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120results about How to "Good antibacterial effect" patented technology

Phytobacterium plantarum capable of inhibiting growth of monascus and application of phytobacterium plantarum

The invention relates to the technical field of microorganisms, and discloses a plant lactobacillus capable of inhibiting growth of monascus and application of the plant lactobacillus. The preservation number of the plant lactobacillus is CGMCC (China General Microbiological Culture Collection Center) No.34851. According to the present invention, the plant lactobacillus CCNH295 has strong bacterial inhibition ability on common soybean meal contaminating molds, such as aspergillus flavus, aspergillus ochraceus, fusarium moniliforme and penicillium; the plant lactobacillus CCNH295 has excellent bacteriostatic ability to monascus, and when the plant lactobacillus CCNH295 is used for fermentation production of soybean meal, growth of monascus can be remarkably inhibited, so that mildewing of the fermented soybean meal is effectively inhibited, and the prepared fermented soybean meal does not mildew after being placed at 37 DEG C for 6 months; besides, the fermented soybean meal produced by solid state fermentation of the plant lactobacillus CCNH295 is used as a feed raw material, so that the stability of the feed can be improved, and the palatability of the feed can be improved.
Owner:COFCO NUTRITION AND HEALTH RESEARCH INSTITUTE CO LTD +1

Astragaloside synergistic composition as well as preparation method and application thereof

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.
Owner:JIANGXI CHENGBIXIN BIOTECHNOLOGY CO LTD

A method for preparing an oral hydrocolloid dressing

The application discloses a preparation method of a hydrocolloid dressing for oral cavity, and relates to the technical field of medical supplies. Baicalin extract and a polyvinyl pyrrolidone solution are mixed to obtain a baicalin extract solution; chitosan fibers, hydroxymethyl cellulose and the baicalin extract solution are mixed to obtain a mixed solution; vacuum degassing: the prepared mixed solution is vacuumized, pressure is maintained, and primary degassing is performed; ultrasonic degassing: the mixed solution after primary degassing is subjected to ultrasonic degassing; static degassing: the solution after ultrasonic degassing is sealed by using a preservative film, and is subjected to secondary degassing at room temperature; a PU film is fixed in a film laying frame, the degassed mixed solution is poured into the film laying frame, and the film laying frame is placed into an air-blowing drying box to solidify and form a protective layer, so that the hydrocolloid dressing is obtained. The hydrocolloid dressing prepared by the method has good adhesion, can be used on a wound for a long time, and can effectively promote the repair of damaged cells and wounds, so that the healing of the wound in the oral cavity is promoted.
Owner:XILING (ZHENJIANG) MEDICAL TECH CO LTD

Waterproof elastic bandage with good air permeability

The waterproof elastic bandage with the good breathability comprises a hydrophobic layer, a breathable layer and a deformation layer, and the breathable layer is of a corrugated structure; the deformation layer is made of a skin-friendly elastic material; the breathable layer is made of a polytetrafluoroethylene material; the lower surface of the hydrophobic layer is fixedly attached to the upper surface of the breathable layer, and the lower surface of the breathable layer is fixedly attached to the upper surface of the deformation layer. Compared with the prior art, the waterproof elastic bandage with the good air permeability has the advantages that the corrugated polytetrafluoroethylene breathable layer is arranged, so that the bandage is waterproof, and meanwhile, the bandage with the same area has better air permeability.
Owner:ZHONGSHAN HOSPITAL XIAMEN UNIV

A water-based nano-dispersion of far-infrared negative oxygen ion material

This solution relates to the coatings field and proposes an aqueous nano-dispersion of far-infrared negative oxygen ion material. By weight, it comprises: 300-350 parts water; 35-45 parts wetting agent; 40-60 parts dispersant; 25-35 parts defoamer; 35-45 parts multifunctional additive; 5-7 parts thickener; 400-600 parts activated far-infrared negative oxygen ion material; 1-3 parts accelerator; and 3-5 parts shielding agent. This solution designs a multi-component synergistically promoting activated far-infrared negative oxygen ion material, which can improve the hemispherical spectral emissivity in the 4-14μm band, even reaching above 0.95 in the key 8-12μm band, effectively promoting formaldehyde decomposition with a long-lasting effect, while also improving antibacterial properties.
Owner:QUZHOU TRUMPQI NEW MATERIALS TECHNOLOGY CO LTD

Broad-spectrum antibacterial peptide with low hemolytic activity, application thereof and broad-spectrum antibacterial drug

PendingCN122277668ABroad spectrum antibacterial propertiesStrong inhibitory activityAntimicrobial drugAntimicrobial peptides
This invention belongs to the field of antimicrobial peptide technology, and particularly relates to a broad-spectrum antimicrobial peptide with low hemolytic activity and its applications, as well as a broad-spectrum antibacterial drug. The antimicrobial peptide is named AY6, and its amino acid sequence is shown in SEQ ID NO.1. Antimicrobial peptide AY6 exhibits significant antibacterial effects against both Gram-positive and Gram-negative bacteria, with a bactericidal rate far exceeding that of traditional antibiotics, enabling highly effective responses to bacterial infections. AY6 has low hemolytic activity and good biocompatibility, making it suitable for medical anti-infective applications. The antimicrobial peptide provided in this application has a short sequence, is easy to synthesize chemically, can save on large-scale production costs, and has broad application prospects.
Owner:ANHUI MEDICAL UNIV

Lactobacillus plantarum for inhibiting brown stain of soybean paste and application of lactobacillus plantarum

The invention relates to the technical field of microorganisms and the field of food, in particular to lactobacillus plantarum for inhibiting brown stain of soybean paste and application of lactobacillus plantarum. The lactobacillus plantarum is screened from traditional naturally-fermented peasant soybean paste in northeast China, and is preserved in China General Microbiological Culture Collection Center (CGMCC) on June 30, 2025, and the preservation number is CGMCC No.35048. The lactobacillus plantarum has an obvious browning inhibition effect and can be widely applied to fermented food production.
Owner:SHENYANG AGRI UNIV

Plant gel patch and preparation method thereof

This invention provides a plant-based gel patch and its preparation method. The plant-based gel patch is prepared by mixing and freezing the following components, including modified polyvinyl alcohol, modified chitosan, functionalized borate ester, and distilled water; the preparation method is as follows: (1) modification of chitosan; (2) synthesis of functionalized borate ester; (3) preparation of allyl dihydrocaffeic acid; (4) graft modification of polyvinyl alcohol; (5) molding of the plant-based gel patch; the plant-based gel patch prepared by this invention can be used as a dressing for skin wound healing, and has antibacterial, good adhesion and self-healing ability.
Owner:WUHAN JINYUAN SHIJIA MEDICAL TECHNOLOGY CO LTD

Microbial compound fermentation inoculant, straw fermentation product and application of straw fermentation product

PendingCN121950581AAlleviating obstacles to continuous croppingIncrease pyrogallic acid contentFungiBacteriaContinuous croppingBacillus subtilis
The invention discloses a microbial compound fermentation inoculant, a straw fermentation product and application of the straw fermentation product, and belongs to the technical field of agricultural microorganisms. The preparation method comprises the following steps: compounding bacillus subtilis, trichoderma harzianum and trichoderma longibrachiatum to form a microbial compound fermentation inoculant; when the microbial compound fermentation inoculant is used for fermenting ginger straws, the content of pyrogallic acid in a prepared straw fermentation product can be synergistically improved. The pyrogallic acid has an obvious antibacterial effect on fusarium moniliforme and fusarium laminatum which cause the apple continuous cropping obstacle; the growth of apple seedlings planted in continuous cropping soil can be effectively promoted. Therefore, the straw fermentation product disclosed by the invention can be used for preventing and treating apple continuous cropping obstacles, improving the biomass and root activity of apple seedlings under continuous cropping conditions and reducing the quantity of harmful fusarium in continuous cropping soil.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

High-strength flame-retardant packaging material and method for producing the same

The application relates to the technical field of packaging materials, in particular to a high-strength flame-retardant packaging material and a preparation method thereof. According to weight parts, the packaging material comprises the following raw materials: 70-90 parts of polylactic acid, 6-12 parts of polybutylene adipate terephthalate, 4-15 parts of a flame retardant, 3-7 parts of modified montmorillonite, 3-5 parts of maleic anhydride grafted polypropylene, 0.3-0.5 parts of an antioxidant and 0.5-1 part of a lubricant. The packaging material has excellent flame-retardant performance, bacteriostatic performance, barrier performance and mechanical performance.
Owner:SHANGHAI RUITU NEW MATERIALS TECH CO LTD

Amino acid facial cleanser composition and application thereof

The invention discloses an amino acid facial cleanser composition and application thereof, and aims to overcome the defects that the existing acne-removing facial cleanser is high in irritation, acne removal and mild cleaning are difficult to consider, and a single component only acts on a single target spot of acne. According to the composition, 5.0-25.0 wt% of sodium cocoyl glycinate, 0.1-2.0 wt% of capryloyl glycine, 0.2-5.0 wt% of nicotinamide and 0.01-0.5 wt% of a hydrolysis yeast extract are taken as core active components, the four components are specifically proportioned to form a synergistic effect, oil control and acne removal are realized through a closed-loop passage of pore cleaning, source oil control and targeted bacteriostasis, and the mild property is guaranteed by amino acid surface activity, and the skin barrier is not damaged. The composition disclosed by the invention can be prepared into facial cleanser and facial mousse, and is excellent in cleaning power and foamability, good in use experience and high in industrialization value.
Owner:BIOCREATECH (SHENZHEN) BIOTECHNOLOGY CO LTD

Probiotic compositions for improving diarrhea and their uses

This invention provides a probiotic composition for improving diarrhea and its uses. The probiotic composition of this invention comprises space-occupying bacteria, organic acid-producing bacteria, and oxygen-depleting bacteria, wherein the oxygen-depleting bacteria are *Weizmannii*, the organic acid-producing bacteria are *Lactobacillus* or *Lactobacillus lactis*, and the space-occupying bacteria are *Bifidobacterium*. The probiotic composition of this invention can effectively improve diarrhea and is therefore suitable for the prevention and / or treatment of diarrhea-related functional gastrointestinal disorders.
Owner:HANGZHOU GRAND BIOLOGIC PHARMA INC

Composite solid decolorizing powder and its preparation method

The application discloses a composite solid decoloring powder and a preparation method thereof, and belongs to the technical field of water treatment agent preparation. The modified nano titanium dioxide is obtained by coating titanium dioxide with 3-methyl acrylic acid sulfopropyl potassium salt grafted polydopamine. The titanium dioxide has photocatalytic effect and antibacterial property, can catalytically decompose pollutants in sewage, inhibit the breeding of bacteria in water, and can catalytically decompose free formaldehyde in dicyandiamide formaldehyde polycondensate. The modified nano titanium dioxide is loaded on phenolic resin foam, and after calcination, the nano titanium dioxide / foam carbon powder is formed. The large specific surface area and porous property of the foam carbon can increase the capture and fixation of free formaldehyde, and can synergistically accelerate the catalytic degradation of formaldehyde with the titanium dioxide. The dicyandiamide formaldehyde polycondensate grafted with castor oil is in-situ polymerized on the surface of the matrix. The castor oil grafting can significantly improve the dicyandiamide formaldehyde polycondensate, significantly increase the molecular weight, and increase the capture capacity.
Owner:无锡市田鑫化工有限公司

Bacteriostatic and deodorizing zeolite cat litter and preparation method thereof

The application discloses a bacteriostatic and deodorizing zeolite cat litter and a preparation method thereof, and belongs to the technical field of zeolite cat litter preparation. The bacteriostatic and deodorizing zeolite cat litter is composed of the following components in parts by weight: 55-75 parts of modified zeolite, 3-6 parts of bacteriostatic gel, 2-5 parts of adhesive, and 1-3 parts of filler. The modified zeolite is prepared from sulfamic acid, N,N-dimethylformamide, lignocellulose and zeolite, and the bacteriostatic agent is prepared from four-arm polyethylene glycol, succinic anhydride, triethylamine, N-hydroxyl glutarimide, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and polylysine. The zeolite cat litter prepared by the method has excellent water absorption, antibacterial property and deodorizing property.
Owner:HULUDAO MEIDA ENVIRONMENTAL PROTECTION ENG CO LTD

A melt-blown material with antibacterial and soundproofing properties, and a method for preparing and using the same

This invention discloses a meltblown material with antibacterial and sound-insulating properties, its preparation method, and its application, relating to the field of meltblown fabric production technology. By adjusting the spinning equipment, the angle θ between the spinneret and the condensing screen, the vertical distance L between them, and other process parameters, the fiber packing pattern and packing density can be altered to obtain a meltblown material with a three-dimensional structure. This increases the specific surface area of ​​the meltblown material, effectively improving its sound absorption and heat insulation effects under the same resistance conditions, and also exhibiting good antibacterial properties. Furthermore, it improves the uniformity of the transverse fibers in the meltblown fabric, reduces the difference in mechanical properties between the transverse and longitudinal directions, increases the fiber bonding strength during the meltblowing process, and thus increases the mechanical strength of the meltblown material. This effectively mitigates the problem of decreased sound absorption efficiency in the obtained meltblown material, and the resulting meltblown material has high bulkiness.
Owner:SCD NEW MATERIAL TECH SHANGHAI CO LTD

Recombinant bacteriophage lyase and application thereof

PendingCN121825932AGood antibacterial effectExpand the potential value of prevention and controlAntibacterial agentsBacteriaHelicobacterPharmaceutical drug
The invention discloses recombinant bacteriophage lyase and application thereof. The amino acid sequence of the recombinant bacteriophage lyase E8-3 is as shown in SEQ ID NO: 43, and an in-vitro minimum inhibitory concentration experiment shows that the recombinant bacteriophage lyase E8-3 has a bacteriostatic effect on helicobacter pylori and acinetobacter baumannii, and particularly has a wide application prospect in the development of anti-helicobacter pylori drugs.
Owner:SHANGHAI HI TECH BIOENG

Antibacterial fabric for underwear and preparation method thereof

InactiveCN121875099Aachieve antibacterialachieve moisture absorptionBiochemical fibre treatmentFibre typesFiberPolymer science
The invention discloses an antibacterial fabric for underwear and a preparation method of the antibacterial fabric, and relates to the technical field of textile fabrics. According to the invention, 2-(chloromethyl) 1, 3-butadiene and dodecyl dimethyl tertiary amine are used as reaction raw materials to prepare quaternary ammonium salt, and then the quaternary ammonium salt and vinyl-terminated silicone oil are subjected to a polymerization reaction to generate an organosilicon quaternary ammonium salt antibacterial agent, so that bacterial adhesion can be effectively prevented, and the antibacterial performance of the fabric is enhanced; ethylene glycol and 2, 5-dimercapto terephthalic acid are condensed to obtain sulfydryl-containing polyester fibers, ethylene glycol disodium salt is added to obtain modified polyester fibers, the antibacterial performance of the fabric is improved, meanwhile, the moisture absorption performance of the fabric is improved, and the fabric is easy to dye; soaking the modified polyester fiber into the organosilicon quaternary ammonium salt antibacterial agent mixed solution, performing water treatment, drying, and weaving to obtain the antibacterial fabric for underwear. The prepared antibacterial fabric for underwear has excellent antibacterial, moisture-absorbing and easy-to-dye effects.
Owner:黄威钊

Culture medium for lactic acid bacteria postbiotics and application of culture medium

The invention provides a culture medium for lactic acid bacteria after-generation and application, the culture medium takes trehalose as a carbon source and a yeast extract as a nitrogen source, so that the growth biomass of lactobacillus plantarum, lactobacillus casei and lactobacillus pentosus can be remarkably increased, the pH is reduced, and the antibacterial ability is improved. Lactobacillus plantarum, lactobacillus casei and lactobacillus pentosus are prepared through the culture medium for the lactobacillus after-generation, so that the lactobacillus after-generation has a good inhibition effect on main food-borne pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, pseudomonas aeruginosa and listeria monocytogenes; the preservative can be widely applied to preservation and preservation of meat products such as chilled chicken and pork. The preparation method of the lactic acid bacteria metagen is simple, convenient, low in cost, natural, safe and suitable for large-scale production.
Owner:UNIV OF JINAN

Fat powder for reducing the death rate of weaned piglets, and preparation method and application thereof

ActiveCN117958361BOvercome prone energy supply shortagesOvercome problems like diarrheaFood processingAccessory food factorsBiotechnologyTributyrin
The present application relates to a kind of fat powder for reducing weaning piglet dead rate and its preparation method and application, and the composite lipid in the preparation raw material of fat powder includes 1,3-di-oleic acid-2-palmitic acid triglyceride, 24 degrees palm oil, rice bran oil, coconut oil, linseed oil, caprylic triglyceride, capric acid triglyceride, alpha-lauric acid monoglyceride and tributyrin.The present application develops the fat acid composition close to pig milk fat structure, let piglet continue lactation period in weaning period to enable approach mainly with lipid, meet the compound energy demand of fast, medium and slow, avoid falling into energy potential difference;And the specific combination of medium and short chain fatty acids, both can improve the energy efficiency of weaning piglet, also have bacteriostatic disease characteristics, can improve the immunity of piglet, reduce the diarrhea rate.This composite lipid overcomes the problem such as piglet energy deficiency and indigestion caused by single raw material oil due to unsuitable lipid structure, can significantly reduce weaning stress, reduce the diarrhea rate and dead rate.
Owner:HUBEI YOUBATE BIOLOGICAL ENG CO LTD +1

Application of NSC348884 in resisting mycobacterium tuberculosis infection

The invention belongs to the technical field of biological medicines, and particularly relates to application of a compound NSC348884 in preparation of a medicine for resisting mycobacterium tuberculosis. Experimental results show that the NSC348884 has remarkable in-vitro bacteriostatic activity on standard strains and clinical isolates of mycobacterium tuberculosis. The MIC of the strain to a standard strain is 2 [mu] g / mL, and the MIC distribution of the strain to a clinical isolated strain is 0.5-4 [mu] g / mL. Further bacteriostatic activity evaluation shows that after the mycobacterium tuberculosis is treated by NSC348884 (1 [mu] g / mL) for 3 days, the growth of the mycobacterium tuberculosis is obviously inhibited, and the inhibition rate is 41.82% + / -10.14%. Compared with a DMSO control group, the CFU is reduced by about 0.24 log. The discovery prompts that NSC348884 has the potential of being developed into a novel anti-tuberculosis drug.
Owner:BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1

Virus lysozyme from deep sea cold spring as well as preparation method and application of virus lysozyme

The invention belongs to the technical field of biology, and discloses virus lysozyme from a deep sea cold spring as well as a preparation method and application of the virus lysozyme. The virus lysozyme provided by the invention comprises amino acid fragments of which the sequences are as shown in one or more of SEQ ID NO: 1-7. The virus lysozyme is derived from a deep sea cold spring virus, the sequence and the structure of the virus lysozyme can keep structural stability and activity in extreme environments such as low temperature and high pressure, and the virus lysozyme has relatively good bacterial cell wall lysis capability and bacteriostatic action; the method has important significance on research and development of bacteriostatic agents under special ecological or technological conditions such as low-temperature food preservation, biological processing and ocean engineering.
Owner:THIRD INSTITUTE OF OCEANOGRAPHY STATE OCEANI C ADMINISTRATION

A soothing antibacterial anti-hair loss hair care formulation of a polypeptide in synergy with a plant active and a method of making the same

PendingCN122499052Agood hairhorny surface kiss
This invention belongs to the field of scalp care formulation technology, and discloses a soothing, antibacterial, anti-hair loss, and hair-strengthening formulation with peptides and plant active ingredients, and its preparation method. The formulation includes a stabilized peptide-plant active ingredient pre-complex liquid, a matrix moisturizer, a scalp conditioner, a thickener, a pH adjuster, a preservative, and deionized water. The pre-complex liquid is prepared by pre-dispersion, weakly acidic pre-complexation, and stabilization treatment of licorice extract, scutellaria baicalensis extract, rosemary extract, hydrolyzed keratin peptides, plant-derived hydrolyzed peptides, glycerin, 1,3-propanediol, β-glucan, and sodium hyaluronate. In preparation, a plant active ingredient pre-dispersion liquid is first formed, then a low-molecular-weight peptide complex is added, followed by β-glucan and sodium hyaluronate for stabilization, and finally mixed with the formulation matrix and the pH is adjusted. This invention is beneficial for improving the dispersion stability, scalp and hair surface retention, and antibacterial persistence of plant active ingredients, and is suitable for soothing, antibacterial, anti-hair loss, and hair-strengthening care.
Owner:SUZHOU QINGSI CENTENARY BIOTECHNOLOGY CO LTD

Aerogel type composite fresh-keeping pad as well as preparation method and application thereof

ActiveCN121991404ARealize NanoizationImprove mechanical propertiesClimate change adaptationMeat/fish preservation using solidsCellulosePolymer science
The invention belongs to the technical field of food fresh-keeping materials, and particularly relates to an aerogel type composite fresh-keeping pad as well as a preparation method and application thereof. The preparation method of the aerogel type composite fresh-keeping pad comprises the following steps: S1, mixing polyethylene glycol, oxalic acid and polyacrylic acid, and stirring at 70-80 DEG C to obtain a eutectic solvent; the method comprises the following steps: mixing a biomass raw material with a deep eutectic solvent, extracting, and filtering to obtain solid residues; s2, mixing the obtained solid residues with water, performing high-pressure homogenization treatment, mixing the obtained cellulose-containing suspension with a gelatin solution and a cross-linking agent, pouring the obtained mixed solution into a forming mold, performing freeze-drying treatment, and taking out to obtain the aerogel type composite fresh-keeping pad. The aerogel type composite fresh-keeping pad prepared by the method disclosed by the invention has good mechanical property, water absorption and antibacterial activity, and shows an excellent fresh-keeping effect in fresh-keeping of fish slices.
Owner:JIMEI UNIV

A salicylic acid-cyclodextrin-amino acid ternary inclusion compound, a preparation method and application thereof

ActiveCN120918962BGood water solubilityImprove inclusion efficiencyCosmetic preparationsAntibacterial agentsPolymer scienceAmino acid side chain
The application discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by non-covalent bond interaction of salicylic acid, amino acid and cyclodextrin derivatives, wherein the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, wherein the salicylic acid molecules are included in the cavity of the cross-linked beta-cyclodextrin polymer, and meanwhile, the guanidino group or carboxyl group of the amino acid side chain interacts with the hydroxyl group outside the cross-linked beta-cyclodextrin polymer or the exposed part of the salicylic acid molecules after inclusion. The application uses the cross-linked beta-cyclodextrin polymer and introduces arginine as a synergist to construct a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary inclusion compound, and through charge neutralization and hydrogen bond network synergistic effect, the inclusion efficiency is significantly improved, and the water solubility of salicylic acid is improved.
Owner:AIXIMEI (ZHUHAI) BIOTECHNOLOGY CO LTD

An eye wash solution containing phmb and a method of making the same

PendingCN122582091ASuitable for long-term eye care useImprove stability
The application discloses an eye lotion containing PHMB and a preparation method thereof, and belongs to the field of eye care preparations. The eye lotion takes PHMB as a bacteriostatic component, is matched with isotonicity regulators, buffers, humectants and EDTA2Na, and simultaneously adds trehalose and allantoin to construct a synergistic stable protection system. The eye lotion is prepared through a process flow of low-temperature light-shielding, preparation of a base liquid first and then addition of PHMB, two-stage sterilization filtration and aseptic filling. The application solves the technical problems that PHMB is easy to degrade in a liquid preparation, has poor stability, and the effective component is easy to attenuate after opening and use. Meanwhile, EDTA2Na and PHMB have a synergistic effect, trehalose and allantoin further stabilize the PHMB structure from a molecular level and inhibit oxidative degradation, so that the product can realize wide-spectrum and high-efficiency bacteriostasis at a low concentration. The obtained eye lotion is mild and non-irritating, clear and stable, and can still maintain stable physicochemical and bacteriostatic properties for a long time after opening, is suitable for industrial production, and can be used for daily eye cleaning, flushing, moisturizing and bacteriostatic care.
Owner:SHANDONG SHENLIAN PHARM CO LTD +3

A polypeptide against drug-resistant bacteria and its pharmaceutical uses

PendingCN122562912AGood antibacterial effectGood in vitro antibacterial properties
This invention belongs to the field of peptide drugs, specifically relating to an anti-drug-resistant bacterial peptide and its pharmaceutical uses. Using Rink amide MBHA amino resin as a solid-phase carrier, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 20V and 24Y replaced by S5, yielding the target stapling peptide PL-9. Compared to the template peptide PL-0, the stapling peptide PL-9 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.
Owner:SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI

PFM-nanocellulose-hydroxyapatite synergistically reinforced biodegradable materials and applications

PendingCN122255687AImprove mechanical propertiesAddressing resiliencePolymer scienceLiquid medium
The application relates to the technical field of biodegradable toy materials, and discloses a PFM-nanocellulose-hydroxyapatite synergistically reinforced biodegradable material and application, which is prepared from components such as polylactic acid, polybutylene adipate terephthalate, polypropylene carbonate, polybutylene succinate, hydrophobic pore-keeping modified plant fiber micro powder, antibacterial microcapsules, nanocellulose paste and grafting compatibilizer. In the preparation process, quaternary resin is premixed and melted, nanocellulose paste is injected laterally, and a high-vacuum in-situ devolatilization process is combined, so that liquid medium is removed in real time and in-situ dispersion of nanocellulose is realized. According to the scheme, a physical interwoven space reinforcing structure is constructed in the matrix, the toughness and the mechanical modulus of the material are synergistically improved, long-acting bacteriostasis is realized by relying on controlled release of the microcapsules, the problems of reinforcing phase agglomeration and short bacteriostasis time are solved, and the application is suitable for production of high-performance long-acting antibacterial biodegradable toys.
Owner:SHOUKANG MEDICAL SCI & TECH (SHANDONG) CO LTD

A hydroxytyrosol nanoparticle with high antioxidant capacity and stability and a preparation method thereof

This invention relates to hydroxytyrosol nanoparticles with high antioxidant capacity and stability, and a method for preparing the same. The method includes the following steps: (1) preparing a cyclic γ-polyglutamic acid solution; (2) preparing an ε-polylysine solution; (3) preparing a hydroxytyrosol solution; (4) adding the hydroxytyrosol solution to the ε-polylysine solution, stirring until homogeneous, and obtaining a mixed solution; then adding the cyclic γ-polyglutamic acid solution dropwise to the mixed solution, stirring the reaction mixture, and dialysis of the reaction solution to obtain hydroxytyrosol nanoparticles with high antioxidant capacity and stability. This invention utilizes the characteristics of cyclic γ-polyglutamic acid side chains containing a large number of negatively charged free carboxyl groups and ε-polylysine side chains containing a large number of positively charged free amino groups. By dissolving cyclic γ-polyglutamic acid, hydroxytyrosol, and ε-polylysine in water and mixing them, the antioxidant capacity and stability of hydroxytyrosol are effectively improved, solving the problem of poor stability and easy oxidation and decomposition of hydroxytyrosol under light conditions.
Owner:SHANDONG FENGJIN MEIYE TECH CO LTD

A Litsea cubeba essential oil preparation and its application

This invention discloses a Litsea cubeba essential oil preparation, which is prepared by mixing a 1% (w / w) chitosan quaternary ammonium salt solution with a Litsea cubeba essential oil ethanol mixture at a volume ratio of 4:1; the volume ratio of Litsea cubeba essential oil to anhydrous ethanol in the Litsea cubeba essential oil ethanol mixture is 2:3. The Litsea cubeba essential oil preparation prepared by this invention exhibits good dispersibility and stability, achieving 100% short-term and long-term antibacterial effect against Aspergillus flavus. This is significantly superior to using Litsea cubeba essential oil or chitosan quaternary ammonium salt alone, as well as other chitosan quaternary ammonium salt-Litsea cubeba essential oil preparations, and even more superior to commonly available antifungal agents. Its preparation method is simple, non-toxic, harmless, and does not pollute the environment. It has low production costs and can be used to prevent or inhibit the growth of Aspergillus flavus, reducing its damage to wooden household products.
Owner:RES INST OF SUBTROPICAL FORESTRY CHINESE ACAD OF FORESTRY +1