890 results about "Healing wounds" patented technology

Provided herein are compositions that are useful in healing wounds and / or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and / or treating inflammatory skin conditions using the compositions of the disclosure.

The invention discloses a tissue adhesive based on mussel mucin as well as a preparation method and application thereof. The tissue adhesive is prepared from mussel mucin and an anionic compound containing a hydrophobic group, the mussel worm electrostatic self-assembly bionic composite material is developed on the basis of triple bionic principles of dopa adhesion of mussel byssus, electrostatic self-assembly polymerization of sandburg worms and hydrophobic acting force of barnacles. The preparation method of the tissue adhesive is simple, the tissue adhesive can be obtained only by mixing and oscillating the two stock solutions, the gel forming condition is simple and easy to implement, the pH range and the stock solution concentration range required by gel forming are large, the gel forming range is wide, the raw materials required in the preparation process are few, and the cost is low. Only two key raw materials including the mussel mucin and the anionic compound containing the hydrophobic group are needed, and the prepared tissue adhesive is high in adhesion speed and high in adhesion strength, has good cell compatibility and biological safety and can promote wound healing.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention relates to the technical field of biological medicine, in particular to a wound repair material and a preparation method and application thereof.The wound repair material is in a gel shape and comprises hydrogel and platelet-rich plasma, the hydrogel is formed by dynamic crosslinking of collagen and oxidized hyaluronic acid, and the hydrogel physically encapsulates the platelet-rich plasma. The gelatinous wound repair material provides bionic mechanical support through a dynamic cross-linked network, synergistically regulates and controls an inflammation microenvironment and sequential release of PRP growth factors, remarkably promotes angiogenesis and wound healing, is suitable for the clinical treatment fields of diabetic ulcer, chronic difficult-to-heal wounds and the like, and has broad application prospects. The material has the functions of mechanical support, anti-inflammatory regulation and growth factor controlled release.

The invention belongs to the technical field of medical instruments, and particularly relates to a postoperative hemostasis nursing device for thoracic surgery rehabilitation, which comprises a nursing box and a plastic cushion block arranged on one side of the nursing box, a controller is mounted on the side wall of the nursing box, a detachable gauze pad is mounted at the bottom of the plastic cushion block, and the postoperative hemostasis nursing device further comprises a pressure cylinder, a pressure cylinder is fixedly connected to the side wall of one side of the plastic cushion block in an inserted mode, a movable piston is arranged in the pressure cylinder in a sliding mode, and a supporting spring is fixedly arranged between the movable piston and the inner wall of the pressure cylinder; the connecting block is arranged on one side of the pressure cylinder, and the connecting block and the moving piston are jointly provided with a tension detection mechanism. According to the device, the binding force on the incision of a patient can be automatically adjusted, the situation that the pressure borne by the incision is increased due to breathing of the patient is avoided, cold compress compression can be continuously conducted on the incision, wound healing is promoted, meanwhile, continuous disinfection and bacteriostasis treatment can be conducted on the periphery of the incision, and the protection effect on the incision is good.

The invention discloses a rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material for massive hemorrhage is tannic acid modified carboxymethyl chitosan. The invention also provides a preparation method and application of the rapid hemostasis powder material for massive hemorrhage, and a rapid hemostasis microgel composition containing the rapid hemostasis powder material for massive hemorrhage. The rapid hemostasis powder material and microgel composition for massive hemorrhage have excellent water solubility, hemostasis performance and biocompatibility, have multiple effects of sterilization, anti-inflammation, wound healing promotion and the like, and are beneficial to rapid healing of wound parts after hemostasis.

The present invention relates to the field of biomedicine and discloses a platelet-rich plasma for anti-aging and promoting tissue repair and regeneration, a preparation method, and an application thereof, comprising the following steps: obtaining concentrated platelet plasma, and treating the concentrated platelet plasma with low-intensity pulsed ultrasound; the treatment conditions are one of the following treatment methods: 1) the treatment power is 2 to 5 W / cm 2 , the pulse period is 50%, and the ultrasonic treatment time is 2~10 min; 2) First, the first ultrasonic treatment is performed: using 0.2~1.0 W / cm 2 , the pulse period is 50%, ultrasonic treatment is 1~5 min; then the second ultrasonic treatment is carried out: 1.5~5.0 W / cm 2 , the pulse period is 50%, and the ultrasonic treatment is 1 to 5 minutes; the present invention adopts a special ultrasonic treatment system to obtain a PRR product with special activation and lysis characteristics. The product has active substances that are beneficial to tissue repair and regeneration and anti-aging, and shows excellent effects in promoting cell proliferation, cell migration and wound healing.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The invention discloses a vascular endothelial growth factor (VEGF) and antibacterial peptide (AMP) loaded chitosan methacrylic acid (CSMA) hydrogel microneedle patch as well as a preparation method and application thereof, the microneedle patch takes CSMA hydrogel as a main body material, the CSMA hydrogel is crosslinked and cured through ultraviolet light, and the microneedle patch has the characteristics of simplicity and convenience in preparation and stable material performance. The microneedle patch can continuously and stably release VEGF and AMP, promote wound healing and inhibit bacterial infection. Experiments show that the hydrogel microneedle is non-toxic to cells, has good biocompatibility and biodegradability, and also has excellent antibacterial performance. The invention provides an efficient and safe novel treatment tool for repairing infectious wounds.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention belongs to the technical field of medical equipment, and particularly relates to a cardiovascular intervention postoperative radial artery compressor which comprises a U-shaped base, a rubber sleeve is fixedly connected to the inner wall of the bottom end of the U-shaped base, a metal iron plate is fixedly connected to the upper surface of the rubber sleeve, and an auxiliary mechanism is fixedly connected to the outer wall of the metal iron plate. The radial artery compressor has a compression force visualization function, can help medical care to precisely regulate and control compression force, formulate a personalized scheme, facilitate real-time monitoring and data analysis, reduce the complication risk of a patient and improve the nursing effect, also has a skin heat preservation function, can promote local blood circulation, accelerate wound healing and relieve discomfort of the patient, and has a good application prospect. And the compressor has the functions of stabilizing a punctured arm and adjusting the height, and is beneficial to venous return, swelling reduction, reduction of blood deposition at a puncture point and improvement of the use reliability and effect of the compressor.

The invention provides an autologous fat-derived mesenchymal stem cell composition as well as a preparation method and application thereof, and belongs to the technical field of medical auxiliary materials. The method comprises the following steps: separating mesenchymal stem cells from autologous fat particles, culturing in a stem cell culture medium added with cell stimulation particles and fetal calf serum, separating to obtain stem cells and an extracellular matrix, preparing the stem cells into stem cell lipidosome, and preparing the stem cell lipidosome into the mesenchymal stem cells. Sanguinarine and curcumin are embedded in a composite shell material of chitosan and beta-cyclodextrin to prepare the sustained release microspheres. The mesenchymal stem cell composition of the autologous fat source prepared by the invention has good air permeability, softness, certain mechanical property and good biocompatibility, can quickly promote wound healing, is convenient to remove, and does not cause secondary injury.

The invention relates to a bioelectronic surgical suture for suture tension monitoring, the surgical suture comprises a cannula and a conductive material, the cannula is a hollow capillary tube, and the conductive material is arranged in the cannula through perfusion and is subjected to first laser scanning treatment after perfusion; a micro-nano structure is manufactured on the outer wall of the sleeve through second laser scanning. According to the principle of friction nanometer power generation, the tension of the surgical suture causes the change of the contact area between the suture and tissue and the change of an output electric signal in the collection process, the tension of the surgical suture can be reversely deduced, and the purpose of monitoring the surgical suture tension is achieved. The operation line is a self-powered sensor, and an external power supply is not needed. The operation line can provide different quantitative feedbacks according to different suturing modes and suturing parts, and is combined with clinical suturing experience of doctors to assist in establishing a tension quantitative model, so that the doctors are helped to optimize operation procedures, postoperative complications are reduced, and wound healing is promoted.

The invention belongs to the technical field of medicines, and discloses a near-infrared cyanine probe for detecting penicillin G acylase as well as a preparation method and application of the near-infrared cyanine probe. According to the research, a near-infrared fluorescent probe Cy-NEO-PA responding to penicillin G acylase (PGA) is developed, so that the influence of environmental factors on the formation of an acinetobacter baumannii biological membrane is observed. Research results show that glucose inhibits the generation of PGA to enhance the formation of a biological membrane, while phenylacetic acid (PAA) stimulates the generation of PGA and inhibits the formation of the biological membrane. The observation results highlight the excellent capability of Cy-NEO-PA in accurately measuring PGA kinetics, and reveal the key effect of PGA in biological membrane development. In addition, the Cy-NEO-PA has good biocompatibility, strong active oxygen generation, efficient photo-thermal conversion and bacterial targeting ability, so that the Cy-NEO-PA becomes a promising drug for resisting bacterial infection and promoting wound healing through photo-thermal / photodynamic therapy.

The invention provides a hydrogel microneedle patch for treating oral ulcer and a preparation method, and belongs to the technical field of biomedical engineering. The technical problems that in the traditional oral ulcer administration process, medicine is difficult to retain at the focus for a long time, is easily scoured by saliva and is influenced by tongue and cheek movement are solved. According to the technical scheme, the method comprises the following steps: 1) designing and preparing a microneedle patch mold; (2) synthesizing drug-loaded polydopamine nano particles; (3) preparing a microneedle patch; and 4) evaluating the performance of the microneedle patch. The invention has the following beneficial effects: on one hand, the combination of the drug-loaded nanoparticles and the hydrogel microneedle array can reduce the dosage through drug sustained release; and on the other hand, the problems of high drug instability, low targeting property, poor bioavailability and hindering treatment effect are effectively solved, and the preparation can be widely applied to the fields of drug sustained release, wound healing, tissue engineering and the like.

The invention discloses application of conductive hydrogel combined with electrical stimulation in treatment of diabetic foot ulcer caused by neuropathy, and belongs to the field of biological medicine. The conductive hydrogel is obtained by mixing chitosan, polyvinyl alcohol, MXene and gelatin; the chitosan is catechol group modified chitosan, the MXene is polyphenol and Mg ion modified MXene, the gelatin is phenylboronic acid modified gelatin, the electrical stimulation condition is 100 mV cm <-1 >, and the diabetic foot ulcer comprises diabetic foot ulcer caused by neuropathy. Experiments prove that the prepared conductive hydrogel can promote cell migration in combination with electrical stimulation, wound healing of the diabetic foot ulcer can be accelerated, functional repair can be achieved, and a new thought is provided for clinical treatment of the diabetic foot ulcer caused by neuropathy.

The invention discloses a negative pressure electric field dressing, comprising a dressing body, a flexible sealing film for sealing and fixing the dressing body on the wound surface, an iodine ion gel layer is arranged below the dressing body, a negative pressure component connected with the dressing body and generating negative pressure is arranged on the flexible sealing film, and an electric field component connected with the iodine ion gel layer and generating an electric field is also arranged on the flexible sealing film. The dressing has the advantages of convenient replacement and promoting wound healing.

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

The invention provides a composition for beautifying, which comprises a blood platelet concentrated solution prepared by differentiation of human pluripotent induced stem cells (iPSC), and an additive for preparing a blood platelet suspension or gel, and is characterized in that the composition for beautifying comprises the following components: a blood platelet concentrated solution prepared by differentiation of human pluripotent stem cells (iPSC), and an additive for preparing the blood platelet suspension or gel. The invention aims to provide a functional platelet-rich composition which can be prepared in a large scale, is stable in batch and can be produced in a standardized manner in the aspect of promoting wound healing. According to the composition, the platelet concentrate and platelet-rich plasma (PRP) separated from blood in the composition are completely different in component, the component is stable, and the slow-release growth factor is beneficial to tissue repair.

The invention belongs to the technical field of pressure sore treatment, and discloses an experimental test method for treating stress injury based on danshen emodin, which comprises the following specific steps: step 1, preparing experimental materials, selecting a healthy SD (Sprague Dawley) rat, and preparing a clean and sterile magnet and a shaver; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1 part of isoflurane, 1 part of iodophor, 1 part of Vaseline, 1 part of Rhapontigenin and 1 part of resveratrol. The method comprises the following steps: modeling a stress injury model for an SD (Sprague Dawley) rat so as to simulate a stress injury disease, then respectively smearing three medicines, i.e., Danjie emodin, resveratrol and vaseline, tracking the healing condition of a stress injury wound, and finally performing ELISA (Enzyme-Linked Immunosorbent Assay) and Hamp; according to the present invention, the detection analysis is performed through the dyeing E, and the results show that the rheum emodin has good treatment effect on the stress injury, can reduce the expression of the proinflammatory factor, can promote the wound healing, has characteristics of environmental protection and low cost, and provides the new research direction for the treatment of the stress injury.

The present invention refers to a method for coating a collagen like protein onto a surface of a polymer-scaffold comprising or consisting the following steps: a) plasma-treating the surface of the polymer-scaffold, b) providing a collagen like protein in a solvent, to obtain a collagen like protein-containing solution, c) bringing the plasma treated polymer-scaffold and the collagen like protein containing solution into contact followed by an optionally rinsing, d) removing the solvent and thereby obtaining a collagen like protein coated polymer-scaffold. Furthermore, the present invention refers to an article obtained by the method of the present invention. Moreover, the present invention refers to the use of the article according to the invention for wound healing and bone repair as well as for flask-coating and plate-coating in cell culture.

The invention discloses cinnamyl aldehyde at nano calcium carbonate / chitosan hydrogel. The hydrogel comprises a hydrogel matrix formed by cross-linking nano calcium carbonate and chitosan, and cinnamyl aldehyde loaded on the hydrogel matrix. The hydrogel system which is loaded with traditional Chinese medicine components and intelligently controls effective release of the traditional Chinese medicine components is prepared by utilizing the mutual adsorption effect of cinnamyl aldehyde and nano calcium carbonate. The hydrogel has excellent antibacterial activity and a function of accelerating wound healing, and the effect of the hydrogel is obviously superior to that of common calcium carbonate / chitosan hydrogel. A new direction is provided for application of the cinnamyl aldehyde and nano calcium carbonate / chitosan nano system, and a new strategy is provided for designing advanced functional materials modified by traditional Chinese medicine ingredients.

The present invention refers to a method for coating a collagen like protein onto a surface of a polymer-scaffold comprising or consisting the following steps: a) plasma-treating the surface of the polymer-scaffold, b) providing a collagen like protein in a solvent, to obtain a collagen like protein-containing solution, c) bringing the plasma treated polymer-scaffold and the collagen like protein containing solution into contact followed by an optionally rinsing, d) removing the solvent and thereby obtaining a collagen like protein coated polymer-scaffold. Furthermore, the present invention refers to an article obtained by the method of the present invention. Moreover, the present invention refers to the use of the article according to the invention for wound healing and bone repair as well as for flask-coating and plate-coating in cell culture.

The invention discloses an environment-friendly composite tree wound healing agent and a preparation method and application thereof, and belongs to the technical field of garden maintenance, the environment-friendly composite tree wound healing agent comprises the following raw materials by weight: 40-70 parts of a film forming substrate, 10-20 parts of an active component, and 10-20 parts of a functional auxiliary agent; the film-forming substrate is prepared from the following raw materials in parts by weight: 10 to 20 parts of chitosan, 20 to 30 parts of modified starch and 10 to 20 parts of vegetable wax; the active component is prepared from the following raw materials in parts by weight: 0.1 to 0.5 part of indolebutyric acid, 5 to 10 parts of tea tree essential oil, 3 to 5 parts of radix scutellariae extract, 1 to 2 parts of zinc sulfate and 0.5 to 1 part of boric acid; the functional additive comprises the following raw materials in parts by weight: 2-5 parts of nano titanium dioxide, 3-5 parts of a thickening agent and 5-10 parts of a humectant; the positive effect is achieved on tree wound healing.

An acellular product may be derived from human placenta and may be used in various scenarios for wound healing. Because the product may be acellular, the product may be processed for storage and transportation with minimal degradation. The product may include various scaffolding such as biomaterials or human tissue, and the scaffolding may be infused with various plasmas and agents. The cell-free treatment may maintain the biological activity of many therapeutic agents found within cells and may possess multiple structural components to support cellular attachment. The structural components or scaffolds may function as a reservoir of highly diffusible chemotactic and cellular-programming factors that may be useful to treat injury and disease.

The invention belongs to the technical field of gel dressings, and particularly relates to a bio-based gel dressing for wound treatment and a preparation method thereof.The bio-based gel dressing is prepared from, by weight, 10-17 parts of mussel mucin, 13-20 parts of silk fibroin, 1-5 parts of plant vesicles, 2-4 parts of traditional Chinese medicine polysaccharide, 0.05 part of antibacterial peptide, 1.5 parts of glycerinum and 0.3 part of cross-linking agent; nano plant vesicles which are extracted from a traditional Chinese medicine prescription and have the effect of promoting wound healing are used as a carrier for encapsulating antibacterial peptide, and then the antibacterial peptide is encapsulated in a three-dimensional gel network formed by natural protein, so that controlled release and slow release of antibacterial and anti-inflammatory components are realized, and efficient wound healing is promoted.

The invention relates to the technical field of medical dressings, and discloses a preparation method of a three-dimensional structure hydrogel dressing for diabetic foot ulcers, the hydrogel dressing is prepared from polyvinyl alcohol, polyacrylic acid, hyaluronic acid, chitosan, poly (N-isopropylacrylamide), manganese dioxide and other materials, and through formula optimization and a 3D printing technology, the three-dimensional structure hydrogel dressing for diabetic foot ulcers is prepared. High-precision structure control is realized, and the preparation requirements of hydrogel dressings in complex shapes are met; strong electrostatic interaction and hydrogen-bond interaction occur between the interface of the grid structure hydrogel and the interface of the low-viscosity colloid, so that a stable three-dimensional flexible network structure is formed; the dressing has excellent flexibility, biocompatibility, antibacterial property and a function of promoting wound healing, and can be naturally gelated and participate in treatment of a wound microenvironment.

The invention discloses a preparation method of antibacterial dual-oxygen-supply manganese-doped carbon dot-oxygen-carrying microbubbles, and belongs to the field of preparation of medical configuration products, and the preparation method comprises the following steps: attaching biotinylated manganese-doped carbon dots to oxygen-carrying microbubbles by using biotin-avidin connection to prepare micron-level manganese-doped carbon dot-oxygen-carrying microbubbles; the size of the micron-level manganese-doped carbon dot-oxygen-carrying microbubble is 1000-2500nm. The antibacterial dual-oxygen-supply manganese-doped carbon dot-oxygen-carrying microbubble prepared by the invention has the advantages of simple synthesis, clear structure, adjustable size and the like, and the material preparation method is simple, mild in reaction condition and suitable for large-scale production; manganese-doped carbon dot-oxygen-carrying microbubbles provide dual oxygen supply to enhance the sonodynamic therapy effect, so that efficient antibacterial activity is achieved, angiogenesis is promoted, wound healing is accelerated, and the method is a promising wound healing therapy method.

The invention provides a conductive hydrogel dressing, a preparation method and application of the conductive hydrogel dressing in electrically promoted healing, and belongs to the technical field of biomedical materials in the chemical aspect of bandages, dressings, absorbent pads or surgical supplies. The preparation method of the conductive hydrogel dressing comprises the following steps: mixing a biocompatible high polymer material, borax, tannic acid and keratin for full reaction to obtain conductive hydrogel; the mass percentage content of the biocompatible high polymer material is 5-10%, the mass percentage content of the tannic acid is 0.25-2%, the mass percentage content of the keratin is 0.25-2%, and the mass percentage content of the borax is 0.5-2%. The biocompatible high polymer material is selected from one of polyvinyl alcohol, polyacrylic acid, a polyvinyl alcohol derivative and a polyacrylic acid derivative. The conductive hydrogel dressing has excellent conductivity, can be used for promoting cell migration and proliferation and accelerating wound healing, and also can monitor the electrical signal change of wound healing in real time through the conductivity of the conductive hydrogel dressing.

The invention relates to the technical field of biological medicine, and discloses anti-aging and tissue repair and regeneration promoting platelet-rich plasma and a preparation method and application thereof.The preparation method comprises the following steps that concentrated platelet plasma is obtained, and low-intensity pulse ultrasound is adopted for treating the concentrated platelet plasma; the treatment conditions are one of the following treatment modes: 1) the treatment power is 2-5 W / cm < 2 >, the pulse period is 50%, and the ultrasonic treatment time is 2-10 min; (2) first ultrasonic treatment is carried out, specifically, 0.2-1.0 W / cm < 2 > is adopted, the pulse period is 50%, and ultrasonic treatment is carried out for 1-5 min; carrying out second ultrasonic treatment for 1-5 minutes by adopting 1.5-5.0 W / cm < 2 > and a pulse period of 50%; a special ultrasonic treatment system is adopted, the PRR product with special activation and lysis characteristics is obtained, and the product contains active substances beneficial to tissue repair and regeneration and anti-aging, and shows excellent effects in the aspects of promoting cell proliferation, cell migration and wound healing.