10646 results about "Immunity" patented technology

The invention relates to a composition for killing virus and preventing influenza and a cold prevention plaster prepared by the composition. An aromatic traditional Chinese medicine volatile extract product and fragrant plant essential oil are used as effective components of the plaster; high-molecular colloid, which can be compatible with the effective components and has a stereo network structure, and an excipient are used to wrap the effective components to prepare a microcapsule; the microcapsule is used to coat on a matrix to prepare a tablet; a double faced adhesive tape is used to plaster the tablet at the position close to mouth and nose (such as collar, shoulder, chest and the like) so as to allow the effective components to slowly release at uniform speed. The plaster can be used to kill pathogen and virus in the air and enhance the immunity of upper respiratory tract, has an obvious effect of preventing influenza, and has a certain prevention effect for common cold, hand-foot-mouth disease, varicella, measles, epidemic encephalitis B, epidemic mumps, chronic respiratory tract diseases and the like. The plaster is convenient to use, has fragrant smell and is safe without side-effect.

The invention provides a micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry, and a preparation method thereof. The invention is characterized in that traditional Chinese medicines are combined with the modern microbial fermentation technology to develop a novel feed additive, i.e. traditional Chinese medicines such as astragalus root, eucommia, licorice, bupleurum and the like are directly fermented by two or more of sporeformer, microzyme, lactobacillus to obtain the product. The micro-ecological traditional Chinese medicine preparation provided by the invention has the efficacies of enhancing the body immunity of livestock and poultry, maintaining the gastrointestinal microbial flora balance of animals, preventing and treating alimentary and respiratory diseases of livestock and poultry, promoting healthy and quick growth of the animals, and improving the qualities of meat, egg and milk; the micro-ecological traditional Chinese medicine preparation has no toxic side effect, no pollution and no residue, can not generate drug resistance, and is suitable for use at each growth stage of the livestock and poultry; and the effect is stable and reliable and can meet the requirements of people for safety in production of livestock and poultry products. The micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry can be increased in dose to be used as a veterinary medicine for application.

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence of high serum antibody titers and also longer seroconversion and seroprotection. The improvement in immune responses is seen for both influenza A virus and influenza B virus strains, but it is particularly marked for influenza B virus. Moreover, while the existing vaccine provides poor immunity in children after a single dose, the adjuvanted vaccine provides high seroprotection rates against the influenza A virus H3N2 subtype even after a single dose. Furthermore, the adjuvanted vaccine offers significantly better seroprotection against mismatched strains of influenza A virus.

Fusion proteins and DNA conjugates are disclosed which contain a TLR / CD40 / agonist and optional antigen combination. The use of these protein and DNA conjugates as immune adjuvants and as vaccines for treatment of various chronic diseases such as HIV infection is also provided.

The present invention concerns methods and compositions for subunit-based vaccines for inducing immunity against poxvirus infections, such as smallpox. Preferred embodiments concern immunoconjugates comprising one or more subunit antigenic peptides attached to an antibody or fragment thereof that targets antigen-producing cells (APCs). More preferably, the antibody binds to HLA-DR and the antigenic peptide is from an immunomodulating factor, such as the viral IL-18 binding protein (vIL18BP). However, mixtures of antigenic peptides from different viral proteins may also be used. The vaccine is capable of inducing immunity against poxvirus without risk of disseminated infection in immunocompromised hosts or transmission to susceptible contacts.

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

The invention discloses a functional health-preserving treasure composition. By adopting the functional health-preserving treasure composition, the problems of poor health care effects and relatively large side effects existing in the prior art can be solved. The functional health-preserving treasure composition is characterized by comprising the following components in percentage by weight: 25-35% of foods and medicines for enriching qi and blood, 15-25% of foods and medicines for tonifying yang and astringing, 15-25% of foods and medicines for activating blood circulation and dissipating blood stasis, 5-15% of foods and medicines for nourishing the heart and tranquilizing mind, 5-15% of foods and medicines for tonifying yin and invigorating the stomach and 1-5% of foods and medicines for warming interior and removing toxicity. By adopting the functional health-preserving treasure composition disclosed by the invention, the immunity of a human body can be significantly enhanced, and the disease resistance can be strengthened so as to ensure that the physique of the human body can be significantly superior to that of the general population, and cold catching times and frequencies can be greatly reduced.

The invention relates to a composite fresh flower, fruit, vegetable and herb enzyme, and a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the composite fresh flower, fruit, vegetable and herb enzyme, dozens of kinds of common fruits, vegetables, grains, fresh flowers and edible medicine herbaceous plants are adopted as raw materials to comprehensively supplement nutrients, microbes, trace elements and dietary fiber required by bodies; through addition of the fresh flowers, the fresh flower, fruit, vegetable and herb enzyme provided by the invention has the fragrance of the flowers and contains plant anthocyanidin; anthocyanidin substances are plant antioxidants which are high in property; in an enzyme high-acidity solution, anthocyanidin can be well extracted and released, so that the oxidation resistance of the enzyme is improved; most of the edible medicine herbaceous plants have the efficacies of improving immunity and reducing blood fat, blood sugar and blood pressure; through addition of probiotics, polysaccharides and functional ingredients of the herbaceous plants can be completely extracted out, so that the health efficacy of the enzyme is improved. The preparation method for the enzyme is simple, and the problems of pollution and odd flavor generation in the layer-by-layer fermentation process can be effectively solved.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

The present invention discloses and claims virus like particles (VLPs) that express and / or contains RSV proteins. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing immunity to infections, including RSV.

The invention relates to a micro-ecological preparation and the application thereof, in particular to a micro-ecological preparation containing a variety of probiotics and the application thereof. The micro-ecological preparation contains any three or four of the components including CGMCC No. 2383 bacillus licheniformis powder, bacillus subtilis powder, CGMCC No. 2386 enterococcus faecalis powder, lactobacillus acidophilus powder, and CGMCC No. 2388 saccharomyces cerevisiae. The micro-ecological preparation has content of live bacteria, has the adversity resistance such as gastric acid resistance, bile salt resistance, high-temperature resistance, common antibiotic resistance, and the like and the probiotic functions of producing acid and enzyme and resisting pathogenic bacteria. The variety and the proportion of the probiotics and carrier can be determined according to different kinds of animals and different animal growth phase. The micro-ecological preparation can improve the feed utilization efficiency, increase the yield of meat, eggs and milk, promote the growth of the animal, improve the immunity and the disease resistance of the animal, replace the antibiotic and improve the quality of the animal product.

The present invention discloses and claims virus like particles (VLPs) that express and / or contains seasonal influenza virus proteins, avian influenza virus proteins and / or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

The invention relates to a prebiotic peptide biological feed additive and a preparation method and application thereof. The prebiotic peptide biological feed additive is prepared by mixing and fermentation of seed solution with one or more of bacillus, yeast and lactic acid bacteria in plant protease hydrolysate. After animal and plant protein is subjected to enzymolysis at constant or changeable temperature, the seed solution with one or more of bacillus, yeast and lactic acid bacteria is added for fermentation according to a certain proportion, and the fermented solution is concentrated and dried to obtain a powdery product. The problems of high content of bitter peptides and poor palatability of enzymolysis processes using acid, alkali and protease can be solved. The immune function of animals can be stimulated by active peptides in the prebiotic peptide biological feed additive, the immunity of the animals can be improved, the intestinal environment of the animals can be improved by probiotics, the resistance of the animals to a variety of diseases can be enhanced, the feed conversion rate can be increased, and the breeding cost can be reduced.

The invention relates to a blueberry health care beverage and a preparation method thereof. The beverage is prepared from blueberry and Chinese medicine components and contains pure biological active bacteria, the beverage is prepared from the following components in weight proportion: 20-80 parts of blueberry, 5-20 parts of semen cassiae, 2-10 parts of medlar, 2-10 parts of Chinese date, 1-8 parts of stevioside, 1-10 parts of composite mother liquor, 0.5-3 parts of crystal sugar and 0.5-5 parts of honey. In the invention, the blueberry and the traditional Chinese components are utilized to culture a bacterium solution, and fermentation is carried out multiple times to obtain the beverage, and the obtained beverage has the health care effects of delaying senility, inhibiting and resisting to cancer, improving the immunity of human bodies, protecting eyesight, reinforcing the memory, and the like.

The present invention is based on the discovery of novel species of the genus Helicobacter that are associated with gastro-esophageal ulceration in pigs. In particular, a novel species, H. cerdo, has been used as a source of antigenic material for the development of vaccine for the treatment of the gastro-esophageal disorders. Most advantageously, the novel Helicobacter and the porcine circoviruses associated with PMWS in pigs are useful for providing combination vaccines whereby immunogens derived from both types of pathogens may be codelivered to the target animal to stimulate the generation of protective antibodies and immunity. The invention, therefore, provides vaccines that are useful for the tratment of gastro-esophageal ulceration and PMWS in porcines. The present invention includes, therefore, multivalent immunogenic compositions and vaccines, multivaccine kits, and combined immunization or vaccination methods which make it possible to use such combined immunization or vaccination programmes.

The invention relates to a core premix for organic beef cattle, which comprises the following components in percentage by weight: 10-40% of compound galenical preparation, 10-40% of compound enzyme preparation, 10-30% of compound micro-ecological preparation, 20-40% of natural mineral substances, 15-30% of natural vitamins and 5-30% of other preparations. The product can be mixed with organic crop straws, corn, cakes, wheat bran, grass powder, iodized salt, bone powder, calcium powder and the like in certain proportions to be used as a diet for the beef cattle; and by feeding the beef cattle with the diet all year round, not only the immunity of the organic beef cattle can be improved in the feeding process, but also the quality and taste of the beef are improved. Because the product uses the galenical preparation of a plurality of natural traditional Chinese medicines such as cordate houttuynia, honeysuckle flower, radix astragali, forsythia, tuckahoe, fleece-flower root, atractylodes rhizome, white atractylodes rhizome, hawthorn, liquorice and the like as additives to replace the western medicines and antibiotics, uses the compound enzyme preparation to improve the feed utilization ratio and uses the compound micro-ecological preparation to improve the intestinal tract environment of the beef cattle, thus ensuring the food safety of the organic beef.

The invention discloses a method and an automatic instrument device for enriching and extracting target cells and separating single cells by using a positive magnetic bead method and performing immunity and molecular biology identification and analysis on single cells. By the method and the instrument device, the on / off of a capture magnet and a release magnet is controlled by various methods to complete target cell searching, capturing, cleaning and releasing operation once or for multiple times, so that the target cell detection sensitivity and stability are improved. When the capture magnet searches and captures the target cells, the search line is circular, square, comb-shaped, S-shaped or U-shaped. In addition, the captured substances are filtered, most free micro magnetic beads are removed, the purity of the product is further improved and the product can be used as a good experimental material. By combining a special filter and the adsorption of the capture magnet, more than 95 percent of free micro magnetic beads can be effectively removed. Meanwhile, the types of the single cells are identified and biological characteristics of the single cells are analyzed by an immunofluorescence staining method and a method in molecular biology, and effective biological indexes are provided for clinical diagnosis and treatment of cancers.

The invention discloses a natural Chinese herbal medicine animal feed additive which comprises the components in parts by weight: 5-40 parts of medicinal plant extract group I, 5-40 parts of medicinal plant extract group II, 1-10 parts of medicinal plant group, and 10-80 parts of natural mineral carriers. The natural Chinese herbal medicine animal feed additive disclosed by the invention can improve the immunity of livestock, prevent diseases, improve the survival rate, accelerate digestive absorption, improve the daily gain and the feed utilization ratio, lower the production cost and improve the meat quality. All raw materials are from natural products which are safe and non-toxic, rich in material and low in cost, so that the additive is convenient to popularize and apply.

The invention relates to the technical field of porcine pseudorabies viruses (PRVs) and in particular relates to a porcine PRV variant PRV-ZJ01 with collection number of CGMCCNo.8170 and an application of the porcine PRV variant PRV-ZJ01 in preparation of vaccines. The porcine PRV variant PRV-ZJ01 has the beneficial effects that a water-soluble inactivated vaccine is prepared by adopting a PRV-ZJ01 variant virus solution and is subjected to a swine immune protection test with live vaccines of Bartha-K61, Bucharest and HB-98 strains and the results show that the inactivated vaccine of the ZJ01 strain has relatively high safety and has the immune protection efficiency obviously higher than that of immunity groups of the live vaccines of the Bartha-K61, Bucharest and HB-98 strains, and the live vaccines of the Bartha-K61, Bucharest and HB-98 strains can not provide full protection for the ZJ01 very virulent strain; the inactivated vaccine of ZJ01 has relatively good immune protection effects on the PRV variant and the traditional strains; infected with 10<6.0>TCID50 (Tissue culture infectious dose 50) / ml nasal drops of the PRV-ZJ01 variant, all the 85-day-old non-immune swine can become ill and die; results prove that the virulence of the virus strain is obviously enhanced, the antigenicity is varied and the virus strain has relatively good immunogenicity after being inactivated and can be used for research and development of the vaccine of the virus strain and the diagnostic methods.

The present invention provides a method of identifying agents that enhance innate immunity in a subject. The invention further provides a method of selectively supressing sepsis by suppressing expression of a proinflammatory gene while maintaining expression of an anti-inflammatory gene. Also provided are methods of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described, methods of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response, and compounds and agents identified by the methods of the invention.

The invention relates to a CD47 and PD-L1 targeting bifunctional fusion protein, belongs to the field of biomedicine, and solves the problems that anti-PD-1 / PD-L1 treatment is poor in a low-immunogenicity tumor treatment effect and anti-CD47 treatment is poor in a targeting ability. The fusion protein is composed of a CD47 binding part and a PD-L1 binding part which are linked by a disulfide bond, can block the binding of CD47 and SIRPalpha, can block the binding of PD-L1 and PD-1, can achieve the effects of activating macrophages to phagocytize tumor cells and promoting antigen presentation in natural immunity, can achieve an effect of promoting the activation of tumor specific T cells in acquired immunity, and has lower blood toxicity; and as compared with the single use of anti-PD-L1 or anti-CD47 for treatment, the fusion protein has better antitumor curative effects and blood safety.

The invention relates to a Chinese herbal medicine feed supplement for laying hens in egg laying period. The mass ratio of components of the Chinese herbal medicine feed supplement is hawthorn: medicated leaven: tangerine peel: lycium chinense: milkvetch: ligustrum lucidum ait: motherwort: common selfheal fruit-spike: shorthorned epimedium herb: forsythia: atractylodes: pilose asiabell root: herba houttuyniae: chilli powder: fortune paulownia flower: pine needle powder: dandelion: liquorice root = (0.1-0.2):(0.2-0.3):(0.1-0.3):(0.2-0.6):(0.2-0.6):(1.0-3.0):(1.0-3.0):(2.0-3.0):(1.0-2.0):(0.2-0.6):(0.2-0.6):(0.1-0.5):(0.1-0.5):(0.2-0.5):(5.0-25.0):(5.0-55.0):(5.0-15.0):(1.0-8.0). On the basis of the ratio, the components are dried and smashed to be 80 meshes, the components are mixed uniformly and added into daily ration of the laying hens in the egg laying period with 1% of additive amount, and by means of continuous usage, the Chinese herbal medicine feed supplement has effects that the egg weight is increased, the egg color and the egg quality are improved, simultaneously the organism immunity is improved, the morbidity is reduced, and the like. The Chinese herbal medicine feed supplement has an extremely broad application prospect.

The invention discloses a method an a system for intelligently identifying and reading an immunity-chromatography test strip and application thereof. The method comprises the following steps that: the immunity-chromatography test strip with a bar code is arranged in a test strip test jack; light emitted by a light source in a bar code identification circuit is irradiated on the bar code of the immunity-chromatography test strip with the bar code by a lens; the emitted light is converted into an electric signal by a photoelectric converter; the signal is transmitted to a CPU by an amplification and rectification circuit; and the CUP fetches an analysis programme corresponding the type of the immunity-chromatography test strip with the bar code according to the received electric signal from the bar code identification circuit. The system obtained according to the method has high intelligent degree and simple operation. The operator only needs to insert the immunity-chromatography test strip with the bar code in a designated position of the device and then makes a loading end of the immunity-chromatography test strip in contact with a sample so as to know the result of the test item by a display screen.

The invention relates to an SARS-CoV-2 (severe acute respiratory syndrome-corona virus disease-2) inhibitor and application thereof and in particularly relates to a neutralizing antibody for SARS-CoV-2 and application of the neutralizing antibody. According to the antibody, a phage display technology is adopted to construct a high-capacity human immunity phage antibody library, and an SARS-CoV-2 protein is adopted a target, human antibody single-chain antibody fragments are screened, and an antibody with a good neutralizing function on SARS-CoV-2 viruses is obtained. The antibody provided by the invention can be used for treating diseases caused by infection of novel corona viruses, and has significant clinical application value.

The invention relates to natural attractants, belonging to the field of feed additives. One natural attractant is mainly composed of a dried tangerine peel crushed substance, a hawthorn crushed substance, a cinnamon crushed substance, a mugwort leaf crushed substance, and composite microbial powder. The other natural attractant is mainly composed of a dried tangerine peel extractive, a hawthorn extractive, a cinnamon extractive, a mugwort leaf extractive, and composite microbial powder. The attractants provided by the invention has the advantages of promoting the ingestion of livestock, poultry and aquatic animals, increasing the ingestion speed and feed intake of the livestock, poultry and aquatic animals, avoiding the indigestion caused by overfeeding, increasing the feed intake and digestibility of the animals to the feeds hard to digest, expanding the application range and usage amount of unconventional feed materials, enhancing the immunity and anti-stress capability of the animals, resisting diseases, promoting growth, decreasing the production cost of the animal feeds and increasing the production benefits; the attractants contain no antibiotic and chemical medicine as well as drug residue, can be used for a long time without causing drug resistance, and have safety and high efficiency.

The invention discloses a microecological preparation, a preparation method and applications thereof, and relates to the field of aqua culture. The microbiological preparation comprises at least one component selected from bacillus subtilis and bacillus pumillus, and at least one component selected from lactobacillus plantarum and lactobacillus acidophilus; wherein the bacillus subtilis comprises Bacillus subtilis 1A05680, the bacillus pumillus comprises Bacillus pumilus 1A08151, the lactobacillus plantarum comprises Lactobacillus plantarum 1A07806, and the lactobacillus acidophilus comprises Lactobacillus acidophilus PL7. The microecological preparation can be applied to preparation of preparations, which are used for promoting growth of prawn or grouper, improving immunity and disease resistance of prawn or grouper, preventing and treating diseases, increasing the survival rate, and purifying the culture water.

The invention provides a late-stage fortified feed for fattening pigs and a preparation method thereof. The fortified feed is prepared from corn, soybean meal, fermented soybean meal, rapeseed meal, vitamins, trace elements, immunomodulator, anti-stress agent and other raw materials by crushing, mixing, granulating and other processing modes. From the perspectives of nutrition and immunity, the invention changes the traditional feed for fattening pigs, reduces the animal stress and enhances the proteinosis of pigs, thereby meeting the market requirements for feed safety, good body types of pigs, high meat factor and the like.

The invention discloses a radiation-resistant and moisture-retention sun-blocking skin-care product, which contains 2-5 wt% of oat beta-glucan. The radiation-resistant and moisture-retention sun-blocking skin-care product provided by the invention can be used to raise radiation resistance and immunity of the whole skin and construct healthy skin, has an anti-allergic effect, can effectively prevent / alleviate various inflammation and symptoms such as erythema, and can preserve moisture, minimize fine lines and smoothen skin.

The invention relates to a capsule for forcedly improving the immunity, which is a capsule formulation prepared by traditional Chinese medicines of parasites detoxifying and destroying type, heat dry dampness clearing, detoxifying and blood cooling type, cough and asthma relieving and phlegm reducing type, temperature cooling and exterior relieving type, kidney warming and yang enhancing type, health building type, resolving damp with aromatics and blood enriching type, qi invigorating type, spleen and stomach strengthening and interior warming type, invigorating blood circulation by removing blood stasis type, liver soothing and qi regulating type, yin tonifying and converging type, digestion helping type, liver clearing, vision helping and resuscitation inducing type, deswelling and pain stopping type, heart nourishing as well as fever reducing and fire purging type according to a certain preparation method. The capsule has the functions as follows: forcedly improving the immunity, clearing away heat and toxic material, detoxifying and destroying parasites, soothing the liver and regulating qi, invigorating blood circulation by removing blood stasis, building health, invigorating qi and enriching blood, regulating qi and stopping pain, inducing diuresis and excreting dampness, eliminating phlegm, relieving cough and asthma, warming kidney and enhancing yang, invigorating the spleen and stomach and the like. The capsule has effects for various headaches, dizzy and neurasthenia, and various intestinal tract diseases, abdominal pains and abdominal distension, and various waist and leg pains and various tumors, and can cure diseases when in ill, build body when not in ill, and can achieve the goal of healthy and long life if the long-term or discontinuous taking is carried out.