The invention discloses health-care wine used for dispelling toxoplasma gondii and a preparation method thereof. The health-care wine used for dispelling toxoplasma gondii is characterized by being prepared from, by weight, 1-3 parts of Chinese herbal extract powder and 7-9 parts of wine, wherein the Chinese herbal extract powder is prepared from 1-3 parts of chrysanthemums, 2-5 parts of rhizoma polygonati, 1-3 parts of Chinese wolfberry fruit, 1-3 parts of dandelions and 1-4 parts of oysters, the chrysanthemums, the rhizoma polygonati, the Chinese wolfberry fruit, the dandelions, the oysters and the wine are taken in proportion, water with the weight 5 times that of the chrysanthemums, the rhizoma polygonati, the Chinese wolfberry fruit, the dandelions and the oysters is added, soaking is performed for 12 h after boiling, leach liquor is obtained, drying and powder spraying are performed after the leach liquor is concentrated into thick paste through filtering and pressure reduction, then the mixture is added into the wine and stirred to be fully dissolved, supernatant is obtained after standing lasts for 24 h, and the health-care wine used for dispelling toxoplasma gondii is obtained. The health-care wine can be used for effectively dispelling toxoplasma gondii, and meanwhile the physique and the immunity of human bodies are enhanced.