulsion with a particle size strictly controlled within the range of 10–40 nm and a polydispersity index ≤0.15. The system is uniform and delicate, without stratification, flocculation, or oil droplet aggregation.

A micronutrient composition for infants and children from 6 months of age, characterized in that it is a liquid oral formulation containing the following main active ingredients: microencapsulated lutein, microencapsulated zeaxanthin, proanthocyanidins, anthocyanins, taurine, zinc, vitamin A and vitamin E, wherein the composition serves to support healthy retinal development in infants, to relieve visual fatigue and to build an antioxidant defense system in the eye.

The utility model relates to the technical field of procyanidine processing, in particular to a raw material sterilization device for extracting procyanidine, which comprises a sterilization box, a sealing door is arranged on the side surface of the sterilization box, a visual window is arranged at the center of the side surface of the sealing door, and a handle is fixedly welded on the side surface of the sealing door. Anti-skid supporting legs are fixedly welded to the bottom surface of the sterilization box, an air heater is fixedly connected to the inner wall of the sterilization box, and an ozone generator is fixedly connected to the top surface of the sterilization box. Efficient sterilization and drying treatment of materials is achieved through the synergistic effect of ozone and hot air, ozone generated by an ozone generator is evenly input into the device through multiple stages of pipelines, and the materials make full contact with the ozone in combination with a dynamic turning structure driven by a rotating motor, so that the sterilization rate of the materials is increased, and the drying efficiency is improved. After sterilization, the hot-air blower is used for circularly drying the internal materials, and residual ozone in the device is synchronously decomposed, so that the ozone is prevented from polluting the environment.

The invention relates to a combination containing an extract of Coleus forskohlii, an apple extract rich in proanthocyanidins, an extract of grape pomace and a phloretin powder.

The application relates to the technical field of high-barrier environment-friendly packaging films, and discloses a high-barrier environment-friendly packaging film with antibacterial function, which comprises, from bottom to top, a base layer, a nano-composite barrier layer, a bio-based functional layer and an outer protective layer, and the layers are tightly attached through a coated starch-based adhesive. The high-barrier environment-friendly packaging film with antibacterial function is prepared by using polyhydroxyaliphatic ester in the base layer film, biodegradable polycaprolactone in the nano-composite barrier layer film and konjac glucomannan in the bio-functional layer film, all of which have good biodegradability and can be decomposed into carbon dioxide and water by microorganisms in various environments, and have excellent flexibility and processing performance, can adapt to different packaging requirements, provide basic flexibility and structural support for the overall packaging film and green environmental protection effect, and the procyanidins arranged in the outer protective layer film provide stronger antibacterial performance and water solubility for the overall packaging film.

This invention relates to the field of natural product separation and purification technology, specifically to a proanthocyanidin C1 extraction system and method. The aim is to solve the problems of high spectral overlap between proanthocyanidin C1 and its homomeric isomers, overlapping peak edges, and the inability of traditional fixed elution flow rates to adapt to real-time micro-changes in peak shape, leading to inaccurate fraction collection and low extraction purity and yield. In liquid chromatography detection, a real-time spectral micro-shift data capture unit extracts the shoulder peak spectral micro-shift values ​​within a narrow wavelength range at the edge of the characteristic absorption peak. A micro-shoulder peak shift correction algorithm unit fits the instantaneous correlation coefficient between the shift value and the elution flow rate using the least squares method, generating a flow rate adjustment command. A dynamic elution flow rate adjustment unit drives the elution pump to adjust the flow rate, establishing a dynamic coupling relationship. The fraction collection node calculates compensation for the shift and locks the characteristic peak position of the pure component, precisely controlling the start and end times of collection, thereby improving the extraction purity and yield of proanthocyanidin C1.

This invention belongs to the field of analytical chemistry, specifically relating to a method and its application for separating and purifying proanthocyanidins from lotus seed shells. This invention uses mesoporous activated carbon as an adsorbent for dispersed solid-phase extraction, selectively adsorbing and removing alkaloids from lotus seed shells to purify proanthocyanidins, followed by analysis using ultrafluid chromatography-tandem triple quadrupole mass spectrometry (UPLC-QQQ-MS / MS). The mesoporous activated carbon used in this invention is biochar, rich in oxygen-containing groups on its surface, and has a large specific surface area. Adding mesoporous activated carbon to the lotus seed shell extract and performing one-step vortex dispersion adsorption to remove alkaloids achieves a removal rate of 53%-92%, and a proanthocyanidin recovery rate of 75%-90%. This method is simple, rapid, and low-cost. DPPH free radical scavenging experiments showed that the scavenging rate of proanthocyanidin extract from lotus seed shells increased from 48% to 56% after treatment with mesoporous activated carbon.

This invention discloses the application of geraniol in the preparation of a drug for treating Sjögren's syndrome. In vivo experiments using a NOD mouse model of Sjögren's syndrome demonstrated that geraniol treatment significantly improved salivary secretion disorders and reduced abnormally high water intake in the mice; significantly reduced lymphocyte infiltration in salivary gland tissue, improved glandular pathological damage, downregulated the levels of characteristic autoantibodies (Anti-SSA / Ro and Anti-SSB / La) in serum, upregulated the expression levels of AQP5 and AR, and reduced organ indices in salivary glands, spleen, and thymus tissue, comprehensively improving dry mouth symptoms in mice. In vitro experiments also showed that geraniol treatment upregulated the expression levels of AQP5 and AR. Therefore, this invention provides the application of geraniol in the preparation of a drug for treating Sjögren's syndrome, which has the advantages of significant efficacy and addressing both the symptoms and root cause, and possesses good clinical application prospects.

The application discloses a soil conditioner and a preparation method and application thereof, and comprises the following raw material components in parts by weight: 65-70 parts of straw, 25-30 parts of silicon dioxide, 2.5-4.9 parts of anhydrous calcium chloride, and 0.1-0.5 parts of a biological denitrification inhibitor, wherein the biological denitrification inhibitor is proanthocyanidin. The soil conditioner can reduce soil acidity, cultivate and fertilize the soil, promote soil aggregation, reduce the loss of effective nitrogen components in the soil, and effectively increase the soil consumption capacity through stirring, rolling and granulation, so that the synergistic effect of various material components is enhanced, the plough layer soil obstacle problem is directly improved through deep application, the soil pore structure is improved, and the resource recycling of crop straw is realized.

To provide a composition that can improve or maintain vascular functions, or in particular, can improve or maintain vascular functions, hematologic properties, a blood flow and the like.SOLUTION: The present invention provides a composition containing procyanidin, and ceramide or nucleic acids.SELECTED DRAWING: Figure 1

This invention belongs to the field of traditional Chinese medicine quality testing technology, specifically disclosing a method for constructing a characteristic chromatogram and determining the content of *Actinidia chinensis* root. The method for constructing the characteristic chromatogram includes the following steps: S1: Take *Actinidia chinensis* root as a reference material, add 70% methanol for ultrasonic extraction, filter, and obtain a reference solution; separately take catechin, epicatechin, proanthocyanidin B1, and proanthocyanidin B2 reference standards, add 70% methanol to prepare a mixed reference solution; S2: Take *Actinidia chinensis* root powder, add 70% methanol for ultrasonic extraction, add weight, filter, and obtain the final product; S3: Inject the samples separately, record the chromatograms, and construct the characteristic chromatogram. This invention establishes a characteristic chromatogram of *Actinidia chinensis* root using high-performance liquid chromatography (HPLC) and simultaneously determines the content of four components: proanthocyanidin B1, catechin, proanthocyanidin B2, and epicatechin, achieving comprehensive, accurate, and stable quality control of *Actinidia chinensis* root.

This invention discloses a Torreya grandis MATE transporter protein TgMATE72, its encoding gene, and its applications. The amino acid sequence of the transporter protein TgMATE72 is shown in SEQ ID NO.2, and the nucleotide sequence of the encoding gene is shown in SEQ ID NO.1. This invention also provides the application of the transporter protein TgMATE72 and its encoding gene in regulating the transport of proanthocyanidin precursors and increasing proanthocyanidin content in plants. Based on the combined analysis of transcriptome data from Torreya grandis seed development and the content of proanthocyanidins and their monomers, this invention screened and obtained TgMATE72, and its expression level is positively correlated with the accumulation of catechin monomers. Sequence alignment and phylogenetic analysis show that the transporter protein TgMATE72 belongs to the plant MATE transporter protein family. Heterologous expression and transport activity detection results in Xenopus laevis oocytes show that TgMATE72 can mediate the transport of catechin monomers. This invention provides gene resources and application methods for improving proanthocyanidin-related traits in plants, and can be used for molecular breeding and quality improvement of Torreya grandis and other plants.

The application discloses application of dihydroeugenol in preparation of a medicine for treating Sjogren's syndrome. Through in-vivo experiments of a Sjogren's syndrome model of NOD mice, it is proved that after dihydroeugenol treatment, the saliva secretion disorder of the Sjogren's syndrome model mice can be significantly improved, the abnormally increased water consumption can be reduced, the lymphocyte infiltration of the salivary gland tissue can be significantly reduced, the pathological damage of the gland can be improved, the level of the characteristic autoantibody (Anti-SSA / Ro and Anti-SSB / La) in serum can be lowered, the expression level of AQP5 and AR can be raised, the organ index of the salivary gland, spleen and thymus tissue can be reduced, and the dry mouth symptom of the mice is comprehensively improved. In-vitro experiments also show that after dihydroeugenol treatment, the expression level of AQP5 and AR can be raised. Therefore, the application of dihydroeugenol in preparation of the medicine for treating Sjogren's syndrome has the advantages of significant curative effect, treating both the symptoms and the root cause, and good clinical application prospect.

This invention discloses a method for preparing proanthocyanidin microcapsules through complex coagulation self-assembly, belonging to the field of microcapsule preparation technology. It aims to solve problems such as the easy degradation and inactivation of proanthocyanidins, the high-temperature degradation of activity in existing preparation methods, and cumbersome processes. The method uses proanthocyanidins as the core material and sodium alginate and whey protein as the wall material. The product is obtained through a four-step process: wall material solution preparation, core material solution preparation, complex coagulation self-assembly reaction, and proanthocyanidin encapsulation and solidification. The wall material solution consists of a 1-3% (w / w) sodium alginate solution and a 1.0-5.0% (whey protein) solution. The core material solution is prepared by dissolving proanthocyanidins in anhydrous ethanol and ultrasonically dispersing them. The pH of the complex coagulation reaction is adjusted to 3.5-7.5, and the reaction is carried out with stirring at 30-50°C. Finally, the microcapsules are obtained by calcium chloride cross-linking solidification and vacuum freeze-drying. The preparation conditions of this invention are mild, without high-temperature and long-term treatment, and the core material encapsulation rate reaches 85% to 95%. The product has strong antioxidant activity and good stability. Moreover, the process steps are few, no organic solvents or additional excipients are required, the raw materials are readily available, and the production cost is low. It can also be applied to the encapsulation of other polyphenols and flavonoid active ingredients, and has broad application prospects in the fields of medicine, food, and cosmetics.