9 results about "Tetramer" patented technology

The invention is applicable to the technical field of metal organic framework materials, and provides a pillararene-based metal organic framework material and a preparation method thereof.The pillararene-based metal organic framework material takes a compound PY2-P5 as a ligand, and the material is one of PMOF1, PMOF2 and PMOF3; the PMOF1 is of a Cu4I4 cubic tetramer structure; the PMOF2 is of a Cu4I4 ladder tetramer structure, and the Cu4I4 ladder tetramer structure is a And the PMOF3 has a CuI one-dimensional chain structure. By introducing the pillararene ligand and regulating and controlling the coordination mode of the pillararene ligand and cuprous iodide, the metal organic framework material with stable structure and functional characteristics is constructed, the metal organic framework material has the dual advantages of host recognition site and fluorescence signal response, and can selectively distinguish 1-bromoalkane and 2-bromoalkane; a remarkable fluorescent blue shift signal is shown in the adsorption process, so that the visualization of molecular recognition and sensing is realized; the excellent molecular recognition capability of pillararene is maintained, the stability and reusability of the material are improved through framing, and a new way is provided for selective detection and separation of volatile organic compounds.

The present invention relates to a composition, a kit and a detection method for detecting hydrogen peroxide on the basis of self-biotinylation according to the peroxidation activity of a guanine quadruplex, and, more specifically, to a composition, a kit and a detection method for detecting hydrogen peroxide, the composition comprising: i) a guanine quadruplex-hemin complex (G-quadruplex-hemin complex); ii) biotinyl tyramide; and iii) a probe capable of binding to the guanine quadruplex.

Provided is a method for improving the stability of urate oxidase. The inventors have discovered that combining an active ingredient urate oxidase or chemically modified urate oxidase with a stabilizer xanthine through a non-covalent bond can significantly improve the in vivo and in vitro stability of urate oxidase and chemically modified urate oxidase in the form of a tetramer, thereby effectively improving the stability of urate oxidase.

The invention relates to the technical field of functional materials, and discloses a preparation method of an iron-based metal complex and application of the iron-based metal complex in peroxidase-like activity, the chemical formula of the iron-based metal complex is [Fe2 (H4L4) (H2O) 4]. (H2O) 2, H4L4 is a deprotonated tetramer ligand, and the iron-based metal complex is prepared by taking FeSO4. 7H2O as a metal salt to react with the tetramer ligand. The iron-based metal complex disclosed by the invention is simple and convenient in synthesis process, high in purity and stable in structure, has excellent peroxidase-like activity, keeps catalytic performance in a wide range of pH value of 3-8, achieves the best activity when the pH value is 3, breaks through the dependence of most nano-enzymes on an acidic environment, and has a wide application prospect. And a catalytic material with wider adaptability is provided for biological catalysis and in-vitro detection.

This invention relates to a highly selective ethylene tetramer Cr(III) metal catalyst system and its application method. The catalyst system comprises: a chromium compound; a ligand with the general structural formula (Ph2)P-X-P(Ph2); and an activator or co-catalyst, wherein the chromium compound is one of an organic salt, inorganic salt, coordination complex, or organometallic complex of trivalent chromium. The ethylene tetramer Cr(III) metal catalyst system and its application method provided by this invention improve upon existing PNP chromium-based catalysts, increasing the selectivity for 1-octene, reducing waxy products, and maintaining high activity.

The invention relates to a process for preparing a tetramer of the formula (I), or salts thereof, wherein R1is hydrogen or is a link to a solid support and PROT is an ester protecting group, to a crystalline polymorph of the tetramer of formula I and its preparation and to its use as intermediate in the preparation of a GLP-1R / GIPR agonist.

Disclosure herein relates to, inter alia, inventive cucurbituril compounds and novel methods of preparing thereof using a glycoluril compound having the formula (II), a glycoluril compound having the formula (II′), a glycoluril bis-ether of formula (III), a glycoluril dimer of formula (IV), a glycoluril tetramer compound of formula (V), and Sodium 4,4′-(1,4-phenylenebis(oxy))bis(butane-1-sulfonate, which result in significantly improved purity and yield of the intermediates and of the final products.

The invention discloses a high performance liquid detection method for glycoluril tetramer. The invention provides a high performance liquid chromatography detection method for glycoluril tetramer, which comprises the following steps: carrying out gradient elution on a glycoluril tetramer sample solution in a chromatographic column by adopting high performance liquid chromatography; the filler of the chromatographic column is octadecyl silane bonded silica gel; the mobile phase A is prepared from the following components in percentage by volume: 5 percent to 50 percent of hexafluoroisopropanol and 50 percent to 95 percent of water; the mobile phase B is prepared from the following components in percentage by volume: 20 percent to 100 percent of hexafluoroisopropanol and 0 percent to 80 percent of water. The detection method can sensitively, accurately and quickly detect the related substances and purity of the glycoluril tetramer with good reproducibility, and has outstanding technical advantages.

The invention relates to a tetramer of the formula (I), or salts thereof, wherein R1 is hydrogen or is a link to a solid support and PROT is an ester protecting group or hydrogen, to a process for the preparation of a tetramer of the formula I and to its use as intermediate in the preparation of a GLP-1R / GIPR agonist.