135 results about "Proanthocyanidin" patented technology

The invention belongs to the field of nano-medicine and traditional Chinese medicine, and particularly discloses an antioxidant nano-material based on self-assembly of traditional Chinese medicine and copper ions and a preparation method thereof.The nano-material is prepared from BPCu nano-particles formed by self-assembly of berberine and procyanidine B2 under induction of the copper ions, the BPCu nano-particles are further subjected to surface modification through polyvinylpyrrolidone, and the antioxidant nano-material is prepared. And the stably dispersed PVP-coated BPCu nano structure is obtained. The material is small in particle size, uniform in distribution, good in water solubility and storage stability, excellent in free radical scavenging capacity and catalase-like activity and suitable for adjuvant therapy of oxidative stress related diseases, and the preparation method is easy and convenient to operate, does not need an organic solvent and has good industrialization and disease treatment potential.

The invention belongs to the technical field of microorganisms, and relates to a plant lactobacillus NXU-F1 strain and application thereof. The classification name of the bacterial strain is lactobacillus plantarum, the bacterial strain is preserved in Guangdong Microbial Culture Collection Center on June 20, 2025, and the preservation number of the bacterial strain is GDMCC No.66563. The invention also discloses a preparation method of the bacterial strain. The plant lactobacillus is strong in growth capability, has good adaptive capacity to environment, and can obviously increase the content of antioxidant substances when being applied to plant matrix fermentation. The lycium barbarum and grape compound fermented beverage is prepared by fermenting the lycium barbarum and grape compound fermented beverage, the content of polyphenol, flavone, polysaccharide and procyanidine in the beverage is obviously increased, and the increase of resveratrol and ferulic acid is particularly obvious; meanwhile, ester compounds are increased and aldehyde substances are reduced, so that the beverage is endowed with strong longan fruity flavor, and the flavor of harmonious sour and sweet taste and lingering aftertaste is formed.

The invention relates to the field of aquatic feed, and provides a low-temperature adhesive type aquatic feed particle composition and a preparation method thereof. The composition is composed of puffed soybean meal, flour, fish meal, low-temperature directed enzyme, microcrystalline cellulose, modified zein nanoparticles, a protein adhesive and a modified zein ethanol water solution. The preparation method comprises the following specific steps: reacting soybean protein isolate with cross-linking enzyme to generate a protein adhesive, reacting proanthocyanidins with gallic acid to generate gallic acylated proanthocyanidins, and carrying out multi-step treatment on zein. Experimental results show that the composition has excellent water resistance and oxidation resistance, and the growth efficiency and the survival rate of aquatic animals are remarkably improved. The preparation method is simple, the cost is low, heat-sensitive substances in the feed are not damaged, and an economical, efficient and nutrient-rich feed solution is provided for aquaculture.

The application belongs to the technical field of food processing, and particularly relates to an oat protein-pectin-proanthocyanidin compound and a preparation method thereof. The oat protein is mixed with water, and an alkali liquor is added to adjust the pH to obtain a protein material solution for medium grinding. Then, pectin is added to the ground protein material solution, and proanthocyanidin powder is added after the pH is adjusted, and secondary medium grinding is performed to obtain an oat protein-pectin-proanthocyanidin solution. Then, hydrochloric acid is slowly added to adjust the pH to 6.8-7.0. Finally, the protein solution is centrifuged, and the supernatant is spray dried to obtain the oat protein-pectin-proanthocyanidin compound. The oat protein-pectin-proanthocyanidin compound prepared by the method is a brand-new protein system, and solves the problems of poor dispersibility, nutritional defects and poor emulsifying property of oat protein, and has a wide application prospect.

The invention relates to the technical field of preparation of Pickering emulsion stabilizers, in particular to a protein-polyphenol-polysaccharide ternary covalent complex as well as a preparation method and application thereof. The method comprises the following steps: step 1, preparing a whey protein isolate aqueous solution, completely hydrating the whey protein isolate aqueous solution, compounding a grape seed oligomeric proanthocyanidins aqueous solution and a hydrated protein aqueous solution, adjusting the pH value, and carrying out stirring reaction and dialysis freeze-drying to prepare a protein-polyphenol binary compound; and 2, compounding the binary compound solution with the lycium barbarum polysaccharide solution, uniformly stirring, carrying out Maillard reaction to obtain a ternary compound solution, and freeze-drying to obtain the protein-polyphenol-polysaccharide ternary compound. The invention provides a non-toxic, harmless and pollution-free natural emulsifier and stabilizer, and simultaneously prepares a Chinese wolfberry seed oil Pickering emulsion capable of loading nutritional ingredients and active substances, thereby providing reference for screening research of the natural emulsifier and protection of nutritional ingredients of Chinese wolfberry seed oil, which are easy to photodecompose and oxidize; the problem that the effect of protein serving as a Pickering emulsion stabilizer in the prior art is poor is solved.

A trace element supplement consisting of lutein, zeaxanthin, astaxanthin, anthocyanins, and proanthocyanidins is designed to improve retinal health in children and adolescents, relieve eye strain, and slow the progression of myopia. The daily dose is 1–20 mg lutein, 0.2–4 mg zeaxanthin, 0.5–8 mg astaxanthin, 10–700 mg taurine, and 0.5–8.5 mg zinc; the nighttime dose is 1–100 mg eyebright extract, 10–300 mg chamomile extract, 1–200 mg anthocyanins, and 1–500 mg proanthocyanidins.

The utility model discloses equipment for preparing a peanut membrane extract containing proanthocyanidins with the concentration of more than 50%. The equipment comprises a base, the shell is connected with the base, and a containing cavity is defined by the shell and the base; the filter cartridge is accommodated in the accommodating cavity and comprises a cartridge body which is detachably connected with the base; the top cover is arranged on the cylinder body, the top cover is detachably connected with the cylinder body, an inner cavity is defined, and the inner cavity is used for containing a peanut film; the retaining ring is respectively connected with the barrel and the top cover to limit the top cover to move relative to the barrel; and the driving device is arranged on the base, is in transmission connection with the cylinder body and is used for driving the filter cylinder to rotate along the circumferential direction. The device can prevent expanded peanut membranes from entering filtrate, improves the filtering effect, increases the yield, prepares peanut membrane extracts containing proanthocyanidins with the concentration of more than 50%, and plays roles in regulating blood sugar and body fat, resisting aging and the like.

The invention relates to the field of functional additives for daily chemicals, and particularly discloses hydrolyzed procyanidine freeze-dried powder and a preparation method thereof. The hydrolyzed procyanidine freeze-dried powder is prepared by freeze-drying and comprises the following raw materials in parts by weight: 0.1-0.2 part of hydrolyzed procyanidine, 25-35 parts of carnosine, 10-20 parts of a stabilizer, 0.1-0.3 part of acetyl hexapeptide-8 and 45-55 parts of water. The stabilizer is selected from at least one of mannan, trehalose, mannitol, cane sugar, betaine, whey protein, PVP (Polyvinyl Pyrrolidone), PEG (Polyethylene Glycol), glycine, histidine, leucine, sodium alginate, beta-cyclodextrin, maltodextrin and chitosan. The hydrolyzed procyanidine freeze-dried powder has good storage stability, can keep activity for a long time, is still stable after being dissolved in water for a long time, and has less activity loss.

The invention discloses a procyanidine trimer compound, which has a chemical structure as shown in the specification. The hypoglycemic potential of the compound is evaluated through an in-vitro enzyme inhibition experiment, and the result shows that the compound has a remarkable inhibition effect on alpha-amylase, has good water solubility, is derived from natural plant resources, is clear in structure and good in safety, and has a huge application prospect in development of novel natural-source hypoglycemic drugs.

The invention belongs to the field of starch modification processing, and provides a method for preparing starch-polyphenol RS5 type resistant starch. According to the method, through physical-polyphenol composite synergistic modification, a procyanidine polyphenol structure and sweet potato starch are utilized to form a hydrogen bond / hydrophobic effect, starch molecular chains are induced to be directionally rearranged, a resistant crystal structure is stabilized, and the preferable process conditions are as follows: the temperature is 85-90 DEG C, the time is 18-20 minutes, the addition amount of procyanidine is 3-7% of a starch dry basis, and the final resistant starch content reaches 36.39-46.86%. Compared with a traditional method, the raw material utilization rate and the product yield are remarkably improved. The whole process has the advantages of no chemical reagent, simple operation, low equipment cost, and stable resistant starch content of the product.

This invention relates to a method for preparing ginkgo leaf extract, the ginkgo leaf extract obtained by the method, and pharmaceutical or food supplements containing the extract.

The present invention relates to a functional composition and uses thereof, and in particular towards a composition that maintains or improves mental clarity. The composition includes a combination of at least two of: a pine bark extract containing proanthocyanidin(s); a berryfruit extract containing anthocyanin(s); and a source of L-theanine. The invention also relates to methods of use and treatment of said composition.

This invention relates to the field of feed additive technology, specifically to a Bacillus subtilis composition for improving animal intestinal health and its preparation method. It comprises the following raw materials: Bacillus subtilis engineered bacterial powder, cinnamaldehyde microcapsules, proanthocyanidins B2, selenium-enriched yeast culture, glycoterpenes, trehalose, and a carrier. The core of this invention lies in using Bacillus subtilis EhrBS-9 (CGMCC No. 24947) as the strain, constructing a dual-function engineered bacterium with tolerance and transformation through gradient cinnamaldehyde domestication and cad gene integration. This, combined with the intestinal-targeted delivery of cinnamaldehyde microcapsules, barrier strengthening of proanthocyanidins B2, and the construction of a multidimensional anti-stress network of selenium-enriched yeast, glycoterpenes, and trehalose, forms a synergistic mechanism of gut microbiota regulation, immune enhancement, and stress buffering. This addresses the industry pain point of insufficient synergistic effects of existing feed additives in terms of high-efficiency antibacterial activity, safe immune regulation, root-cause anti-stress, and ecological safety.

The invention belongs to the technical field of food safety, and relates to application of peanut red skin proanthocyanidin nano-liposome in inhibition of salmonella typhimurium, and the peanut red skin proanthocyanidin nano-liposome causes cell death by causing permeability change of cell membranes and cell walls of salmonella typhimurium. According to the present invention, the inherent limitation of the natural antibacterial substance PSPc is overcome through the efficient delivery system of the nano-liposome, such that the salmonella typhimurium inhibition activity of the nano-liposome can be completely performed and durably maintained, the method is efficient and safe, the application potential in the food preservation aspect is provided, and the value-added utilization of the peanut resource is improved.

The invention discloses procyanidine B2G2 from purple sweet potato Ningzi No.4 and application thereof, and belongs to the technical field of biological medicine, the molecular formula of the procyanidine B2G2 is C44H34O20, and the molecular weight of the procyanidine B2G2 is 882.736 Da. The procyanidine B2G2 remarkably relieves acute lung injury ALI by inhibiting inflammatory response and ferroptosis induced by klebsiella pneumoniae KP; experiments show that B2G2 can reduce the lung tissue injury score, the lung wet / dry ratio, the expression of inflammatory factors TNF-alpha, IL-6 and IL-1beta and the bacterial load, and up-regulate the expression of ferroptosis related proteins GPX4, SLC7A11 and HO-1; in addition, B2G2 is non-toxic to liver and kidney functions and has good safety, and the application provides a new drug candidate scheme for preparation of drugs for treating acute lung injury.

The invention relates to the technical field of procyanidine extraction, and provides a green extraction method of procyanidine in grape pips, which comprises the following steps: carrying out physical wall breaking treatment on dry grape pips; mixing the pretreated grape seeds with the eutectic solvent precursor liquid, and carrying out solid-liquid separation to obtain a clear extracting solution; adding an azobenzene chitosan solution into the clarified extracting solution, mixing under a dark condition, irradiating by adopting light with a first specific wavelength to form a compound precipitate, and separating to obtain a precipitate; dispersing the compound precipitate in an aqueous medium, irradiating with light with a second specific wavelength to release the proanthocyanidins from the compound, separating to obtain a supernatant containing the proanthocyanidins, and recycling regenerated azobenzene chitosan; and concentrating and drying the supernate to obtain a procyanidine product. According to the technical scheme, the extraction efficiency and purity of the procyanidine are improved, and efficient selective precipitation separation and mild release are realized by utilizing the photoresponsive carrier.

The invention belongs to the field of daily chemicals, and particularly relates to a preparation method and application of a radix gentianae extract, according to the preparation method, the radix gentianae extract is extracted through tissue breaking in cooperation with a microwave extraction process, the extraction rate is high, and the purity is high. The radix gentianae extract prepared by the invention is combined with vitamin C, vitamin E, resveratrol and procyanidine according to the mass ratio of (0.01-6): (0.01-5): (0.01-1.5): (0.05-5): (0.01-0.2), and has a synergistic interaction mechanism of oxidation resistance, inflammation resistance and cell repair, so that the radix gentianae extract can be applied to oral care and other daily chemical products. The composition obtained by combining the radix gentianae extract / gentiopicroside, the vitamin C, the vitamin E, the resveratrol and the procyanidine has outstanding effects in the aspects of oral cavity restoration, oral mucosal barrier function regulation, gingival protection and the like.

The invention relates to the field of separation and extraction of active ingredients of natural products, in particular to a comprehensive separation process of various active ingredients in peanut coats. Through reasonable matching of all the steps, various peanut coat active ingredients including peanut coat total sterol, peanut coat saturated fatty acid, peanut coat unsaturated fatty acid, peanut coat total flavonoid compounds and peanut coat procyanidine can be obtained with high yield through a set of process, the yield is high, and the method is a method capable of effectively and comprehensively utilizing peanut coat resources and improving the production efficiency. And the method is suitable for industrial technological processes.

The application belongs to the technical field of anti-inflammatory and specifically relates to a pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system, a preparation method and application thereof. The pH-sensitive self-assembled PACs@ZIF-8 nano temperature-controlled slow-release system provided by the application comprises a hydrogel matrix and PACs@ZIF-8 nanoparticles wrapped in the hydrogel matrix; the PACs@ZIF-8 nanoparticles comprise ZIF-8 nanoparticles and procyanidins loaded on the ZIF-8 nanoparticles. The application not only can exert the response release of ZIF-8 in an acidic microenvironment, improve the stability of PACs and solve the problem of poor bioavailability, but also realizes local forming and long-acting slow release by using the hydrogel matrix, thereby synergistically enhancing the treatment advantages of PACs. The system provided by the application plays a role in anti-inflammatory and antioxidant and provides a new treatment method for the treatment of periodontitis.

The application belongs to the technical field of skin care products, and discloses a kind of repair anti-aging skin care composition and preparation method thereof;The composition comprises ceramide complex, polyphenol supramolecular complex, polyol humectant, emollient oil, oil-soluble emulsifier, water-soluble thickener, ectoine, preservative, chelating agent and pH regulator;The ceramide complex is compounded by ceramide NP, ceramide AP, ceramide EOP, phytosphingosine and cholesterols according to molar ratio, and the polyphenol supramolecular complex is ternary inclusion nanocomposite formed by oligomeric procyanidins, hydroxypropyl-beta-cyclodextrin and ceramide NP through supramolecular self-assembly;The composition has barrier repair and anti-aging dual effects, and solves the problem that ceramide repair components and polyphenol anti-aging components are difficult to be stable in the same formula system.

The invention discloses functional nano zinc oxide as well as a preparation method and application thereof, and belongs to the technical field of food packaging materials and functional nano composite materials. The preparation method comprises the following steps: dissolving dialdehyde cellulose in a hydrochloric acid solution, mixing with a procyanidine solution dissolved in DMSO (Dimethylsulfoxide), heating to react, dialyzing and drying to obtain a cellulose-polyphenol graft; and uniformly mixing the cellulose-polyphenol graft aqueous solution with a zinc nitrate aqueous solution, adjusting the pH value, carrying out a hydrothermal reaction, carrying out centrifugal separation, washing the precipitate, and drying to obtain the functional zinc oxide nanoparticles. Through an aldehyde cellulose-polyphenol grafting strategy, the particle size controllability and dispersity of ZnO nano particles are improved, the ZnO nano particles are endowed with higher specific surface area and functionality, and after the ZnO nano particles are loaded to a chitosan film, the oxidation resistance, antibacterial property and mechanical strength of the film are remarkably enhanced.

The invention provides an anti-alcohol functional water based on liver enzyme activation, and relates to the technical field of functional water. The hangover alleviating functional water based on liver enzyme activation is prepared from radix puerariae isoflavone aglycone, globe artichoke water-soluble polysaccharide, emblic leafflower fruit procyanidine oligomer, an electrolyte combination, a pH buffer system, hovenia dulcis thunb, fructus gardeniae, beta-nicotinamide mononucleotide, hydrogen-rich water, vitamin C, vitamin E and curcumin, and the electrolyte combination is prepared from sodium chloride, potassium chloride and sodium bicarbonate. Alcohol dehydrogenase and acetaldehyde dehydrogenase in the liver can be activated through the radix puerariae isoflavone aglycone, the globe artichoke water-soluble polysaccharide, the emblic leafflower fruit proanthocyanidin oligomer and the like, so that decomposition and metabolism of alcohol are accelerated, the retention time of the alcohol in the body can be remarkably shortened by activating the enzymes and dispelling drunkenness, and the symptoms of drunkenness and hangover are reduced.

A dietary supplement, as a single-dose oral suspension, comprising lactoferrin, xyloglucan, proanthocyanidins and simethicone as active ingredients, useful in the joint prevention of gastrointestinal and urinary tract infections. The dietary supplement ingredients are stored in a container with a storage closure and in a vial, wherein the storage closure contains a composition in solid powdered form comprising lactoferrin, xyloglucan and cranberry extract, while the vial contains a flavoured simethicone suspension. The composition in solid powdered form of lactoferrin, xyloglucan and cranberry extract in the closure storage cap and the flavored simethicone suspension contained in the vial are mixed in a direct process, just before use, forming a flavored single-dose oral suspension that can be used directly from its container.

To provide a simple procyanidin analysis method that can be performed at a low cost, and in the form of preliminary analysis for selecting a sample for precision analysis in HPLC, that is, screening.SOLUTION: Cell size liposomes 10, 10' are composed of a lipid component system in which one or more phospholipids 2, 3 and one or more sterol-based lipids 5 are used in a constant composition, and procyanidin 8, where different phase separation domain generation patterns are generated depending on the concentration of procyanidin 8, which can be used for estimating the procyanidin concentration from the phase separation domain generation pattern. The phospholipids 2, 3 are unsaturated phospholipid or saturated phospholipid.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of functional compositions, and particularly relates to a composition containing glabridin and application and a product thereof. The composition disclosed by the invention consists of glabridin and procyanidine, wherein the mass ratio of the glabridin to the procyanidine in the composition is 1: (1-100). The composition disclosed by the invention can effectively reduce the MDA level and has an anti-oxidation effect; the melanogenesis and tyrosinase activity can be effectively inhibited, and the melanin index can be reduced. The composition disclosed by the invention is relatively good in safety, can be applied to preparation of cosmetics, health-care products or foods and medicines with antioxidant or whitening effects, and has a wide industrial application prospect.

The invention relates to the technical field of microorganisms, in particular to a blood glucose regulating composition as well as a preparation method and application thereof. The raw materials of the adjusting composition comprise a procyanidine solution and a lactobacillus reuteri solution, the mass concentration w1 of the procyanidine solution and the number N2 of viable bacteria of the lactobacillus reuteri solution meet the relational expression that w1: N1 is larger than or equal to 20: 1 * 10 < 9 >, and if the unit of w1 is mg / mL, the unit of N1 is CFU / mL; proanthocyanidin is introduced on the basis that original lactobacillus reuteri can regulate blood sugar, the mass ratio of proanthocyanidin to lactobacillus reuteri is controlled, and it is found through a large number of experiments that proanthocyanidin and lactobacillus reuteri cooperate to further improve the blood sugar improving effect of lactobacillus reuteri; the procyanidine is widely derived from various plants, so that the lactobacillus reuteri matched with the intestinal probiotics can form the regulating composition comprising dietary therapy food and the intestinal probiotics, and the regulating composition is wide in source and free of side effects on organisms.

The invention discloses a method for extracting procyanidine from green kernels and black beans, and belongs to the technical field of plant active ingredient extraction. Mixing and dispersing the green kernel and black bean skin powder, the immobilized active enzyme and water to form a first mixed solution, performing ultrasonic treatment on the first mixed solution, and performing centrifugal separation to obtain a first extracting solution and filter residues; mixing and dispersing the filter residues and a mixed solvent to form a second mixed solution, performing hydrothermal treatment on the second mixed solution, and performing centrifugal separation to obtain a second extracting solution; mixing the first extracting solution and the second extracting solution, filtering to obtain filtrate, and purifying the filtrate through macroporous resin to obtain procyanidine-containing filtrate so as to finish extraction. By means of the preparation technology, safe and environment-friendly extraction of the procyanidine is achieved, and the extraction efficiency of the procyanidine is good.

The present application relates to a kind of grape seed extract preparation system, including shell and inside from top to bottom arrangement of tipping bucket assembly, transmission assembly and sorting assembly.Tipping bucket assembly uses the tipping bucket container of eccentric arrangement to cooperate elastic energy storage piece, it is realized based on the sudden jump of liquid weight threshold value and is overturned, and through the rigid collision of trigger lever and limit stopper inertia vibration is generated to shake off residual liquid film, solve the cross contamination caused by high adhesion of proanthocyanidin.Transmission assembly is stepped by driving arm impact to drive ratchet disc, and it is realized physical hard lock by unidirectional transmission structure and positioning pawl, solve the alignment deviation caused by signal drift of electric control system.Sorting assembly includes distribution disc with collection bottle installation slot and distribution pipe assembly.The present application realizes precision sorting, with zero cumulative error and nondestructive emptying etc.Advantages, suitable for the automatic preparation of natural products in high volatile solvent environment.

The invention discloses a grape wine color protection method based on alternaria MG1, and belongs to the technical field of fermented wine brewing. According to the method, alternaria MG1 is taken as a research object, a phenylpropane metabolic pathway of alternaria MG1 is activated through various stimulation methods such as ultraviolet radiation, exogenous addition of oligomeric proanthocyanidins, co-culture with other endophytic filamentous fungi and the like, and the alternaria MG1 and saccharomyces cerevisiae are subjected to mixed fermentation, so that an optimal color protection process for grape wine color is explored. The invention deeply discusses the influence of the mixed fermentation on the color and the related quality characteristics of the wine, provides a new theoretical support and a process optimization strategy for the application of the multi-strain synergistic fermentation based on the grape endophyte in wine brewing, and has important guiding significance for production practice.

The invention relates to the technical field of natural product separation engineering, discloses a method for synchronously separating and purifying multiple active components of camellia oleifera shells based on synergistic extraction-gradient desorption-targeted refining, and aims to solve the technical bottleneck that high-purity tannin, proanthocyanidin and tea saponin cannot be efficiently and synchronously obtained from the camellia oleifera shells in the prior art. The core innovation is as follows: 1) an ultrasonic-microwave synergistic extraction parameter matching system is designed, and efficient synergistic dissolution of three active components is realized through precise matching of ultrasonic power and microwave power (0.5-1.7): 1 in combination with a 65-75% ethanol aqueous solution; (2) a three-stage incremental ethanol concentration gradient elution strategy is innovatively adopted, and directed preliminary separation of component groups is realized through step-by-step elution of 20-30% ethanol, 50-60% ethanol and 80-95% ethanol according to polarity differences of the three components; and (3) establishing a targeted refining technology combination, adopting Sephadex LH-20 gel chromatography according to the molecular weight characteristics of proanthocyanidin, and adopting high-speed counter-current chromatography of an ethyl acetate-n-butyl alcohol-water system in a specific ratio according to the structural characteristics of tea saponin homologues to realize deep purification. The continuous synchronous preparation of three active components in the camellia oleifera shells is realized for the first time, the purity of tannin in the obtained product is greater than or equal to 75%, the purity of proanthocyanidin is greater than or equal to 90%, and the purity of tea saponin is greater than or equal to 92% (the proportion of oleanane saponin is greater than or equal to 85%), the utilization rate of raw materials is increased by 30% or above, and the solvent consumption is reduced by 25%. An efficient, economical and environment-friendly integrated technical scheme is provided for high-value utilization of the camellia oleifera shells, and the method has a remarkable industrial application value.