73 results about "Hemostatic function" patented technology

In some embodiments, the disposable system includes a multi-channel or multi-chamber test cartridge device configured to operate with a test system for assessing hemostasis in a subject by assessing a test sample from the subject in vitro. In some embodiments, the disposable system is configured to interrogate the test sample to assess clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes that occur during coagulation and / or lysis of the resulting clot.

The invention belongs to the field of biomedical materials, and particularly relates to a self-adhesion composite patch for tooth extraction cavity wound repair and a preparation method thereof. The self-adhesion composite patch comprises a wound filling layer and an adhesion blocking layer, the wound filling layer is located in the middle of the adhesion blocking layer, the wound filling layer is made of a biological sponge material, and the adhesion blocking layer is made of polymer fibers and biological glue. The self-adhesion composite patch has excellent hemostasis, repairing, blocking, biosafety, biodegradability and water absorption, due to the excellent water absorption and biodegradability, the wound filling layer can achieve the excellent hemostasis function under the condition of a small filling amount, and meanwhile, the self-adhesion composite patch has the advantages that the self-adhesion composite patch is good in hemostasis effect and good in barrier effect. Due to the reduction of the wound filling layer and the excellent degradation performance, the self-adhesion composite patch cannot generate adverse effects on wound healing, and secondary operation for taking out the patch is not needed.

A series of sofalcone derivatives are provided.SOLUTION: A series of sofalcone derivatives provided by the present invention are, for example, compounds having a structure of formula (I), and have platelet aggregation inhibitory and antithrombotic effects. The sofalcone derivatives of the present invention are TxA2 receptor antagonists, have an inhibitory effect on platelet agglutination, and do not easily affect the hemostatic function. The present invention also provides a method for preparing the sofalcone derivative, and a method for using the sofalcone derivative for preventing or treating thrombotic diseases, or for inhibiting platelet aggregation.SELECTED DRAWING: None

This invention discloses a method for preparing a thermosensitive hemostatic gel, which is prepared by mixing a thermosensitive polymer solution with a solution of micron-sized polymer particles or microspheres with hemostatic function. The concentration of the solution of micron-sized polymer particles or microspheres with hemostatic function is 3-100 mg / mL; the concentration of the thermosensitive polymer solution is 200-450 mg / mL; the diameter of the micron-sized polymer particles or microspheres with hemostatic function is 300-900 micrometers; the gelation temperature of the thermosensitive hemostatic gel from a flowing liquid state to a solid state is greater than 15 degrees Celsius, and it is a flowing liquid state at temperatures below 15 degrees Celsius. Under the condition of warming up in response to the human body temperature, the flowing liquid hemostatic gel transforms into a solid hemostatic gel, thereby achieving the hemostatic function. The micron-sized polymer particles or microspheres in the thermosensitive hemostatic gel will not enter the damaged blood vessel during the hemostasis process.

The invention provides a medical absorbable collagen antibacterial suture line and a preparation method thereof. The preparation method comprises the following steps: S1, sequentially carrying out pretreatment, homogenization, digestion, sterilization, salting-out and purification on animal skin to obtain collagen; s2, performing solution blending on collagen and a chitosan derivative to prepare a spinning solution; s3, performing wet spinning on the spinning solution to obtain a wire rod; and S4, crosslinking or weaving the wire rod to prepare the medical antibacterial suture line capable of absorbing collagen. The suture line is high in collagen purity, in a special fiber bundle shape, low in antigenicity, good in spinnability, smooth in surface, soft and smooth in line body and easy to knot, does not need to be soaked before being used, can reduce scar hyperplasia and avoid centipede-shaped suture traces during suture, has antibacterial and hemostatic functions, and is suitable for clinical application. A physical hemostasis barrier can be quickly generated in the suturing process, and an excellent suturing effect is achieved.

Novel binding molecules comprising humanized antibodies, fragments, variants, and derivatives thereof, as well as compositions, methods, and kits comprising the same, are described, wherein the binding molecules specifically bind to FX1 and FX1a. The binding molecules are capable of binding to the factor X1A2 domain and forming immune complexes, thereby disrupting the contact activation molecule complex without affecting the activity or activation of hemostatic factor XI. The binding molecules disclosed herein are suitable for safely inhibiting thrombosis and inflammation without impairing hemostasis. Thus, the binding molecules, compositions, methods, and kits provided herein are intended for treating diseases and conditions, particularly those associated with thrombosis and inflammation. In addition, polynucleotides encoding the binding molecules disclosed herein, vectors comprising the polynucleotides, and host cells for producing the polynucleotides are also provided.

The invention relates to the technical field of hemostasis, and discloses a medical wrist strap with a hemostasis function, which comprises a main body assembly, a wrist strap body and a locking assembly, an information nameplate is fixed on one side of the wrist strap body, the wrist strap body is made of an elastic bandage, the locking assembly is arranged on the wrist strap body and comprises a rotating part, and the rotating part comprises a fixed frame. The wrist strap has the beneficial effects that the wrist strap is made of an elastic bandage material and is matched with the locking assembly, when hemostasis is needed in emergency, hemostasis can be carried out on the bleeding part of a patient through the wrist strap, the length of the wrist strap can be adjusted, the wrist strap can be bound to different bleeding parts of the patient, and after hemostasis is carried out for a certain period of time, the wrist strap can be fixed. In addition, the wrist strap can be automatically relaxed for a short time and tightened again, so that blood circulation of the far end of the limb can be temporarily recovered, and serious injury, such as muscle necrosis, nerve injury and the like, of limb tissue caused by long-time ischemia is avoided.

The present invention discloses an anorectal hemostasis and stripping device, which relates to the technical field of medical devices and is intended to solve the technical problem that doctors need to repeatedly pick up and alternately use hemostatic forceps and stripping scissors during anorectal surgery, which is inconvenient in operation. The present invention includes two rotatably connected scissor bodies, each of which includes a scissor head, and the upper and lower end faces of each scissor head are bent inward and extend in the direction close to the other scissor head. The two ends of each scissor head extending inward are respectively provided with a hemostatic surface and a stripping surface, and the two hemostatic surfaces are arranged relative to each other to form a hemostatic part, and the two stripping surfaces are arranged relative to each other to form a stripping part. The present invention adopts a hemostatic surface, a stripping surface, etc. to combine the hemostatic function and the stripping function into one device, thereby realizing the conversion of the stripping function and the hemostatic function, without having to repeatedly pick up and use the hemostatic forceps and stripping scissors during the operation, thereby making it more convenient for doctors to use the device. It can improve surgical efficiency and reduce operation time.

The invention relates to the technical field of hemostatic materials, in particular to composite hemostatic gel as well as a preparation method and application thereof. The composite hemostatic gel is prepared from the following components in percentage by mass: 0.5 to 3 percent of carboxymethyl chitosan, 0.5 to 5 percent of trehalose, 1 to 10 percent of glycerol, 0.1 to 2 percent of carbomer, 0.1 to 2 percent of recombinant blood coagulation factor III, 0.005 to 0.05 percent of benzalkonium chloride and the balance of Tris-HCl buffer solution. Based on the synergistic effect of a natural high polymer material carboxymethyl chitosan and a bioactive component recombinant blood coagulation factor III, the gel constructs a'physical adsorption-blood coagulation activation 'dual hemostasis pathway, realizes a rapid and multi-mechanism hemostasis function, has antibacterial and repair promoting characteristics, can be widely applied to various bleeding scenes such as cutting wounds and surgical wounds, and has wide application prospects. The wound healing is effectively promoted.

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.

The biopsy and hemostasis integrated balloon catheter for the bronchoscope comprises a catheter body, and a working hole channel, a balloon channel and a guide wire channel which are independent of one another are integrally arranged on the catheter body; wherein the working hole channel is used as a channel when the freezing probe performs biopsy operation; a hemostasis balloon communicated with the balloon channel is arranged at the catheter head end of the catheter body, hemostasis medicine is arranged on the outer surface of the hemostasis balloon, and the hemostasis balloon is inflated and expanded through the balloon channel to achieve compression hemostasis; a guide wire is arranged in the guide wire channel, and the catheter body is guided to reach a target position in the trachea through the guide wire. According to the application, the functions of freezing biopsy and instant hemostasis are integrated.

The invention relates to the technical field of medical instruments, in particular to a cardiology department nursing pressing hemostasis device which mainly comprises an installation frame, a supporting frame fixedly installed on the top face of the installation frame, a fixing rod fixedly installed on the bottom face of the supporting frame, a pressing block and a buffering sponge arranged on one side of the supporting frame, and an adjusting mechanism arranged on one side of the supporting frame. The fixing mechanism is arranged on one side of the supporting frame, and the locking mechanism is arranged on one side of the supporting frame. By adjusting the butterfly nut and the bolt rod, then pushing the bolt rod to drive the connecting block and the fixing sleeve to rotate by a certain angle, the fixing sleeve drives the rotating strip to rotate by a certain angle, and the rotating strip drives the pressing block below to rotate by a certain angle, so that the pressing block is matched with the inclined side surface of a patient; the pressing block is used for pressing and stopping bleeding of the inclined side face bleeding part of the patient and can give full play to the due bleeding stopping function, and therefore the pressing and bleeding stopping effect is improved.

The utility model belongs to nursing paste technical field, and disclose a kind of local cold compress and hemostasis integration nursing paste after inoculation, including backing layer, the lower surface of backing layer is equipped with cold compress layer, and the lower surface of cold compress layer is equipped with hemostasis layer, the lower surface of backing layer is fixedly equipped with the fit circle, the outer surface of cold compress layer and hemostasis layer is all with fit circle movable fit, the lower surface of fit circle is connected with isolation layer with adhesion, the upper surface of cold compress layer is fixedly equipped with positioning column symmetrically, the upper surface of backing layer is equipped with column groove symmetrically, the upper end of positioning column is penetrated through corresponding column groove and is fixedly connected with limit ball. Through the above scheme, cold compress and hemostasis function are integrated in nursing paste, simplify inoculation nursing process, save time manpower, reduce pain swelling, accelerate wound healing, reduce infection risk;Meanwhile, through positioning column, limit ball and fit circle design, guarantee cold compress layer stability, improve nursing paste fit degree and use experience.

This invention belongs to the field of biomedical functional materials technology, and relates to an antibacterial and healing-promoting photosensitizer, its preparation method, and its uses. The photosensitizer is a defective MIL-88B@MIL-88C composite material, wherein defective MIL-88B serves as the substrate, and MIL-88C grows on the surface and / or in the pores of the defective MIL-88B. This photosensitizer significantly improves the photogenerated carrier separation efficiency, reduces impedance, enhances photocurrent response, and can efficiently generate reactive oxygen species under light irradiation. Antibacterial experiments show that it has excellent bactericidal effects against Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus, and is not prone to inducing drug resistance. Simultaneously, this photosensitizer has good biocompatibility, promotes cell migration, and has significant hemostatic function. Animal models show that it can effectively accelerate the healing of skin defects.

The present disclosure provides a Paenibacillus strain, and a hemostatic polysaccharide produced by same and use thereof. In the present disclosure, a Paenibacillus sp. 1229 has a deposit number of CCTCC NO: M 2022553. A produced exopolysaccharide (EPS) Hemoadhican has a hemostatic function, and can be prepared as a hemostatic material in different dosage forms for different types of hemostasis. The hemostatic material has a high hemostatic speed, no need for applying pressures to the wound for a long time, safety and non-toxicity, desirable biocompatibility, and no requirement of removal after use. The material is suitable for the application of hemostasis in irregular bleeding such as solid organs in vitro or in vivo and diffuse bleeding.

A vessel closure device for delivering immediate hemostasis at a puncture site in a wall of a blood vessel includes an intravascular anchor having one or more suture attachment points, an extravascular cap having a lumen, a sealant, and a suture connected to at least one of the one or more suture attachment points of the intravascular anchor and threaded through the lumen of the extravascular cap, wherein each of the intravascular anchor, extravascular cap, sealant, and suture are formed of bioabsorbable materials.

The application discloses an amino acid surfactant with hemostatic function and a preparation method thereof. The method is to make the tranexamic acid and long aliphatic acyl chloride undergo condensation reaction under the action of alkali, and then perform acidification and esterification reaction to obtain the amino acid surfactant with hemostatic function. Compared with the long-chain fatty acyl thrombin acid salt reported in the prior art, the amino acid surfactant has good fat solubility, better transdermal permeability and better toner dispersibility. The preparation method has mild reaction conditions, simple operation, simple product separation and purification and high yield, and is suitable for industrial production.

The application belongs to the technical field of vascular covered stent, and relates to a vascular covered stent for emergency hemorrhage and a preparation method thereof. The vascular covered stent comprises a tubular stent framework and a double-layer composite fiber membrane covering the outer surface of the tubular stent framework. The double-layer composite fiber membrane is composed of an inner buffer layer and an outer structural layer. The inner buffer layer is a polyvinyl alcohol porous fiber membrane, and the outer structural layer is a biodegradable elastomer fiber membrane. In the preparation, the tubular stent framework subjected to surface activation treatment is first fixed on an electrospinning collector, and polyvinyl alcohol porous fiber membranes and biodegradable elastomer fiber membranes are spun on the outer surface of the tubular stent framework in sequence, and then the stent with the double-layer covering membranes is annealed to obtain the vascular covered stent. The product has excellent compression damage resistance, instant hemostasis function and good delivery. The preparation method is simple and easy to implement.

This invention belongs to the technical field of hemostatic devices, and particularly relates to a compression hemostatic device for blood purification. It includes: a frame with Velcro straps wound around it, and a connecting shell fixedly connected to the frame; a lifting rod threadedly connected to the connecting shell, rotatably connected to a connecting rod, and a spring fixedly connected between the connecting rod and the connecting shell; an adjusting rod slidably connected to the connecting rod, and a hemostatic plate hinged to the adjusting rod; an arc-shaped plate disposed on the hemostatic plate; and a sliding frame slidably connected to the frame, slidably connected to a movable frame, with symmetrically distributed compression rods fixedly connected to the movable frame. When performing secondary wound care on a patient, this invention rotates the hemostatic plate and the arc-shaped plate, causing the arc-shaped plate to compress the area around the patient's wound and lift the hemostatic plate. This maintains the hemostatic function while separating the hemostatic plate from the patient's wound, facilitating secondary wound care by staff.

The invention relates to the technical field of medical bandages, and discloses a biomass bacteriostatic hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite bacteriostatic functional layer loaded on the bandage base material, and the functional layer is composed of a composite bacteriostatic unit and lysozyme; the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol slow-release shell and an enzymolysis cellulose bracket. According to the invention, a cationic antibacterial core-polyphenol slow-release shell-enzymolysis cellulose support composite antibacterial unit is constructed, and lysozyme is cooperatively loaded, so that the biomass antibacterial hemostatic bandage which has a broad spectrum, is long-acting, is not easy to generate drug resistance and has a hemostatic function is formed. The bandage shows remarkable technical advantages in coping with complex wound infection, especially gram-negative bacterium infection and drug-resistant bacterium challenge, provides an efficient and safe solution for clinical wound management, and has important clinical application value and wide market prospect.

The present invention belongs to the field of biopharmaceutical materials technology, and specifically relates to a patch with a repairing effect, a preparation method, and applications. The patch comprises the following raw materials: an acidic chitosan solution, a kudzu root powder solution, glycerol, and a polypeptide, wherein the volume ratio of the acidic chitosan solution to the kudzu root powder solution is 1 to 9:9 to 1. The present invention uses chitosan, kudzu root powder, and polypeptide as raw materials, and mixes the polypeptide with a natural composite matrix chitosan / kudzu root powder to prepare a patch with good mechanical properties, excellent biocompatibility, excellent biodegradability, good antibacterial properties, the ability to promote wound healing, and hemostasis. The patch is non-irritating to oral ulcer surfaces, is safe and has no toxic side effects, can adhere to the ulcer surface, and has pain relief, antibacterial, anti-inflammatory, and repair-promoting effects. It can effectively promote ulcer healing, repair and protect wounds from infection, and has excellent biocompatibility and biodegradability. The preparation method is simple and easy to operate.

The utility model relates to a pair of biopsy forceps with a hemostasis function for the department of biliary and pancreatic surgery, which belongs to the technical field of medical instruments and comprises a forceps rod, an extension tube, an insulating sleeve, forceps heads and electrode ends, and watering structures are mounted on the insulating sleeve and the forceps rod. The watering structure comprises a spray head, a water conveying pipe and an external pipe, the two ends of the water conveying pipe are fixedly communicated with the spray head and the external pipe respectively, and an adjusting structure extending to the clamp rod is arranged on the outer surface of the spray head; the adjusting structure comprises an adjusting cover installed on the outer surface of the spray head in a sleeving mode, a pull rope fixed to one side of the adjusting cover, a portal frame fixed to the outer surface of the clamp rod and a lifting block installed on the inner side of the portal frame in a sliding mode. According to the biopsy forceps with the hemostasis function for the biliary and pancreatic surgery department, infusion equipment is connected with a water conveying pipe through an external connecting pipe, liquid is sprayed out through a spray head, the operation convenience of the surgery is further improved, and the biopsy forceps have the advantages of being high in practicability, capable of achieving medicine spraying and the like.

The invention discloses a novel application with a cold compress hemostasis function for hemodialysis, and relates to the technical field of medical supplies. The plaster comprises a plaster body, a first opening is formed in the plaster body, internal threads are formed in the upper side of the plaster body and located in the first opening and the inner wall of a mounting head, and bandages used for binding are arranged on the two sides of the plaster body; the hydrocolloid dressing layer is attached to the lower side of the application body. The hydrocolloid dressing layer can be directly and firmly adhered to the skin at the edge of a wound and can absorb seepage, the pressing cylinder is arranged and moves downwards by rotating the pressing cylinder so as to slowly press and stop bleeding of the wound, and the cold insulation ring is arranged so that local blood vessels around the wound can be conveniently constricted. And the traditional Chinese medicine preparation can be immediately used after dialysis, so that the wound can be scientifically nursed, and the pain of a patient can be relieved.

This invention provides a cardiology compression hemostasis device, belonging to the field of medical devices. It includes a closed elastic bandage made of textile material with elastic extensibility, a component mounting port located in the middle of the closed elastic bandage, an elastic compression mechanism, and a planar pre-tensioning adjustment mechanism. Internally, it includes a hollow inner annular body installed in the component mounting port, and three pull ropes arranged in a ring array that can move within the inner annular body and exert tension on one end of a first helical spring. This cardiology compression hemostasis device can provide elastic pressure adjustable compression hemostasis to wounds, thus possessing stable pressure resistance. Furthermore, the device adjusts the compression intensity through planar rotation, thereby reducing the longitudinal height of the compression components and reducing the range of motion restriction for the patient, thus minimizing the occurrence of secondary injuries caused by accidental impact at height.

Intracerebral hemorrhage (ICH), defined as spontaneous bleeding into the brain, is the deadliest, most disabling, and least treatable form of stroke. The aim of the present invention is to generate large amount of hemostatic mEVs to be used as hemostatic patches in different preclinical models of ICH. Indeed, the exogenous mEVs pf the present invention bearing TF and PSGL-1 improve outcome after collagenase-induced ICH by acting as intravascular hemostatic patches. The present invention thus relates to monocyte extracellular vesicles (mEVs) functionalized with tissue factor (TF) and P-Selectin Glycoprotein Ligand 1 (PSGL-1).

This invention discloses a tearable catheter sheath with hemostatic function, relating to the field of medical device technology, which solves the problem of inconvenience for financial personnel in binding vouchers. It includes: a sheath assembly comprising two symmetrical tearable tube seats, with a tearable sheath tube commonly disposed on the inner edge surface of the bottom openings of the two tearable tube seats; tear lines are provided on the tearable sheath tube along the symmetrical axis of the two tearable tube seats to ensure that the tearable sheath tube can be torn simultaneously when the two tearable tube seats are torn outwards; and a limiting component disposed between the tearable tube seats and the tearable sheath tube; the limiting component includes a limiting ring disposed on the outer edge surface of the tearable sheath tube, which ensures that the opening position of the tearable sheath tube when peeled is above the puncture incision, preventing the tearable sheath tube from pulling the puncture incision to the sides and causing incision expansion when it is peeled off and withdrawn from the blood vessel.

The application discloses a hydrogel with antibacterial and hemostatic functions and a preparation method and application thereof. The composite hydrogel is mainly prepared by mixing polyvinyl alcohol (PVA), natural honey and a nano-silver solution. The preparation method comprises the following steps: firstly, a stable dispersed nano-silver base solution is prepared by using a high-molecular dispersant and a reducing agent, and dialysis purification is performed on the base solution; then, deionized water and PVA are added and heated and stirred until completely dissolved; after cooling, natural honey is added dropwise and uniformly mixed, and physical cross-linking molding is performed by using a freeze-thaw cycle technology after ultrasonic defoaming. The hydrogel can quickly absorb exudates on a wound surface and promote blood coagulation by using the strong and tough porous network of PVA, and can realize multiple synergistic antibacterial under a low-toxicity and safe concentration by combining the microscopic physical damage of nano-silver and the high-osmotic and slightly acidic environment of natural honey. The hydrogel preparation process is green and safe, no chemical cross-linking agent is left, and the hydrogel has excellent dynamic and non-invasive adhesion and long-acting moisturizing properties, and can be widely applied to rapid sealing, hemostasis and healing promotion treatment of complex infected wounds.

The invention discloses a wound dressing with a hemostatic function, which is characterized in that a gel fiber fabric with hydrophilicity and a porous structure is used as a base material, and hemostatic drugs are distributed in surface micropores or internal pore spaces of the gel fiber base material through surface smearing or soaking loading; the gel fiber fabric is prepared from one or more of acylated chitosan fiber, carboxymethyl chitosan fiber, carboxymethyl cellulose (CMC) fiber, carboxyethyl cellulose fiber, alginate fiber and hydrophilic formalized polyvinyl alcohol fiber; the hemostatic drug is tranexamic acid or a derivative thereof, thrombin, chitosan or fibrinogen in an internal pore space. By utilizing the hygroscopicity of the gel fiber dressing and the softness of the wet gel, the hemostatic medicine is effectively sent to each part of the wound surface, so that the aim of effectively stopping bleeding on the complex wound surface is fulfilled.

The application relates to the technical field of collagen materials, and particularly discloses a collagen material, a preparation method thereof and application of the collagen material in collagen hemostatic powder. The preparation method of the collagen material is as follows: enzyme hydrolysis reaction: adjusting a raw material sample liquid to pH 3.5-6.0, adding a composite enzyme, carrying out enzyme hydrolysis at a temperature of 30-40 DEG C for 4-12 h, and centrifuging to obtain a supernatant; the composite enzyme is composed of trypsin and phospholipase in a weight ratio of 1-5:0.02-0.08; alkali treatment: adjusting the supernatant to pH>13, and carrying out alkali treatment at a temperature of 15-25 DEG C for more than 40 h; neutralization reaction: adjusting pH to 6.8-7.6, eluting, and removing water by extrusion, so that the collagen material is obtained. The application also provides application of the collagen material in the collagen hemostatic powder. The collagen hemostatic powder provided by the application has excellent hemostatic function and water absorption efficiency, and the hemostatic material has high stability.