1004results about How to "Good hemostatic effect" patented technology

The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.

Bioabsorbable, water-soluble hemostatic cellulose based gauze matrix structures are described, including one or more species of chitosan, etherized cellulose, nonionic surfactant, water-soluble polysaccharide hydrocolloid and/or gum. Approximately 85% to 95% deacetylated decrystallized chitosan, present in an amount from about 2% to about 15% by weight, is found to be particularly advantageous. Favorable properties are found related to rapid stoppage of bleeding and bioabsorbability, among other properties.

The invention provides gelatin sponge, gelatin aqueous solution is irradiated to crosslink to form gelatin hydrogel, and then the gelatin hydrogel is swollen, frozen and dried to obtain the gelatin sponge. The invention also provides a preparation method of the gelatin sponge by an irradiation crosslinking way, the whole process flow is finished in a pure water system, the irradiation and crosslinking processes have sterilizing function and good controllability, the obtained product has better structural uniformity compared with a chemical crosslinking method, and the gelatin sponge has unique advantages as biomedical materials.

The invention provides a preparation method of high-purity collagen protein sponge, and relates to a preparation method of collagen protein sponge. The preparation method of the high-purity collagen protein sponge is used for solving the problems that the collagen protein sponge prepared by using a conventional method is long in production cycle and low in yield and purity and has poor hemostasis performance. The preparation method of the high-purity collagen protein sponge comprises the following steps: step one. pretreating fresh bovine heel tendons; step two. extracting collagen protein; step three. centrifuging; step four. salting out; step five. dissolving; step six. carrying out gradient dialysis; step seven. pre-freezing; step eight. carrying out freeze drying; and step nine. sterilizing. The final product prepared by using the method has a smooth and flat surface and relatively good hemostatic performance and is uniform in pore size distribution. The product has relatively high purity (the total amount of amino acids reaches 97.73%), an obvious hemostatic effect and no abnormal taste, is safe, non-toxic, high in yield and short in time; liquid is clear without impurities; the production cycle is shortened; the whole preparation process is carried out at a room temperature; the biological activity of the collagen protein is maintained; and the application of the high-purity collagen protein sponge in clinical is improved.

The invention relates to a medical flocking hemostasis material for stopping bleeding and protecting arteries, veins and wounds of tissues, application of the medical flocking hemostasis material and a method for preparing the medical flocking hemostasis material. The medical flocking hemostasis material comprises a flocking layer and a base layer, the flocking layer is used as a wound contacting layer and made of functional fibers, and the functional fibers are fixed on the upper surface of the base layer in a flocking method. The flocking method comprises a mechanical flocking method and an electrostatic flocking method. The medical flocking hemostasis material can be used for stopping bleeding and protecting the arteries, the veins and the wounds of the tissues, and further can be used as a medicine slow-release carrier. The invention further discloses method for controlling bleeding of the arteries, bleeding of the veins and bleeding of the wounds of the tissues by the aid of the medical flocking hemostasis material. Compared with a hemostasis material in the prior art, the medical flocking hemostasis material has the advantages that a hemostasis performance, comfortableness and the like are greatly improved.

The invention supplies a biodegradable nanometer channel multi orifice stanching material and manufacturing method which uses chitosan as raw material. It includes orifice making, forming, orifice making agent removing. The multi orifice structure can be gained by adding orifice making agent in preparation, removing it in forming, which emulsifies to form latex, solidifies to form hydrogel, removes the agent by alcohol or ketone solvent, dries the hydrogel, or processes cross linking for the formaldehyde, glutaraldehyde, solidifies chitosan aqueous solution to form hydrogel, removes the agent by water, dries the hydrogel. This material can fast adsorb the moisture in the blood to stanch.

A process for preparing the collagen sponge includes such steps as extracting collagen in acetic acid by digestion of pepsinum, filtering, taking supernatant, neutralizing by sodium hydroxide, salting out in sodium chloride solution, centrifugal separation of deposit, dissolving it in acetic acid, dialyzing by acetic acid and then by the solution of bisodium hydrogen phosphate, and freeze drying.

The invention discloses a medicinal composition for treating gynecological inflammation, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and/or Chinese medicaments for releasing toxin and sterilizing such as collagen and lizardtail, glabrous greenbrier rhizome, Vietnamese sophora root and the like which are prepared into a plurality of dosage forms bycombining the prior art, and is mainly used for treating vaginitis, pelvic inflammation, urethritis and cervicitis diseases. The technical scheme overcomes the defects that the prior externally-applied preparations such as lotion, gel, suppository, ointment and the like have extremely slow response, longer disease course, repeated outbreak and the like, and creatively combines and applies the collagen and the Chinese medicament, can accelerate the healing of ulcer and erosion faces caused by the inflammation, and can greatly shorten the required time for tissue repair.

The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS/PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.

The invention discloses a collagen/chitosan micro-nano fiber composite hemostatic membrane material and a preparation method thereof. The preparation method is characterized by comprising the following steps of: extracting a medical biological skin sheet serving as a raw material by an ultrasonic technology to prepare I type collagen; mixing hexafluoroisopropanol and acetic acid according to different volume ratios to prepare a spinning solvent; mixing the prepared I type collagen and chitosan in a certain mass ratio and adding the mixture into the spinning solvent; stirring in an ultrasonic cleaner at room temperature until the material is transparent to prepare electrostatic spinning mother liquid at the concentration of 4 to 10 percent; injecting the electrostatic spinning mother liquid into an electrostatic spinning machine and performing electrostatic spinning to obtain a collagen/chitosan micro-nano fiber composite membrane; soaking the collagen/chitosan micro-nano fiber composite membrane into natural biomacromolecules and Chinese herbal medicines sequentially; and freeze-drying to obtain the collagen/chitosan micro-nano fiber composite hemostatic membrane material. The collagen/chitosan micro-nano fiber composite hemostatic membrane material has excellent biocompatibility, biodegradability, adhesion property and the like, can quickly stop bleeding, resist inflammation, ease pain and promote wound healing, and can be applied to trauma hemostasis and repair and general civil hemostasis emergency treatment.

The invention relates to a starch hemostatic microsphere and a preparation method thereof. The starch hemostatic microsphere is prepared from legume starch, potato starch and cereal starch which serve as raw materials by virtue of an inverse suspension polymerization method, and has a molecular weight of between 50000 and 5000000 and the grain diameter of between 0.1 and 1000mu m. The preparationmethod of the starch hemostatic microsphere comprises the following steps: mixing the three types of raw starches, and alkalizing; dispersing with a surfactant and vegetable oil under a condition that the pH is between 8.5 and 10.5; performing crosslinking with a crosslinking agent; cleaning, and performing spray drying; and packaging, and sterilizing with cobalt 60. The starch hemostatic microsphere prepared by using the method has good biocompatibility, and is used for a hemostatic process of a surgical operation; the water absorption rate is multiple times that of a conventional hemostaticmaterial, the water absorption speed is remarkably increased, and the hemostatic effect is reinforced. The starch hemostatic microsphere has easily available raw materials, simple process, low production cost and wide application prospect.

A hemostatic device has a flexible band that can be wrapped around a hemostasis-requiring site of a limb, a securing portion that secures the band in a state where the band is wrapped around the limb, and an inflation portion that interlocks with the band, and that inflates when a fluid is injected. The inflation portion has a plurality of convex portions in a width direction orthogonal to a longitudinal direction of the band when the inflation portion inflates.

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

The invention relates to the technical field of medical articles, in particular to alginate medical dressing and a preparation method thereof. The medical dressing is prepared by soaking alginate fibers in a functional soaking solution, wherein the functional soaking solution is prepared from, by weight, 2-4% of carboxymethyl chitosan, 1-2% of oligochitosan, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6 % of calcium chloride, 0.005-0.05% of epidermal growth factor, 0.02-0.05% of aloe extracts and the balance water. The chitosan substances, the antibacterial agent, carboxymethyl cellulose, calcium chloride, the epidermal growth factor and the aloe extracts are loaded in the alginate fibers, so that the medical dress is endowed with the remarkable effects of preventing bacteria, stopping bleeding, promoting healing, preventing wound adherence and preventing scars.

The invention relates to a method for preparing thrombin-chitosan self-assembly nano particles and application thereof. The method comprises: adding chitosan into an acetic acid aqueous solution to form a chitosan solution; adding thrombin into a buffer solution to form a thrombin solution; uniformly mixing the thrombin solution and the chitosan solution, adding a crosslinking agent for stirring, pouring the mixture into liquid paraffin for stirring, adding a dispersant, and performing emulsification; and adding the crosslinking agent for crosslinking reaction through water bath, performing filtration and acetone washing, using ethanol for washing and dehydration, and finally performing vacuum drying to obtain the thrombin-chitosan self-assembly nano particles. The method feeds the thrombin and the chitosan according to proportion to prepare thrombin-chitosan which is self-assembled into nano particles for the first time, maintains the stability of the thrombin of the thrombin-chitosan self-assembly nano particles, and gives better play to the comprehensive hemostatic effect of the thrombin and the chitosan of the thrombin-chitosan self-assembly nano particles. The method can be widely applied to tissue hemostasis, tissue sealing and tissue adhesion in the surgical fields such as general surgery, orthopaedics, heat and chest surgery, neurosurgery and gynaecology and obstetrics.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

The invention provides a preparation method for an oxidized regenerated cellulose hemostatic material with a surface nanostructure. In order to solve problems of small specific surface area, water insolubility, single hemostatic effect mechanism and low hemostatic speed of the traditional oxidized cellulose hemostatic material, the invention provides the preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The method comprises the following steps of: (1) preparing a collagen aqueous solution; (2) preparing a viscose fiber gauze; (3) preparing oxidized viscose staple fiber and oxidized viscose fiber gauze; (4) preparing an oxidized regenerated cellulose sodium solution or an oxidized regenerated cellulose potassium solution; (5) preparing an oxidized regenerated cellulose gauze; and (6) after collagen particles are sprayed, freezing and drying the oxidized regenerated cellulose gauze, so as to finish the preparation of the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure, provided by the invention, is applied to the preparation field of the oxidized regenerated cellulose hemostatic materials.

The invention discloses a nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material and a preparation method thereof. The drug sustained-release material comprises nanometer cellulose, polydopamine and a drug loaded on the polydopamine, can be applied to the field of various drug sustained release and is especially suitable for the aspects of wound treatment, tumor postoperative treatment, and the like. The drug sustained-release material disclosed by the invention can load hydrophilic and hydrophobic drugs, is simply prepared, is mild and is capable of saving cost. The nanometer cellulose and the polydopamine both have biocompatibility, can completely degrade, are easy for waste treatment and are beneficial to environmental protection. The drug sustained-release material is especially suitable for wound healing and later treatment of tumor operation.