99 results about "Sulfamonomethoxine" patented technology

The invention relates to a compound sulfamonomethoxine sodium injection for veterinary use and a preparation method thereof, and belongs to the technical field of medicines for veterinary use. The raw material components of the compound sulfamonomethoxine sodium injection for veterinary use comprise sulfamonomethoxine sodium, dexamethasone sodium phosphate, trimethoprim, imidocarb, astragalus polysaccharide, organic solvent and water for injection. As a special compound preparation for veterinary use, the injection has remarkable efficacy on strengthening resistance of livestock and poultry, and treating mixed infection and severe diseases caused by a plurality of pathogenic bacteria and viruses. The injection has the advantages of convenient use, short treatment course, low drug resistance and the like.

The invention relates to a long acting compound sulfamonomethoxine suspension which consists of 10g of sulfamonomethoxine, 2g of trimethoprim, 0.3g of sodium hydroxide, 0.3g of carboxymethylcellulose sodium, 30g of propylene glycol and 0.05g of tween-80. A preparation method thereof comprises the steps that: (1) the carboxymethylcellulose sodium swells by using 20ml of water used for injection; (2) then the propylene glycol is added; (3) the sodium hydroxide is dissolved with 5ml of water for standby; (4) the products of Step (1) and Step (2) are placed upside down in a beaker, added with the trimethoprim, the sulfamonomethoxine and the tween-80 in sequence and stirred while being adding; the sodium hydroxide is used for adjusting and controlling the pH value to be 5.3 to 5.6; and (5) the solution is put into a colloid mill so as to be milled for 10 minutes, thus obtaining the compound sulfamonomethoxine suspension. The veterinary drug has the advantages of long half life, less untoward effects, good curative effect, and the like.

The invention aims to disclose a compound sulfamonomethoxine sodium solution and a preparation method of the compound sulfamonomethoxine sodium solution. The compound sulfamonomethoxine sodium solution comprises 100ml of the following components: 5-20g of sulfamonomethoxine sodium, 1-5g of trimethoprim, 20-70ml of an organic solvent, 0.1-0.5g of an antioxidant and 0.1-0.5g of a metal complex. Compared with an injection liquid, the prepared compound sulfamonomethoxine sodium solution has the advantages of convenience for administration, resource economization, wide application, strong product activity, high bioavailability, stable efficacy, obvious effect, stable shape and properties, slow degradation of main drugs, capability of continuously keeping bioactivity and the like, and thus the aim of the invention is realized.

The invention discloses a surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine and a preparation method thereof and application thereof. The surface molecularly imprinted polymer used for selectively absorbing sulfamonomethoxine uses methanol as a solvent, vinyl silicone as a carrier, sulfamonomethoxine as template molecule, chloride1-allyl-3-vinyl imidazole ionic liquid as functional monomer, ethylene glycol dimethacrylate as a cross-linking agent, and azodiisobutyronitrile as an initiator, and the sulfamonomethoxine molecularly imprinted polymer adsorbent is prepared by chain initiation polymerization. The invention also discloses the preparation method of the surface molecularly imprinted polymer, and the application thereof in the pretreatment of the selective separation and enrichment of trace sulfamonomethoxine in the environment. The surface molecularly imprinted polymer adsorbent prepared by the invention has uniform particle size, strong preferential adsorption property, high adsorption capacity, and good mechanical property, and is easy to recycle.

The invention discloses injection for treating porcine mixed infection. Each 100 liters of injection contains 10 to 15 kilograms of sulfamonomethoxine sodium, 2 to 5 kilograms of ofloxacin, 2 to 4 kilograms of diclofenac sodium, 1 to 2 kilograms of baicalin, 2 to 4 kilograms of trimethoprim, 0.1 to 0.2 kilogram of dexamethasone sodium phosphate, 0.1 to 0.2 kilogram of sodium thiosulfate, 3 to 6 liters of ethanolamine, 3 to 6 liters of phenyl carbinol, 30 to 60 liters of propylene glycol and the balance of water for injection. Compared with the conventional compound preparation for treating the porcine mixed infection, the injection effectively treats the porcine mixed infection and is convenient to use.

The invention discloses a method and special immune affinity adsorbent for extracting quinolone compound and/or sulfonamide compound. The immune affinity adsorbent consists of a solid-phase carrier and Norfloxacin monoclonal antibody and/or sulfamethoxazole monoclonal antibody coupled with the carrier, wherein the Norfloxacin monoclonal antibody and the sulfamethoxazole monoclonal antibody are obtained by taking Norfloxacin hapten, sulfamethoxazole hapten and carrier protein conjugate as immunogen; the quinolone compound is at least one of the following 13 types of compounds: Ciprofloxacin, Norfloxacin, Pefloxacin, Ofloxacin, Enoxacin, Marbofloxacin, Lomefloxacin, Danofloxacin, Enrofloxacin, Sarafloxacin, Difloxacin, Oxolinic acid and Flumequine; and the sulfonamide compound is at least one of the following 6 types of compounds: sulfapyridine, sulfathiazole, sulphapyridine, sulfamethizole, sulfamonomethoxine and sulfamethoxazole.

The invention discloses a compound sulfadiazine injection and a preparation method thereof. The compound injection comprises the following components in parts by weight: 5-12 parts of sulfamonomethoxine sodium, 1-5 parts of trimethoprim (TMP), 0.1-0.3 part of anhydrous sodium sulfite, 0.01-0.05 part of disodium ethylene diamine tetraacetate, 8-10 parts of sulfamethoxazole, 20-50 parts of propylene glycol, 1-5 parts of ethanolamine and 45-79 parts of injection water. Compared with the single sulfamonomethoxine sodium, the compound preparation prepared from the sulfamonomethoxine sodium, the sulfamethoxazole and the TMP expands an antibacterial spectrum, enhances the curative effect of the injection and enlarges the clinical application range; and the compound preparation can be applied to treating infection caused by bacteria as well as fever, high fever and dyspnea caused by toxoplasma, and the preparation has better treatment effect on diseases such as appetite decrease and even anorexia, diarrhea and the like.

The invention relates to an Acalypha australis L. and sulfamonomethoxine sodium containing compound medicine for livestock and poultry. The compound medicine comprises the following raw materials in parts by weight: 3-30 parts of sulfamonomethoxine sodium and 5-200 parts of Acalypha australis L. Studies prove that after Acalypha australis L. is added to an antibacterial medicine, the resistance of bacteria to the antibacterial medicine can be reversed, thus improving the treatment effects of the antibacterial medicine. By preparing the compound medicine into powder, tablets, oral liquid or granules according to conventional methods and adding the compound medicine to feeds for livestock and poultry according to the additive amount of 0.1-7g of main medicine/kg of feed to feed the livestock and poultry, the medicine cost and the medicine residues can be substantially reduced, higher economic benefits can be created for farmers, and food safety is simultaneously ensured.

The invention relates to a molecularly imprinted electrochemical sensor for detecting trace sulfamonomethoxine. The molecularly imprinted sensor for sulfamonomethoxine (SMM) is prepared by electropolymerization with a cyclic voltammetry by taking sulfamonomethoxine as template molecules and dopamine as functional monomer, an electrochemical signal is enhanced by modification with reduced graphene oxide (rGO), and a detection limit of the method is improved. In a phosphate buffered solution of which the pH is 8, potassium ferricyanide is taken as a probe, a differential pulse voltammetry is taken as an electrochemical excitation signal, and research results display that the peak current difference and the SMM concentration have a favorable linear relation within a range of 20.0 to 1600.0nM, wherein r is equal to 0.9964, and the detection limit is 1.0nM. The sensor disclosed by the invention is used for detection of an actual sample with favorable reproducibility and stability, and the recovery rate reaches 92.4 to 97.9 percent.

The invention discloses a method for predicting a residue of metabolite-related sulfamonomethoxine in a pig. The method comprises the following steps of (1) supposing a physiologic pharmacokinetic model of the pig and establishing a model structure; (2) establishing a mass-balance equation of the sulfamonomethoxine and acetylated metabolites thereof in various tissues in the pig according to the established model structure; (3) collecting physiological anatomical parameters of the pig and specific parameters of the sulfamonomethoxine and the acetylated metabolites thereof, carrying out model fitting according to the measured data to obtain a final value of the model parameter and finishing establishing of the model; and (4) inputting sulfamonomethoxine dose for pig injection, running the model to obtain predicted values of the residual concentration of the sulfamonomethoxine in various tissues of the pig at different time points after medication. The established physiologic pharmacokinetic model relates to metabolites of the sulfamonomethoxine in the pig, the physiologic pharmacokinetic model is closer to the true situation and the predicted result is more accurate.

The invention discloses a detection kit of sulfamonomethoxine as well as a preparation method and application thereof, belonging to the field of biochemistry. The detection kit comprises a micropore plate and a detection reagent, wherein the micropore plate is an opaque plastic plate, and each pore of the micropore plate is coated with a peridium antibody of sulfamonomethoxine with the concentration of 2mug/mL; and the detection reagent comprises an enzyme labeled antigen (HRP-SMM (Horseradish Peroxide- Sulfamonomethoxine)), a sulfamonomethoxine standard substance gradient solution, an enzyme labeled antigen sample diluent, a chemiluminescent base solution A, a chemiluminescent base solution B and a cleaning solution. The detection kit of the sulfamonomethoxine is used for detecting the sulfamonomethoxine content in milk, eggs, meats and products thereof; and the design method of the kit is novel, convenient for quick on-the-spot inspection on a large scale, has the advantages of low cost, simplicity for operation and high sensitivity and specificity and has better application prospect for detecting the sulfamonomethoxine residue of a veterinary medicine.

The invention discloses an injection for treating the paratyphoid of dogs and a preparation method thereof, which aim to provide an injection which has quick effect and can reduce the drug resistant probability of pathogenic bacteria, treat both symptoms and root causes and quicken the recovery, and a preparation method which has simple process and is easy to realize. Per 100L of the injection comprises 2-15kg of sulfamonomethoxine sodium, 1-10kg of lincomycin hydrochloride, 0.05-0.3kg of atropine sulfate, 0.06kg of dexamethasone sodium phosphate, 0.2kg of sodium bisulfite, 0.01kg of EDTA-2Na and the balance of water. The injection adopts antibacterial drugs, antibiotics, glucocorticoids for diminishing inflammation and detoxifying and atropine sulfate for controlling the diarrhea of the dogs and reducing dehydration, and a compound preparation prepared by reasonably proportioning the dosages of the components has the function of double anti-bacteria, can reduce the drug resistant probability of salmonella typhimuria, control the infection of other gram negative bacteria and positive bacteria and accelerate the recovery and has high cure rate.

The invention discloses a veterinary compound pharmaceutical composition containing albendazole and ivermectin, and relates to the field of veterinary drug technical preparation. The veterinary compound pharmaceutical composition comprises the following components: albendazole, ivermectin, sulfamonomethoxine, lactobacillus and soluble starch. The veterinary antiparasitic pharmaceutical composition is convenient to use, is mutually synergistic, has broad spectrum of insect resistance and good insect-resistant effect, can increase gastric motility, increases feed intake, and is in favor of the growth of livestock. The pharmaceutical compound of the invention can be a dry suspension, can be directly added in an automatic drinking device in proportion, is convenient to use, and has wide application prospects.

The invention belongs to the technical field of veterinary drug preparations, in particular to temperature-sensitive type gel for curing endometritis of livestock and a preparation method for the temperature-sensitive type gel. The temperature-sensitive type gel comprises the following main drug: one of 5 to 10 percent of ofloxacin, 1 to 2 percent of sodium new houtluyfonate, 1 to 2 percent of sodium houttuyfonate, 5 to 20 percent of sulfadiazine sodium, 5 to 20 percent of sulfamonomethoxine sodium and 10 to 20 percent of lincomycin hydrochloride, the following auxiliary materials: 10 to 30 percent of gel matrix, 1 to 2 percent of release rate regulator, 0.1 to 0.5 percent of antioxygen and 0.5 percent of acetic acid, and balance of water for injection in weight percentage. By fully utilizing the characteristics of good flowability, long resistance time, slow drug release and lasting and stable drug effect of the temperature-sensitive type gel disclosed by the invention, the endometritis of the female livestock is effectively cured, and the curative effect is thorough; meanwhile, the labor strength of a cultivation worker is reduced; the temperature-sensitive type gel is more convenient in therapeutic use.

The invention discloses a compound sulfamonomethoxine sodium injection and a preparation method thereof. The compound sulfamonomethoxine sodium injection comprises, by weight, 5-30 parts of sulfamonomethoxine sodium, 1-4 parts of trimethoprim, 0.2-0.4 part of antioxidants, 25-45 parts of organic solvents, 1-2 parts of acid form modifiers, 1-5 parts of alkali form modifiers and 45-65 parts of water for injection. Through the technological improvement of the compound sulfamonomethoxine sodium injection, the using quantity of organic solvents is reduced, cost can be greatly lowered, and the risk for causing clinical irritation is lowered.

The invention discloses compound amoxicillin soluble powder for treating duck oromeningitis and a preparation method thereof, aiming at providing soluble powder which has high effect on treating duckinfection, reduces germ medicine resisting probability and treats both principal and secondary aspects of diseases; and the invention also discloses a preparation method of the composition. The compound amoxicillin soluble powder for treating duck oromeningitis comprises the following components by weight percent: 2-20 percent of amoxicillin, 2-20 percent of sulfamonomethoxine sodium, 0.4-4 percent of trimethoprim lactate, 2-10 percent of sodium dichlorophenolate, 1-8 percent of natrium carbonicum calcinatum and the balance of anhydrous dextrose. The compound amoxicillin soluble powder combines the amoxicillin and the sulfamonomethoxine sodium, can greatly reduce the medicine resistance of duck Riehmer bacillus, increase pathogeny resisting capability, has a stronger inhabiting or killingfunction and can prevent other secondary bacterial infection, and meanwhile, the trimethoprim lactate can effectively increase the antibacterial capability of the amoxicillin and the sulfamonomethoxine sodium, greatly enhance an antibacterial function, kill pathogeny and relieve clinical symptoms after being combined with the functions of refrigeration and inflammation resistance of the sodium dichlorophenolate.

The invention relates to a compound medicine comprising herba lycopi and sulfamonomethoxine sodium and used for livestock and poultry. The compound medicine comprises the following raw materials in parts by weight: 7 to 30 parts of sulfamonomethoxine sodium and 10 to 160 parts of herba lycopi. The raw materials are uniformly mixed to be prepared into powder, tablets, an oral liquid or granules to be added into livestock and poultry feed according to the additive amount of 0.1-5 g/kg for feeding, and drug resistance of antibacterial on bacteria can be reversed, so that the treatment effect of the antibacterial can be improved, the medicine cost can be greatly reduced, and higher economic benefits are created for farmers.

The invention provides a compound antibacterial dry suspension for livestock and poultry. The dry suspension is prepared from the following raw materials and auxiliaries in parts by weight: 8-12 parts of sulfamonomethoxine, 3-7 parts of enrofloxacin, 15-25 parts of a suspending agent, 3-9 parts of a deflocculant and 40-78 parts of a flavoring agent. Furthermore, the invention provides a preparation method of the dry suspension. The compound dry suspension is relatively high in oral blood concentration, and in comparison with a preparation in a normal dosage form, the dry suspension is high in effective blood concentration peak and long in effective blood concentration duration; the dry suspension is convenient to use, simple in quality control and favorable for administration; the continuous administration frequency is lowered, and the dry suspension is specifically suitable for veterinary clinical field.

The invention relates to the technical field of veterinary medicine preparation, and particularly relates to wettable sulfamonomethoxine (sodium) powder and a preparation method thereof. The wettable sulfamonomethoxine (sodium) powder provided by the invention is added with potassium citrate, a suspending agent and a wetting agent on the basis of effective components of the original medicine; by reasonable medicine proportioning, the invention provides the wettable sulfamonomethoxine (sodium) powder which is easy to disperse evenly in water, convenient to absorb by animals, and small in toxic and side effects. Compared with commercially available compound sulfamonomethoxine (sodium) powder, the wettable sulfamonomethoxine (sodium) powder is convenient to use and good in therapeutic effect. The invention also provides the preparation method of the wettable sulfamonomethoxine (sodium) powder, and the preparation method is simple in technology, low in production cost and suitable to industrialized production.

The invention provides a method for sulfonamide medicine extraction and analysis by utilizing a DPX pipette tip type dispersive solid-phase extraction microcolumn, and relates to sulfonamide medicineresidue detection methods for animal-sourced foods. The method is provided to overcome a problem that there is no effective method for sulfonamide medicine detection for animal-sourced foods, especially quantitative, high-precision, high-throughput and low-consumption determination. A high performance liquid chromatography-tandem mass spectrometry manner for residue analysis of twelve sulfonamidemedicines in animal-sourced foods is established in the method. The method is suitable for residue amount detection of one or a plurality of medicines selected from sulfacetamide, sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxypyridazine, sulfamonomethoxine, sulfochloropyridazine, sulfamethoxazole, sulfadimethoxypyridazine, sulfadimethisoxazol, sulfabenzamide and sulfaquinoxalin in animal-sourced foods.

The invention discloses a preparation method of an immunoaffinity column. The immunoaffinity column is a compound affinity column which is mainly prepared from three types of immunoaffinity columns through mixed packing in a volume ratio being 1:1:1, and the three types of immunoaffinity columns are prepared from three antibodies and a coupling matrix through coupling and wet packing. The column capacity of the immunoaffinity column is 2,500 ng, the immunoaffinity column is good in purification effect and can be repeatedly used three times, and average recovery rate is 67%-107%. The compound immunoaffinity column has good specific adsorption property for at least 12 sulfonamides including sulfaquinoxaline, sulfadiazine, sulfapyridine, sulfametoxydiazine, sulfadimidine, sulfamethoxazole, sulfafurazole, sulfadimethoxypyrimidine, sulfathiazole, sulfamerazine, sodium N-sulphanilamidate and sulfamonomethoxine. The immunoaffinity column which is high in coupling rate, specific adsorption property, column capacity and recovery rate is prepared, and a sensitive, rapid and simple analysis method capable of detecting residues of the 12 sulfonamides simultaneously is provided.

The invention discloses an anti-toxoplasma composition drug and a screening method thereof, and belongs to the field of medicine. According to the anti-toxoplasma composition drug and the screening method thereof, mouse test toxoplasmosis animal models are established, the ten drugs of a sulfadiazine sodium injection, a compound sulfamethoxazole, a lincomycin hydrochloride injection, a sulfamonomethoxine sodium injection, a florfenicol injection, acetylspiramycin, pyrimethamine, roxithromycin, artemisinin and radix sophorae flavescentis are selected out, two compositions which have the best anti-toxoplasma effect are screened out, one composition comprises the sulfamonomethoxine, the pyrimethamine and TMP, and the other composition comprises the compound sulfamethoxazole and the acetylspiramycin; animal models in mice and pigs are established, it is verified that the two compositions are both effective on the treatment of artificially infected toxplasmosis in pigs, and the treatment effect on the pigs is in accordance with that of the mouse models. By means of the anti-toxoplasma composition drug and the screening method thereof, it is proved that the the feasible method is achieved by utilizing the mouse test toxoplasmosis models to evaluate the efficacy of drugs on treating toxplasmosis in pigs, and meanwhile two anti-toxoplasma drug compositions with good effects are provided.

The invention provides a method for preparing sodium sulfamonomethoxine. The method comprises the following steps: (1) putting sulfamonomethoxine and sodium hydroxide into water, and stirring to reactfor 0.8-1.2 hours at 70-90 DEG C; (2) adjusting the pH value of the reaction liquid to 9.80-10.50, adding activated carbon which accounts for 0.2-0.4% of the sulfamonomethoxine, stirring and decoloring for 0.3-0.8 hours, and filtering the hot liquid so as to obtain filtrate; (3) carrying out vacuum distillation on the filtrate till the water content is smaller than or equal to 10%, adding alcohol, stirring, heating, and backflowing for 30-60 minutes; (4) cooling the reaction liquid obtained in the step (3) 3.5-5 hours at 0-5 DEG C, and filtering; (5) washing filtrate residues obtained in thestep (4) with alcohol, and carrying out vacuum drying for 2.5-4 hours at 55-60 DEG C, so as to obtain the sodium sulfamonomethoxine. The method for preparing the sodium sulfamonomethoxine, which is provided by the invention, is small in waste alkali amount in the production process and high in yield, and the prepared product is high in purity.

The invention discloses a compound sulfamonomethoxine sodium micro-capsule preparation and a preparation method thereof. The compound sulfamonomethoxine sodium micro-capsule preparation is prepared from sulfamonomethoxine with 8-12% of mass ratio, trimethoprim with 1-3% of mass ratio, the balance glucosum anhydricum and the balance addition agent. The preparation has the advantages that the cooperative use of 10% of sulfamonomethoxine, 2% of trimethoprim micro-capsule and addition agent is adopted, the preparation penetrating power is effectively improved, and toxoplasma cysts can be penetrated, and toxoplasmosis can be effectively prevented and controlled. Damage to the pig kidney is relieved through a micro-capsule technology, and the preparation is specially applied to the use of pregnant sows.