Antibacterial black phosphorus nanometer material and preparation method thereof

A nanomaterial, black phosphorus technology, applied in the field of antibacterial applications, amino ligand-modified black phosphorus nanomaterials and its preparation field, can solve the problem that black phosphorus nanomaterials do not have antibacterial effects, are difficult to achieve large-scale production, and have antibacterial activity Less research and other issues, to achieve the effect of improving application potential, excellent antibacterial efficacy, and improving antibacterial efficacy

Active Publication Date: 2018-05-18
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] ①The modification process is complex and the yield is low, making it difficult to achieve large-scale production;
[0008] ②The cost of the modifier used is high, the modification effect is not ideal, and the biocompatibility is po

Method used

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  • Antibacterial black phosphorus nanometer material and preparation method thereof
  • Antibacterial black phosphorus nanometer material and preparation method thereof
  • Antibacterial black phosphorus nanometer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation of Black Phosphorus (BP) Nanosheets

[0054] Take 25mg of black phosphorus crystals, add NMP solution to 25mL while grinding, probe ultrasonic for 10h, 400W low-temperature water bath for 10h, centrifuge the sample at 2000rpm for 10min, and take the supernatant dispersion to prepare two-dimensional black phosphorus nanosheets.

Embodiment 2

[0056] The amino ligand of formula II structure is used in this embodiment

[0057]

[0058] Dissolve 12 mg of amino ligand in 1 mL of dichloromethane, add it to 1 mL of dichloromethane dispersion with 50 μg of black phosphorus nanosheets under the protection of argon and avoid light, and avoid Light heating and reflux reaction for 15 hours, followed by centrifugation at a speed of 7,000 to 10,000 rpm for 10 to 20 minutes, removing the supernatant, redispersing the solid in ultrapure water, and obtaining the material of amino ligand modified black phosphorus. 1 H-NMR (D 2 O) detect as figure 1 shown. Subsequent examples all use this amino ligand to modify the black phosphorus material.

Embodiment 3

[0060] From figure 1 It can be seen that the NMR signals of the amino ligands are all on the black phosphorus material, indicating that the sulfamate is successfully coordinated to the surface of the black phosphorus.

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Abstract

The invention discloses an amino ligand surface modified black phosphorus nanometer material and a preparation method thereof, and applications of the amino ligand surface modified black phosphorus nanometer material in antibacterial field. According to the present invention, the antibacterial amino group in the sulfanilamide-based group is introduced into the surface of the nanometer material soas to provide the antibacterial performances of wide antibacterial spectrum, high sterilization efficiency and less drug resistance for the nanometer material; the preparation method has characteristics of simple and easy operation, high yield, good reproducibility, low cost and large-scale production; the use of the black phosphorus nanometer material does not cause secondary pollution to the environment; and the modified two-dimensional black phosphorus nanometer material can significantly inhibit the growth of gram-negative bacteria and gram-positive bacteria, and has excellent antibacterial effect so as to provide great application potential in the field of medical materials.

Description

technical field [0001] The invention relates to the field of modified nanomaterials, in particular to an amino ligand-modified black phosphorus nanomaterial, its preparation method and its application in the antibacterial field. Background technique [0002] As an emerging class of ultrathin nanomaterials, two-dimensional (2D) nanomaterials have shown high biocompatibility and wide potential for biomedical applications due to their unique structural characteristics and physical and chemical properties. Two-dimensional nanomaterials are the thinnest nanomaterials known so far. The low-dimensional nanostructures enable them to have ultra-high specific surface area and biological reactivity, as well as a broad optical response band. Nowadays, two-dimensional nanomaterials have been explored for various biomedical applications. Such as drug loading and delivery, contrast imaging of target areas in vivo, cancer diagnosis, photothermal therapy, etc. [0003] At present, the rese...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K47/54A61P31/04A61K31/18A61K31/63
CPCA61K31/18A61K31/63A61K33/42A61K2300/00
Inventor 喻学锋李志斌吴列王怀雨
Owner SHENZHEN INST OF ADVANCED TECH
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