213 results about "Sulfanilamide" patented technology

The invention provides a preparation method of an iron and nitrogen co-doped biomass-based carbon material, which can be applied to the technical fields of environmental functional materials and advanced oxidation. The preparation method comprises the following steps: obtaining target charcoal precursor powder; mixing the charcoal precursor powder with soluble ferric salt and urea to form initial mixed powder, adding water into the initial powder, and drying after water bath to obtain mixed powder; and heating and calcining the mixed powder according to preset process parameters to obtain the iron and nitrogen co-doped biomass-based carbon material. The prepared iron and nitrogen co-doped biomass-based carbon material FeOx has a high specific surface area and a rich pore structure, FeOx is uniformly dispersed on a nitrogen-doped carbon substrate, ozone catalytic activity and electron conduction performance are improved, and reactive oxygen species (ROS) can be efficiently generated to degrade sulfamethoxazole.

The present invention discloses a method for degrading sulfamethoxazole using QXT-31-Mn, which belongs to the field of sewage treatment technology. QXT-31-Mn was deposited with the General Microbiology Center of the China Culture Collection Administration on December 3, 2024, with the deposit number CGMCC No. 32889 and the deposit address at No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The taxonomic name is Arthrobacter sp. The present invention utilizes QXT-31-Mn to produce a safer and more environmentally friendly cathode material that can efficiently degrade SMX.

The invention relates to the technical field of biological sewage treatment, and particularly discloses a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Bioreactor) membrane. The invention provides a process for combined treatment of antibiotic wastewater by a compound microorganism-MBR (Membrane Biological Reactor) membrane, which comprises the following steps of: performing directional domestication and toxicity screening on activated sludge through COD (Chemical Oxygen Demand) gradient increase and decrease and removal rate control, and constructing a microbial community resistant to sulfamethoxazole impact; further, a compound bacteria solution composed of marine Arfiv bacteria and Rhodopseudomonas faecalis is introduced, so that synergistic degradation of high COD and sulfamethoxazole is realized under a proper pH condition, and the COD removal rate is still kept at a relatively high level when the concentration is increased; and the tail end is matched with MBR membrane separation, and efficient biodegradation and efficient solid-liquid separation are coupled, so that the sulfamethoxazole and COD in the wastewater are efficiently removed under the conditions of low drug consumption and near neutrality.

The present invention discloses an anti-sulfadiazine nano-antibody and its application, belonging to the field of nano-antibody technology. In order to provide a nano-antibody for detecting sulfadiazine that has a small molecular weight, strong penetrating power, good stability, strong antigen binding ability, and can recognize antigen epitopes that are difficult for conventional antibodies to recognize. The present invention provides a nano-antibody for detecting sulfadiazine, the amino acid sequence of CDR1 of the variable region of the nano-antibody is shown as SEQ ID NO.6, the amino acid sequence of CDR2 of the variable region of the nano-antibody is shown as SEQ ID NO.7, and the amino acid sequence of CDR3 of the variable region of the nano-antibody is shown as SEQ ID NO.8. The indirect competitive ELISA method established by the present invention is a simple, rapid, sensitive, and low-cost immunoassay method, which has great application prospects in the detection of sulfadiazine residues in animal-derived foods.

The invention discloses a sulfaguanidine modified inorganic tin-based perovskite light-emitting diode and a preparation method thereof, and belongs to the field of luminescent material preparation, the preparation method comprises the following steps: preparing a perovskite precursor solution which comprises cesium iodide, stannous iodide, sulfaguanidine and an organic solvent; applying the perovskite precursor solution to a substrate to form a wet film; carrying out annealing treatment on the wet film so as to form a perovskite light-emitting layer containing CsSnI3 perovskite and sulfaguanidine; a hole transport layer is formed on an anode conductive substrate, and a perovskite light-emitting layer is adopted on the hole transport layer; and sequentially forming an electron transport layer, an electron injection layer and a cathode electrode on the perovskite light-emitting layer. The process is simple and suitable for popularization and application.

The application relates to the technical field of high polymer materials, and discloses a phosphorus-containing flame-retardant epoxy resin and a preparation method thereof, which comprises the following components by weight: 50-65 parts of bisphenol A type epoxy resin, 4-6 parts of phosphorus-containing modified benzimidazole, 2-3 parts of epoxy-based sulfanilamide thiazole and 2-4 parts of m-phenylenediamine curing agent. The bisphenol A type epoxy resin is added into a stirrer, heated, and then the phosphorus-containing modified benzimidazole and the epoxy-based sulfanilamide thiazole are continuously added into the stirrer; after cooling, the m-phenylenediamine curing agent is continuously added into the stirrer, and then curing is carried out, so that the phosphorus-containing flame-retardant epoxy resin is obtained. The phosphorus-containing flame-retardant epoxy resin has good flame-retardant effect.

The utility model relates to the technical field of medicine raw material crushing and screening devices, and discloses a raw material crushing and screening device for compound sulfamonomethoxine sodium, which comprises a crushing mechanism, a primary screening mechanism arranged at the bottom end of the crushing mechanism and used for primarily screening the compound sulfamonomethoxine sodium raw material, and a secondary screening mechanism arranged at the bottom end of the crushing mechanism, a secondary screening mechanism used for conducting secondary screening on the compound sulfamonomethoxine sodium raw materials is arranged in the box body. The raw material of the compound sulfamonomethoxine sodium is crushed by arranging the crushing mechanism, and the crushed raw material of the compound sulfamonomethoxine sodium is primarily screened by arranging the primary screening mechanism; the secondary screening mechanism is arranged to conduct secondary screening on the raw materials of the compound sulfamonomethoxine sodium subjected to primary screening, and the function of conducting multiple times of screening on the raw materials of the compound sulfamonomethoxine sodium is achieved.

The invention provides a preparation method of a compound sulfonamide medicinal preparation. The compound sulfonamide medicinal preparation contains a premix prepared from sulfadiazine, sulfamethoxazole, trimethoprim, sodium bicarbonate and a slow-release coating medium. Compared with sulfadiazine, sulfamethoxazole and trimethoprim preparations, the sodium bicarbonate coated compound is high in bioavailability, and after the sodium bicarbonate coated compound is added, caking in urine can be remarkably reduced, and the stability of the preparation is not affected.

The invention discloses a preparation method of a floating type cocatalyst and application of the floating type cocatalyst in Fenton reaction. Nano tungsten sulfide prepared by a hydrothermal method and graphene oxide prepared by a Harmer method are used as raw materials, and the floating type cocatalyst is synthesized by a simple impregnation method. The prepared cocatalyst (MS-WS2-GO) can effectively promote the circulation rate of Fe < 3 + > / Fe < 2 + >, the cocatalysis Fenton-like system can achieve the removal effect of 90% or above on organic pollutants in water only under the condition that 0.5 mM H2O2 and 20 mg / L FeSO47H2O are added, and the system does not generate iron mud. The MS-WS2-GO / Fenton small-scale test system constructed by the invention is continuously operated for 31 days, and the degradation rate of sulfamethoxazole is still kept to be 100% or above. The preparation process of the floating type cocatalyst is mild in condition, simple and convenient to operate and easy to implement.

This invention discloses a method for extracting the intermediate ACH, belonging to the field of fine chemicals. The method involves passing a layered acid containing acesulfame potassium (DCM) and a dichloromethane solution into a rotary extraction tower for extraction. The temperature of the layered acid entering the tower is 30-31°C. The extraction pressure and the temperature of the dichloromethane entering the tower are controlled. The extracted dichloromethane layer enters a vibrating extraction tower for back-extraction with deionized water. The back-extracted DCM is neutralized, concentrated, crystallized, and dried to obtain the finished product, potassium acesulfame potassium. Using this method, the ACH content in the extracted acid is reduced to below 0.1%, and the ACH extraction yield reaches over 98%. Because the rotary extraction tower effectively reduces the acid carryover in the DCM, it lowers the back-extraction load, ensuring the product quality of potassium acesulfame potassium. Simultaneously, it simplifies the process conditions, reduces energy consumption, and saves production costs.

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

The invention belongs to the technical field of antibiotic wastewater treatment, and particularly relates to a Z-type CdWO4 / Bi2WO6 catalyst as well as a preparation method and application thereof. The catalyst is formed by loading CdWO4 particles on a Bi2WO6 nanosheet unit. The Z-type CdWO4 / Bi2WO6 catalyst is prepared by adopting a hydrothermal process, the photo-generated charge separation efficiency and the sulfadiazine degradation rate of the catalyst are remarkably improved through energy band structure regulation and interface optimization, and meanwhile, the catalyst has excellent structural stability and recycling performance. The Z-type heterojunction is constructed by accurately controlling integration of CdWO4 and a Bi2WO6 substrate, and the Z-type CdWO4 / Bi2WO6 catalyst is high in light adsorption capacity, high in electron hole separation efficiency, stable in material structure, fast in photon-generated carrier transmission and capable of effectively inhibiting recombination of photon-generated carriers.

This application discloses a cobalt-supported peanut shell biochar / peracetic acid synergistic system for water treatment and its application. The synergistic system includes cobalt-supported peanut shell biochar, peracetic acid, and water. The cobalt-supported peanut shell biochar comprises a peanut shell biochar matrix and cobalt-containing substances supported on the matrix. The cobalt-containing substances include metallic cobalt and / or cobalt oxides. The mass ratio of cobalt-supported peanut shell biochar to peracetic acid is (2-132):1. The atomic ratio of cobalt to carbon in the matrix is ​​(0.2-0.3):1. The cobalt-supported peanut shell biochar has a mesoporous structure with a total pore volume of not less than 0.07 cm³ / g and a specific surface area of ​​not less than 100 m². 2 / g. When this synergistic system is used to treat water containing organic pollutants, especially sulfamethoxazole, it can achieve a removal rate of over 90% within 3-5 minutes. The system maintains high activity and good stability over a wide pH range and in the presence of common anions, exhibiting excellent continuous operation performance. The degradation pathway of this synergistic system is environmentally friendly and can effectively reduce the toxicity of the products.

This invention provides a combination for use in treating cancers that express prostate-specific membrane antigen (PSMA). [Solution] A combination comprising a PD-1 inhibitor, a CTLA-4 inhibitor, and a radiolabeled compound of formula Ia for use in treating PSMA-expressing cancer in the subject. JPEG2026049728000042.jpg45132 The aforementioned combination comprises one or more further anticancer agents, wherein the further anticancer agents are selected from octreotide, lanreotide, vapreotide, pasireotide, satreotide, everolimus, temozolomide, telotristat, sunitinib, sulfatinib, ribociclib, entinostat, and pazopanib.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of sulfaguanidine. The invention provides a preparation method of sulfaguanidine, which comprises the following steps: mixing p-acetamidobenzene sulfonyl chloride, guanidine salt, strong base and ketone solvent for the first time, and then carrying out condensation reaction to obtain sulfaguanidine; mixing acetylsulfaguanidine with water for the second time, then adjusting the pH value to 8-9, and adding amide hydrolase for hydrolysis to obtain sulfaguanidine. According to the preparation method provided by the invention, a biological enzyme method is introduced for hydrolysis, so that the hydrolysis efficiency is high, the product conversion rate is high, the enzyme can be repeatedly recycled, the mother liquor is simple in component, can be directly recycled and reused, is simple to treat, and does not cause pressure to environmental protection; the raw materials are cheap and easy to obtain, the preparation cost is low, the reaction conditions are mild, the operation is simple and convenient, and industrial safe production is facilitated; the sulfaguanidine prepared by the preparation method provided by the invention has relatively high purity and relatively high yield.

The present application relates to the application of sulfasalazine combined with lactate dehydrogenase inhibitor in preparing the inhibition of TIF1 gamma lactic acid product, belongs to the field of biological medicine technology. The present application finds that sulfasalazine can block the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma (TIF1 gamma), and the combination of sulfasalazine and lactate dehydrogenase inhibitor can strengthen the block of the lactic acidification of the 763th and 769th lysine of transcription intermediate factor 1 gamma, improve the expression level of TIF1 gamma, and then improve the treatment effect on TIF1 gamma related cancer.

The invention discloses a hydrogen phagocystis strain SNF1, which belongs to the field of wastewater treatment, the hydrogen phagocystis strain SNF1 is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.35006, and the preservation date is June 25, 2025; the invention further discloses a fermentation compound, the fermentation compound is used for removing sulfamethoxazole in wastewater, and the compound comprises the hydrogen phagocystis strain SNF1 and microalgae; the invention further discloses a method for removing sulfamethoxazole in wastewater, and the hydrophage strain SNF1 is used in the method.

The utility model relates to the related technical field of veterinary drug processing equipment, and provides an efficient crushing unit for processing sulfachlorpyridazine sodium, which comprises an equipment frame and a grinding roller, the grinding roller is arranged in the equipment frame, a door-shaped frame is fixed at the top of the equipment frame, a first crushing assembly is arranged between the door-shaped frame and the equipment frame, and a second crushing assembly is arranged between the equipment frame and the door-shaped frame. The driving and grinding assembly is arranged between the equipment frame and the grinding roller, the smashing assembly comprises a feeding cover, the feeding cover is connected to the top of the equipment frame, a driving motor is installed at the top of the n-shaped frame, a driving shaft is arranged at the output end of the driving motor, and the driving shaft is slidably connected with a smashing tool rest in a sleeving mode. By means of the technical scheme, the problems that in the prior art, a crusher only conducts primary crushing, particles are not uniform after crushing, crushing is not thorough, secondary treatment is needed, the treatment process is increased, and the efficiency is reduced are solved.

This invention discloses a method for degrading sulfamethoxazole and a method for purifying wastewater. The method for degrading sulfamethoxazole involves adding low-valence vanadium oxide and sodium percarbonate to the sulfamethoxazole. The low-valence state refers to vanadium with a valence of +3 or +4. The initial pH of the reaction system is 3–9. The vanadium oxide needs to be acid-washed before use. Vanadium oxide exhibits good catalytic activity towards sodium percarbonate, significantly improving the degradation rate of sulfamethoxazole in a short time. This provides a new solution for the degradation of sulfamethoxazole, fills the gap in the decontamination performance of vanadium-based heterogeneous sodium percarbonate systems, deepens the understanding of reducing agent applications, and can be used for wastewater purification.

The present application belongs to the technical field of herbicide safener, and particularly relates to the use of chlorindole hydrazide as a herbicide safener, chlorindole hydrazide as a safener of nicosulfuron, carfentrazone-ethyl, benzenesulfonamide and quizalofop-p-ethyl, which can relieve or eliminate the crop phytotoxicity caused by the above herbicides, and is applied after or before the crop phytotoxicity is caused. The application amount of chlorindole hydrazide (converted into the original drug) is 1-2 g / mu, the mass concentration of chlorindole hydrazide is 0.00667-0.01333% when applied, and a very good control effect can be achieved.

The utility model relates to a sulfadiazine wastewater treatment system which comprises a wastewater storage tank used for storing wastewater to be treated; the resin towers are communicated with the wastewater storage tank and are used for carrying out decoloration treatment on the wastewater and adsorbing sulfadiazine in the wastewater; the centrifugal pump is communicated with the resin tower through a three-way valve; the anaerobic tank is communicated with the centrifugal pump, and a stirrer is arranged in the anaerobic tank; the ozone reaction tank is communicated with the anaerobic tank, and an aeration structure is arranged in the ozone reaction tank; the ozone generation assembly is communicated with the aeration structure and is used for conveying generated ozone to the aeration structure; the flocculation tank is communicated with the ozone reaction tank; and the sedimentation tank is communicated with the flocculation tank. The sulfadiazine wastewater can be subjected to decoloration, adsorption, anaerobic treatment and ozone decomposition, and qualified discharge of the wastewater is realized.

The utility model relates to a sodium sulfadiazine dispersing stirrer which comprises a stirring mechanism and a lifting mechanism, the lifting mechanism is connected with the stirring mechanism, and the lifting mechanism is used for driving the stirring mechanism to lift up and down in the vertical direction while the stirring mechanism works; the stirring mechanism comprises a first driving motor, a rotating rod and a stirring rotating wheel, one end of the rotating rod and the stirring rotating wheel are fixedly installed together, and the first driving motor drives the rotating rod to rotate, so that the first driving motor drives the stirring rotating wheel to rotate.

The present application belongs to the technical field of wastewater treatment, and particularly relates to a seawater breeding wastewater antibiotic removal method based on oyster shell composite filler. Fine gravel, oyster shell and functional mineral are compounded in a fixed volume ratio of 2:1:1, and are laid in a structure with a limited particle size range and homogeneity without stratification. A salinity-directed salt-tolerant domestication process and a tidal intermittent operation mode of 48h hydraulic retention + 24h emptying and reoxygenation are matched, and salt-tolerant functional bacterial flora of Proteobacteria, Paracoccus and Shigella are enriched. The present application can adapt to a wide range of salinity conditions of 10‰-30‰, relieve high salt inhibition and ion competition, simultaneously and efficiently remove three typical antibiotics of conventional pollutants, sulfamethoxazole, trimethoprim and enrofloxacin, and reduce resistance genes. The sulfamethoxazole removal rate can reach 93.94% under the condition of 30‰ high salinity, the system runs stably and has strong adaptability, and has certain engineering application value and large-scale popularization potential in the field of seawater breeding wastewater treatment.

This invention provides a method for treating wastewater using molybdenum carbide-activated peracetic acid, relating to the field of advanced oxidation water treatment. The method includes the following steps: mixing organic wastewater and peracetic acid in a reactor, adjusting the pH, and then adding molybdenum carbide to initiate the oxidation reaction, rapidly degrading pollutants in the water. The pH of the organic wastewater is preferably weakly alkaline. In this invention, organic pollutants can be oxidized and degraded by active species generated by molybdenum carbide-activated peracetic acid, such as organic free radicals and hydroxyl free radicals. The degradation efficiency of sulfamethoxazole in the organic wastewater is highest at an initial pH of 9, achieving a removal rate of over 95% for different concentrations of sulfamethoxazole within two minutes. It also has a certain removal effect on other organic pollutants such as methylene blue. Molybdenum carbide is a solid powder, making it easily removed from water. This invention requires no additional energy intake, and peracetic acid also disinfects and sterilizes the water.

The invention discloses a hydrophilic chromatographic stationary phase simply modified by polyethyleneimine and carbon dots as well as a preparation method and application of the hydrophilic chromatographic stationary phase, and belongs to the technical field of high performance liquid chromatography separation. The preparation method of the stationary phase comprises the following steps: preparing carboxyl carbon dots by taking citric acid as a carbon source through a pyrolysis method; the preparation method comprises the following steps: dispersing acidified bare silica gel, polyethyleneimine and carboxyl carbon dots in an ethanol-water solution in proportion to form a uniform system; and then carrying out physical coating through two-step heating reflux under the protection of nitrogen, and finally washing and drying to obtain the product. The complex silica gel alkylation step is omitted, and the process is simple, green and environmentally friendly. The surface of the prepared stationary phase is provided with cation sites provided by polyethyleneimine and anion sites provided by carboxyl carbon dots, so that a multiple hydrophilic and ionic interaction mechanism is formed, and more than thirty polar compounds, including nucleoside / basic groups, sulfanilamide, antibiotics, alkaloids, flavones, amino acids and saccharides, can be subjected to efficient baseline separation; the method has important application value in the fields of drug analysis, environment detection and the like.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

This invention discloses the use of a single-celled green algae for removing sulfamethoxazole from water. This invention is based on the inventors' discovery that Chlamydopodium sp. HS01 can remove sulfamethoxazole. This algae strain can grow in water containing sulfamethoxazole and efficiently remove it, demonstrating its potential for eliminating antibiotics from wastewater.

The utility model discloses a sulfanilamide crystal separation device which comprises a tank body provided with double-layer side walls, and a plurality of uniformly distributed partition plates are arranged between the double-layer side walls of the tank body; the multiple annular cooling plates are sequentially arranged in the tank body in a sleeved mode and communicate with the two opposite cooling cavities in the tank body. The stirring device is arranged at the top of the tank body; the utility model relates to the technical field of sulfanilamide processing, cooling liquid in the side wall of the tank body is used for cooling a solution on the outer side, a plurality of annular cooling plates sleeved in the tank body are used for cooling a solution in the middle of the tank body, and the cooling uniformity of the solution in the tank body is ensured; the stirring device is used for stirring in the gaps between the annular cooling plates and the inner wall of the tank body, so that the reaction efficiency of a solution is improved, crystals on the inner wall of the tank body and the side walls of the annular cooling plates are scraped off through the scraping plates, a large amount of crystals are prevented from being adhered to influence heat transfer, and the crystallization efficiency of the solution is ensured.

The invention discloses a selective detection and monitoring culture medium for streptococcus sobrinus as well as a preparation method and application of the selective detection and monitoring culture medium, and belongs to the technical field of microorganisms. The culture medium comprises a carbon source, a nitrogen source, 4-5g / L of monopotassium phosphate, an additive and 15g / L of agar, the carbon source comprises 1-5g / L of glucose and 40-50g / L of sucrose; the nitrogen source comprises 12-18g / L of multivalent peptone and 3-7g / L of casein tryptone; the additive is prepared from 0.9-1.2 mg / L of crystal violet, 0.05-0.08 g / L of trypan blue, 2-10 mg / L of potassium tellurite, 40-60 mg / L of carumonan and 70-100 mg / L of sulfadimidine. The selective detection and monitoring culture medium for streptococcus sobrinus is high in growth selectivity, good in gram-positive bacterium growth inhibition effect, capable of well inhibiting fungus growth, sensitive in streptococcus sobrinus detection, high in specificity, simple in preparation procedure and suitable for industrial production. The practical operation feasibility is high, and the application of the culture medium for selectively detecting and monitoring the distant streptococcus is also included.

This invention provides the application of indexsulfanilamide in the preparation of drugs for the prevention and / or treatment of multiple myeloma, belonging to the field of oncology drug technology. Indexsulfanilamide exhibits significant anti-multiple myeloma effects in various multiple myeloma cell lines, primary cells, and multiple myeloma mouse models, and inhibits tumor growth in multiple myeloma mice while demonstrating good safety. Furthermore, the combination of indexsulfanilamide and bortezomib produces a synergistic effect, suggesting that indexsulfanilamide has a promising therapeutic prospect for multiple myeloma.