1291 results about "Healing wounds" patented technology

The invention discloses an ear-nose-throat nursing scheme intelligent recommendation system based on cloud computing, and relates to the technical field of big data analysis. The intelligent recommendation platform is in communication connection with a data acquisition and preprocessing module, a knowledge graph construction module, a patient portrait construction module, a nursing scheme recommendation module, an evaluation and adjustment module and a user interaction and feedback module. According to the intelligent recommendation system for the ear-nose-throat nursing scheme based on cloud computing, deep analysis and mining are carried out on real-time physiological data, ear-nose-throat related symptoms, wound healing conditions and function recovery progress of patients by utilizing the powerful data processing capability of a cloud computing platform, individual differences and rehabilitation requirements of the patients are accurately recognized, and the intelligent recommendation system for the ear-nose-throat nursing scheme based on cloud computing is provided for the patients. And personalized nursing schemes are customized for the patients, so that the pertinence and effectiveness of nursing are improved, and the prolonged rehabilitation time and the discomfort of the patients caused by the improper schemes are greatly reduced.

The invention provides temperature and pH responsive hydrogel entrapped with chlorogenic acid lipidosome as well as a preparation method and application of the temperature and pH responsive hydrogel, and relates to the technical field of biology. The temperature and pH responsive hydrogel entrapping chlorogenic acid lipidosome contains chlorogenic acid lipidosome, phenylboronic acid grafted modified gelatin and dopamine grafted oxidized hyaluronic acid, the concentration of the phenylboronic acid grafted modified gelatin is 3-10 wt%, the concentration of the dopamine grafted oxidized hyaluronic acid is 3-10 wt%, and the concentration of chlorogenic acid is 1-20 [mu] M. The temperature and pH responsive hydrogel can effectively promote wound healing independently or in combination with blue light.

The invention discloses multifunctional hydrogel and application thereof, and belongs to the technical field of biological medicine. According to the multifunctional hydrogel, ketal mercaptan with two hydrazide ends and oxidized dextran are cross-linked to form a cross-linked network containing dynamic covalent bonds. The preparation method comprises the following steps: dissolving ketal mercaptan with two hydrazide ends in deionized water to obtain a ketal mercaptan solution, dissolving oxidized dextran in deionized water to obtain an oxidized dextran solution, mixing the ketal mercaptan solution with the oxidized dextran solution, and standing to obtain the multifunctional hydrogel. The multifunctional hydrogel has pH / ROS dual responsiveness, can respond to inflammation microenvironment and low pH of infectious wounds, remove active oxygen, release therapeutic drugs, regulate macrophage polarization and relieve bacterial infection, thereby playing a key role in inflammation, proliferation and remodeling stages of wound healing to accelerate wound healing. The curcumin-encapsulated liposome is added into the multifunctional hydrogel, so that the antibacterial effect can be further improved.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

Provided herein are compositions that are useful in healing wounds and / or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and / or treating inflammatory skin conditions using the compositions of the disclosure.

The invention discloses a tissue adhesive based on mussel mucin as well as a preparation method and application thereof. The tissue adhesive is prepared from mussel mucin and an anionic compound containing a hydrophobic group, the mussel worm electrostatic self-assembly bionic composite material is developed on the basis of triple bionic principles of dopa adhesion of mussel byssus, electrostatic self-assembly polymerization of sandburg worms and hydrophobic acting force of barnacles. The preparation method of the tissue adhesive is simple, the tissue adhesive can be obtained only by mixing and oscillating the two stock solutions, the gel forming condition is simple and easy to implement, the pH range and the stock solution concentration range required by gel forming are large, the gel forming range is wide, the raw materials required in the preparation process are few, and the cost is low. Only two key raw materials including the mussel mucin and the anionic compound containing the hydrophobic group are needed, and the prepared tissue adhesive is high in adhesion speed and high in adhesion strength, has good cell compatibility and biological safety and can promote wound healing.

The invention discloses a drug electric controlled release hydrogel patch for wound healing, and belongs to the technical field of biomedical materials, the hydrogel patch comprises sheet electrodes, conductive hydrogel, a liquid storage tank and a flexible circuit, the two sheet electrodes are respectively attached to two side surfaces of the conductive hydrogel to form a sandwich structure, and a hole is formed in the middle of one sheet electrode; the two sheet electrodes are connected to the flexible circuit through wires, and the flexible circuit controls the two sheet electrodes to generate voltage difference. The liquid storage tank is used for storing a medicine solution and comprises a liquid storage tank cavity and a liquid storage tank hole, the conductive hydrogel and the liquid storage tank cavity form a closed space through the liquid storage tank hole, one part of the conductive hydrogel is exposed outside, and the other part of the conductive hydrogel is in the liquid storage tank cavity; the conductive hydrogel is exposed outside, and the surface, attached with the sheet-shaped electrode with a hole in the middle, of the conductive hydrogel is a treatment surface facing a wound surface. The hydrogel patch can realize long-term continuous supplement of drugs in hydrogel and program-controlled drug release, and wound healing is promoted through cooperation of electrical stimulation and drug release.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention relates to the technical field of biological medicine, in particular to a wound repair material and a preparation method and application thereof.The wound repair material is in a gel shape and comprises hydrogel and platelet-rich plasma, the hydrogel is formed by dynamic crosslinking of collagen and oxidized hyaluronic acid, and the hydrogel physically encapsulates the platelet-rich plasma. The gelatinous wound repair material provides bionic mechanical support through a dynamic cross-linked network, synergistically regulates and controls an inflammation microenvironment and sequential release of PRP growth factors, remarkably promotes angiogenesis and wound healing, is suitable for the clinical treatment fields of diabetic ulcer, chronic difficult-to-heal wounds and the like, and has broad application prospects. The material has the functions of mechanical support, anti-inflammatory regulation and growth factor controlled release.

The invention provides a hydrogel composition. The hydrogel composition is prepared from the following components in percentage by weight: 0.5 to 15 percent of an adhesion component, 0.5 to 10 percent of a moisturizing component, 0.01 to 5 percent of a bioactive component, 0.01 to 5 percent of a physical crosslinking agent, 0.01 to 2 percent of a flavoring component, 0.01 to 2 percent of an antimicrobial component and the balance of medical purified water, wherein the bioactive component comprises at least one of lipoic acid, tea polyphenol, lactic acid bacteria extract and metabiotics; the antimicrobial component comprises at least one of copper ions, benzyl alcohol, p-hydroxyacetophenone, sodium methyl hydroxybenzoate and sodium ethyl hydroxybenzoate. According to the hydrogel composition disclosed by the invention, the low-concentration antimicrobial component is introduced, so that the antimicrobial component has more stable and effective bactericidal activity and can be more stably adhered to a wound, and the hydrogel composition can have better antibacterial performance and a function of promoting wound healing without additionally adding antibiotics.

The invention belongs to the technical field of medical instruments, and particularly relates to a postoperative hemostasis nursing device for thoracic surgery rehabilitation, which comprises a nursing box and a plastic cushion block arranged on one side of the nursing box, a controller is mounted on the side wall of the nursing box, a detachable gauze pad is mounted at the bottom of the plastic cushion block, and the postoperative hemostasis nursing device further comprises a pressure cylinder, a pressure cylinder is fixedly connected to the side wall of one side of the plastic cushion block in an inserted mode, a movable piston is arranged in the pressure cylinder in a sliding mode, and a supporting spring is fixedly arranged between the movable piston and the inner wall of the pressure cylinder; the connecting block is arranged on one side of the pressure cylinder, and the connecting block and the moving piston are jointly provided with a tension detection mechanism. According to the device, the binding force on the incision of a patient can be automatically adjusted, the situation that the pressure borne by the incision is increased due to breathing of the patient is avoided, cold compress compression can be continuously conducted on the incision, wound healing is promoted, meanwhile, continuous disinfection and bacteriostasis treatment can be conducted on the periphery of the incision, and the protection effect on the incision is good.

The invention provides a nanoparticle compound for inhibiting bone and soft tissue infection as well as a preparation method and application thereof, and belongs to the technical field of medical biological materials. The nanoparticle compound is a gentiopicroside, sericin, hyaluronic acid and endolysin liposome nanoparticle, and a gentiopicroside, sericin, hyaluronic acid and endolysin co-delivery nano drug delivery system targeting the S100A4 site is designed based on the target S100A4 closely related to bone infection through Ai molecular docking and nano drug delivery technologies. The nanoparticle compound provided by the invention has better stability and bioavailability, and can be used for improving and relieving inflammatory response and increasing wound healing effect.

The invention discloses a rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material for massive hemorrhage is tannic acid modified carboxymethyl chitosan. The invention also provides a preparation method and application of the rapid hemostasis powder material for massive hemorrhage, and a rapid hemostasis microgel composition containing the rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material and microgel composition for massive hemorrhage have excellent water solubility, hemostasis performance and biocompatibility, have multiple effects of sterilization, anti-inflammation, wound healing promotion and the like, and are beneficial to rapid healing of wound parts after hemostasis.

The present invention relates to the field of biomedicine and discloses a platelet-rich plasma for anti-aging and promoting tissue repair and regeneration, a preparation method, and an application thereof, comprising the following steps: obtaining concentrated platelet plasma, and treating the concentrated platelet plasma with low-intensity pulsed ultrasound; the treatment conditions are one of the following treatment methods: 1) the treatment power is 2 to 5 W / cm 2 , the pulse period is 50%, and the ultrasonic treatment time is 2~10 min; 2) First, the first ultrasonic treatment is performed: using 0.2~1.0 W / cm 2 , the pulse period is 50%, ultrasonic treatment is 1~5 min; then the second ultrasonic treatment is carried out: 1.5~5.0 W / cm 2 , the pulse period is 50%, and the ultrasonic treatment is 1 to 5 minutes; the present invention adopts a special ultrasonic treatment system to obtain a PRR product with special activation and lysis characteristics. The product has active substances that are beneficial to tissue repair and regeneration and anti-aging, and shows excellent effects in promoting cell proliferation, cell migration and wound healing.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The invention discloses a vascular endothelial growth factor (VEGF) and antibacterial peptide (AMP) loaded chitosan methacrylic acid (CSMA) hydrogel microneedle patch as well as a preparation method and application thereof, the microneedle patch takes CSMA hydrogel as a main body material, the CSMA hydrogel is crosslinked and cured through ultraviolet light, and the microneedle patch has the characteristics of simplicity and convenience in preparation and stable material performance. The microneedle patch can continuously and stably release VEGF and AMP, promote wound healing and inhibit bacterial infection. Experiments show that the hydrogel microneedle is non-toxic to cells, has good biocompatibility and biodegradability, and also has excellent antibacterial performance. The invention provides an efficient and safe novel treatment tool for repairing infectious wounds.

This disclosure provides a novel method and system for wound assessment and treatment to improve wound healing. The disclosed method and system employs machine learning models to extract information from collected wound images and other data to determine wound healing rates and appropriate treatment plans.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention belongs to the technical field of medical equipment, and particularly relates to a cardiovascular intervention postoperative radial artery compressor which comprises a U-shaped base, a rubber sleeve is fixedly connected to the inner wall of the bottom end of the U-shaped base, a metal iron plate is fixedly connected to the upper surface of the rubber sleeve, and an auxiliary mechanism is fixedly connected to the outer wall of the metal iron plate. The radial artery compressor has a compression force visualization function, can help medical care to precisely regulate and control compression force, formulate a personalized scheme, facilitate real-time monitoring and data analysis, reduce the complication risk of a patient and improve the nursing effect, also has a skin heat preservation function, can promote local blood circulation, accelerate wound healing and relieve discomfort of the patient, and has a good application prospect. And the compressor has the functions of stabilizing a punctured arm and adjusting the height, and is beneficial to venous return, swelling reduction, reduction of blood deposition at a puncture point and improvement of the use reliability and effect of the compressor.

The invention relates to a degradable surgical suture capable of self-constricting under the driving of near-infrared light and accelerating wound healing as well as a preparation method and application of the degradable surgical suture, and the degradable surgical suture capable of self-constricting under the driving of the near-infrared light is developed by virtue of a photo-thermal conversion effect of polydopamine on the basis of a thermal response characteristic of a shape memory material. And on the basis, a thermal control drug release system is endowed to the suture line to synergistically accelerate the wound healing process, and various suture problems confronted by the internal wound of the body are solved.

The invention provides an autologous fat-derived mesenchymal stem cell composition as well as a preparation method and application thereof, and belongs to the technical field of medical auxiliary materials. The method comprises the following steps: separating mesenchymal stem cells from autologous fat particles, culturing in a stem cell culture medium added with cell stimulation particles and fetal calf serum, separating to obtain stem cells and an extracellular matrix, preparing the stem cells into stem cell lipidosome, and preparing the stem cell lipidosome into the mesenchymal stem cells. Sanguinarine and curcumin are embedded in a composite shell material of chitosan and beta-cyclodextrin to prepare the sustained release microspheres. The mesenchymal stem cell composition of the autologous fat source prepared by the invention has good air permeability, softness, certain mechanical property and good biocompatibility, can quickly promote wound healing, is convenient to remove, and does not cause secondary injury.

The invention discloses a recombinant fibronectin fusion protein and application thereof. The recombinant fibronectin fusion protein comprises a recombinant fibronectin mutant (FN1) and a platelet factor 4 (PF4), the amino acid sequence of the recombinant fibronectin is as shown in SEQ ID NO. 3 or SEQ ID NO. 4. The molecular weight of the recombinant fibronectin fusion protein is less than 90KDa, and the recombinant fibronectin fusion protein is good in solubility, simple in preparation process and convenient to purify; the recombinant fibronectin provided by the invention has novel recombinant fibronectin, and can inhibit inflammation in a wound healing process, so that mouse skin injury healing is efficiently promoted, and a new thought can be provided for development of wound healing drugs. In addition, when the platelet factor 4 is creatively fused to the N end of the fibronectin mutant, the cell proliferation activity can be obviously and effectively promoted.

The invention provides a high-water-absorption sodium alginate hydrogel dressing which is composed of a solution A and a solution B. The solution A is a sodium alginate solution, and the solution B is a calcium ion solution which comprises poloxamer, zinc hyaluronate and carbomer 941. The mass concentration range of the sodium alginate solution is 1%-7%, and the concentration range of the calcium ion solution is 100-400 mM; the volume ratio of the solution A to the solution B is (1: 2)-(3: 1). The smooth and transparent moist dressing can be rapidly obtained, the dressing can be customized according to the shape and size of a wound, the moisture retention rate is 86% or above, the swelling rate is 4000% or above, wound seepage can be absorbed, the moist environment of the wound is kept, and therefore wound healing is promoted.

The invention relates to a bioelectronic surgical suture for suture tension monitoring, the surgical suture comprises a cannula and a conductive material, the cannula is a hollow capillary tube, and the conductive material is arranged in the cannula through perfusion and is subjected to first laser scanning treatment after perfusion; a micro-nano structure is manufactured on the outer wall of the sleeve through second laser scanning. According to the principle of friction nanometer power generation, the tension of the surgical suture causes the change of the contact area between the suture and tissue and the change of an output electric signal in the collection process, the tension of the surgical suture can be reversely deduced, and the purpose of monitoring the surgical suture tension is achieved. The operation line is a self-powered sensor, and an external power supply is not needed. The operation line can provide different quantitative feedbacks according to different suturing modes and suturing parts, and is combined with clinical suturing experience of doctors to assist in establishing a tension quantitative model, so that the doctors are helped to optimize operation procedures, postoperative complications are reduced, and wound healing is promoted.

The invention belongs to the technical field of hydrogel preparation, and particularly discloses a preparation method of CS-Pr / Odex / EGCG composite hydrogel, the hydrogel is prepared by compounding proline modified chitosan CS-Pr, oxidized dextran and EGCG, so that the prepared hydrogel not only has good injectable performance, wound healing performance and biocompatibility, but also has good biocompatibility, and can be used for preparing the hydrogel. And excellent anti-oxidation and anti-bacterial capabilities are also realized.

The invention belongs to the technical field of medicines, and discloses a near-infrared cyanine probe for detecting penicillin G acylase as well as a preparation method and application of the near-infrared cyanine probe. According to the research, a near-infrared fluorescent probe Cy-NEO-PA responding to penicillin G acylase (PGA) is developed, so that the influence of environmental factors on the formation of an acinetobacter baumannii biological membrane is observed. Research results show that glucose inhibits the generation of PGA to enhance the formation of a biological membrane, while phenylacetic acid (PAA) stimulates the generation of PGA and inhibits the formation of the biological membrane. The observation results highlight the excellent capability of Cy-NEO-PA in accurately measuring PGA kinetics, and reveal the key effect of PGA in biological membrane development. In addition, the Cy-NEO-PA has good biocompatibility, strong active oxygen generation, efficient photo-thermal conversion and bacterial targeting ability, so that the Cy-NEO-PA becomes a promising drug for resisting bacterial infection and promoting wound healing through photo-thermal / photodynamic therapy.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention discloses application of conductive hydrogel combined with electrical stimulation in treatment of diabetic foot ulcer caused by neuropathy, and belongs to the field of biological medicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin; the chitosan is catechol group modified chitosan, the MXene is polyphenol and Mg ion modified MXene, the gelatin is phenylboronic acid modified gelatin, the electrical stimulation condition is 100 mV cm <-1 >, and the diabetic foot ulcer comprises diabetic foot ulcer caused by neuropathy. Experiments prove that the prepared conductive hydrogel can promote cell migration in combination with electrical stimulation, wound healing of the diabetic foot ulcer can be accelerated, functional repair can be achieved, and a new thought is provided for clinical treatment of the diabetic foot ulcer caused by neuropathy.

The invention discloses a negative pressure electric field dressing, comprising a dressing body, a flexible sealing film for sealing and fixing the dressing body on the wound surface, an iodine ion gel layer is arranged below the dressing body, a negative pressure component connected with the dressing body and generating negative pressure is arranged on the flexible sealing film, and an electric field component connected with the iodine ion gel layer and generating an electric field is also arranged on the flexible sealing film. The dressing has the advantages of convenient replacement and promoting wound healing.

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.