278 results about "Sulfanilamide" patented technology

The invention discloses a preparation method of a high-dispersion and high-thermal-conductivity filler based on carbon black, and relates to the technical field of carbon black modification, and the preparation method specifically comprises the following steps: treating carbon black in a first acid solution to obtain activated carbon black; treating the single-walled carbon nanotube in a second acid solution to obtain an activated single-walled carbon nanotube; treating the activated single-walled carbon nanotube with a sulfanilamide solution to obtain a functionalized single-walled carbon nanotube; placing the graphene nanosheets in a third acid solution for treatment to obtain activated graphene nanosheets; the preparation method comprises the following steps: mixing amino silane hydrolysate and epoxy silane hydrolysate, adding activated carbon black, functionalized single-walled carbon nanotubes and activated graphene nanosheets, and treating to obtain a pre-modified filler; amino acid and a cross-linking agent are pre-polymerized to obtain an amino acid pre-polymerized solution, and the pre-modified filler is treated by the amino acid pre-polymerized solution to obtain the high-dispersion and high-thermal-conductivity filler. The method disclosed by the invention is simple to operate and low in energy consumption, the prepared filler is good in thermal conductivity and good in dispersity in a polymer matrix, and the thermal conductivity and the mechanical property of a polymer are greatly improved.

The invention relates to the technical field of solid waste treatment, in particular to a method for removing antibiotics and resistance genes in aerobic composting of chicken manure. Comprising the following steps: adding a composting auxiliary material into chicken manure to enable the carbon-nitrogen ratio to be (25-30): 1, and adjusting the initial moisture content to 55-65% to obtain an initial composting material; adding persulfate and zero-valent iron into the initial compost material, and uniformly mixing; loading the mixed material into a container for composting; during the composting period, stirring is performed regularly, and the aerobic composting time is 30-40 days. The method has the advantages that the persulfate advanced oxidation technology and the aerobic composting technology are combined, the potassium persulfate and the zero-valent iron are added to serve as the aerobic composting additive, the zero-valent iron can continuously activate the potassium persulfate, persulfate free radicals and hydroxyl free radicals are generated, and removal of antibiotics and antibiotic resistance genes is promoted; high-concentration oxytetracycline, sulfamethoxazole and ciprofloxacin in the chicken manure are effectively removed; and the abundance of antibiotic resistance genes with high risk levels is obviously reduced.

The invention provides a preparation method of an iron and nitrogen co-doped biomass-based carbon material, which can be applied to the technical fields of environmental functional materials and advanced oxidation. The preparation method comprises the following steps: obtaining target charcoal precursor powder; mixing the charcoal precursor powder with soluble ferric salt and urea to form initial mixed powder, adding water into the initial powder, and drying after water bath to obtain mixed powder; and heating and calcining the mixed powder according to preset process parameters to obtain the iron and nitrogen co-doped biomass-based carbon material. The prepared iron and nitrogen co-doped biomass-based carbon material FeOx has a high specific surface area and a rich pore structure, FeOx is uniformly dispersed on a nitrogen-doped carbon substrate, ozone catalytic activity and electron conduction performance are improved, and reactive oxygen species (ROS) can be efficiently generated to degrade sulfamethoxazole.

The invention discloses anti-cracking concrete and a preparation method thereof, and the anti-cracking concrete is prepared from the following raw materials in parts by weight: 400-450 parts of cement, 600-700 parts of fine aggregate, 900-1000 parts of gravel, 70-80 parts of a composite additive, 30-40 parts of modified fiber, 4-5 parts of a water reducing agent and 160-180 parts of water, the composite additive is prepared from fly ash, modified sepiolite, calcium sulphoaluminate and an air entraining agent; the modified sepiolite is obtained by taking sepiolite as a raw material, pretreating the sepiolite through a silane coupling agent and then sequentially reacting the pretreated sepiolite with sulfanilamide and dodecyl chloride. According to the invention, through the synergistic effect of the composite additive and the modified fiber, the comprehensive improvement of the crack resistance and mechanical strength of the concrete is realized, in the composite additive, the moderate expansion of calcium sulphoaluminate compensates the early shrinkage stress, the microbubble system formed by the air entraining agent relieves the stress concentration, and the dispersion effect of the polycarboxylate superplasticizer is matched, so that the crack resistance and mechanical strength of the concrete are improved. The hardened body forms a compact and uniform microstructure, and the tensile strength of the concrete is improved.

The invention provides application of sulfasalazine and a combined drug thereof in drug-resistant head and neck malignant tumors, which comprises the following steps: when the sulfasalazine is independently used, the sulfasalazine has a treatment effect on the drug-resistant head and neck malignant tumors and can delay the growth of the drug-resistant head and neck malignant tumors; combined use of sulfasalazine and chemotherapeutic drugs has a synergistic effect, and the sulfasalazine can be used for treating drug-resistant head and neck malignant tumors. The technical problem to be solved by the invention is to explore the drug activity of sulfasalazine in the treatment of drug-resistant head and neck malignant tumors and solve the limitation of drug resistance to treatment in the drug treatment process.

The invention relates to a microbial fuel cell and application thereof, in particular to a photocatalytic / microbial coupled anode microbial fuel cell and application thereof in enhanced degradation of sulfamethoxazole. Aiming at the degradation treatment of typical refractory antibiotics such as sulfamethoxazole, the invention provides a photocatalytic / microbial coupled anode microbial fuel cell which can induce a photo-generated hole generated by a photocatalyst through a biological electric field generated by microbial degradation of pollutants, thereby promoting the separation of photo-generated electron hole pairs of the photocatalyst, and further improving the degradation efficiency of the antibiotics. The problem that photo-generated electron hole pairs of a photocatalyst are easy to compound is solved. Meanwhile, due to the existence of the photocatalyst, the electron transfer between the anode electroactive microorganisms and the anode can be improved through the generation of photo-generated holes, and the extracellular electron transfer of the microorganisms is enhanced. When being used for degrading sulfamethoxazole, the photocatalytic / microbial coupled anode microbial fuel cell disclosed by the invention has an extremely important scientific research value and a wide practical application prospect.

The invention discloses a ZIF-based catalytic ceramic membrane, a preparation method and application of the ZIF-based catalytic ceramic membrane in water treatment, and belongs to the technical field of environmental functional materials and membrane separation. According to the method, a bimetallic precursor solution and an organic ligand solution are adopted, ZIF crystals grow on a ceramic membrane in situ, and then the ZIF-based catalytic ceramic membrane with Co-Co metallic bond and Co-N coordination double active sites is prepared through high-temperature pyrolysis and acid pickling treatment. The prepared ZIF-based catalytic ceramic membrane has high porosity (the specific surface area is greater than or equal to 360 m < 2 > / g) and strong binding force, can stably operate for 3720 minutes or more in a continuous flow reaction, has a removal rate of up to 90% for electronic-enriched pollutants such as sulfamethoxazole and the like, and can resist water quality interference. The process is simple, active sites are controllable, and the method is suitable for high-efficiency low-consumption treatment of industrial wastewater.

The present invention discloses a method for degrading sulfamethoxazole using QXT-31-Mn, which belongs to the field of sewage treatment technology. QXT-31-Mn was deposited with the General Microbiology Center of the China Culture Collection Administration on December 3, 2024, with the deposit number CGMCC No. 32889 and the deposit address at No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The taxonomic name is Arthrobacter sp. The present invention utilizes QXT-31-Mn to produce a safer and more environmentally friendly cathode material that can efficiently degrade SMX.

The invention is suitable for the technical field of fine chemical engineering, and provides a synthesis method of sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide, which comprises the following specific steps: Step 1, taking salicylic acid as a raw material, taking DMF as a catalyst, and carrying out acylation reaction with thionyl chloride to obtain acylation liquid, and entering the next process; 2, ammoniating the acylation liquid with ammonia water at a low temperature to obtain salicylic acid formamide, and drying to obtain an intermediate 1; 3, TMS-Cl is used for protecting phenolic hydroxyl groups, then chlorosulfonic acid is dropwise added, a chlorosulfonation reaction is carried out, and an intermediate 2 solution is obtained after the reaction is completed; and Step 4, dropwise adding the solution of the intermediate 2 into stronger ammonia water for reaction, carrying out suction filtration, and recrystallizing with ethanol to obtain the sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide. The route synthesis is simple, and the quality can reach 95% or above; in addition, the method has the advantages of cheap and easily available raw materials, mild reaction conditions, low energy consumption, simple process structure, easy operation and the like.

Disclosed is a new pharmaceutical composition for oral administration containing sulfasalazine and / or a sulfasalazine organic salt, production processes and uses, in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and / or the gastro-intestinal tract.

The invention relates to the technical field of biological sewage treatment, and particularly discloses a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Bioreactor) membrane. The invention provides a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Biological Reactor) membrane, which comprises the following steps of: performing directional domestication and toxicity screening on activated sludge through COD (Chemical Oxygen Demand) gradient increase and decrease and removal rate control, and constructing a microbial community resistant to sulfamethoxazole impact; further, a compound bacteria solution composed of marine Arfiv bacteria and Rhodopseudomonas faecalis is introduced, so that synergistic degradation of high COD and sulfamethoxazole is realized under a proper pH condition, and the COD removal rate is still kept at a relatively high level when the concentration is increased; and the tail end is matched with MBR membrane separation, and efficient biodegradation and efficient solid-liquid separation are coupled, so that the sulfamethoxazole and COD in the wastewater are efficiently removed under the conditions of low drug consumption and near neutrality.

The present invention discloses an anti-sulfadiazine nano-antibody and its application, belonging to the field of nano-antibody technology. In order to provide a nano-antibody for detecting sulfadiazine that has a small molecular weight, strong penetrating power, good stability, strong antigen binding ability, and can recognize antigen epitopes that are difficult for conventional antibodies to recognize. The present invention provides a nano-antibody for detecting sulfadiazine, the amino acid sequence of CDR1 of the variable region of the nano-antibody is shown as SEQ ID NO.6, the amino acid sequence of CDR2 of the variable region of the nano-antibody is shown as SEQ ID NO.7, and the amino acid sequence of CDR3 of the variable region of the nano-antibody is shown as SEQ ID NO.8. The indirect competitive ELISA method established by the present invention is a simple, rapid, sensitive, and low-cost immunoassay method, which has great application prospects in the detection of sulfadiazine residues in animal-derived foods.

The invention discloses a sulfaguanidine modified inorganic tin-based perovskite light-emitting diode and a preparation method thereof, and belongs to the field of luminescent material preparation, the preparation method comprises the following steps: preparing a perovskite precursor solution which comprises cesium iodide, stannous iodide, sulfaguanidine and an organic solvent; applying the perovskite precursor solution to a substrate to form a wet film; carrying out annealing treatment on the wet film so as to form a perovskite light-emitting layer containing CsSnI3 perovskite and sulfaguanidine; a hole transport layer is formed on an anode conductive substrate, and a perovskite light-emitting layer is adopted on the hole transport layer; and sequentially forming an electron transport layer, an electron injection layer and a cathode electrode on the perovskite light-emitting layer. The process is simple and suitable for popularization and application.

The application relates to the technical field of high polymer materials, and discloses a phosphorus-containing flame-retardant epoxy resin and a preparation method thereof, which comprises the following components by weight: 50-65 parts of bisphenol A type epoxy resin, 4-6 parts of phosphorus-containing modified benzimidazole, 2-3 parts of epoxy-based sulfanilamide thiazole and 2-4 parts of m-phenylenediamine curing agent. The bisphenol A type epoxy resin is added into a stirrer, heated, and then the phosphorus-containing modified benzimidazole and the epoxy-based sulfanilamide thiazole are continuously added into the stirrer; after cooling, the m-phenylenediamine curing agent is continuously added into the stirrer, and then curing is carried out, so that the phosphorus-containing flame-retardant epoxy resin is obtained. The phosphorus-containing flame-retardant epoxy resin has good flame-retardant effect.

The utility model relates to the technical field of medicine raw material crushing and screening devices, and discloses a raw material crushing and screening device for compound sulfamonomethoxine sodium, which comprises a crushing mechanism, a primary screening mechanism arranged at the bottom end of the crushing mechanism and used for primarily screening the compound sulfamonomethoxine sodium raw material, and a secondary screening mechanism arranged at the bottom end of the crushing mechanism, a secondary screening mechanism used for conducting secondary screening on the compound sulfamonomethoxine sodium raw materials is arranged in the box body. The raw material of the compound sulfamonomethoxine sodium is crushed by arranging the crushing mechanism, and the crushed raw material of the compound sulfamonomethoxine sodium is primarily screened by arranging the primary screening mechanism; the secondary screening mechanism is arranged to conduct secondary screening on the raw materials of the compound sulfamonomethoxine sodium subjected to primary screening, and the function of conducting multiple times of screening on the raw materials of the compound sulfamonomethoxine sodium is achieved.

The invention provides a preparation method of a compound sulfonamide medicinal preparation. The compound sulfonamide medicinal preparation contains a premix prepared from sulfadiazine, sulfamethoxazole, trimethoprim, sodium bicarbonate and a slow-release coating medium. Compared with sulfadiazine, sulfamethoxazole and trimethoprim preparations, the sodium bicarbonate coated compound is high in bioavailability, and after the sodium bicarbonate coated compound is added, caking in urine can be remarkably reduced, and the stability of the preparation is not affected.

The present invention discloses a preparation method of a highly dispersed and highly thermally conductive filler based on carbon black, which relates to the technical field of carbon black modification. Specifically, the method includes: treating carbon black in a first acid solution to obtain activated carbon black; treating single-walled carbon nanotubes in a second acid solution to obtain activated single-walled carbon nanotubes; treating the activated single-walled carbon nanotubes with a sulfanilamide solution to obtain functionalized single-walled carbon nanotubes; treating graphene nanosheets in a third acid solution to obtain activated graphene nanosheets; mixing an amino-silane hydrolysis solution and an epoxy-silane hydrolysis solution, and adding the activated carbon black, the functionalized single-walled carbon nanotubes, and the activated graphene nanosheets for treatment to obtain a pre-modified filler; pre-polymerizing an amino acid and a cross-linking agent to obtain an amino acid prepolymer solution, and treating the pre-modified filler with the amino acid prepolymer solution to obtain a highly dispersed and highly thermally conductive filler. The method of the present invention is simple to operate and has low energy consumption. The prepared filler has good thermal conductivity and good dispersibility in a polymer matrix, greatly improving the thermal conductivity and mechanical properties of the polymer.

The invention discloses a preparation method of a floating type cocatalyst and application of the floating type cocatalyst in Fenton reaction. Nano tungsten sulfide prepared by a hydrothermal method and graphene oxide prepared by a Harmer method are used as raw materials, and the floating type cocatalyst is synthesized by a simple impregnation method. The prepared cocatalyst (MS-WS2-GO) can effectively promote the circulation rate of Fe < 3 + > / Fe < 2 + >, the cocatalysis Fenton-like system can achieve the removal effect of 90% or above on organic pollutants in water only under the condition that 0.5 mM H2O2 and 20 mg / L FeSO47H2O are added, and the system does not generate iron mud. The MS-WS2-GO / Fenton small-scale test system constructed by the invention is continuously operated for 31 days, and the degradation rate of sulfamethoxazole is still kept to be 100% or above. The preparation process of the floating type cocatalyst is mild in condition, simple and convenient to operate and easy to implement.

This invention discloses a method for extracting the intermediate ACH, belonging to the field of fine chemicals. The method involves passing a layered acid containing acesulfame potassium (DCM) and a dichloromethane solution into a rotary extraction tower for extraction. The temperature of the layered acid entering the tower is 30-31°C. The extraction pressure and the temperature of the dichloromethane entering the tower are controlled. The extracted dichloromethane layer enters a vibrating extraction tower for back-extraction with deionized water. The back-extracted DCM is neutralized, concentrated, crystallized, and dried to obtain the finished product, potassium acesulfame potassium. Using this method, the ACH content in the extracted acid is reduced to below 0.1%, and the ACH extraction yield reaches over 98%. Because the rotary extraction tower effectively reduces the acid carryover in the DCM, it lowers the back-extraction load, ensuring the product quality of potassium acesulfame potassium. Simultaneously, it simplifies the process conditions, reduces energy consumption, and saves production costs.

Composition including an artificial sweetener (e.g. ace-K, saccharin, sucralose, cyclamate, sugar alcohol (e.g. xylitol, mannitol, sorbitol, erythritol, maltitol, lactitol)) or a derivative thereof in

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

The invention belongs to the technical field of antibiotic wastewater treatment, and particularly relates to a Z-type CdWO4 / Bi2WO6 catalyst as well as a preparation method and application thereof. The catalyst is formed by loading CdWO4 particles on a Bi2WO6 nanosheet unit. The Z-type CdWO4 / Bi2WO6 catalyst is prepared by adopting a hydrothermal process, the photo-generated charge separation efficiency and the sulfadiazine degradation rate of the catalyst are remarkably improved through energy band structure regulation and interface optimization, and meanwhile, the catalyst has excellent structural stability and recycling performance. The Z-type heterojunction is constructed by accurately controlling integration of CdWO4 and a Bi2WO6 substrate, and the Z-type CdWO4 / Bi2WO6 catalyst is high in light adsorption capacity, high in electron hole separation efficiency, stable in material structure, fast in photon-generated carrier transmission and capable of effectively inhibiting recombination of photon-generated carriers.

This application discloses a cobalt-supported peanut shell biochar / peracetic acid synergistic system for water treatment and its application. The synergistic system includes cobalt-supported peanut shell biochar, peracetic acid, and water. The cobalt-supported peanut shell biochar comprises a peanut shell biochar matrix and cobalt-containing substances supported on the matrix. The cobalt-containing substances include metallic cobalt and / or cobalt oxides. The mass ratio of cobalt-supported peanut shell biochar to peracetic acid is (2-132):1. The atomic ratio of cobalt to carbon in the matrix is ​​(0.2-0.3):1. The cobalt-supported peanut shell biochar has a mesoporous structure with a total pore volume of not less than 0.07 cm³ / g and a specific surface area of ​​not less than 100 m². 2 / g. When this synergistic system is used to treat water containing organic pollutants, especially sulfamethoxazole, it can achieve a removal rate of over 90% within 3-5 minutes. The system maintains high activity and good stability over a wide pH range and in the presence of common anions, exhibiting excellent continuous operation performance. The degradation pathway of this synergistic system is environmentally friendly and can effectively reduce the toxicity of the products.

This invention provides a combination for use in treating cancers that express prostate-specific membrane antigen (PSMA). [Solution] A combination comprising a PD-1 inhibitor, a CTLA-4 inhibitor, and a radiolabeled compound of formula Ia for use in treating PSMA-expressing cancer in the subject. JPEG2026049728000042.jpg45132 The aforementioned combination comprises one or more further anticancer agents, wherein the further anticancer agents are selected from octreotide, lanreotide, vapreotide, pasireotide, satreotide, everolimus, temozolomide, telotristat, sunitinib, sulfatinib, ribociclib, entinostat, and pazopanib.

The invention provides a preparation method of Bainapenem. The preparation method comprises the following steps: by taking 5-N-(4-nitrocarbobenzoxy)-2-thia-5-azabicyclo [2.2. 1] hept-3-one (1) and sulfamirone acetate (2) as initial raw materials, carrying out condensation reaction to form a compound (3); and then combining with MAP (4) to form an important intermediate compound (5). And carrying out hydrogenation reaction deprotection on the compound (5) to obtain the besipenem. The method is short in synthetic route, mild and controllable in reaction condition, safe and reliable in operation process and suitable for industrial production.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of sulfaguanidine. The invention provides a preparation method of sulfaguanidine, which comprises the following steps: mixing p-acetamidobenzene sulfonyl chloride, guanidine salt, strong base and ketone solvent for the first time, and then carrying out condensation reaction to obtain sulfaguanidine; mixing acetylsulfaguanidine with water for the second time, then adjusting the pH value to 8-9, and adding amide hydrolase for hydrolysis to obtain sulfaguanidine. According to the preparation method provided by the invention, a biological enzyme method is introduced for hydrolysis, so that the hydrolysis efficiency is high, the product conversion rate is high, the enzyme can be repeatedly recycled, the mother liquor is simple in component, can be directly recycled and reused, is simple to treat, and does not cause pressure to environmental protection; the raw materials are cheap and easy to obtain, the preparation cost is low, the reaction conditions are mild, the operation is simple and convenient, and industrial safe production is facilitated; the sulfaguanidine prepared by the preparation method provided by the invention has relatively high purity and relatively high yield.

The present application relates to the application of sulfasalazine combined with lactate dehydrogenase inhibitor in preparing the inhibition of TIF1 gamma lactic acid product, belongs to the field of biological medicine technology. The present application finds that sulfasalazine can block the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma (TIF1 gamma), and the combination of sulfasalazine and lactate dehydrogenase inhibitor can strengthen the block of the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma, improve the expression level of TIF1 gamma, and then improve the treatment effect on TIF1 gamma related cancer.

The invention discloses a bacteriostatic light cage for light-controlled rapid release of sulfadiazine, a preparation method and application thereof, and the bacteriostatic light cage is based on a light-controlled release system of a Sanger reagent, and realizes efficient space-time release and targeted antibiosis of SD. The light-operated bacteriostatic light cage capable of rapidly releasing sulfadiazine, disclosed by the invention, has sulfadiamidine-2, 4-dinitrobenzene derivative # imgabs0 # with a structure as shown in a formula SD-Py-N < + >

The invention discloses a hydrogen phagocystis strain SNF1, which belongs to the field of wastewater treatment, the hydrogen phagocystis strain SNF1 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.35006, and the preservation date is June 25, 2025; the invention further discloses a fermentation compound, the fermentation compound is used for removing sulfamethoxazole in wastewater, and the compound comprises the hydrogen phagocystis strain SNF1 and microalgae; the invention further discloses a method for removing sulfamethoxazole in wastewater, and the hydrophage strain SNF1 is used in the method.