16 results about "Tetramer" patented technology

The invention is applicable to the technical field of metal organic framework materials, and provides a pillararene-based metal organic framework material and a preparation method thereof.The pillararene-based metal organic framework material takes a compound PY2-P5 as a ligand, and the material is one of PMOF1, PMOF2 and PMOF3; the PMOF1 is of a Cu4I4 cubic tetramer structure; the PMOF2 is of a Cu4I4 ladder tetramer structure, and the Cu4I4 ladder tetramer structure is a And the PMOF3 has a CuI one-dimensional chain structure. By introducing the pillararene ligand and regulating and controlling the coordination mode of the pillararene ligand and cuprous iodide, the metal organic framework material with stable structure and functional characteristics is constructed, the metal organic framework material has the dual advantages of host recognition site and fluorescence signal response, and can selectively distinguish 1-bromoalkane and 2-bromoalkane; a remarkable fluorescent blue shift signal is shown in the adsorption process, so that the visualization of molecular recognition and sensing is realized; the excellent molecular recognition capability of pillararene is maintained, the stability and reusability of the material are improved through framing, and a new way is provided for selective detection and separation of volatile organic compounds.

The present invention relates to a composition, a kit and a detection method for detecting hydrogen peroxide on the basis of self-biotinylation according to the peroxidation activity of a guanine quadruplex, and, more specifically, to a composition, a kit and a detection method for detecting hydrogen peroxide, the composition comprising: i) a guanine quadruplex-hemin complex (G-quadruplex-hemin complex); ii) biotinyl tyramide; and iii) a probe capable of binding to the guanine quadruplex.

Provided is a method for improving the stability of urate oxidase. The inventors have discovered that combining an active ingredient urate oxidase or chemically modified urate oxidase with a stabilizer xanthine through a non-covalent bond can significantly improve the in vivo and in vitro stability of urate oxidase and chemically modified urate oxidase in the form of a tetramer, thereby effectively improving the stability of urate oxidase.

The application discloses a construction method of a UPLC characteristic spectrum of a radix-lithospermi and application thereof, 1) preparation of a control medicinal material reference solution; 2) preparation of a control reference solution: a certain amount of protocatechuic acid, protocatechuic aldehyde, ferulic acid, rosmarinic acid, caffeic acid tetramer and danshensu are taken to prepare a mixed solution by adding methanol, serving as the control reference solution; 3) preparation of a test solution; 4) determination: the control medicinal material reference solution, the control reference solution and the test solution are respectively taken and injected into a liquid chromatograph to determine characteristic spectra, wherein the characteristic spectra include at least 12 characteristic peaks; 5) qualitative analysis of a sample to be determined is carried out by using the characteristic spectra obtained in the above steps. The characteristic spectrum includes 12 characteristic peaks, can effectively distinguish radix-lithospermi (Xinjiang radix-lithospermi) and its pseudo products of different origins, and embodies the integrity of quality control of radix-lithospermi.

Inventors describe herein the functional and structural characteristics of the MGL from the anaerobic alkaliphilic thermophile Thermobrachium celere (TcMGL), which was compared to that from Pseudomonas putida (PpMGL). Catalysis was limited to L-Met, L-homocysteine, and L-cysteine, with the highest catalytic efficiency (keat / KM) towards L-Met. The half-life of active TcMGL in human plasma at 37°C was 9.2 hour. Half-life increased from 11.3 hour to 66.7 hour with increasing PLP concentration from 2 to 200 µM, in much greater magnitude than in PpMGL case. TcMGL crystal structure resolution revealed that the enzyme is a tetramer of two catalytic dimers containing a mobile region with open and closed conformations resulting in differences for access to the active site. TcMGL possesses favourable characteristics which makes it a suitable candidate for treatment of cancer. The present invention relates to a polypeptide comprising an amino acid sequence as set forth by SEQ ID NO: 1 or a function-conservative variant thereof.

The disclosure herein relates, inter alia, to inventive cucurbituril compounds and glycoluril compounds having formula (II), glycoluril compounds having formula (II'), glycoluril bisethers of formula (III), glycoluril dimers of formula (IV), glycoluril tetramer compounds of formula (V), and novel methods for their preparation using sodium 4,4'-(1,4-phenylenebis(oxy))bis(butane-1-sulfonate), which result in significantly improved purity and yields of intermediates and final products.

The invention relates to the technical field of functional materials, and discloses a preparation method of an iron-based metal complex and application of the iron-based metal complex in peroxidase-like activity, the chemical formula of the iron-based metal complex is [Fe2 (H4L4) (H2O) 4]. (H2O) 2, H4L4 is a deprotonated tetramer ligand, and the iron-based metal complex is prepared by taking FeSO4. 7H2O as a metal salt to react with the tetramer ligand. The iron-based metal complex disclosed by the invention is simple and convenient in synthesis process, high in purity and stable in structure, has excellent peroxidase-like activity, keeps catalytic performance in a wide range of pH value of 3-8, achieves the best activity when the pH value is 3, breaks through the dependence of most nano-enzymes on an acidic environment, and has a wide application prospect. And a catalytic material with wider adaptability is provided for biological catalysis and in-vitro detection.

This invention relates to a highly selective ethylene tetramer Cr(III) metal catalyst system and its application method. The catalyst system comprises: a chromium compound; a ligand with the general structural formula (Ph2)P-X-P(Ph2); and an activator or co-catalyst, wherein the chromium compound is one of an organic salt, inorganic salt, coordination complex, or organometallic complex of trivalent chromium. The ethylene tetramer Cr(III) metal catalyst system and its application method provided by this invention improve upon existing PNP chromium-based catalysts, increasing the selectivity for 1-octene, reducing waxy products, and maintaining high activity.

The invention discloses a preparation method of a 2, 2, 4-trimethyl-1, 2-dihydroquinoline monomer, which comprises the following steps: dropwise adding acetone into a solution containing aniline, an acid catalyst and a polymerization inhibitor at a condensation reaction temperature, and distilling after dropwise adding to obtain the 2, 2, 4-trimethyl-1, 2-dihydroquinoline monomer; the condensation reaction temperature is 100-160 DEG C; and the distillation comprises the following steps: firstly distilling out low-boiling-point substances, then heating to 160-200 DEG C under a 1mm mercury column, and distilling out the 2, 2, 4-trimethyl-1, 2-dihydroquinoline monomer. According to the method, the polymerization inhibitor is added in the reaction process, so that the polymerization reaction of the 2, 2, 4-trimethyl-1, 2-dihydroquinoline monomer is effectively avoided, the generation of dimer, trimer and tetramer is reduced, and meanwhile, the yield of more than 80% and the purity of more than 95% can be obtained by optimizing the reaction conditions. The method does not need to use a strong corrosive acid catalyst, is simple in purification operation, and is suitable for industrial production.

The invention relates to a process for preparing a tetramer of the formula (I), or salts thereof, wherein R1is hydrogen or is a link to a solid support and PROT is an ester protecting group, to a crystalline polymorph of the tetramer of formula I and its preparation and to its use as intermediate in the preparation of a GLP-1R / GIPR agonist.

Disclosure herein relates to, inter alia, inventive cucurbituril compounds and novel methods of preparing thereof using a glycoluril compound having the formula (II), a glycoluril compound having the formula (II′), a glycoluril bis-ether of formula (III), a glycoluril dimer of formula (IV), a glycoluril tetramer compound of formula (V), and Sodium 4,4′-(1,4-phenylenebis(oxy))bis(butane-1-sulfonate, which result in significantly improved purity and yield of the intermediates and of the final products.

The invention discloses a high performance liquid detection method for glycoluril tetramer. The invention provides a high performance liquid chromatography detection method for glycoluril tetramer, which comprises the following steps: carrying out gradient elution on a glycoluril tetramer sample solution in a chromatographic column by adopting high performance liquid chromatography; the filler of the chromatographic column is octadecyl silane bonded silica gel; the mobile phase A is prepared from the following components in percentage by volume: 5 percent to 50 percent of hexafluoroisopropanol and 50 percent to 95 percent of water; the mobile phase B is prepared from the following components in percentage by volume: 20 percent to 100 percent of hexafluoroisopropanol and 0 percent to 80 percent of water. The detection method can sensitively, accurately and quickly detect the related substances and purity of the glycoluril tetramer with good reproducibility, and has outstanding technical advantages.

The present invention relates to an antistatic ABS sheet and a preparation method thereof, belonging to the technical field of polymer composite materials. The ABS sheet comprises the following raw materials, measured by weight: 100 parts of ABS resin, 5.8-7.2 parts of a modified antistatic agent, 0.25-0.3 parts of an antioxidant, and 0.4-0.5 parts of a lubricant. The modified antistatic agent is formed by ring-opening and ring-closing reactions of triethanolamine and epichlorohydrin to form an epoxy matrix, which is then self-polymerized by N-phenyl-p-phenylenediamine to form an amino-terminated aniline tetramer. The epoxy matrix and the aniline tetramer are then ring-opened to form a modified intermediate, which is finally quaternized with 2-iodoethanol. The modified intermediate forms an "umbrella-shaped" distribution in the ABS matrix, achieving a deep-surface synergistic electrostatic dissipation network and enhancing surface properties.

The invention relates to a tetramer of the formula (I), or salts thereof, wherein R1 is hydrogen or is a link to a solid support and PROT is an ester protecting group or hydrogen, to a process for the preparation of a tetramer of the formula I and to its use as intermediate in the preparation of a GLP-1R / GIPR agonist.

Disclosed are deuterated glycoluril tetramer compounds having aryl groups incorporated at both ends represented by formula (1), pharmaceutical compositions containing the compounds. The deuterated compounds are useful for antagonizing clinically used non-depolarizing muscle relaxants, and have significantly superior antagonistic activity against rocuronium and vecuronium to sugammadex at the same dose, and significantly superior antagonistic activity against cisatracurium and rocuronium to a non-deuterated control molecule.

An embodiment of the present specification provides an iron isomaltose anhydride complex comprising iron oxyhydroxide and isomaltose anhydride stably associated with the iron oxyhydroxide, the content of pentamer saccharides in the isomaltose anhydride being about 16% to about 25% based on the total weight of the isomaltose anhydride, the hexamer saccharide content is from about 14% to about 23%, and the tetramer saccharide content is from about 9% to about 17%.