57 results about "Artemisinin" patented technology

The invention discloses an artemisinin extraction intelligent tracking and identification method, and relates to the technical field of image data processing. According to the method, an integrated closed-loop system is constructed through cooperation of four core technical means: based on classified filtering of foam stability difference and bimodal adaptive segmentation, dynamic foam is accurately removed, and preliminary interface extraction is optimized; the attention enhancement U-Net network is embedded into a channel attention module and an edge enhancement branch to realize accurate positioning and fluctuation tracking of a layered interface; the attention mechanism dynamically adjusts the bimodal weight, and completes multi-index cooperative tracking in combination with a partitioning strategy and an improved network; a crystal growth model is introduced to correct particle weight, a tracking effect is optimized by adopting layered resampling, and a closed-loop feedback mechanism of a crystal state and process parameters is established. All technical means are deeply coordinated, intelligent and accurate management and control of the whole extraction process are achieved, and reliable technical support is provided for artemisinin extraction production.

The invention discloses a polymer composite material based on artemisinin modification, which is characterized in that the polymer composite material comprises organic silicon polyurethane modified by an artemisinin compound and organic silicon polyurea, and the mass ratio of the organic silicon polyurethane modified by the artemisinin compound to the organic silicon polyurea is (2-1): (1-2). The coating is high in hardness, good in mechanical performance, low in elastic modulus, good in stain removal effect and good in adhesion performance, can be stably attached to a substrate and is not prone to falling off, meanwhile, has an excellent antibacterial effect, is not prone to being hydrolyzed by water in seawater or air in the using process on the premise that all the conditions are met, is good in water resistance and can be widely applied to the field of water treatment. Therefore, the long-term stability of the composite coating is ensured, the comprehensive performance of the coating can be comprehensively improved, and the marine antifouling coating serving as an environment-friendly marine antifouling coating has a good application prospect.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

The formula comprises the following raw materials in parts by weight: 70-85 parts of base liquor, 5-15 parts of fresh pandan leaves, 0.5-3 parts of baked pandan leaf powder, 1-3 parts of a flavor modifier, 3-8 parts of a sugar source and 0.1-0.6 part of a functional additive. The unique flavor of the pandan leaves originates from the rich 2-acetyl-1-pyrroline, and the pandan leaves give out charming rice dumpling fragrance and have the effects of promoting appetite and metabolism at the same time. The pandan leaves are blended into the food, so that the delicious taste is improved, and additional nutritional value is also brought. The pandan leaves are rich in dietary fibers, vitamin B family, vitamin C and various minerals. The composition also contains squalene, linoleic acid, estragole, phytol and other active ingredients. Squalene is a natural organic terpenoid, widely exists in a living body, and has remarkable effects in the aspects of promoting blood circulation, resisting oxidation, resisting inflammation, resisting tumors and the like. The prepared pandan wine has multiple effects and is beneficial to body health after being drunk for a long time.

The invention discloses a compound containing an artemisinin similar structure or a pharmaceutical salt thereof, and the structural general formula is as follows: # imgabs0. The compound containing the artemisinin similar structure, provided by the invention, has a relatively obvious proliferation inhibition effect on solid tumor cells such as lung cancer A549, colon cancer HCT116 and liver cancer HepG2; wherein the high-activity compound has an excellent proliferation inhibition effect on leukemia cells HL-60 and MV4-11, is better than a marketed drug SAHA, and can be used as an anti-tumor candidate drug for deeper research.

The invention belongs to the field of plant biotechnology and medicinal plant cultivation, and relates to application of melatonin in artemisinin biosynthesis and a method for increasing the content of artemisinin in artemisia apiacea. The melatonin is applied to the artemisia apiacea plants, the content of artemisinin in the artemisia apiacea is increased, and compared with an existing method, the method is more economical and efficient.

The invention provides an artemisinin analogue compound containing a hydroxamic acid structure or a medicinal salt thereof as well as a preparation method and application of the artemisinin analogue compound. The structural formula of the artemisinin analogue compound is shown as a formula I in the specification. The compound has a brand new skeleton structure and excellent anti-tumor activity, and can be used for preparing anti-tumor drugs.

The present invention discloses an artemisinin PROTACs, a preparation method and application thereof, wherein the structural formula is: The present invention uses artemisinin modified product artesunate as POI ligand, lenalidomide and pomalidomide as E3 ligands, and linkers selected from amino acid chains, PEG chains and fatty chains. The anticancer activity thereof is superior to that of artesunate, and the present invention has good potential application prospects in anticancer drugs and treatment of critical malaria.

The utility model belongs to the technical field of vacuum drying ovens, particularly relates to an artemisinin double-cone vacuum drying oven, and provides the following scheme aiming at the problems that in the using process of an existing double-cone vacuum drying oven, materials are inconvenient to scatter, the materials cannot be prevented from being adhered to the inner wall of the oven, and the drying effect of the materials is affected. The device comprises a base; the number of the vertical plates is two, and the two vertical plates are fixedly installed on the top of the base; the number of the connecting pipes is two, the two connecting pipes are rotationally installed on the two vertical plates correspondingly, and one ends of the two connecting pipes are connected with the same drying oven body; according to the material scattering device, in the using process, materials can be scattered conveniently, the materials can be prevented from being stuck to the inner wall of the drying oven, then the material drying effect can be effectively guaranteed, and the material scattering device is simple in structure and convenient to use.

The invention discloses a chiral amino alcohol modified artemisinin derivative as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the present invention, the alkali is adopted as the catalyst, the esterification reaction of the artesunate and the chiral amino alcohol is achieved for the first time, a series of the brand new derivatives simultaneously containing the artemisinin structure unit and the chiral amino alcohol structure unit are constructed, the synthesis path of the artemisinin derivative is expanded, and the research blank in the field is filled. The preparation method is novel, simple to operate, free of complex equipment, mild in reaction condition, high in reaction rate and high in yield, provides a new candidate compound for developing efficient and low-toxicity antitumor drugs, and has important clinical application value and market prospect.

The invention belongs to the technical field of biological medicine, and particularly relates to a rheumatism immune disease treatment composition combining traditional Chinese medicine active ingredients and immune regulation and application of the rheumatism immune disease treatment composition, and the rheumatism immune disease treatment composition comprises the following components in parts by weight: 10-50 parts of a traditional Chinese medicine active ingredient compound; 0.01 to 1 part of an immune regulation factor; 50 to 90 parts of pharmaceutic adjuvants; wherein the traditional Chinese medicine active component compound is prepared from the following components: astragaloside, artemisinin, curcumin and triptolide in a weight ratio of (2-5): (1-3): (1-4): (0.5-2); the immunoregulation factor is composed of recombinant human interleukin-10 (rhIL-10), a transforming growth factor-beta1 (TGF-beta1) and a CTLA4-Ig fusion protein according to a weight ratio of (1-3): (0.5-2): (1-4). The active ingredients of the traditional Chinese medicine cover a plurality of links of anti-inflammation, anti-oxidation, immunoregulation and the like, and immunoregulatory factors accurately intervene in immune cell activation and a cell factor network to jointly inhibit abnormal immune response.

The present invention provides an antimalarial composition comprising arjunetin and artemisinin. The composition exhibits synergistic antimalarial effect against malaria causing Plasmodium species including Plamsodium falciparum, P berghe species. The composition comprising Arjunetin and Artemisinin demonstrated potent antimalarial activity in vivo and in vitro with better survival and low parasite burden in the blood.

The invention discloses a novel oil-soluble micelle preparation. The component A comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, cardiolipin, cephalin and dipalmitoyl phosphatidylcholine, and the component B comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, phosphatidylcholine, cephalin and dipalmitoyl phosphatidylcholine; one or more of dipalmitoyl phosphatidyl ethanolamine and dipalmitoyl phosphatidyl ethanolamine; the component B comprises a component B1 and a component B2, and the component B1 comprises one or more of phytosterol, cholesterol, ergosterol, protopanoxadiol, protopanaxatriol, ganoderic acid, phytol, isophytol, retinol, andrographolide, paclitaxel, artemisinin and bisabolol; and the component B2 is prepared from one or more of 1, 2-hexanediol, ethylhexylglycerin, cyclohexyl glycerin, absolute ethyl alcohol and isosorbide dimethyl ether. The key point of the invention is to provide a low-cost formula and a low-cost preparation method for preparing the oil-soluble micelle preparation.

This invention proposes an auxiliary system for artemisinin extraction, comprising a processor and a memory. The processor acquires dynamic data, static data, and parameter data affecting extraction efficiency and purity at each node during the artemisinin extraction process, generating multidimensional feature data. The dynamic data includes real-time dynamic data of each node at different time points during the artemisinin extraction process, and the static data includes the geometry, capacity, weight, and volume of each node. The nodes are arranged according to the order of the artemisinin extraction process to obtain a node sequence. Node discrimination coefficients are initialized, and the node discrimination coefficients are weights of the parameters affecting extraction efficiency and purity. The node discrimination coefficients are trained and updated to obtain a discrimination threshold. Abnormal nodes are identified based on the comparison between the discrimination threshold and the node discrimination coefficients, and the real-time dynamic data, static data, and corresponding parameter data affecting extraction efficiency and purity of the abnormal nodes are used as the first type of data.

The invention relates to the technical field of medicines, in particular to application of artemisia vulgaris in preparation of an anti-depression medicine. According to the application disclosed by the invention, the depression is systematically researched through a chronic depression model induced by chronic unpredictable mild stress (CUMS) and an acute depression model induced by lipopolysaccharide (LPS). Experimental results show that under the stimulation of CUMS or LPS, experimental animals show obvious depression-like behaviors. Compared with a negative control group, depression-like behaviors of mice in the CUMS model group and the LPS model group are confirmed, and behavior abnormalities induced by the two models can be effectively improved after intervention of the artemisinin. Further comparative research finds that the antidepressant effect of the clinically common antidepressant drug venlafaxine with the dosage of 10 mg / kg can be achieved under the dosage of 1 mg / kg of the artemisinin, and the artemisinin has remarkable antidepressant activity. The application has a good application prospect when being applied to the development of anti-depression drugs.

The present invention relates to an artemisinin derivative having at least one of the following structural formulas: [The text then abruptly shifts topics.] This invention uses indole iodide as a target to construct tumor-targeted mitochondria, achieving tumor-targeted delivery of artemisinin-based drugs. This invention uses Cy7 to link artemisinin, improving its targeting and bioavailability, and enhancing its anti-tumor effects.

The invention provides a low-temperature ionic crosslinking type artemisinin-sodium alginate microcapsule and a preparation method and application thereof.The preparation method comprises the steps that sodium alginate is dissolved in distilled water to be subjected to low-temperature ultrasonic dissolution, and then artemisinin is dissolved in a sodium alginate solution to obtain a mixed solution; sucking the mixed solution, injecting the mixed solution into a CaCl2 aqueous solution to obtain a suspension suspended with fine microsphere particles, slowly stirring at room temperature, and standing; and finally, centrifuging or carrying out reduced-pressure suction filtration separation, washing with distilled water, and collecting to obtain a product. The microcapsule obtained by the invention has a pH-responsive dual release mechanism and oral adaptability. The release logic is that the outer layer quickly responds, the Ca < 2 + >-sodium alginate network on the surface of the microcapsule is dissolved when encountering saliva, and the Ca < 2 + > is instantly released to promote coagulation; the artemisinin-sodium alginate hydrophobic inner core is continuously diffused through a multi-stage pore channel, the effective bacteriostatic concentration is maintained for 48 hours, and the artemisinin-sodium alginate antibacterial agent plays a key role in oral care.

The invention discloses an artemisinin compound containing a piperazine side chain or a pharmaceutical salt thereof, and the structural general formula is shown in the specification. The artemisinin compound containing the piperazine side chain and the pharmaceutical salt thereof provided by the invention have a brand-new skeleton structure and better anti-malaria and anti-tumor activity, can be used as an anti-tumor drug and an anti-malarial drug, and can be used as an anti-malarial drug. And more choices can be provided for clinical treatment.

Provided are an artemisinin derivative and a preparation method and use thereof. A structural formula of the artemisinin derivative is shown in Formula I. The compound has suitable solubility and is relatively stable under storage conditions. Pharmacokinetic experiments on the compound have shown that artemisinin is detectable in ocular tissues and is present in cornea, conjunctiva, and aqueous humor at a relatively high drug concentration. The compound is therefore an excellent precursor to artemisinin. The compound shown in Formula I exhibits remarkable absorbability, and the drug concentration in the ocular tissues indicates that the compound is well absorbed. The compound exhibits significantly better inhibitory effects on neovascularization in burn models than artemisinin, and can be prepared into liquid formulations such as eye drops, injection, etc., for treatment of ocular tissue diseases.

A method for extracting artemisinin, relating to the field of artemisinin extraction technology, includes the steps of extraction, enhanced extraction, separation, concentration, and purification. The purification employs an innovative column chromatography method, specifically a column height-to-diameter ratio of 1.2:1; adding hexane and diethyl ether eluent at a volume ratio of 8:2, with the added packing material height being 1.20-1.25 times the column diameter; and obtaining artemisinin after column chromatography. Alternatively, the innovative recrystallization method involves dissolving a paste in a crystallization vessel containing 50°C hot methanol, then lowering the temperature to 9-11°C, while locally heating and maintaining the temperature at the bottom of the crystallization vessel during cooling. Solid crystallization occurs under a uniform temperature distribution within the vessel, followed by filtration. This process is repeated twice to obtain artemisinin. The beneficial effects include an increased theoretical plate number of the chromatography column, significantly improved separation efficiency, and a significantly higher purity of artemisinin; the uniform temperature distribution within the crystallization vessel effectively improves the purity of the crystals.

The present invention belongs to the technical field of ultrasonic imaging agents, and specifically relates to a microcapsule ultrasonic contrast agent and a preparation method thereof. The method comprises dissolving artemisinin in an organic solvent, dispersing iohexol in the organic solvent, adding bovine serum albumin to obtain an organic solution of iohexol as an oil phase; dissolving λ-carrageenan in hot water as an aqueous phase, mixing and ultrasonicating to obtain a primary oil-in-water emulsion; passing through a membrane, centrifuging, washing with water, and freeze-drying to obtain an ultrasound contrast agent. After accelerated testing, it was verified that the content of related substances of the active ingredient in the contrast agent was significantly reduced, the storage stability was significantly improved, and it was used in clinical practice, meeting higher standards of quality control requirements.

The invention relates to the technical field of medicine, and discloses an artemisinin external patch for repairing wounds of scalds and burns and a preparation method and application thereof.The patch comprises a backing layer, medicine storage liquid and an anti-sticking layer, the backing layer is coated with the medicine storage liquid, and the medicine storage liquid is prepared from, by mass, 0.5%-2.0% of artemisinin, 8%-15% of solubilizer, 3%-10% of matrix material, 1%-3% of anti-sticking layer and the balance water. 1-5% of a transdermal enhancer, 0.1-0.5% of a stabilizer, 0.5-2.0% of a pH regulator, 0.1-0.5% of a preservative, 5-10% of a humectant and the balance of purified water. According to the patch, reactive oxygen species (ROS) is removed through a peroxide bridge structure of artemisinin, key signal channels such as NF-kappa B and TGF-beta are cooperatively regulated and controlled, and the multiple effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting repair and resisting scars are achieved. Experiments prove that the composition can significantly accelerate wound healing and inhibit inflammation, oxidative injury and scar formation, solves the problems of short action time, low transdermal efficiency and single function of a traditional external product, and provides a multi-mechanism synergistic, safe, convenient and innovative external composition for treatment of scalds and burns.

The present application provides a plant expression vector, a recombinant transformant, artemisia and its application for increasing the content of artemisinin in artemisia. The first aspect of the present application provides a plant expression vector, wherein the plant expression vector comprises a gene encoding a transcription factor AabHLH39, and the gene encoding the transcription factor AabHLH39 has a nucleotide sequence as shown in SEQ ID NO: 1. The present application constructs a plant expression vector comprising a gene encoding a transcription factor AabHLH39, and transforms the artemisia, so that the artemisia overexpresses the transcription factor AabHLH39, thereby increasing the content of artemisinin in the artemisia.

The invention relates to a drug delivery method of hydatid capsule wall penetrating type artemisinin based on bone targeting nanometer, and the drug delivery method comprises the four steps of nano carrier preparation and drug loading, nano carrier characterization, in-vitro function evaluation and in-vivo drug effect evaluation, and the drug delivery method of the hydatid capsule wall penetrating type artemisinin based on the bone targeting nanometer comprises the following steps of: preparing a nano carrier; a bone targeting ligand modified on the surface of a nano-carrier is used for specifically recognizing hydroxyapatite in bone tissue, enrichment of drugs at a focus part is achieved, the penetrating capacity of the drugs on the cyst wall of a peridid is enhanced through size regulation and control and surface charge optimization of nano-particles, and the nano-carrier loads artemisinin or derivatives thereof, so that the drug has a good application prospect. Releasing is triggered at the focus in response to the microenvironment, and the local drug concentration is improved.

The invention provides a compound containing an artemisinin similar structure and a preparation method and application of the compound, the structural formula of the compound is shown in the formula I. The compound has excellent histone deacetylase inhibitory activity and anti-tumor and anti-malarial activity and can be used for preparing anti-tumor and anti-malarial drugs.

The invention discloses an artemisinin compound containing a 10-bit ether side chain or a pharmaceutical salt thereof, the structural general formula is one of the following structures: the artemisinin compound containing the 10-bit ether side chain provided by the invention has a relatively obvious proliferation inhibition effect on liver cancer HepG2, lung cancer A549, intestinal cancer HCT116, hematologic tumors MV-4-11 and HL-60; the anti-tumor activity of part of the compounds is higher than that of commercially available drugs SAHA and belinostat, and the compounds are expected to be developed into novel anti-tumor drugs. In addition, the performance of a plurality of compounds is superior to the in-vitro antimalarial activity of artemisinin, and the compounds are expected to be developed into novel antimalarial drugs.

The invention belongs to the technical field of biological medicine, and discloses a method for analyzing an action target of artemisinin for treating renal clear cell carcinoma based on network pharmacology and a molecular docking technology, and the method comprises the following steps: S1, screening the action target of an artemisinin active component; s2, identifying candidate disease targets; s3, acquiring an intersection target point; s4, constructing a protein-protein interaction network and performing network topology analysis; s5, core target biological function and molecular action signal path analysis and visualization; s6, constructing an artemisinin-renal clear cell carcinoma-target spot-pathway network diagram; s7, exploring an action mechanism of artemisinin for improving the renal clear cell carcinoma based on a molecular docking technology; s8, carrying out survival analysis on the core target spot based on the TCGA database, and drawing a Kaplan-Meier curve; and S9, observing the influence of artemisinin and derivatives thereof on the activity of renal clear cell carcinoma 786-O cells by adopting a CCK-8 method. Network pharmacology and molecular docking technologies are applied, multiple omics data are integrated from the perspective of system biology, a drug-target-disease network is constructed, the interaction between artemisinin and renal clear cell carcinoma related targets is deeply analyzed, and the action mechanism of artemisinin on the aspects of genes, proteins, signal channels and the like is comprehensively revealed.

The application belongs to the technical field of analytical chemistry, and relates to a class of free fluorophore type fluorescent probes and a preparation method and application thereof, in particular to a class of fluorescent probes for detecting tumor cells sensitive to ferriheme, divalent iron ions and artemisinin compounds and a preparation method and application thereof. The fluorescent dye of the point-on type probe is located on the side of the carbon free radical generated after the probe molecule is broken. The synthesized probe can detect ferriheme with high sensitivity and can also detect divalent iron ions. After the fluorescent probe molecule reacts with ferriheme, free fluorescent dyes are mainly generated, which has obvious advantages in detecting tumor cells at low concentrations of probe molecules. When the fluorescent probe is used to detect tumor cells sensitive to artemisinin compounds by using a flow cytometer, the fluorescent probe has the advantages of easy operation, high selectivity, high sensitivity and the like. Therefore, the fluorescent probe has potential practical application value in evaluating the killing ability of artemisinin compounds on different tumor cells.

The invention relates to the technical field of biological medicine preparations, in particular to a recessive infected toxoplasma gondii repellent and a preparation method thereof, and the preparation method comprises the following steps: S1, sieving all the components; s2, mixing the artemisinin extract with a prepared carrier to prepare a premix A; s3, mixing the garlic extract with the turmeric extract to prepare a premix B; s4, dissolving vitamin C, zinc gluconate and sodium selenite in purified water to prepare a solution C; s5, mixing the premix A, the premix B and the solution C to form a main mixture D; s6, adding probiotic powder and a flavoring agent into the main mixture D to obtain a final mixture E; and S7, drying, granulating and forming to obtain a finished product of the repellent. According to the invention, through the synergistic combination of various plant extracts, micronutrients and probiotics and a low-temperature step-by-step preparation process, the efficient expelling of the recessive infected toxoplasma gondii and the stable regulation of the host immune environment are realized.

The application discloses an intelligent tracking and identification method for artemisinin extraction, and relates to the technical field of image data processing; the method cooperatively constructs an integrated closed-loop system through four core technical means: type filtering and bimodal adaptive segmentation based on foam stability difference, accurate removal of dynamic foam and optimization of preliminary interface extraction; attention-enhanced U-Net network embedding channel attention module and edge-enhanced branch, realizing accurate positioning and fluctuation tracking of layered interfaces; attention mechanism dynamically adjusts bimodal weight, combined with partition strategy and improved network to complete multi-index collaborative tracking; the crystallization growth model is introduced to correct particle weight, hierarchical resampling is adopted to optimize tracking effect, and a closed-loop feedback mechanism of crystallization state and process parameters is established. Deep cooperation of each technical means realizes intelligent and accurate control of the whole extraction process, and provides reliable technical support for artemisinin extraction production.