47 results about "Hemostatic function" patented technology

A series of sofalcone derivatives are provided.SOLUTION: A series of sofalcone derivatives provided by the present invention are, for example, compounds having a structure of formula (I), and have platelet aggregation inhibitory and antithrombotic effects. The sofalcone derivatives of the present invention are TxA2 receptor antagonists, have an inhibitory effect on platelet agglutination, and do not easily affect the hemostatic function. The present invention also provides a method for preparing the sofalcone derivative, and a method for using the sofalcone derivative for preventing or treating thrombotic diseases, or for inhibiting platelet aggregation.SELECTED DRAWING: None

This invention discloses a method for preparing a thermosensitive hemostatic gel, which is prepared by mixing a thermosensitive polymer solution with a solution of micron-sized polymer particles or microspheres with hemostatic function. The concentration of the solution of micron-sized polymer particles or microspheres with hemostatic function is 3-100 mg / mL; the concentration of the thermosensitive polymer solution is 200-450 mg / mL; the diameter of the micron-sized polymer particles or microspheres with hemostatic function is 300-900 micrometers; the gelation temperature of the thermosensitive hemostatic gel from a flowing liquid state to a solid state is greater than 15 degrees Celsius, and it is a flowing liquid state at temperatures below 15 degrees Celsius. Under the condition of warming up in response to the human body temperature, the flowing liquid hemostatic gel transforms into a solid hemostatic gel, thereby achieving the hemostatic function. The micron-sized polymer particles or microspheres in the thermosensitive hemostatic gel will not enter the damaged blood vessel during the hemostasis process.

The invention provides a medical absorbable collagen antibacterial suture line and a preparation method thereof. The preparation method comprises the following steps: S1, sequentially carrying out pretreatment, homogenization, digestion, sterilization, salting-out and purification on animal skin to obtain collagen; s2, performing solution blending on collagen and a chitosan derivative to prepare a spinning solution; s3, performing wet spinning on the spinning solution to obtain a wire rod; and S4, crosslinking or weaving the wire rod to prepare the medical antibacterial suture line capable of absorbing collagen. The suture line is high in collagen purity, in a special fiber bundle shape, low in antigenicity, good in spinnability, smooth in surface, soft and smooth in line body and easy to knot, does not need to be soaked before being used, can reduce scar hyperplasia and avoid centipede-shaped suture traces during suture, has antibacterial and hemostatic functions, and is suitable for clinical application. A physical hemostasis barrier can be quickly generated in the suturing process, and an excellent suturing effect is achieved.

The invention relates to the technical field of hemostatic materials, in particular to composite hemostatic gel as well as a preparation method and application thereof. The composite hemostatic gel is prepared from the following components in percentage by mass: 0.5 to 3 percent of carboxymethyl chitosan, 0.5 to 5 percent of trehalose, 1 to 10 percent of glycerol, 0.1 to 2 percent of carbomer, 0.1 to 2 percent of recombinant blood coagulation factor III, 0.005 to 0.05 percent of benzalkonium chloride and the balance of Tris-HCl buffer solution. Based on the synergistic effect of a natural high polymer material carboxymethyl chitosan and a bioactive component recombinant blood coagulation factor III, the gel constructs a'physical adsorption-blood coagulation activation 'dual hemostasis pathway, realizes a rapid and multi-mechanism hemostasis function, has antibacterial and repair promoting characteristics, can be widely applied to various bleeding scenes such as cutting wounds and surgical wounds, and has wide application prospects. The wound healing is effectively promoted.

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.

The biopsy and hemostasis integrated balloon catheter for the bronchoscope comprises a catheter body, and a working hole channel, a balloon channel and a guide wire channel which are independent of one another are integrally arranged on the catheter body; wherein the working hole channel is used as a channel when the freezing probe performs biopsy operation; a hemostasis balloon communicated with the balloon channel is arranged at the catheter head end of the catheter body, hemostasis medicine is arranged on the outer surface of the hemostasis balloon, and the hemostasis balloon is inflated and expanded through the balloon channel to achieve compression hemostasis; a guide wire is arranged in the guide wire channel, and the catheter body is guided to reach a target position in the trachea through the guide wire. According to the application, the functions of freezing biopsy and instant hemostasis are integrated.

The invention relates to the technical field of medical instruments, in particular to a cardiology department nursing pressing hemostasis device which mainly comprises an installation frame, a supporting frame fixedly installed on the top face of the installation frame, a fixing rod fixedly installed on the bottom face of the supporting frame, a pressing block and a buffering sponge arranged on one side of the supporting frame, and an adjusting mechanism arranged on one side of the supporting frame. The fixing mechanism is arranged on one side of the supporting frame, and the locking mechanism is arranged on one side of the supporting frame. By adjusting the butterfly nut and the bolt rod, then pushing the bolt rod to drive the connecting block and the fixing sleeve to rotate by a certain angle, the fixing sleeve drives the rotating strip to rotate by a certain angle, and the rotating strip drives the pressing block below to rotate by a certain angle, so that the pressing block is matched with the inclined side surface of a patient; the pressing block is used for pressing and stopping bleeding of the inclined side face bleeding part of the patient and can give full play to the due bleeding stopping function, and therefore the pressing and bleeding stopping effect is improved.

The utility model belongs to nursing paste technical field, and disclose a kind of local cold compress and hemostasis integration nursing paste after inoculation, including backing layer, the lower surface of backing layer is equipped with cold compress layer, and the lower surface of cold compress layer is equipped with hemostasis layer, the lower surface of backing layer is fixedly equipped with the fit circle, the outer surface of cold compress layer and hemostasis layer is all with fit circle movable fit, the lower surface of fit circle is connected with isolation layer with adhesion, the upper surface of cold compress layer is fixedly equipped with positioning column symmetrically, the upper surface of backing layer is equipped with column groove symmetrically, the upper end of positioning column is penetrated through corresponding column groove and is fixedly connected with limit ball. Through the above scheme, cold compress and hemostasis function are integrated in nursing paste, simplify inoculation nursing process, save time manpower, reduce pain swelling, accelerate wound healing, reduce infection risk;Meanwhile, through positioning column, limit ball and fit circle design, guarantee cold compress layer stability, improve nursing paste fit degree and use experience.

This invention belongs to the field of biomedical functional materials technology, and relates to an antibacterial and healing-promoting photosensitizer, its preparation method, and its uses. The photosensitizer is a defective MIL-88B@MIL-88C composite material, wherein defective MIL-88B serves as the substrate, and MIL-88C grows on the surface and / or in the pores of the defective MIL-88B. This photosensitizer significantly improves the photogenerated carrier separation efficiency, reduces impedance, enhances photocurrent response, and can efficiently generate reactive oxygen species under light irradiation. Antibacterial experiments show that it has excellent bactericidal effects against Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus, and is not prone to inducing drug resistance. Simultaneously, this photosensitizer has good biocompatibility, promotes cell migration, and has significant hemostatic function. Animal models show that it can effectively accelerate the healing of skin defects.

The present disclosure provides a Paenibacillus strain, and a hemostatic polysaccharide produced by same and use thereof. In the present disclosure, a Paenibacillus sp. 1229 has a deposit number of CCTCC NO: M 2022553. A produced exopolysaccharide (EPS) Hemoadhican has a hemostatic function, and can be prepared as a hemostatic material in different dosage forms for different types of hemostasis. The hemostatic material has a high hemostatic speed, no need for applying pressures to the wound for a long time, safety and non-toxicity, desirable biocompatibility, and no requirement of removal after use. The material is suitable for the application of hemostasis in irregular bleeding such as solid organs in vitro or in vivo and diffuse bleeding.

The application discloses an amino acid surfactant with hemostatic function and a preparation method thereof. The method is to make the tranexamic acid and long aliphatic acyl chloride undergo condensation reaction under the action of alkali, and then perform acidification and esterification reaction to obtain the amino acid surfactant with hemostatic function. Compared with the long-chain fatty acyl thrombin acid salt reported in the prior art, the amino acid surfactant has good fat solubility, better transdermal permeability and better toner dispersibility. The preparation method has mild reaction conditions, simple operation, simple product separation and purification and high yield, and is suitable for industrial production.

The application belongs to the technical field of vascular covered stent, and relates to a vascular covered stent for emergency hemorrhage and a preparation method thereof. The vascular covered stent comprises a tubular stent framework and a double-layer composite fiber membrane covering the outer surface of the tubular stent framework. The double-layer composite fiber membrane is composed of an inner buffer layer and an outer structural layer. The inner buffer layer is a polyvinyl alcohol porous fiber membrane, and the outer structural layer is a biodegradable elastomer fiber membrane. In the preparation, the tubular stent framework subjected to surface activation treatment is first fixed on an electrospinning collector, and polyvinyl alcohol porous fiber membranes and biodegradable elastomer fiber membranes are spun on the outer surface of the tubular stent framework in sequence, and then the stent with the double-layer covering membranes is annealed to obtain the vascular covered stent. The product has excellent compression damage resistance, instant hemostasis function and good delivery. The preparation method is simple and easy to implement.

This invention belongs to the technical field of hemostatic devices, and particularly relates to a compression hemostatic device for blood purification. It includes: a frame with Velcro straps wound around it, and a connecting shell fixedly connected to the frame; a lifting rod threadedly connected to the connecting shell, rotatably connected to a connecting rod, and a spring fixedly connected between the connecting rod and the connecting shell; an adjusting rod slidably connected to the connecting rod, and a hemostatic plate hinged to the adjusting rod; an arc-shaped plate disposed on the hemostatic plate; and a sliding frame slidably connected to the frame, slidably connected to a movable frame, with symmetrically distributed compression rods fixedly connected to the movable frame. When performing secondary wound care on a patient, this invention rotates the hemostatic plate and the arc-shaped plate, causing the arc-shaped plate to compress the area around the patient's wound and lift the hemostatic plate. This maintains the hemostatic function while separating the hemostatic plate from the patient's wound, facilitating secondary wound care by staff.

The invention relates to the technical field of medical bandages, and discloses a biomass bacteriostatic hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite bacteriostatic functional layer loaded on the bandage base material, and the functional layer is composed of a composite bacteriostatic unit and lysozyme; the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol slow-release shell and an enzymolysis cellulose bracket. According to the invention, a cationic antibacterial core-polyphenol slow-release shell-enzymolysis cellulose support composite antibacterial unit is constructed, and lysozyme is cooperatively loaded, so that the biomass antibacterial hemostatic bandage which has a broad spectrum, is long-acting, is not easy to generate drug resistance and has a hemostatic function is formed. The bandage shows remarkable technical advantages in coping with complex wound infection, especially gram-negative bacterium infection and drug-resistant bacterium challenge, provides an efficient and safe solution for clinical wound management, and has important clinical application value and wide market prospect.

The utility model relates to a pair of biopsy forceps with a hemostasis function for the department of biliary and pancreatic surgery, which belongs to the technical field of medical instruments and comprises a forceps rod, an extension tube, an insulating sleeve, forceps heads and electrode ends, and watering structures are mounted on the insulating sleeve and the forceps rod. The watering structure comprises a spray head, a water conveying pipe and an external pipe, the two ends of the water conveying pipe are fixedly communicated with the spray head and the external pipe respectively, and an adjusting structure extending to the clamp rod is arranged on the outer surface of the spray head; the adjusting structure comprises an adjusting cover installed on the outer surface of the spray head in a sleeving mode, a pull rope fixed to one side of the adjusting cover, a portal frame fixed to the outer surface of the clamp rod and a lifting block installed on the inner side of the portal frame in a sliding mode. According to the biopsy forceps with the hemostasis function for the biliary and pancreatic surgery department, infusion equipment is connected with a water conveying pipe through an external connecting pipe, liquid is sprayed out through a spray head, the operation convenience of the surgery is further improved, and the biopsy forceps have the advantages of being high in practicability, capable of achieving medicine spraying and the like.

The invention discloses a novel application with a cold compress hemostasis function for hemodialysis, and relates to the technical field of medical supplies. The plaster comprises a plaster body, a first opening is formed in the plaster body, internal threads are formed in the upper side of the plaster body and located in the first opening and the inner wall of a mounting head, and bandages used for binding are arranged on the two sides of the plaster body; the hydrocolloid dressing layer is attached to the lower side of the application body. The hydrocolloid dressing layer can be directly and firmly adhered to the skin at the edge of a wound and can absorb seepage, the pressing cylinder is arranged and moves downwards by rotating the pressing cylinder so as to slowly press and stop bleeding of the wound, and the cold insulation ring is arranged so that local blood vessels around the wound can be conveniently constricted. And the traditional Chinese medicine preparation can be immediately used after dialysis, so that the wound can be scientifically nursed, and the pain of a patient can be relieved.

This invention provides a cardiology compression hemostasis device, belonging to the field of medical devices. It includes a closed elastic bandage made of textile material with elastic extensibility, a component mounting port located in the middle of the closed elastic bandage, an elastic compression mechanism, and a planar pre-tensioning adjustment mechanism. Internally, it includes a hollow inner annular body installed in the component mounting port, and three pull ropes arranged in a ring array that can move within the inner annular body and exert tension on one end of a first helical spring. This cardiology compression hemostasis device can provide elastic pressure adjustable compression hemostasis to wounds, thus possessing stable pressure resistance. Furthermore, the device adjusts the compression intensity through planar rotation, thereby reducing the longitudinal height of the compression components and reducing the range of motion restriction for the patient, thus minimizing the occurrence of secondary injuries caused by accidental impact at height.

Intracerebral hemorrhage (ICH), defined as spontaneous bleeding into the brain, is the deadliest, most disabling, and least treatable form of stroke. The aim of the present invention is to generate large amount of hemostatic mEVs to be used as hemostatic patches in different preclinical models of ICH. Indeed, the exogenous mEVs pf the present invention bearing TF and PSGL-1 improve outcome after collagenase-induced ICH by acting as intravascular hemostatic patches. The present invention thus relates to monocyte extracellular vesicles (mEVs) functionalized with tissue factor (TF) and P-Selectin Glycoprotein Ligand 1 (PSGL-1).

This invention discloses a tearable catheter sheath with hemostatic function, relating to the field of medical device technology, which solves the problem of inconvenience for financial personnel in binding vouchers. It includes: a sheath assembly comprising two symmetrical tearable tube seats, with a tearable sheath tube commonly disposed on the inner edge surface of the bottom openings of the two tearable tube seats; tear lines are provided on the tearable sheath tube along the symmetrical axis of the two tearable tube seats to ensure that the tearable sheath tube can be torn simultaneously when the two tearable tube seats are torn outwards; and a limiting component disposed between the tearable tube seats and the tearable sheath tube; the limiting component includes a limiting ring disposed on the outer edge surface of the tearable sheath tube, which ensures that the opening position of the tearable sheath tube when peeled is above the puncture incision, preventing the tearable sheath tube from pulling the puncture incision to the sides and causing incision expansion when it is peeled off and withdrawn from the blood vessel.

The application discloses a hydrogel with antibacterial and hemostatic functions and a preparation method and application thereof. The composite hydrogel is mainly prepared by mixing polyvinyl alcohol (PVA), natural honey and a nano-silver solution. The preparation method comprises the following steps: firstly, a stable dispersed nano-silver base solution is prepared by using a high-molecular dispersant and a reducing agent, and dialysis purification is performed on the base solution; then, deionized water and PVA are added and heated and stirred until completely dissolved; after cooling, natural honey is added dropwise and uniformly mixed, and physical cross-linking molding is performed by using a freeze-thaw cycle technology after ultrasonic defoaming. The hydrogel can quickly absorb exudates on a wound surface and promote blood coagulation by using the strong and tough porous network of PVA, and can realize multiple synergistic antibacterial under a low-toxicity and safe concentration by combining the microscopic physical damage of nano-silver and the high-osmotic and slightly acidic environment of natural honey. The hydrogel preparation process is green and safe, no chemical cross-linking agent is left, and the hydrogel has excellent dynamic and non-invasive adhesion and long-acting moisturizing properties, and can be widely applied to rapid sealing, hemostasis and healing promotion treatment of complex infected wounds.

The application relates to the technical field of collagen materials, and particularly discloses a collagen material, a preparation method thereof and application of the collagen material in collagen hemostatic powder. The preparation method of the collagen material is as follows: enzyme hydrolysis reaction: adjusting a raw material sample liquid to pH 3.5-6.0, adding a composite enzyme, carrying out enzyme hydrolysis at a temperature of 30-40 DEG C for 4-12 h, and centrifuging to obtain a supernatant; the composite enzyme is composed of trypsin and phospholipase in a weight ratio of 1-5:0.02-0.08; alkali treatment: adjusting the supernatant to pH>13, and carrying out alkali treatment at a temperature of 15-25 DEG C for more than 40 h; neutralization reaction: adjusting pH to 6.8-7.6, eluting, and removing water by extrusion, so that the collagen material is obtained. The application also provides application of the collagen material in the collagen hemostatic powder. The collagen hemostatic powder provided by the application has excellent hemostatic function and water absorption efficiency, and the hemostatic material has high stability.

The invention relates to the technical field of medical instruments, and discloses a hemostatic hydrophilic polyurethane foam dressing and a preparation method thereof. The dressing is prepared by mixing and foaming a hemostatic hydrophilic prepolymer and a functional foaming mixture according to the mass ratio of (1: 2)-(2: 1), the hemostatic hydrophilic prepolymer is obtained by reacting polyether polyol, isocyanate, tranexamic acid, a chain extender and an antioxidant; the functional foaming mixture is prepared by mixing polyether glycol, a surfactant, a foam stabilizer and purified water. The tranexamic acid directly reacts with the polyether polyol, the isocyanate and the like to prepare the hemostatic hydrophilic prepolymer, the prepared polyurethane foam dressing has an excellent hemostatic function, meanwhile, the good liquid absorption rate and the anti-adhesion effect of polyurethane foam are not affected, and wound healing can be effectively promoted.

The invention relates to the technical field of medical instruments, in particular to an integrated trephine with cutting, bone separation and self-blade coating hemostasis functions. The trephine comprises a tubular body and far-end sawteeth of the tubular body, and is characterized in that a hemostatic material carrying structure is arranged on the outer wall of the trephine body, is a concave area formed in the outer wall and is provided with a one-way limiting structure; and the cutting surfaces of the sawteeth are inclined relative to the axis of the trephine. Before an operation, a hemostatic material is pre-filled in the structure; in an operation, when the trephine rotates to cut the bone, the one-way limiting structure can prevent the hemostatic material from returning and enable the hemostatic material to move downwards synchronously along with the trephine, the trephine can move transversely to the bone wound surface to scrape the hemostatic material and coat the hemostatic material on the bone wound surface, and continuous trephine cutting, bone separation and bone surface hemostasis are achieved. The trephine highly integrates cutting, bone separation and hemostasis functions into the trephine body, is convenient to operate, and can effectively reduce bleeding in an operation and improve an operation field.

The invention relates to a bandage with a hemostatic function and a preparation method thereof, and belongs to the technical field of bandages, the bandage is a woven plain weave, and is obtained by warp and weft interweaving of drug-loaded core-spun yarns; the medicine-carrying core-spun yarn is prepared by coating PTT memory filaments with mixed fibers to prepare core-spun yarn and then loading slow-release anti-inflammatory particles on the core-spun yarn. The sustained-release anti-inflammatory granules are prepared from the following raw materials in parts by weight: 35 to 45 parts of a sustained-release carrier material, 5 to 15 parts of chlorogenic acid, 8 to 16 parts of quercetin, 0.5 to 2 parts of dipotassium glycyrrhizinate, 1 to 3 parts of methyl salicylate, 0.5 to 0.8 part of monopotassium glycyrrhizinate and 0.1 to 0.3 part of ibuprofen. According to the invention, the PTT memory filament is used as the core wire, the bandage is endowed with excellent elasticity and shape memory performance, and meanwhile, the mixed coating layer composed of the bamboo fiber and the long stapled cotton is matched, so that the softness and skin friendliness of the bandage are ensured, the structural strength of the bandage is improved, and the bandage is not easy to deform and loosen and is higher in binding and fitting degree.

The present invention relates to a biotransplantation polymer material having a bleeding-inhibiting function, and a preparation method therefor. Disclosed are a biotransplantation polymer material and a preparation method therefor, the polymer material having an excellent bleeding-inhibiting function and excellent biodegradability so as to be suitable for inhibiting bleeding at a surgical site, and having an antithrombotic function through additional plasma surface treatment.

The application discloses a shrinkage and pressure bandaging hemostasis device and belongs to the technical field of hemostasis bandaging. The device comprises a retractor assembly, a shrinkage assembly and a pressure filling assembly. The retractor assembly comprises a retractor fixing seat, a skin retractor fixed on the lower surface of the retractor fixing seat and a pull rope connected with the retractor fixing seat. The shrinkage assembly comprises a base body, an inner cylinder installed in the middle part of the base body and penetrating through the upper and lower parts and an outer cylinder sleeved on the outer part of the inner cylinder and limited from reverse rotation by a reverse stopping mechanism. The pressure filling assembly comprises a hollow filling cover connected at the lower end of the inner cylinder and filled with hemostasis filling and a pressure knob installed at the upper end of the inner cylinder and used for pressing the filling in the hollow filling cover. The outer cylinder with the reverse stopping mechanism is used for synchronously winding all the retractor assemblies, so that the synchronous pulling around the wound can be realized quickly. The device is also used for synchronously releasing the hemostasis filling and cooperating with the wound shrinkage function, so that the hemostasis function is better.

This device provides a retractor function for surgical instruments with a diameter of 5 mm, and can simultaneously maintain the function of the surgical instrument. This model, in particular, has a special material bottom, which allows for hemostasis. This device can be applied in any health specialty in the medical industry, specializing in laparoscopic instruments.

In some embodiments, a disposable system includes a multi-channel or multi-chamber test cartridge device configured to operate with a test system for assessing hemostasis in a subject by assessing a test sample from the subject in vitro. In some embodiments, the disposable system is configured to interrogate a test sample to assess clot hardness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occurring during coagulation and / or dissolution of the resulting clot.

Provided is a rotary incision coagulation system, which comprises: a rotary incision apparatus, used for performing a rotary incision operation on a tissue; a coagulation electrode, used for performing a coagulation operation on a wound surface; and a control host, comprising a power supply module, a rotary incision control module, and a coagulation control module. The power supply module is used for supplying power to the rotary incision control module and the coagulation control module, the rotary incision control module is connected to the rotary incision apparatus and used for controlling the operation of the rotary incision apparatus, and the coagulation control module is connected to the coagulation electrode and used for controlling the operation of the coagulation electrode. On the basis of the rotary incision function of the traditional rotary incision system, the rotary incision coagulation system adds an electrocoagulation hemostasis function, and has the advantages of simple structure, convenient use, a wide application range, and the like. Compared with the solution in which a rotary incision device and an electrocoagulation device are separately arranged, the space can be saved.