Medicinal composition and injecta for curing avian toxoplasmosis, and preparation method thereof

A technology of toxoplasmosis and composition, which is applied in the field of veterinary drugs, can solve the problems of large toxic and side effects, unsatisfactory curative effect, and inability to cure, and achieve the effects of low toxic and side effects, alleviating high fever symptoms, and preventing secondary infection

Inactive Publication Date: 2010-09-01
HENAN HUITONGTIANXIA ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the routine treatment of toxoplasmosis generally adopts oral sulfa drugs, pyrimethamine, spiramycin and lincomycin, etc., but these drugs have long treatment course, serious side effects, unsatisfactory curative effect, and cannot cure And other issues

Method used

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  • Medicinal composition and injecta for curing avian toxoplasmosis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0045] Sulfamethoxine 18%

[0046] Sulfamethoxazole 55%

[0047] Trimethoprim 7%

[0048] Pyrimethamine 14%

[0049] Diclofenac Sodium 6%.

[0050] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0051] Sulfamethoxine 5%

[0052] Sulfamethoxazole 15%

[0053] Trimethoprim 2%

[0054] Pyrimethamine 3%

[0055] Diclofenac Sodium 1.5%

[0056] Polyethylene Glycol-400 5%

[0057] Propylene Glycol 20%

[0058] Alpha-Pyrrolidone 45%

[0059] Sodium sulfite 0.1%

[0060] Disodium EDTA 0.01%

[0061] The balance is water for injection.

[0062] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0063] (1) Heat the mixed solution of polyethylene glycol-400, propylene...

Embodiment 2

[0067] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0068] Sulfamethoxine 20%

[0069] Sulfamethoxazole 52%

[0070] Trimethoprim 8%

[0071] Pyrimethamine 13%

[0072] Aspirin 7%.

[0073] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0074] Sulfamethoxine 5.5%

[0075] Sulfamethoxazole 14.5%

[0076] Trimethoprim 2.2%

[0077] Pyrimethamine 3%

[0078] Aspirin 2%

[0079] Polyethylene glycol-400 6%

[0080] Propylene Glycol 22%

[0081] Alpha-Pyrrolidone 35%

[0082] Sodium bisulfite 0.11%

[0083] Disodium EDTA 0.02%

[0084] The balance is water for injection.

[0085] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0086] (1) Heat the mixed solution of polyethylene glycol-400, propylene glycol and α...

Embodiment 3

[0090] 1. The pharmaceutical composition for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0091] Sulfamethoxine 22%

[0092] Sulfamethoxazole 55%

[0093] Trimethoprim 9%

[0094] Pyrimethamine 6%

[0095] Magnesium Salicylate 8%.

[0096] 2. The injection for the treatment of livestock toxoplasmosis consists of the following components by weight percentage:

[0097] Sulfamethoxine 6%

[0098] Sulfamethoxazole 15%

[0099] Trimethoprim 2.5%

[0100] Pyrimethamine 1.6%

[0101] Magnesium Salicylate 2.2%

[0102] Polyethylene glycol-400 7%

[0103] Propylene Glycol 24%

[0104] Alpha-Pyrrolidone 40%

[0105] Sodium metabisulfite 0.12%

[0106] Disodium EDTA 0.02%

[0107] The balance is water for injection.

[0108] 3. The preparation method of the injection for the treatment of livestock toxoplasmosis is carried out according to the following steps:

[0109] (1) Heat the mixed solution of polyethylene glyco...

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Abstract

The invention relates to a medicinal composition and injecta for curing avian toxoplasmosis, and a preparation method thereof. The medicinal composition comprises the following components in percentage by weight: 18 to 36 percent of sulfamonomethoxine, 16 to 65 percent of sulfamethoxazole, 7 to 18 percent of trimethoprim, 4 to 14 percent of pyrimethamine and 6 to 16 percent of nonsteroidal anti-inflammatory medicament. The injecta comprises the following components in percentage by weight: 5 to 10 percent of sulfamonomethoxine, 4 to 20 percent of sulfamethoxazole, 2 to 5 percent of trimethoprim, 1 to 3 percent of pyrimethamine, 1.5 to 4 percent of nonsteroidal anti-inflammatory medicament, 5 to 10 percent of polyethyleneglycol-400, 10 to 30 percent of propylene glycol, 30 to 60 percent of alpha-pyrrolidone, 0.1 to 0.2 percent of antioxidant, 0.01 to 0.02 percent of metal complexing agent and the balance of water for injection. Sulfamonomethoxine, sulfamethoxazole, trimethoprim and pyrimethamine are jointly applied and a long-acting preparation is prepared by adopting composite solvent, so that the medicinal composition and the injecta can prevent the secondary infection of other pathogen at the same time of destroying and expelling toxoplasma so as to relieve different symptoms and complicating diseases caused by the toxoplasma.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a pharmaceutical composition, an injection and a preparation method thereof for treating toxoplasmosis in livestock. Background technique [0002] Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. It has a wide range of hosts and can infect most hosts including humans. Toxoplasma gondii is an obligate intracellular parasite, which can infect various cells of vertebrates, multiply in the cells, and finally destroy the host cells and release parasites, leading to a series of pathological changes. In the body with normal immune function, it is mostly recessive infection. If the body's immune function is impaired, the recessive infection can cause acute attack and endanger life. The entire development process of Toxoplasma gondii requires two hosts, cats are the final host, and more than 200 species of intermediate hosts are currently known, including mammals, birds, reptiles, fis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/505A61K45/00A61K31/196A61P33/02A61K47/10A61K47/22A61K9/08A61J3/00
Inventor 张要齐张新蕾孙雪峰朱静静
Owner HENAN HUITONGTIANXIA ANIMAL MEDICINE
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