100 results about "Artemisinin" patented technology

The invention discloses an artemisinin extraction intelligent tracking and identification method, and relates to the technical field of image data processing. According to the method, an integrated closed-loop system is constructed through cooperation of four core technical means: based on classified filtering of foam stability difference and bimodal adaptive segmentation, dynamic foam is accurately removed, and preliminary interface extraction is optimized; the attention enhancement U-Net network is embedded into a channel attention module and an edge enhancement branch to realize accurate positioning and fluctuation tracking of a layered interface; the attention mechanism dynamically adjusts the bimodal weight, and completes multi-index cooperative tracking in combination with a partitioning strategy and an improved network; a crystal growth model is introduced to correct particle weight, a tracking effect is optimized by adopting layered resampling, and a closed-loop feedback mechanism of a crystal state and process parameters is established. All technical means are deeply coordinated, intelligent and accurate management and control of the whole extraction process are achieved, and reliable technical support is provided for artemisinin extraction production.

The invention discloses a polymer composite material based on artemisinin modification, which is characterized in that the polymer composite material comprises organic silicon polyurethane modified by an artemisinin compound and organic silicon polyurea, and the mass ratio of the organic silicon polyurethane modified by the artemisinin compound to the organic silicon polyurea is (2-1): (1-2). The coating is high in hardness, good in mechanical performance, low in elastic modulus, good in stain removal effect and good in adhesion performance, can be stably attached to a substrate and is not prone to falling off, meanwhile, has an excellent antibacterial effect, is not prone to being hydrolyzed by water in seawater or air in the using process on the premise that all the conditions are met, is good in water resistance and can be widely applied to the field of water treatment. Therefore, the long-term stability of the composite coating is ensured, the comprehensive performance of the coating can be comprehensively improved, and the marine antifouling coating serving as an environment-friendly marine antifouling coating has a good application prospect.

The invention discloses a method and a control system for extracting active ingredients of sweet wormwood by enzymolysis-gradient combination, and particularly relates to the technical field of plant extraction, a high-sensitivity sensor is used for collecting key parameters in enzymolysis reaction, key process parameter characteristics are extracted from high-dimensional data through principal component analysis and a clustering algorithm, and the active ingredients of the sweet wormwood are extracted; establishing a reaction mode library of different extraction risk scores, and identifying an abnormal reaction mode causing artemisinin extraction; evaluating and extracting a risk score in real time by combining real-time and historical data based on a machine learning model, and triggering early warning when the risk exceeds a preset threshold value; the intelligent feedback and prevention and control module applies a control algorithm, automatically adjusts reaction conditions according to risk scores, and forms closed-loop feedback; the concentration and efficiency of artemisinin are monitored in real time through an online high performance liquid chromatography or mass spectrometry system, a verification result is fed back to the extraction risk prediction model, and the system performance is continuously optimized.

The fine sand supply equipment for artemisinin extraction and impurity removal comprises a sand box and a discharging hopper, the lower end of the sand box is provided with a collecting mechanism, the collecting mechanism comprises a mounting frame, the mounting frame is fixedly connected to the lower end of the sand box, the discharging hopper is fixedly connected to the lower end of the mounting frame, the lower end of the discharging hopper is fixedly connected with a connecting pipe, and the connecting pipe is fixedly connected with the sand box. One end of the connecting pipe is fixedly provided with an air blower, and the other end of the connecting pipe is fixedly connected with a conveying pipe. According to the artemisinin extraction device, the screening mechanism is arranged, so that the screening box can reciprocate, large-particle impurities and sand grains which do not meet requirements in sand can be efficiently removed in combination with the design of a screen, the purity of fine sand is remarkably improved, the impurity removal effect of artemisinin extraction is optimized, the efficiency and quality of the whole extraction process are improved, and the production cost is reduced. And due to the design of the turnover mechanism, the screening box can be automatically turned over after screening is completed, and impurities and large sand grains accumulated in the screening box can be conveniently cleaned.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

The formula comprises the following raw materials in parts by weight: 70-85 parts of base liquor, 5-15 parts of fresh pandan leaves, 0.5-3 parts of baked pandan leaf powder, 1-3 parts of a flavor modifier, 3-8 parts of a sugar source and 0.1-0.6 part of a functional additive. The unique flavor of the pandan leaves originates from the rich 2-acetyl-1-pyrroline, and the pandan leaves give out charming rice dumpling fragrance and have the effects of promoting appetite and metabolism at the same time. The pandan leaves are blended into the food, so that the delicious taste is improved, and additional nutritional value is also brought. The pandan leaves are rich in dietary fibers, vitamin B family, vitamin C and various minerals. The composition also contains squalene, linoleic acid, estragole, phytol and other active ingredients. Squalene is a natural organic terpenoid, widely exists in a living body, and has remarkable effects in the aspects of promoting blood circulation, resisting oxidation, resisting inflammation, resisting tumors and the like. The prepared pandan wine has multiple effects and is beneficial to body health after being drunk for a long time.

The invention discloses a compound containing an artemisinin similar structure or a pharmaceutical salt thereof, and the structural general formula is as follows: # imgabs0. The compound containing the artemisinin similar structure, provided by the invention, has a relatively obvious proliferation inhibition effect on solid tumor cells such as lung cancer A549, colon cancer HCT116 and liver cancer HepG2; wherein the high-activity compound has an excellent proliferation inhibition effect on leukemia cells HL-60 and MV4-11, is better than a marketed drug SAHA, and can be used as an anti-tumor candidate drug for deeper research.

The invention belongs to the field of plant biotechnology and medicinal plant cultivation, and relates to application of melatonin in artemisinin biosynthesis and a method for increasing the content of artemisinin in artemisia apiacea. The melatonin is applied to the artemisia apiacea plants, the content of artemisinin in the artemisia apiacea is increased, and compared with an existing method, the method is more economical and efficient.

The present invention provides a medical image segmentation method and system for chronic obstructive pulmonary disease, belonging to the field of medical image processing, including obtaining a chronic obstructive pulmonary disease image and converting it into a grayscale image, performing a non-local means filtering operation on the grayscale image to obtain a filtered image; constructing a corresponding two-dimensional histogram based on the filtered image and the grayscale image; introducing an adaptive transfer strategy and a spiral motion operator into the artemisinin algorithm to obtain an improved artemisinin algorithm; using Renyi entropy as the objective and the improved artemisinin algorithm as the search method to perform threshold search to obtain the optimal segmentation threshold combination; segmenting the chronic obstructive pulmonary disease image according to the optimal segmentation threshold combination and outputting the segmentation result. It provides accurate technical support for the early diagnosis of chronic obstructive pulmonary disease.

The present application discloses a use of an endoperoxy compound in the preparation of an antimicrobial pathogenic bacteria drug. Under anaerobic conditions, in the culture medium of Mycobacterium tuberculosis, the representative artemisinin-based drug of the endoperoxy compound can partially and effectively inhibit the survival of Mycobacterium tuberculosis. The present application also discloses a use of an endoperoxy compound in combination with a respiratory chain inhibitor in the preparation of an antimicrobial pathogenic bacteria drug. Under normal and anaerobic conditions, in the culture medium of Mycobacterium tuberculosis, the endoperoxy compound and a variety of respiratory chain inhibitors have a synergistic effect, and the combined use has a more effective inhibitory effect on Mycobacterium tuberculosis. The endoperoxy compounds include artemisinin and its derivatives, as well as other endoperoxy compounds with a double oxygen bridge structure, which may have a similar mechanism of action, and the internal oxygen bridge is the key group for them to play a role. The present application aims to kill pathogens more quickly or effectively, improve the cure efficiency or shorten the course of treatment, overcome the problem of drug resistance, and reduce the amount of drugs to reduce side effects on patients by introducing endoperoxy compounds represented by artemisinin as drugs.

The invention discloses an artemisinin component compounded periodontal pathogenic bacterium inhibition balance agent, and relates to the technical field of dental bacterium inhibitors, and the main components of the periodontal pathogenic bacterium inhibition balance agent comprise modified porous corn starch, chitosan and artemisinin. According to the artemisinin component compounded periodontal pathogenic bacterium inhibition balance agent, the porous corn starch has a porous structure and a large specific surface area, and after the porous corn starch is modified by octenyl succinic anhydride, the structural characteristic is still kept, so that harmful substances such as bacteria and toxins in the oral cavity can be adsorbed, and the number of periodontal pathogenic bacteria in the oral cavity is reduced; meanwhile, the modified porous corn starch is used as a carrier of the antibacterial component, and the antibacterial component can be well loaded on the starch, so that the antibacterial component can be continuously and slowly released in the oral cavity environment, the inhibition effect on periodontal pathogenic bacteria is maintained for a long time, and all the antibacterial components are not completely released at a time.

The invention provides an artemisinin analogue compound containing a hydroxamic acid structure or a medicinal salt thereof as well as a preparation method and application of the artemisinin analogue compound. The structural formula of the artemisinin analogue compound is shown as a formula I in the specification. The compound has a brand new skeleton structure and excellent anti-tumor activity, and can be used for preparing anti-tumor drugs.

The present invention discloses an artemisinin PROTACs, a preparation method and application thereof, wherein the structural formula is: The present invention uses artemisinin modified product artesunate as POI ligand, lenalidomide and pomalidomide as E3 ligands, and linkers selected from amino acid chains, PEG chains and fatty chains. The anticancer activity thereof is superior to that of artesunate, and the present invention has good potential application prospects in anticancer drugs and treatment of critical malaria.

The invention discloses a targeted protein degradation agent taking an artemisinin analogue as a hydrophobic label as well as a preparation method and application of the targeted protein degradation agent. The structural formula of the targeted protein degradation agent is shown as a formula (II), a formula (III) or a formula (IV). The targeted protein degradation agent disclosed by the invention has the activity of inhibiting human breast cancer cells and also has good degradation activity. The targeted protein degradation agent can also be used for preparing drugs for targeted degradation of estrogen receptors or anti-breast cancer drugs.

The utility model belongs to the technical field of vacuum drying ovens, particularly relates to an artemisinin double-cone vacuum drying oven, and provides the following scheme aiming at the problems that in the using process of an existing double-cone vacuum drying oven, materials are inconvenient to scatter, the materials cannot be prevented from being adhered to the inner wall of the oven, and the drying effect of the materials is affected. The device comprises a base; the number of the vertical plates is two, and the two vertical plates are fixedly installed on the top of the base; the number of the connecting pipes is two, the two connecting pipes are rotationally installed on the two vertical plates correspondingly, and one ends of the two connecting pipes are connected with the same drying oven body; according to the material scattering device, in the using process, materials can be scattered conveniently, the materials can be prevented from being stuck to the inner wall of the drying oven, then the material drying effect can be effectively guaranteed, and the material scattering device is simple in structure and convenient to use.

The invention belongs to the technical field of biological nano-drugs, and discloses an extracellular vesicle-artesunate conjugate, a preparation method and application of the extracellular vesicle-artesunate conjugate in skin drugs. The structure of the conjugate comprises an extracellular vesicle, a Linker fragment and artesunate. According to the method, extracellular vesicle surface active groups and a unique chemical structure of artesunate are fully considered, a proper Linker fragment is successfully designed and optimized, a proper connection strategy and a proper biological site are selected, and the advantages of mild conditions, no toxicity, high efficiency, simplicity and convenience in operation and the like of a biological orthogonal reaction are utilized; the artesunate is coupled with a specific active functional group on the surface of an extracellular vesicle lipid membrane through Linker, so that the extracellular vesicle-artesunate conjugate is successfully prepared. The biochemical coupling process has the advantages that the loading efficiency is high, the morphology, membrane structure and lipid membrane surface protein markers of the extracellular vesicles are not influenced, and the basic biological functions of the extracellular vesicles are maintained.

The invention discloses a chiral amino alcohol modified artemisinin derivative as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the present invention, the alkali is adopted as the catalyst, the esterification reaction of the artesunate and the chiral amino alcohol is achieved for the first time, a series of the brand new derivatives simultaneously containing the artemisinin structure unit and the chiral amino alcohol structure unit are constructed, the synthesis path of the artemisinin derivative is expanded, and the research blank in the field is filled. The preparation method is novel, simple to operate, free of complex equipment, mild in reaction condition, high in reaction rate and high in yield, provides a new candidate compound for developing efficient and low-toxicity antitumor drugs, and has important clinical application value and market prospect.

The invention belongs to the technical field of biological medicine, and particularly relates to a rheumatism immune disease treatment composition combining traditional Chinese medicine active ingredients and immune regulation and application of the rheumatism immune disease treatment composition, and the rheumatism immune disease treatment composition comprises the following components in parts by weight: 10-50 parts of a traditional Chinese medicine active ingredient compound; 0.01 to 1 part of an immune regulation factor; 50 to 90 parts of pharmaceutic adjuvants; wherein the traditional Chinese medicine active component compound is prepared from the following components: astragaloside, artemisinin, curcumin and triptolide in a weight ratio of (2-5): (1-3): (1-4): (0.5-2); the immunoregulation factor is composed of recombinant human interleukin-10 (rhIL-10), a transforming growth factor-beta1 (TGF-beta1) and a CTLA4-Ig fusion protein according to a weight ratio of (1-3): (0.5-2): (1-4). The active ingredients of the traditional Chinese medicine cover a plurality of links of anti-inflammation, anti-oxidation, immunoregulation and the like, and immunoregulatory factors accurately intervene in immune cell activation and a cell factor network to jointly inhibit abnormal immune response.

The invention relates to an artemisinin derivative. The artemisinin derivative has at least one structural formula shown in the following formula: # imgabs0 #. According to the invention, indole iodized salt molecules are used as targets to construct tumor-targeted mitochondria, so that tumor-targeted delivery of artemisinin drugs is realized. According to the invention, the artemisinin is connected through Cy7, so that the targeting property and the bioavailability of the artemisinin are improved, and the anti-tumor effect of the artemisinin is improved.

The present invention provides an antimalarial composition comprising arjunetin and artemisinin. The composition exhibits synergistic antimalarial effect against malaria causing Plasmodium species including Plamsodium falciparum, P berghe species. The composition comprising Arjunetin and Artemisinin demonstrated potent antimalarial activity in vivo and in vitro with better survival and low parasite burden in the blood.

The invention relates to a preparation process of an artemisinin-metal organic framework composite bone hydatid resistant sustained release microsphere, which comprises the four steps of material preparation, artemisinin-metal organic framework compound preparation, sustained release microsphere preparation and post-treatment and characterization, the preparation process of the artemisinin-metal organic framework composite bone hydatid resistant sustained release microsphere comprises the following steps: selecting a UI0-66 material; according to the artemisinin emulsion, the structure can be kept intact for 28 days under the physiological condition, TPGS is adopted as a compound stabilizer, the metal organic framework is pretreated, and TPGS is added into a water phase and an oil phase in the emulsification stage, so that the molecular diffusion coefficient of artemisinin is reduced to 1 / 5, the binding capacity of the metal organic framework and artemisinin is improved by 2.3-2.5 times, the cell intake is increased, and the stability of the artemisinin emulsion is improved. The TPGS is preferentially explained in an enzymolysis environment, a time-dependent release channel is formed, and the stability problem of the artemisinin is solved.

The invention discloses a novel oil-soluble micelle preparation. The component A comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, cardiolipin, cephalin and dipalmitoyl phosphatidylcholine, and the component B comprises lecithin, soya bean lecithin, egg yolk lecithin, 1-palmitoyl-2-oleoyl lecithin, phosphatidylserine, phosphatidylinositol, phosphatidyl glycerol, phosphatidylcholine, cephalin and dipalmitoyl phosphatidylcholine; one or more of dipalmitoyl phosphatidyl ethanolamine and dipalmitoyl phosphatidyl ethanolamine; the component B comprises a component B1 and a component B2, and the component B1 comprises one or more of phytosterol, cholesterol, ergosterol, protopanoxadiol, protopanaxatriol, ganoderic acid, phytol, isophytol, retinol, andrographolide, paclitaxel, artemisinin and bisabolol; and the component B2 is prepared from one or more of 1, 2-hexanediol, ethylhexylglycerin, cyclohexyl glycerin, absolute ethyl alcohol and isosorbide dimethyl ether. The key point of the invention is to provide a low-cost formula and a low-cost preparation method for preparing the oil-soluble micelle preparation.

This invention proposes an auxiliary system for artemisinin extraction, comprising a processor and a memory. The processor acquires dynamic data, static data, and parameter data affecting extraction efficiency and purity at each node during the artemisinin extraction process, generating multidimensional feature data. The dynamic data includes real-time dynamic data of each node at different time points during the artemisinin extraction process, and the static data includes the geometry, capacity, weight, and volume of each node. The nodes are arranged according to the order of the artemisinin extraction process to obtain a node sequence. Node discrimination coefficients are initialized, and the node discrimination coefficients are weights of the parameters affecting extraction efficiency and purity. The node discrimination coefficients are trained and updated to obtain a discrimination threshold. Abnormal nodes are identified based on the comparison between the discrimination threshold and the node discrimination coefficients, and the real-time dynamic data, static data, and corresponding parameter data affecting extraction efficiency and purity of the abnormal nodes are used as the first type of data.

The invention provides a method for separating and purifying kaempferol from an artemisia apiacea byproduct, and belongs to the field of natural product separation engineering. The method for separating and purifying kaempferol from the artemisia apiacea byproduct comprises the following steps: 1, extracting the artemisia apiacea byproduct by adopting an organic solvent 1, filtering, and concentrating filtrate to constant weight to obtain a concentrate 1; the artemisia apiacea byproduct does not contain artemisinin; 2, dissolving the concentrate 1 with an organic solvent 2, extracting with an alkaline solution, and concentrating an organic phase layer to obtain a concentrate 2; 3, carrying out column chromatography separation on the concentrate 2 by using an organic solvent 3 as an eluent, and concentrating the eluent to obtain crude kaempferol; and 4, recrystallizing the crude kaempferol by using an organic solvent 4 to obtain purified kaempferol. According to the method, extraction, column chromatography and recrystallization processes are combined, the process is simple, the artemisia apiacea extract residues obtained after artemisinin is extracted are used as raw materials, the method can be seamlessly connected with a production line for industrially extracting artemisinin, and the cost is saved.

The invention relates to the technical field of medicines, in particular to application of artemisia vulgaris in preparation of an anti-depression medicine. According to the application disclosed by the invention, the depression is systematically researched through a chronic depression model induced by chronic unpredictable mild stress (CUMS) and an acute depression model induced by lipopolysaccharide (LPS). Experimental results show that under the stimulation of CUMS or LPS, experimental animals show obvious depression-like behaviors. Compared with a negative control group, depression-like behaviors of mice in the CUMS model group and the LPS model group are confirmed, and behavior abnormalities induced by the two models can be effectively improved after intervention of the artemisinin. Further comparative research finds that the antidepressant effect of the clinically common antidepressant drug venlafaxine with the dosage of 10 mg / kg can be achieved under the dosage of 1 mg / kg of the artemisinin, and the artemisinin has remarkable antidepressant activity. The application has a good application prospect when being applied to the development of anti-depression drugs.

Provided are an artemisinin derivative and a preparation method and use thereof. A structural formula of the artemisinin derivative is shown in Formula I. The compound has suitable solubility and is relatively stable under storage conditions. Pharmacokinetic experiments on the compound have shown that artemisinin is detectable in ocular tissues and is present in cornea, conjunctiva, and aqueous humor at a relatively high drug concentration. The compound is therefore an excellent precursor to artemisinin. The compound shown in Formula I exhibits remarkable absorbability, and the drug concentration in the ocular tissues indicates that the compound is well absorbed. The compound exhibits significantly better inhibitory effects on neovascularization in burn models than artemisinin, and can be prepared into liquid formulations such as eye drops, injection, etc., for treatment of ocular tissue diseases.

The present invention relates to an artemisinin derivative having at least one of the following structural formulas: [The text then abruptly shifts topics.] This invention uses indole iodide as a target to construct tumor-targeted mitochondria, achieving tumor-targeted delivery of artemisinin-based drugs. This invention uses Cy7 to link artemisinin, improving its targeting and bioavailability, and enhancing its anti-tumor effects.

The invention relates to the technical field of medicine and chemical industry, and discloses an artemisinin C-16 aromatic amine derivative and a preparation method and application thereof, the structural general formula of the artemisinin C-16 aromatic amine derivative is as shown in the formula (1): imgabs0 #, r1 is one of 4-(tert-butyl) benzenesulfonyl, 4-chlorobenzenesulfonyl, 4-fluorobenzenesulfonyl, 4-(trifluoromethyl) benzenesulfonyl, cyclopropyl sulfonyl, cyclopropane formyl, 4-methyl benzoyl, isoquinoline-5-sulfonyl, 4-hydroxybenzenesulfonyl and 6-chloronicotinoyl, and R2 is one of 4-(tert-butyl) benzenesulfonyl, 4-chlorobenzenesulfonyl, 4-fluorobenzenesulfonyl, 4-(trifluoromethyl) benzenesulfonyl, cyclopropyl sulfonyl, cyclopropane formyl, 4-methyl benzoyl, isoquinoline-5-sulfonyl, 4- And n is 1 or 2. According to the artemisinin C-16 site aromatic amine derivative disclosed by the invention, a specific aromatic amide group is introduced to a C-16 site, so that a novel derivative is prepared. The artemisinin C-16 aromatic amine derivative disclosed by the invention has antitumor activity, and a new strategy is provided for chemical research and development of novel artemisinin derivatives and cancer treatment.

Disclosed are artemisinin derivatives, a method for producing the same, and uses thereof. The structural formula of the artemisinin derivative is represented by Formula I. The compound has appropriate solubility, is relatively stable under storage conditions, and according to pharmacokinetic experiments, artemisinin is detected in eye tissues, and is distributed in the cornea, conjunctiva, and aqueous humor, and it has been shown that it can reach a high drug concentration, and it is an excellent artemisinin prodrug. The compound of Formula I has remarkable absorbability, shows high absorbability of drug concentration in eye tissues, and has a significantly better inhibitory effect on neovascularization in a burn model than artemisinin. It is manufactured into liquid preparations such as eye drops and injection solutions, and can be used to treat eye tissue diseases. 【Chemical 1】 TIFF2025518413000019.tif43170

The invention provides a medical image segmentation method and system for a chronic obstructive pulmonary disease, and belongs to the field of medical image processing, and the method comprises the steps: obtaining a chronic obstructive pulmonary disease image, converting the chronic obstructive pulmonary disease image into a gray image, carrying out the non-local mean filtering operation of the gray image, and obtaining a filtered image; constructing a corresponding two-dimensional histogram based on the filtered image and the gray level image; a self-adaptive transmission strategy and a spiral motion operator are introduced into an artemisinin algorithm, and an improved artemisinin algorithm is obtained; taking the Renyi entropy as a target, taking an improved artemisinin algorithm as a search method, and carrying out threshold search to obtain an optimal segmentation threshold combination; and segmenting the chronic obstructive pulmonary disease image according to the optimal segmentation threshold combination, and outputting a segmentation result. And accurate technical support is provided for early diagnosis of the chronic obstructive pulmonary disease.