Medicinal composition and injecta for curing avian toxoplasmosis, and preparation method thereof

Abstract

The invention relates to a medicinal composition and injecta for curing avian toxoplasmosis, and a preparation method thereof. The medicinal composition comprises the following components in percentage by weight: 18 to 36 percent of sulfamonomethoxine, 16 to 65 percent of sulfamethoxazole, 7 to 18 percent of trimethoprim, 4 to 14 percent of pyrimethamine and 6 to 16 percent of nonsteroidal anti-inflammatory medicament. The injecta comprises the following components in percentage by weight: 5 to 10 percent of sulfamonomethoxine, 4 to 20 percent of sulfamethoxazole, 2 to 5 percent of trimethoprim, 1 to 3 percent of pyrimethamine, 1.5 to 4 percent of nonsteroidal anti-inflammatory medicament, 5 to 10 percent of polyethyleneglycol-400, 10 to 30 percent of propylene glycol, 30 to 60 percent of alpha-pyrrolidone, 0.1 to 0.2 percent of antioxidant, 0.01 to 0.02 percent of metal complexing agent and the balance of water for injection. Sulfamonomethoxine, sulfamethoxazole, trimethoprim and pyrimethamine are jointly applied and a long-acting preparation is prepared by adopting composite solvent, so that the medicinal composition and the injecta can prevent the secondary infection of other pathogen at the same time of destroying and expelling toxoplasma so as to relieve different symptoms and complicating diseases caused by the toxoplasma.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating toxoplasmosis in livestock. Background technique [0002] Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. It has a wide range of hosts and can infect most hosts including humans. Toxoplasma gondii is an obligate intracellular parasite, which can infect various cells of vertebrates, multiply in the cells, and finally destroy the host cells and release parasites, leading to a series of pathological changes. In the body with normal immune function, it is mostly recessive infection. If the body's immune function is impaired, the recessive infection can cause acute attack and endanger life. The entire development process of Toxoplasma gondii requires two hosts, cats are the final host, and more than 200 species of intermediate hosts are currently known, including mammals, birds, reptiles, fis...

AI Technical Summary

Problems solved by technology

[0007] At present, the routine treatment of toxoplasmosis generally adopts oral sulfa drugs, pyrimethamine, spiramycin and lincomycin, etc., but these drugs have long treatment course, serious side effects, unsatisfactory curative effect, and cannot cure And other issues

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