108 results about "Hemostatic function" patented technology

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention belongs to the technical field of biological medicines, and particularly relates to hydrogel with photo-thermal multiple antibacterial and hemostatic functions. The multifunctional hydrogel is prepared from epsilon-polylysine (EPL), gallic acid (GA), tannic acid (TA) and ferric trichloride hexahydrate. The polyphenols are obtained through multiple mechanisms such as reaction between the polyphenols and amino groups, metal chelation, pi-pi interaction and electrostatic attraction (as shown in Figure 1). The metal ion and multiple dynamic cross-linking system hydrogel is constructed, the hydrogel with positive charges enriched on the surface can act with blood platelets with negative charges, red blood cell aggregation, blood platelet adhesion and vasoconstriction effects are promoted, and the blood coagulation efficiency is improved. The hydrogel shows excellent antibacterial performance and photo-thermal performance, can prevent infection in the inflammation stage of wound healing, can effectively accelerate wound healing, and has good biological safety.

The invention discloses a ganoderma lucidum extract dressing. The ganoderma lucidum extract dressing comprises ganoderma lucidum source chitosan, ganoderma lucidum polysaccharide, ganoderma lucidum source carboxymethyl chitosan and carbomer. The invention further discloses application of the lucid ganoderma extract dressing in promoting skin wound repair and preparing products for promoting skin wound repair. The invention further discloses a preparation method of the lucid ganoderma extract dressing. The lucid ganoderma extract dressing disclosed by the invention has antibacterial and hemostatic functions, can effectively avoid the situation that common chitosan generates a sensitization effect, accelerates the wound healing and repairing process, and effectively improves the wound healing situation.

The invention belongs to the technical field of medical materials, and relates to a high-toughness antibacterial hemostatic chitosan hydrogel dressing and a preparation method thereof. According to the invention, vinyl rare earth cerium oxide micro-nano particles are introduced into a polymer network as a cross-linking agent, the chitosan hydrogel dressing with excellent mechanical properties and antibacterial and hemostatic functions is successfully constructed, when the micro-nano particles are subjected to external stress, energy can be dissipated through mechanisms such as deformation, unwrapping, chain slippage and the like, so that the chitosan hydrogel dressing is prepared. Therefore, the hydrogel dressing is endowed with excellent strength, toughness and cyclic load resistance.

The invention discloses a preparation method of antibacterial hemostatic gauze, and belongs to the technical field of gauze preparation, the preparation method comprises pretreatment, first soaking treatment, second soaking treatment, third soaking treatment, fourth soaking treatment, fifth soaking treatment, sixth soaking treatment and post-treatment; the primary soaking treatment comprises the following steps: completely soaking the pretreated gauze in 1, 5-pentanediol, standing at room temperature, taking out the gauze, and vertically hanging to obtain the gauze subjected to the primary soaking treatment; the fourth soaking treatment comprises the following steps: completely soaking the gauze subjected to the third soaking treatment in a zinc oxide dispersion liquid, standing at room temperature, taking out the gauze, and vertically hanging to obtain the gauze subjected to the fourth soaking treatment; the gauze prepared by the preparation method disclosed by the invention is good in lasting antibacterial function, hemostatic function, operability, storage resistance and air permeability, and the indexes of the lasting antibacterial function of the surface are uniformly distributed.

In some embodiments, the disposable system includes a multi-channel or multi-chamber test cartridge device configured to operate with a test system for assessing hemostasis in a subject by assessing a test sample from the subject in vitro. In some embodiments, the disposable system is configured to interrogate the test sample to assess clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes that occur during coagulation and / or lysis of the resulting clot.

The invention belongs to the field of biomedical materials, and particularly relates to a self-adhesion composite patch for tooth extraction cavity wound repair and a preparation method thereof. The self-adhesion composite patch comprises a wound filling layer and an adhesion blocking layer, the wound filling layer is located in the middle of the adhesion blocking layer, the wound filling layer is made of a biological sponge material, and the adhesion blocking layer is made of polymer fibers and biological glue. The self-adhesion composite patch has excellent hemostasis, repairing, blocking, biosafety, biodegradability and water absorption, due to the excellent water absorption and biodegradability, the wound filling layer can achieve the excellent hemostasis function under the condition of a small filling amount, and meanwhile, the self-adhesion composite patch has the advantages that the self-adhesion composite patch is good in hemostasis effect and good in barrier effect. Due to the reduction of the wound filling layer and the excellent degradation performance, the self-adhesion composite patch cannot generate adverse effects on wound healing, and secondary operation for taking out the patch is not needed.

Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject having Hermansky Pudlak Syndrome (HPS) or Bernard Soulier Syndrome (BSS), comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. The platelet derivatives can have numerous characteristics provided herein, that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors. Furthermore, provided herein are platelet derivatives, and methods using the same, that have numerous beneficial properties, as provided.

A series of sofalcone derivatives are provided.SOLUTION: A series of sofalcone derivatives provided by the present invention are, for example, compounds having a structure of formula (I), and have platelet aggregation inhibitory and antithrombotic effects. The sofalcone derivatives of the present invention are TxA2 receptor antagonists, have an inhibitory effect on platelet agglutination, and do not easily affect the hemostatic function. The present invention also provides a method for preparing the sofalcone derivative, and a method for using the sofalcone derivative for preventing or treating thrombotic diseases, or for inhibiting platelet aggregation.SELECTED DRAWING: None

This invention discloses a method for preparing a thermosensitive hemostatic gel, which is prepared by mixing a thermosensitive polymer solution with a solution of micron-sized polymer particles or microspheres with hemostatic function. The concentration of the solution of micron-sized polymer particles or microspheres with hemostatic function is 3-100 mg / mL; the concentration of the thermosensitive polymer solution is 200-450 mg / mL; the diameter of the micron-sized polymer particles or microspheres with hemostatic function is 300-900 micrometers; the gelation temperature of the thermosensitive hemostatic gel from a flowing liquid state to a solid state is greater than 15 degrees Celsius, and it is a flowing liquid state at temperatures below 15 degrees Celsius. Under the condition of warming up in response to the human body temperature, the flowing liquid hemostatic gel transforms into a solid hemostatic gel, thereby achieving the hemostatic function. The micron-sized polymer particles or microspheres in the thermosensitive hemostatic gel will not enter the damaged blood vessel during the hemostasis process.

The invention provides a medical absorbable collagen antibacterial suture line and a preparation method thereof. The preparation method comprises the following steps: S1, sequentially carrying out pretreatment, homogenization, digestion, sterilization, salting-out and purification on animal skin to obtain collagen; s2, performing solution blending on collagen and a chitosan derivative to prepare a spinning solution; s3, performing wet spinning on the spinning solution to obtain a wire rod; and S4, crosslinking or weaving the wire rod to prepare the medical antibacterial suture line capable of absorbing collagen. The suture line is high in collagen purity, in a special fiber bundle shape, low in antigenicity, good in spinnability, smooth in surface, soft and smooth in line body and easy to knot, does not need to be soaked before being used, can reduce scar hyperplasia and avoid centipede-shaped suture traces during suture, has antibacterial and hemostatic functions, and is suitable for clinical application. A physical hemostasis barrier can be quickly generated in the suturing process, and an excellent suturing effect is achieved.

Novel binding molecules comprising humanized antibodies, fragments, variants, and derivatives thereof, as well as compositions, methods, and kits comprising the same, are described, wherein the binding molecules specifically bind to FX1 and FX1a. The binding molecules are capable of binding to the factor X1A2 domain and forming immune complexes, thereby disrupting the contact activation molecule complex without affecting the activity or activation of hemostatic factor XI. The binding molecules disclosed herein are suitable for safely inhibiting thrombosis and inflammation without impairing hemostasis. Thus, the binding molecules, compositions, methods, and kits provided herein are intended for treating diseases and conditions, particularly those associated with thrombosis and inflammation. In addition, polynucleotides encoding the binding molecules disclosed herein, vectors comprising the polynucleotides, and host cells for producing the polynucleotides are also provided.

The invention relates to the technical field of hemostasis, and discloses a medical wrist strap with a hemostasis function, which comprises a main body assembly, a wrist strap body and a locking assembly, an information nameplate is fixed on one side of the wrist strap body, the wrist strap body is made of an elastic bandage, the locking assembly is arranged on the wrist strap body and comprises a rotating part, and the rotating part comprises a fixed frame. The wrist strap has the beneficial effects that the wrist strap is made of an elastic bandage material and is matched with the locking assembly, when hemostasis is needed in emergency, hemostasis can be carried out on the bleeding part of a patient through the wrist strap, the length of the wrist strap can be adjusted, the wrist strap can be bound to different bleeding parts of the patient, and after hemostasis is carried out for a certain period of time, the wrist strap can be fixed. In addition, the wrist strap can be automatically relaxed for a short time and tightened again, so that blood circulation of the far end of the limb can be temporarily recovered, and serious injury, such as muscle necrosis, nerve injury and the like, of limb tissue caused by long-time ischemia is avoided.

The present invention discloses an anorectal hemostasis and stripping device, which relates to the technical field of medical devices and is intended to solve the technical problem that doctors need to repeatedly pick up and alternately use hemostatic forceps and stripping scissors during anorectal surgery, which is inconvenient in operation. The present invention includes two rotatably connected scissor bodies, each of which includes a scissor head, and the upper and lower end faces of each scissor head are bent inward and extend in the direction close to the other scissor head. The two ends of each scissor head extending inward are respectively provided with a hemostatic surface and a stripping surface, and the two hemostatic surfaces are arranged relative to each other to form a hemostatic part, and the two stripping surfaces are arranged relative to each other to form a stripping part. The present invention adopts a hemostatic surface, a stripping surface, etc. to combine the hemostatic function and the stripping function into one device, thereby realizing the conversion of the stripping function and the hemostatic function, without having to repeatedly pick up and use the hemostatic forceps and stripping scissors during the operation, thereby making it more convenient for doctors to use the device. It can improve surgical efficiency and reduce operation time.

The present invention discloses the use of HMG-CoA and its pharmaceutically acceptable salts for preparing a platelet preservative. The present invention has confirmed that adding HMG-CoA or its pharmaceutically acceptable salts to platelets to be preserved can effectively alleviate platelet activation and apoptosis, while prolonging the in vivo survival period of platelets after platelet transfusion and protecting the hemostatic function of platelets.

The invention relates to the technical field of hemostatic materials, in particular to composite hemostatic gel as well as a preparation method and application thereof. The composite hemostatic gel is prepared from the following components in percentage by mass: 0.5 to 3 percent of carboxymethyl chitosan, 0.5 to 5 percent of trehalose, 1 to 10 percent of glycerol, 0.1 to 2 percent of carbomer, 0.1 to 2 percent of recombinant blood coagulation factor III, 0.005 to 0.05 percent of benzalkonium chloride and the balance of Tris-HCl buffer solution. Based on the synergistic effect of a natural high polymer material carboxymethyl chitosan and a bioactive component recombinant blood coagulation factor III, the gel constructs a'physical adsorption-blood coagulation activation 'dual hemostasis pathway, realizes a rapid and multi-mechanism hemostasis function, has antibacterial and repair promoting characteristics, can be widely applied to various bleeding scenes such as cutting wounds and surgical wounds, and has wide application prospects. The wound healing is effectively promoted.

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.

The invention relates to the technical field of percutaneous nephroscope sheaths, in particular to a composite percutaneous nephroscope sheath with a hemostasis function, which comprises a tube body, a metal head is mounted at the head end of the tube body, a protective cover is mounted at the tail end of the tube body, and a metal wire is mounted in the tube body and mounted on the inner side of the protective cover. One end of the metal wire is connected with the metal head, the other end of the metal wire is connected with a threaded rod, the outer end of the threaded rod is provided with an electrode slice connector, and the electrode slice connector is connected with an external hemostatic electrode. According to the combined type percutaneous nephroscope sheath with the hemostasis function, the metal wire is in direct contact with a bleeding point through the metal head and is combined with an external hemostasis electrode, electric coagulation hemostasis can be rapidly conducted on the bleeding part in an operation, instruments do not need to be replaced, the bleeding amount in the operation is reduced, the hemostasis operation time is shortened, and the operation risk caused by bleeding is reduced.

The invention provides a blood vessel opening system with a hemostatic function, including a hole opener and a conveying device, the hole opener includes a shell, a cutting assembly and a guide column arranged on the lower side of the shell, the cutting assembly is arranged in the shell, the guide column is a hollow structure and is connected with the shell, the guide column is used to carry the conveying device, and the shell and the guide column form an inclined angle. The invention aims to propose a blood vessel opening system with a hemostatic function to solve the problem of bleeding after the hole opener is removed and before the finger is officially pressed, and after the finger is removed and before the umbrella-shaped hemostat is installed; after the blood vessel opening is completed, the umbrella-shaped hemostat does not need to be re-centered when it is placed in the blood vessel, the operation is faster, and the operation time is saved.

The biopsy and hemostasis integrated balloon catheter for the bronchoscope comprises a catheter body, and a working hole channel, a balloon channel and a guide wire channel which are independent of one another are integrally arranged on the catheter body; wherein the working hole channel is used as a channel when the freezing probe performs biopsy operation; a hemostasis balloon communicated with the balloon channel is arranged at the catheter head end of the catheter body, hemostasis medicine is arranged on the outer surface of the hemostasis balloon, and the hemostasis balloon is inflated and expanded through the balloon channel to achieve compression hemostasis; a guide wire is arranged in the guide wire channel, and the catheter body is guided to reach a target position in the trachea through the guide wire. According to the application, the functions of freezing biopsy and instant hemostasis are integrated.

The invention relates to the technical field of medical instruments, in particular to a cardiology department nursing pressing hemostasis device which mainly comprises an installation frame, a supporting frame fixedly installed on the top face of the installation frame, a fixing rod fixedly installed on the bottom face of the supporting frame, a pressing block and a buffering sponge arranged on one side of the supporting frame, and an adjusting mechanism arranged on one side of the supporting frame. The fixing mechanism is arranged on one side of the supporting frame, and the locking mechanism is arranged on one side of the supporting frame. By adjusting the butterfly nut and the bolt rod, then pushing the bolt rod to drive the connecting block and the fixing sleeve to rotate by a certain angle, the fixing sleeve drives the rotating strip to rotate by a certain angle, and the rotating strip drives the pressing block below to rotate by a certain angle, so that the pressing block is matched with the inclined side surface of a patient; the pressing block is used for pressing and stopping bleeding of the inclined side face bleeding part of the patient and can give full play to the due bleeding stopping function, and therefore the pressing and bleeding stopping effect is improved.

The utility model belongs to nursing paste technical field, and disclose a kind of local cold compress and hemostasis integration nursing paste after inoculation, including backing layer, the lower surface of backing layer is equipped with cold compress layer, and the lower surface of cold compress layer is equipped with hemostasis layer, the lower surface of backing layer is fixedly equipped with the fit circle, the outer surface of cold compress layer and hemostasis layer is all with fit circle movable fit, the lower surface of fit circle is connected with isolation layer with adhesion, the upper surface of cold compress layer is fixedly equipped with positioning column symmetrically, the upper surface of backing layer is equipped with column groove symmetrically, the upper end of positioning column is penetrated through corresponding column groove and is fixedly connected with limit ball. Through the above scheme, cold compress and hemostasis function are integrated in nursing paste, simplify inoculation nursing process, save time manpower, reduce pain swelling, accelerate wound healing, reduce infection risk;Meanwhile, through positioning column, limit ball and fit circle design, guarantee cold compress layer stability, improve nursing paste fit degree and use experience.

This invention belongs to the field of biomedical functional materials technology, and relates to an antibacterial and healing-promoting photosensitizer, its preparation method, and its uses. The photosensitizer is a defective MIL-88B@MIL-88C composite material, wherein defective MIL-88B serves as the substrate, and MIL-88C grows on the surface and / or in the pores of the defective MIL-88B. This photosensitizer significantly improves the photogenerated carrier separation efficiency, reduces impedance, enhances photocurrent response, and can efficiently generate reactive oxygen species under light irradiation. Antibacterial experiments show that it has excellent bactericidal effects against Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus, and is not prone to inducing drug resistance. Simultaneously, this photosensitizer has good biocompatibility, promotes cell migration, and has significant hemostatic function. Animal models show that it can effectively accelerate the healing of skin defects.

The present disclosure provides a Paenibacillus strain, and a hemostatic polysaccharide produced by same and use thereof. In the present disclosure, a Paenibacillus sp. 1229 has a deposit number of CCTCC NO: M 2022553. A produced exopolysaccharide (EPS) Hemoadhican has a hemostatic function, and can be prepared as a hemostatic material in different dosage forms for different types of hemostasis. The hemostatic material has a high hemostatic speed, no need for applying pressures to the wound for a long time, safety and non-toxicity, desirable biocompatibility, and no requirement of removal after use. The material is suitable for the application of hemostasis in irregular bleeding such as solid organs in vitro or in vivo and diffuse bleeding.

A vessel closure device for delivering immediate hemostasis at a puncture site in a wall of a blood vessel includes an intravascular anchor having one or more suture attachment points, an extravascular cap having a lumen, a sealant, and a suture connected to at least one of the one or more suture attachment points of the intravascular anchor and threaded through the lumen of the extravascular cap, wherein each of the intravascular anchor, extravascular cap, sealant, and suture are formed of bioabsorbable materials.

The application discloses an amino acid surfactant with hemostatic function and a preparation method thereof. The method is to make the tranexamic acid and long aliphatic acyl chloride undergo condensation reaction under the action of alkali, and then perform acidification and esterification reaction to obtain the amino acid surfactant with hemostatic function. Compared with the long-chain fatty acyl thrombin acid salt reported in the prior art, the amino acid surfactant has good fat solubility, better transdermal permeability and better toner dispersibility. The preparation method has mild reaction conditions, simple operation, simple product separation and purification and high yield, and is suitable for industrial production.

The utility model provides a minimally invasive bipolar electrocoagulation knife aiming at the defect that a bipolar electrocoagulation knife in the prior art does not have a cutting function, which belongs to the technical field of medical instruments and comprises two knife bodies forming a tweezers-shaped structure, the rear ends of the two knife bodies are converged and connected with an electric connector, the front ends of the knife bodies are electrocoagulation heads, the front ends of the electrocoagulation heads are sharp structures, and the electric connector is connected with the electric connector. A blade and a groove are arranged on the inner side of each electrocoagulation head, the blade on any electrocoagulation head can be embedded into the groove on the other electrocoagulation head, a gap is reserved between the blade and the front end of the electrocoagulation head, and the two blades are matched with each other. The minimally invasive bipolar electrocoagulation knife not only has a hemostasis function, but also has a cutting function.

The application belongs to the technical field of vascular covered stent, and relates to a vascular covered stent for emergency hemorrhage and a preparation method thereof. The vascular covered stent comprises a tubular stent framework and a double-layer composite fiber membrane covering the outer surface of the tubular stent framework. The double-layer composite fiber membrane is composed of an inner buffer layer and an outer structural layer. The inner buffer layer is a polyvinyl alcohol porous fiber membrane, and the outer structural layer is a biodegradable elastomer fiber membrane. In the preparation, the tubular stent framework subjected to surface activation treatment is first fixed on an electrospinning collector, and polyvinyl alcohol porous fiber membranes and biodegradable elastomer fiber membranes are spun on the outer surface of the tubular stent framework in sequence, and then the stent with the double-layer covering membranes is annealed to obtain the vascular covered stent. The product has excellent compression damage resistance, instant hemostasis function and good delivery. The preparation method is simple and easy to implement.

This invention belongs to the technical field of hemostatic devices, and particularly relates to a compression hemostatic device for blood purification. It includes: a frame with Velcro straps wound around it, and a connecting shell fixedly connected to the frame; a lifting rod threadedly connected to the connecting shell, rotatably connected to a connecting rod, and a spring fixedly connected between the connecting rod and the connecting shell; an adjusting rod slidably connected to the connecting rod, and a hemostatic plate hinged to the adjusting rod; an arc-shaped plate disposed on the hemostatic plate; and a sliding frame slidably connected to the frame, slidably connected to a movable frame, with symmetrically distributed compression rods fixedly connected to the movable frame. When performing secondary wound care on a patient, this invention rotates the hemostatic plate and the arc-shaped plate, causing the arc-shaped plate to compress the area around the patient's wound and lift the hemostatic plate. This maintains the hemostatic function while separating the hemostatic plate from the patient's wound, facilitating secondary wound care by staff.