137 results about "Sulfanilamide" patented technology

The invention relates to the technical field of biological sewage treatment, and particularly discloses a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Bioreactor) membrane. The invention provides a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Biological Reactor) membrane, which comprises the following steps of: performing directional domestication and toxicity screening on activated sludge through COD (Chemical Oxygen Demand) gradient increase and decrease and removal rate control, and constructing a microbial community resistant to sulfamethoxazole impact; further, a compound bacteria solution composed of marine Arfiv bacteria and Rhodopseudomonas faecalis is introduced, so that synergistic degradation of high COD and sulfamethoxazole is realized under a proper pH condition, and the COD removal rate is still kept at a relatively high level when the concentration is increased; and the tail end is matched with MBR membrane separation, and efficient biodegradation and efficient solid-liquid separation are coupled, so that the sulfamethoxazole and COD in the wastewater are efficiently removed under the conditions of low drug consumption and near neutrality.

The invention discloses a sulfaguanidine modified inorganic tin-based perovskite light-emitting diode and a preparation method thereof, and belongs to the field of luminescent material preparation, the preparation method comprises the following steps: preparing a perovskite precursor solution which comprises cesium iodide, stannous iodide, sulfaguanidine and an organic solvent; applying the perovskite precursor solution to a substrate to form a wet film; carrying out annealing treatment on the wet film so as to form a perovskite light-emitting layer containing CsSnI3 perovskite and sulfaguanidine; a hole transport layer is formed on an anode conductive substrate, and a perovskite light-emitting layer is adopted on the hole transport layer; and sequentially forming an electron transport layer, an electron injection layer and a cathode electrode on the perovskite light-emitting layer. The process is simple and suitable for popularization and application.

The application relates to the technical field of high polymer materials, and discloses a phosphorus-containing flame-retardant epoxy resin and a preparation method thereof, which comprises the following components by weight: 50-65 parts of bisphenol A type epoxy resin, 4-6 parts of phosphorus-containing modified benzimidazole, 2-3 parts of epoxy-based sulfanilamide thiazole and 2-4 parts of m-phenylenediamine curing agent. The bisphenol A type epoxy resin is added into a stirrer, heated, and then the phosphorus-containing modified benzimidazole and the epoxy-based sulfanilamide thiazole are continuously added into the stirrer; after cooling, the m-phenylenediamine curing agent is continuously added into the stirrer, and then curing is carried out, so that the phosphorus-containing flame-retardant epoxy resin is obtained. The phosphorus-containing flame-retardant epoxy resin has good flame-retardant effect.

The utility model relates to the technical field of medicine raw material crushing and screening devices, and discloses a raw material crushing and screening device for compound sulfamonomethoxine sodium, which comprises a crushing mechanism, a primary screening mechanism arranged at the bottom end of the crushing mechanism and used for primarily screening the compound sulfamonomethoxine sodium raw material, and a secondary screening mechanism arranged at the bottom end of the crushing mechanism, a secondary screening mechanism used for conducting secondary screening on the compound sulfamonomethoxine sodium raw materials is arranged in the box body. The raw material of the compound sulfamonomethoxine sodium is crushed by arranging the crushing mechanism, and the crushed raw material of the compound sulfamonomethoxine sodium is primarily screened by arranging the primary screening mechanism; the secondary screening mechanism is arranged to conduct secondary screening on the raw materials of the compound sulfamonomethoxine sodium subjected to primary screening, and the function of conducting multiple times of screening on the raw materials of the compound sulfamonomethoxine sodium is achieved.

The invention provides a preparation method of a compound sulfonamide medicinal preparation. The compound sulfonamide medicinal preparation contains a premix prepared from sulfadiazine, sulfamethoxazole, trimethoprim, sodium bicarbonate and a slow-release coating medium. Compared with sulfadiazine, sulfamethoxazole and trimethoprim preparations, the sodium bicarbonate coated compound is high in bioavailability, and after the sodium bicarbonate coated compound is added, caking in urine can be remarkably reduced, and the stability of the preparation is not affected.

The invention discloses a preparation method of a floating type cocatalyst and application of the floating type cocatalyst in Fenton reaction. Nano tungsten sulfide prepared by a hydrothermal method and graphene oxide prepared by a Harmer method are used as raw materials, and the floating type cocatalyst is synthesized by a simple impregnation method. The prepared cocatalyst (MS-WS2-GO) can effectively promote the circulation rate of Fe < 3 + > / Fe < 2 + >, the cocatalysis Fenton-like system can achieve the removal effect of 90% or above on organic pollutants in water only under the condition that 0.5 mM H2O2 and 20 mg / L FeSO47H2O are added, and the system does not generate iron mud. The MS-WS2-GO / Fenton small-scale test system constructed by the invention is continuously operated for 31 days, and the degradation rate of sulfamethoxazole is still kept to be 100% or above. The preparation process of the floating type cocatalyst is mild in condition, simple and convenient to operate and easy to implement.

This invention discloses a method for extracting the intermediate ACH, belonging to the field of fine chemicals. The method involves passing a layered acid containing acesulfame potassium (DCM) and a dichloromethane solution into a rotary extraction tower for extraction. The temperature of the layered acid entering the tower is 30-31°C. The extraction pressure and the temperature of the dichloromethane entering the tower are controlled. The extracted dichloromethane layer enters a vibrating extraction tower for back-extraction with deionized water. The back-extracted DCM is neutralized, concentrated, crystallized, and dried to obtain the finished product, potassium acesulfame potassium. Using this method, the ACH content in the extracted acid is reduced to below 0.1%, and the ACH extraction yield reaches over 98%. Because the rotary extraction tower effectively reduces the acid carryover in the DCM, it lowers the back-extraction load, ensuring the product quality of potassium acesulfame potassium. Simultaneously, it simplifies the process conditions, reduces energy consumption, and saves production costs.

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

This application discloses a cobalt-supported peanut shell biochar / peracetic acid synergistic system for water treatment and its application. The synergistic system includes cobalt-supported peanut shell biochar, peracetic acid, and water. The cobalt-supported peanut shell biochar comprises a peanut shell biochar matrix and cobalt-containing substances supported on the matrix. The cobalt-containing substances include metallic cobalt and / or cobalt oxides. The mass ratio of cobalt-supported peanut shell biochar to peracetic acid is (2-132):1. The atomic ratio of cobalt to carbon in the matrix is ​​(0.2-0.3):1. The cobalt-supported peanut shell biochar has a mesoporous structure with a total pore volume of not less than 0.07 cm³ / g and a specific surface area of ​​not less than 100 m². 2 / g. When this synergistic system is used to treat water containing organic pollutants, especially sulfamethoxazole, it can achieve a removal rate of over 90% within 3-5 minutes. The system maintains high activity and good stability over a wide pH range and in the presence of common anions, exhibiting excellent continuous operation performance. The degradation pathway of this synergistic system is environmentally friendly and can effectively reduce the toxicity of the products.

This invention provides a combination for use in treating cancers that express prostate-specific membrane antigen (PSMA). [Solution] A combination comprising a PD-1 inhibitor, a CTLA-4 inhibitor, and a radiolabeled compound of formula Ia for use in treating PSMA-expressing cancer in the subject. JPEG2026049728000042.jpg45132 The aforementioned combination comprises one or more further anticancer agents, wherein the further anticancer agents are selected from octreotide, lanreotide, vapreotide, pasireotide, satreotide, everolimus, temozolomide, telotristat, sunitinib, sulfatinib, ribociclib, entinostat, and pazopanib.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of sulfaguanidine. The invention provides a preparation method of sulfaguanidine, which comprises the following steps: mixing p-acetamidobenzene sulfonyl chloride, guanidine salt, strong base and ketone solvent for the first time, and then carrying out condensation reaction to obtain sulfaguanidine; mixing acetylsulfaguanidine with water for the second time, then adjusting the pH value to 8-9, and adding amide hydrolase for hydrolysis to obtain sulfaguanidine. According to the preparation method provided by the invention, a biological enzyme method is introduced for hydrolysis, so that the hydrolysis efficiency is high, the product conversion rate is high, the enzyme can be repeatedly recycled, the mother liquor is simple in component, can be directly recycled and reused, is simple to treat, and does not cause pressure to environmental protection; the raw materials are cheap and easy to obtain, the preparation cost is low, the reaction conditions are mild, the operation is simple and convenient, and industrial safe production is facilitated; the sulfaguanidine prepared by the preparation method provided by the invention has relatively high purity and relatively high yield.

The present application relates to the application of sulfasalazine combined with lactate dehydrogenase inhibitor in preparing the inhibition of TIF1 gamma lactic acid product, belongs to the field of biological medicine technology. The present application finds that sulfasalazine can block the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma (TIF1 gamma), and the combination of sulfasalazine and lactate dehydrogenase inhibitor can strengthen the block of the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma, improve the expression level of TIF1 gamma, and then improve the treatment effect on TIF1 gamma related cancer.

The invention discloses a hydrogen phagocystis strain SNF1, which belongs to the field of wastewater treatment, the hydrogen phagocystis strain SNF1 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.35006, and the preservation date is June 25, 2025; the invention further discloses a fermentation compound, the fermentation compound is used for removing sulfamethoxazole in wastewater, and the compound comprises the hydrogen phagocystis strain SNF1 and microalgae; the invention further discloses a method for removing sulfamethoxazole in wastewater, and the hydrophage strain SNF1 is used in the method.

The utility model relates to the related technical field of veterinary drug processing equipment, and provides an efficient crushing unit for processing sulfachlorpyridazine sodium, which comprises an equipment frame and a grinding roller, the grinding roller is arranged in the equipment frame, a door-shaped frame is fixed at the top of the equipment frame, a first crushing assembly is arranged between the door-shaped frame and the equipment frame, and a second crushing assembly is arranged between the equipment frame and the door-shaped frame. The driving and grinding assembly is arranged between the equipment frame and the grinding roller, the smashing assembly comprises a feeding cover, the feeding cover is connected to the top of the equipment frame, a driving motor is installed at the top of the n-shaped frame, a driving shaft is arranged at the output end of the driving motor, and the driving shaft is slidably connected with a smashing tool rest in a sleeving mode. By means of the technical scheme, the problems that in the prior art, a crusher only conducts primary crushing, particles are not uniform after crushing, crushing is not thorough, secondary treatment is needed, the treatment process is increased, and the efficiency is reduced are solved.

The present application belongs to the technical field of herbicide safener, and particularly relates to the use of chlorindole hydrazide as a herbicide safener, chlorindole hydrazide as a safener of nicosulfuron, carfentrazone-ethyl, benzenesulfonamide and quizalofop-p-ethyl, which can relieve or eliminate the crop phytotoxicity caused by the above herbicides, and is applied after or before the crop phytotoxicity is caused. The application amount of chlorindole hydrazide (converted into the original drug) is 1-2 g / mu, the mass concentration of chlorindole hydrazide is 0.00667-0.01333% when applied, and a very good control effect can be achieved.

The utility model relates to a sulfadiazine wastewater treatment system which comprises a wastewater storage tank used for storing wastewater to be treated; the resin towers are communicated with the wastewater storage tank and are used for carrying out decoloration treatment on the wastewater and adsorbing sulfadiazine in the wastewater; the centrifugal pump is communicated with the resin tower through a three-way valve; the anaerobic tank is communicated with the centrifugal pump, and a stirrer is arranged in the anaerobic tank; the ozone reaction tank is communicated with the anaerobic tank, and an aeration structure is arranged in the ozone reaction tank; the ozone generation assembly is communicated with the aeration structure and is used for conveying generated ozone to the aeration structure; the flocculation tank is communicated with the ozone reaction tank; and the sedimentation tank is communicated with the flocculation tank. The sulfadiazine wastewater can be subjected to decoloration, adsorption, anaerobic treatment and ozone decomposition, and qualified discharge of the wastewater is realized.

The utility model relates to a sodium sulfadiazine dispersing stirrer which comprises a stirring mechanism and a lifting mechanism, the lifting mechanism is connected with the stirring mechanism, and the lifting mechanism is used for driving the stirring mechanism to lift up and down in the vertical direction while the stirring mechanism works; the stirring mechanism comprises a first driving motor, a rotating rod and a stirring rotating wheel, one end of the rotating rod and the stirring rotating wheel are fixedly installed together, and the first driving motor drives the rotating rod to rotate, so that the first driving motor drives the stirring rotating wheel to rotate.

The present application belongs to the technical field of wastewater treatment, and particularly relates to a seawater breeding wastewater antibiotic removal method based on oyster shell composite filler. Fine gravel, oyster shell and functional mineral are compounded in a fixed volume ratio of 2:1:1, and are laid in a structure with a limited particle size range and homogeneity without stratification. A salinity-directed salt-tolerant domestication process and a tidal intermittent operation mode of 48h hydraulic retention + 24h emptying and reoxygenation are matched, and salt-tolerant functional bacterial flora of Proteobacteria, Paracoccus and Shigella are enriched. The present application can adapt to a wide range of salinity conditions of 10‰-30‰, relieve high salt inhibition and ion competition, simultaneously and efficiently remove three typical antibiotics of conventional pollutants, sulfamethoxazole, trimethoprim and enrofloxacin, and reduce resistance genes. The sulfamethoxazole removal rate can reach 93.94% under the condition of 30‰ high salinity, the system runs stably and has strong adaptability, and has certain engineering application value and large-scale popularization potential in the field of seawater breeding wastewater treatment.

The invention discloses a hydrophilic chromatographic stationary phase simply modified by polyethyleneimine and carbon dots as well as a preparation method and application of the hydrophilic chromatographic stationary phase, and belongs to the technical field of high performance liquid chromatography separation. The preparation method of the stationary phase comprises the following steps: preparing carboxyl carbon dots by taking citric acid as a carbon source through a pyrolysis method; the preparation method comprises the following steps: dispersing acidified bare silica gel, polyethyleneimine and carboxyl carbon dots in an ethanol-water solution in proportion to form a uniform system; and then carrying out physical coating through two-step heating reflux under the protection of nitrogen, and finally washing and drying to obtain the product. The complex silica gel alkylation step is omitted, and the process is simple, green and environmentally friendly. The surface of the prepared stationary phase is provided with cation sites provided by polyethyleneimine and anion sites provided by carboxyl carbon dots, so that a multiple hydrophilic and ionic interaction mechanism is formed, and more than thirty polar compounds, including nucleoside / basic groups, sulfanilamide, antibiotics, alkaloids, flavones, amino acids and saccharides, can be subjected to efficient baseline separation; the method has important application value in the fields of drug analysis, environment detection and the like.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

This invention provides the application of indexsulfanilamide in the preparation of drugs for the prevention and / or treatment of multiple myeloma, belonging to the field of oncology drug technology. Indexsulfanilamide exhibits significant anti-multiple myeloma effects in various multiple myeloma cell lines, primary cells, and multiple myeloma mouse models, and inhibits tumor growth in multiple myeloma mice while demonstrating good safety. Furthermore, the combination of indexsulfanilamide and bortezomib produces a synergistic effect, suggesting that indexsulfanilamide has a promising therapeutic prospect for multiple myeloma.

The present invention belongs to the technical field of analytical chemistry. Specifically disclosed are a magnetic fluorescent gold nanocluster molecularly imprinted polymer, a preparation method therefor, and use thereof in sulfadiazine fluorescence detection. The surface of a Fe3O4 nanoparticle is coated with a silica shell layer, and the shell layer is subjected to surface modification and then combined with gold nanoclusters (AuNCs). On this basis, the molecular imprinting technology is employed, wherein sulfadiazine (SD) is selected to serve as a template molecule, and a mixed silane coupling agent (APTES) is used as a functional monomer to coat the surface of Fe3O4@SiO2@AuNCs with a molecular imprinting layer, thus preparing a magnetic fluorescent gold nanocluster imprinted polymer Fe3O4@SiO2@AuNCs-MIPs. The present invention, by integrating the magnetic separation technology, the high selectivity, simplicity, and rapidity of the molecularly imprinted polymer, and the high sensitivity of fluorescence detection, enables accurate and specific recognition of sulfadiazine and can be effectively applied to the analysis and detection of sulfadiazine.

The invention discloses a carbon-based bimetallic catalyst for an electro-Fenton system, a preparation method of the carbon-based bimetallic catalyst and application of the carbon-based bimetallic catalyst to treatment of sulfadiazine (SDZ) and COD in water by an electro-Fenton process. The preparation method comprises the following steps: 1, mixing zinc nitrate, 2-methylimidazole and two different metal precursors with a methanol solution, stirring, carrying out hydrothermal treatment, centrifugally washing the product, and drying to obtain the bimetal organic framework material. And 2, calcining the bimetallic organic framework material in an inert atmosphere, cooling, and grinding to obtain the carbon-based bimetallic catalyst.

A strain of antibiotic-resistant marine heterotrophic ammonia assimilation-aerobic denitrifying bacteria and its application, belongs to the field of water treatment of aquaculture. The seawater antibiotic-resistant high-efficiency nitrogen removal Marinobacter nitratireducens LAN01 can use polyhydroxyalkanoate as the sole carbon source, and can realize heterotrophic ammonia assimilation and aerobic denitrification function under the stress of different concentrations of sulfamethoxazole antibiotics, and simultaneously transform phosphate. The strain has multiple resistances such as high salinity, high alkalinity and antibiotic, and can be used for seawater aquaculture effluent treatment, seawater recirculating aquaculture water treatment, high-salinity wastewater treatment and saline-alkali soil bioremediation, etc. To realize the simultaneous recovery of nitrogen, phosphorus and other nutrients in the seawater aquaculture environment.

The application discloses an electro-enhanced activation persulfate oxidation method for removing organic pollutants with low consumption through cooperation of anode and cathode, uses LaCoO3 modified Ti4O7 active electrochemical film rich in oxygen vacancy as an anode, and uses in-situ grown nano-carbon modified carbon felt as a cathode to construct an anode-cathode cooperative activation persulfate system, achieves 100% removal of sulfamethoxazole within 37.3 seconds, and the energy consumption is only 0.0015 kWh / m 3 ·order. The technology meets the demand of high flux (1061 L / m 2 ·h) for complete degradation of pollutants, and can also realize deep mineralization (89%) of pollutants at slightly lower flux (212.22 L / m 2 ·h). Compared with the prior art, the bipolar activation persulfate system of the application has the characteristics of significantly improving the space-time efficiency by using bipolar multi-active sites, solving the problems of low wastewater treatment capacity, poor mineralization and high energy consumption of the single-pole system, and efficiently treating actual marine aquaculture wastewater and domestic sewage. The application has excellent pollutant removal and mineralization efficiency, wide pH application range, good stability, long service life, and wide application prospect.

This application discloses a method to solubilize poorly soluble drugs in a liquid crystal vehicle for long-acting injectables. Poorly soluble acidic drugs-hydrophobic basic compounds ion pairs are incorporated into liquid crystal vehicles to solubilize and slowly release the drug after parenteral administration. Ion pairs such as Meloxicam-Dodecylamine, Sulfadiazine-Dodecylamine, Methotrexate-Dodecylamine, Levothyroxine-Dodecylamine, Meloxicam-Tridodecylamine, and Meloxicam-Bupivacaine are incorporated into liquid crystal vehicles to solubilize and control release the drugs.

The invention discloses a series connection synthesis method of 3, 4, 5-trimethoxy benzaldehyde. The 3, 4, 5-trimethoxybenzaldehyde is an important medicine and fine chemical engineering intermediate, and can be used for synthesizing a sulfanilamide synergist trimethoprim and an anti-cancer drug etoposide. According to the invention, 3, 5-dibromo-4-hydroxybenzaldehyde is taken as a raw material, a sodium methoxide-methanol solution is taken as a methoxylation reagent, dimethyl carbonate is taken as a methylation reagent, and tandem synthesis of 3, 4, 5-trimethoxybenzaldehyde is realized by adding a plurality of catalysts under normal pressure. The method does not need to separate a reaction intermediate or use a high-pressure reaction container, and has the advantages of simplicity, convenience and safety in operation, low reagent toxicity, higher yield, short reaction time and the like.

The application discloses a compound enrofloxacin injection, which contains 10-25g of enrofloxacin, 2-10g of sulfadimoxine sodium, 5-12g of florfenicol, 0.5-2.5g of bromhexine hydrochloride, 1-20g of glacial acetic acid, 2-5g of Tween 80, 5-15g of alpha-pyrrolidone and 5-20g of N, N-dimethylformamide per 100ml of the injection, and the rest is water for injection. The compound enrofloxacin injection has advanced and reasonable prescription design, stable and reliable preparation process, good preparation stability and small irritation, and can achieve the effect of treating all samples for respiratory system diseases of livestock and poultry.

The invention discloses a method for enhancing removal of high-concentration antibiotics by a three-dimensional electrode coupled sulfur-mediated biological system. The three-dimensional electrode structure is composed of a two-dimensional electrode and pig manure biochar, when the three-dimensional electrode structure is combined with a sulfur-mediated sewage biological treatment system for use, enrichment of functional microorganisms can be promoted, electron transfer and synergistic metabolism among the functional microorganisms can be improved, efficient synergistic removal of COD-sulfate-ammonia nitrogen-sulfamethoxazole can be promoted, and the effect of removing the COD-sulfate-ammonia nitrogen-sulfamethoxazole can be achieved. And a new technology is provided for treatment of wastewater containing carbon, nitrogen, sulfur and antibiotics. Especially in deep treatment of high-concentration antibiotics and pharmaceutical wastewater, the coupling technology can realize efficient removal of pollutants and long-term stable operation of the system, and a technical path with innovativeness and application potential is provided for treatment of complex refractory wastewater.

The invention belongs to the technical field of materials and advanced oxidation, and particularly relates to a phenanthroline-containing pyrenyl 2D covalent organic framework material as well as a preparation method and application thereof, and the covalent organic framework material is synthesized by taking 1, 3, 6, 8-tetra-(p-aminophenyl)-pyrene and 4, 4 '-(1, 10-phenanthroline-3, 8-diyl) dibenzaldehyde as precursors through Schiff base condensation reaction. According to the COFs material synthesized by the invention, on the basis of containing phenanthroline, by increasing benzene rings, regulation and control on covalent organic framework electron delocalization on the molecular level are realized, so that the capability of activating PMS to degrade organic pollutants is enhanced, and the COFs material is suitable for not only the organic pollutant bisphenol A, but also the organic pollutant PMS. The COFs prepared by the method also has an excellent degradation effect on other organic pollutants such as sulfadiazine and atrazine, and in addition, the COFs also has good cycle stability and does not generate secondary pollution.