The application belongs to the technical field of
disease prevention and treatment of
aquaculture, and particularly relates to application of
honokiol combined with sulfisoxazole
sodium in preparation of a
Vibrio parahaemolyticus inhibitor, characterized by that the
mass ratio of
honokiol to sulfisoxazole
sodium in the composition is 1:0.5-2, the concentration of
honokiol in the composition is 32-64 µg / mL, and the concentration of sulfisoxazole
sodium in the composition is 32-128 µg / mL, and the application further provides a
medicine for improving sensitivity of
Vibrio parahaemolyticus to sulfisoxazole sodium and treating acute
hepatopancreas necrosis disease of prawns, and the
mass ratio of honokiol to sulfisoxazole sodium in the
medicine is 1:0.125-0.5; the composition can significantly reverse
drug resistance of
Vibrio parahaemolyticus to SMM-Na, reduce the use amount of SMM-Na, and produce a rapid sterilization effect through combined action, and meanwhile, the composition exhibits excellent protection
efficacy in
prawn bodies.