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1009results about How to "Good hemostatic effect" patented technology
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Hemostatic sponge
ActiveUS20100318048A1Good hemostasisImprove abilitiesPharmaceutical delivery mechanismBaby linensWound healingMaterials science
The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.
Owner:BAXTER INT INC +1
Denaturated starch absorbable hemostatic material and preparation method thereof
InactiveCN101121041AHigh viscosityImprove water absorption speedSurgical adhesivesPharmaceutical delivery mechanismMedicineBlood plasma
An absorbable modified starch hemostatic material and preparation thereof, wherein the hemostatic material is etherified starch, or a mixture of one or more etherified starches, crosslinked starches. The modified starch has a molecular weight of 15,000 - 10,000,000, a particle size of 10 - 1000µm, and a water absorption rate of 1 - 100. The biocompatible hemostatic material can directly effect on the wound with blood, concentrate the blood quickly to congulate blood; moreover, the gelatiniform mixture formed with blood has high viscosity, which can plug damaged tissue and blood vessel. The biocompatible hemostatic material is easy to swell in the water and easy to be washed so that the residue can be reduced; it is stable, not easy to decompose, and has long shelf life and storage advantage. The biocompatible hemostatic material can also be used as absorbable surgical antisticking material, promoting tissue healing material, surgical sealant and wound no-joint tissue adhesive.
Owner:美国淀粉医疗公司
Biocompatibility modified starch sponges
ActiveCN101455857AFlexibleActive bleeding is easily controlledAbsorbent padsBandagesFreeze-dryingBiocompatibility Testing
The invention relates to biocompatible modified starch sponge and use of the biocompatible modified starch sponge as a hemostatic material, an anti-adhesion material, a material for promoting tissue healing, a surgical sealant or a wound tissue adhesive. Modified starch is one or a combination of more than one among pre-gelatinized starch, acid modified starch, dextrin, oxidized starch, esterified starch, etherified starch, crosslinked starch, grafted starch and composite modified starch. The sponge is prepared by vacuum freeze drying of the modified starch and other biocompatible hemostatic material, coagulant, plasticizer and so on. The biocompatible modified starch sponge has the advantages that the biocompatible modified starch sponge has flexible form and good biocompatibility, can be directly acted on bloody wound surfaces, avoids the conditions of hypersusceptibility, infection and difficult healing of wounds caused by adoption of hemostatic materials such as animal source / human source collagens, obviously improves the water absorption speed, has larger viscosity, forms a zymoplastic mixture which has good adhesion, calks broken tissues and blood vessels, and is used for hemostasis of active hemorrhage.
Owner:BEIJING UNIVERSAL LIKANG TECH CO LTD
Modified starch absorbable hemostasia material and preparation method thereof
ActiveCN101361986AHigh viscosityImprove water absorption speedSurgical adhesivesPharmaceutical delivery mechanismWound healingBiomedical engineering
Owner:BEIJING UNIVERSAL LIKANG TECH CO LTD
Bioabsorbable hemostatic gauze
InactiveUS20070104769A1Improved performance characteristicsImprove liquid absorption capacityOrganic active ingredientsBiocideCelluloseWater soluble polysaccharides
Bioabsorbable, water-soluble hemostatic cellulose based gauze matrix structures are described, including one or more species of chitosan, etherized cellulose, nonionic surfactant, water-soluble polysaccharide hydrocolloid and / or gum. Approximately 85% to 95% deacetylated decrystallized chitosan, present in an amount from about 2% to about 15% by weight, is found to be particularly advantageous. Favorable properties are found related to rapid stoppage of bleeding and bioabsorbability, among other properties.
Owner:LIFESCI PLUS
Gelatin sponge and preparation method thereof
InactiveCN101574539AImprove performancePromote absorptionSurgeryAbsorbent padsGelatin spongeIrradiation
The invention provides gelatin sponge, gelatin aqueous solution is irradiated to crosslink to form gelatin hydrogel, and then the gelatin hydrogel is swollen, frozen and dried to obtain the gelatin sponge. The invention also provides a preparation method of the gelatin sponge by an irradiation crosslinking way, the whole process flow is finished in a pure water system, the irradiation and crosslinking processes have sterilizing function and good controllability, the obtained product has better structural uniformity compared with a chemical crosslinking method, and the gelatin sponge has unique advantages as biomedical materials.
Owner:厦门凝赋生物科技有限公司
Preparation method of high-purity collagen protein sponge
InactiveCN103772734AGood removal effectHigh purityConnective tissue peptidesPeptide preparation methodsFreeze-dryingCollagen sponge
The invention provides a preparation method of high-purity collagen protein sponge, and relates to a preparation method of collagen protein sponge. The preparation method of the high-purity collagen protein sponge is used for solving the problems that the collagen protein sponge prepared by using a conventional method is long in production cycle and low in yield and purity and has poor hemostasis performance. The preparation method of the high-purity collagen protein sponge comprises the following steps: step one. pretreating fresh bovine heel tendons; step two. extracting collagen protein; step three. centrifuging; step four. salting out; step five. dissolving; step six. carrying out gradient dialysis; step seven. pre-freezing; step eight. carrying out freeze drying; and step nine. sterilizing. The final product prepared by using the method has a smooth and flat surface and relatively good hemostatic performance and is uniform in pore size distribution. The product has relatively high purity (the total amount of amino acids reaches 97.73%), an obvious hemostatic effect and no abnormal taste, is safe, non-toxic, high in yield and short in time; liquid is clear without impurities; the production cycle is shortened; the whole preparation process is carried out at a room temperature; the biological activity of the collagen protein is maintained; and the application of the high-purity collagen protein sponge in clinical is improved.
Owner:HARBIN INST OF TECH
Medical flocking hemostasis material, preparation thereof and application
ActiveCN102600013AAvoid burnsNo toxicityAbsorbent padsMacromolecular non-active ingredientsFiberVein
The invention relates to a medical flocking hemostasis material for stopping bleeding and protecting arteries, veins and wounds of tissues, application of the medical flocking hemostasis material and a method for preparing the medical flocking hemostasis material. The medical flocking hemostasis material comprises a flocking layer and a base layer, the flocking layer is used as a wound contacting layer and made of functional fibers, and the functional fibers are fixed on the upper surface of the base layer in a flocking method. The flocking method comprises a mechanical flocking method and an electrostatic flocking method. The medical flocking hemostasis material can be used for stopping bleeding and protecting the arteries, the veins and the wounds of the tissues, and further can be used as a medicine slow-release carrier. The invention further discloses method for controlling bleeding of the arteries, bleeding of the veins and bleeding of the wounds of the tissues by the aid of the medical flocking hemostasis material. Compared with a hemostasis material in the prior art, the medical flocking hemostasis material has the advantages that a hemostasis performance, comfortableness and the like are greatly improved.
Owner:SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
Medicinal composition for treating skin injury and ulcer and application thereof
InactiveCN101648002AStrong coordinationGood hemostatic effectPeptide/protein ingredientsHydroxy compound active ingredientsDiseasePutrefaction
The invention discloses a medicinal composition for treating skin injury and ulcer diseases, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and Chinesemedicaments for fighting bacterium, diminishing inflammation, removing putrefaction and promoting tissue regeneration such as angelica, Szechuan lovage rhizome, salvia root and the like which are prepared into a plurality of dosage forms by matching the prior art. The technology overcomes the defects that the prior preparations for the trauma department have extremely slow response, longer treatment course, adhesion with the skin, influence on scab cicatrization and the like, and has quick and remarkable treatment effect on various skin diabrosis diseases such as mechanical wound, burn / scald,bedsore, chronic leg ulcer, diabetic foot or cancerous ulcer and the like.
Owner:安徽省华鼎生物科技有限公司
Biological-degradable chitosan porous hemostasis material and its preparing method
InactiveCN101024094AImprove water absorptionEnhance hemostasisSurgeryAbsorbent padsChemistryForming processes
The invention supplies a biodegradable nanometer channel multi orifice stanching material and manufacturing method which uses chitosan as raw material. It includes orifice making, forming, orifice making agent removing. The multi orifice structure can be gained by adding orifice making agent in preparation, removing it in forming, which emulsifies to form latex, solidifies to form hydrogel, removes the agent by alcohol or ketone solvent, dries the hydrogel, or processes cross linking for the formaldehyde, glutaraldehyde, solidifies chitosan aqueous solution to form hydrogel, removes the agent by water, dries the hydrogel. This material can fast adsorb the moisture in the blood to stanch.
Owner:南京零一新材料工程研究中心(普通合伙) +1
Technique for preparing sponge produced from collagen
ActiveCN1915437AShorten the production cycleGood lookingAbsorbent padsBandagesAcetic acidHydrogen phosphate
A process for preparing the collagen sponge includes such steps as extracting collagen in acetic acid by digestion of pepsinum, filtering, taking supernatant, neutralizing by sodium hydroxide, salting out in sodium chloride solution, centrifugal separation of deposit, dissolving it in acetic acid, dialyzing by acetic acid and then by the solution of bisodium hydrogen phosphate, and freeze drying.
Owner:SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD +3
Chitosan emergent hemostasis material
ActiveCN102648985AStrong water absorptionSpeed up penetrationAbsorbent padsBandagesSuction forceTissue repair
The invention provides a chitosan emergent hemostasis material, which is provided with at least two layers of structures: a chitosan hemostasis layer as an upper layer, and a polyacrylic acid grafting chitosan lining layer as a lower layer, wherein the chitosan hemostasis layer is of a structure of a porous microsphere, porous fiber, porous sponge, or a compound of the porous microsphere, the porous fiber and the porous sponge; and the polyacrylic acid grafting chitosan lining layer is of a structure of porous fiber, porous sponge, or a compound of the porous fiber and the porous sponge. According to the chitosan emergent hemostasis material, the polyacrylic acid grafting chitosan is used as the lining layer of the chitosan, so that powerful water suction force can be provided, seepage velocity of blood in the chitosan hemostasis material is improved, blood is further concentrated, the density of the hemostasis material is improved simultaneously, the hemostasis material is easier to sink to arrive at a bleeding point, gravity press of a bleeding part is formed, pressurization is convenient, and the hemostasis effect is improved. Meanwhile, the polyacrylic acid grafting chitosan layer also can be used as a medicine-carrying substrate, can be used for carrying antibacterial drug, acesodyne, factors for promoting tissue repair and the like, and is good for preventing and controlling infection while stopping bleeding, relieving pains, and accelerating wound tissue healing.
Owner:欣乐加生物科技温州有限公司
Medicinal composition for treating gynecological inflammation and application thereof
InactiveCN101648003AEase regenerationGood treatment effectPeptide/protein ingredientsHydroxy compound active ingredientsDiseaseUrethritis
The invention discloses a medicinal composition for treating gynecological inflammation, and belongs to the field of Chinese medicament. The medicinal composition consists of collagen and / or Chinese medicaments for releasing toxin and sterilizing such as collagen and lizardtail, glabrous greenbrier rhizome, Vietnamese sophora root and the like which are prepared into a plurality of dosage forms bycombining the prior art, and is mainly used for treating vaginitis, pelvic inflammation, urethritis and cervicitis diseases. The technical scheme overcomes the defects that the prior externally-applied preparations such as lotion, gel, suppository, ointment and the like have extremely slow response, longer disease course, repeated outbreak and the like, and creatively combines and applies the collagen and the Chinese medicament, can accelerate the healing of ulcer and erosion faces caused by the inflammation, and can greatly shorten the required time for tissue repair.
Owner:BEIJING HERUN INNOVATION PHARMA TECH DEV
Biocompatibility pre-gelatinized modified starch and preparation thereof
InactiveCN101497670AAbsorbentSpeed up absorptionSurgical adhesivesFibre treatmentBiocompatibility TestingHigh pressure
The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.
Owner:纪欣
Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof
ActiveCN108912352AImprove antibacterial propertiesImprove the bactericidal effectPharmaceutical delivery mechanismBandagesSelf-healingCross-link
The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS / PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.
Owner:XI AN JIAOTONG UNIV
Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof
ActiveCN103230617AGood biocompatibilityGood biodegradabilityAbsorbent padsBandagesElectrospinningAnti-inflammatory
The invention discloses a collagen / chitosan micro-nano fiber composite hemostatic membrane material and a preparation method thereof. The preparation method is characterized by comprising the following steps of: extracting a medical biological skin sheet serving as a raw material by an ultrasonic technology to prepare I type collagen; mixing hexafluoroisopropanol and acetic acid according to different volume ratios to prepare a spinning solvent; mixing the prepared I type collagen and chitosan in a certain mass ratio and adding the mixture into the spinning solvent; stirring in an ultrasonic cleaner at room temperature until the material is transparent to prepare electrostatic spinning mother liquid at the concentration of 4 to 10 percent; injecting the electrostatic spinning mother liquid into an electrostatic spinning machine and performing electrostatic spinning to obtain a collagen / chitosan micro-nano fiber composite membrane; soaking the collagen / chitosan micro-nano fiber composite membrane into natural biomacromolecules and Chinese herbal medicines sequentially; and freeze-drying to obtain the collagen / chitosan micro-nano fiber composite hemostatic membrane material. The collagen / chitosan micro-nano fiber composite hemostatic membrane material has excellent biocompatibility, biodegradability, adhesion property and the like, can quickly stop bleeding, resist inflammation, ease pain and promote wound healing, and can be applied to trauma hemostasis and repair and general civil hemostasis emergency treatment.
Owner:SICHUAN UNIV
Starch hemostatic microsphere and preparation method thereof
ActiveCN102406956AHigh water absorption rateImprove water absorption speedAbsorbent padsBandagesChemistryActive agent
The invention relates to a starch hemostatic microsphere and a preparation method thereof. The starch hemostatic microsphere is prepared from legume starch, potato starch and cereal starch which serve as raw materials by virtue of an inverse suspension polymerization method, and has a molecular weight of between 50000 and 5000000 and the grain diameter of between 0.1 and 1000mu m. The preparationmethod of the starch hemostatic microsphere comprises the following steps: mixing the three types of raw starches, and alkalizing; dispersing with a surfactant and vegetable oil under a condition that the pH is between 8.5 and 10.5; performing crosslinking with a crosslinking agent; cleaning, and performing spray drying; and packaging, and sterilizing with cobalt 60. The starch hemostatic microsphere prepared by using the method has good biocompatibility, and is used for a hemostatic process of a surgical operation; the water absorption rate is multiple times that of a conventional hemostaticmaterial, the water absorption speed is remarkably increased, and the hemostatic effect is reinforced. The starch hemostatic microsphere has easily available raw materials, simple process, low production cost and wide application prospect.
Owner:天津红日爱乐意药用辅料有限公司
Nanometer mesoporous silicon based xerogel hemostatic material and its preparing method and use
InactiveCN1970090APromote healingRapid scabbing to stop bleedingSilicaPharmaceutical delivery mechanismDielectricChemical composition
Owner:EAST CHINA UNIV OF SCI & TECH
Carboxymerhyl chitosan sponge with water-absorbent dilatability and its preparation method and use thereof
The invention relates to a method for producing a water-absorbing swellable carboxymethyl chitosan sponge and its application, which comprises: adding a little chitosan powder or chitosan powder into the carboxymethyl chitosan solution with a quantitation of glycerin as the elasticizer, making every 100 ml solution with carboxymethyl chitosan of 1-5 g, chitosan powder or chitosan powder of 0.5-2 g and glycer of 1-5 g, stirring to foam and adding the environment-friendly ion-cross linker to cross-linking completely, cooling and drying to get the production. In the invention, using water-soluble materials as raw materials to avoid contamination, and using non-aldehyde group ion-cross linker to avoid residual toxicity of aldehyde group.
Owner:上海美宝生命科技有限公司
Hemostatic device
A hemostatic device has a flexible band that can be wrapped around a hemostasis-requiring site of a limb, a securing portion that secures the band in a state where the band is wrapped around the limb, and an inflation portion that interlocks with the band, and that inflates when a fluid is injected. The inflation portion has a plurality of convex portions in a width direction orthogonal to a longitudinal direction of the band when the inflation portion inflates.
Owner:TERUMO KK
Medical adhesive used for adhering skin and viscus hemostasis, and its prepn. method
A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.
Owner:石平安
Biological and haemostatic wound dressing and preparation method thereof
InactiveCN102580134AAvoid the problem of easy degradationOvercoming the disadvantage of residual toxicityAbsorbent padsBandagesCross-linkWound dressing
The invention discloses biological and haemostatic wound dressing and the preparation method thereof. The biological and haemostatic wound dressing provided by the invention is water-insoluble gel formed through cross linking after mixing water solution of high molecular compound containing carboxyl as well as environment-friendly ion cross-linking agent, and then the water-insoluble gel is placed into a refrigerator tray and a product is obtained after freezing, drying and suppressing are carried out sequentially. Experiment prove that the biological and haemostatic wound dressing provided by the invention has a better adhesive effect on wound surfaces and bleeding, is less susceptible to dropping off from the wound surfaces, and has an obvious hemostatic effect. The biological and haemostatic wound dressing expands rapidly after partly absorbing body fluid and becomes the gel to play the insulating and expanding effect, thereby having excellent haemostatic and anti-adhesion effects.
Owner:山东省医疗器械研究所
Alginate medical dressing and preparation method thereof
ActiveCN107029272AGood moisturizing effectAvoid stickingPharmaceutical delivery mechanismAbsorbent padsSodium carboxymethylcelluloseAloin
The invention relates to the technical field of medical articles, in particular to alginate medical dressing and a preparation method thereof. The medical dressing is prepared by soaking alginate fibers in a functional soaking solution, wherein the functional soaking solution is prepared from, by weight, 2-4% of carboxymethyl chitosan, 1-2% of oligochitosan, 3-6% of chitosan hydrochloride, 1-2% of hyaluronic acid chitosan, 0.03-0.05% of antibacterial agent, 0.5-5% of sodium carboxymethyl cellulose, 1-6 % of calcium chloride, 0.005-0.05% of epidermal growth factor, 0.02-0.05% of aloe extracts and the balance water. The chitosan substances, the antibacterial agent, carboxymethyl cellulose, calcium chloride, the epidermal growth factor and the aloe extracts are loaded in the alginate fibers, so that the medical dress is endowed with the remarkable effects of preventing bacteria, stopping bleeding, promoting healing, preventing wound adherence and preventing scars.
Owner:HENAN HUIBO MEDICAL CO LTD
Medical absorbable skeletal wound hemostatic material and preparation method thereof
InactiveCN102727930AEasy to useHigh hardnessSurgical adhesivesPharmaceutical delivery mechanismWound healingAlcohol
The invention relates to a medical absorbable skeletal wound hemostatic material with accelerating wound healing and a preparation method thereof. The absorbable skeletal wound hemostatic material comprises 40-95 wt% of matrix material and 5-60 wt% of auxiliary material, wherein the matrix material comprises oligosaccharide, polysaccharide or a mixture of oligosaccharide and polysaccharide, and the auxiliary material comprises (1) one or more of polyhydroxy alcohols, (2) one or more of plant oil, and (3) one or more of emulsifiers. The preparation method comprises the following steps: carrying out chemical blending and latex blending on the matrix material and the auxiliary material with the prescribed dose, cooling to form solid clumps, packaging, and then conducting disinfection.
Owner:ZHUHAI ORTUS BIOTECH
Method for preparing fibrin ferment-chitosan self-assembly nano particle and use thereof
ActiveCN101485899AHigh activityImprove stabilitySurgical adhesivesAbsorbent padsWater bathsFiltration
The invention relates to a method for preparing thrombin-chitosan self-assembly nano particles and application thereof. The method comprises: adding chitosan into an acetic acid aqueous solution to form a chitosan solution; adding thrombin into a buffer solution to form a thrombin solution; uniformly mixing the thrombin solution and the chitosan solution, adding a crosslinking agent for stirring, pouring the mixture into liquid paraffin for stirring, adding a dispersant, and performing emulsification; and adding the crosslinking agent for crosslinking reaction through water bath, performing filtration and acetone washing, using ethanol for washing and dehydration, and finally performing vacuum drying to obtain the thrombin-chitosan self-assembly nano particles. The method feeds the thrombin and the chitosan according to proportion to prepare thrombin-chitosan which is self-assembled into nano particles for the first time, maintains the stability of the thrombin of the thrombin-chitosan self-assembly nano particles, and gives better play to the comprehensive hemostatic effect of the thrombin and the chitosan of the thrombin-chitosan self-assembly nano particles. The method can be widely applied to tissue hemostasis, tissue sealing and tissue adhesion in the surgical fields such as general surgery, orthopaedics, heat and chest surgery, neurosurgery and gynaecology and obstetrics.
Owner:GUANGZHOU BIOSEAL BIOTECH
Preparation method of oxidized regenerated cellulose hemostatic material with micro-nano composite structure
ActiveCN102908651APromote absorptionShort hemostatic timeArtificial filaments from cellulose derivativesAbsorbent padsMicro nanoDecomposition
The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.
Owner:WEIGAO HLDG +1
Preparation method for oxidized regenerated cellulose hemostatic material with surface nanostructure
ActiveCN102912622AAchieve hemostasisImprove adhesionFibre treatmentAbsorbent padsPolymer scienceViscose
The invention provides a preparation method for an oxidized regenerated cellulose hemostatic material with a surface nanostructure. In order to solve problems of small specific surface area, water insolubility, single hemostatic effect mechanism and low hemostatic speed of the traditional oxidized cellulose hemostatic material, the invention provides the preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The method comprises the following steps of: (1) preparing a collagen aqueous solution; (2) preparing a viscose fiber gauze; (3) preparing oxidized viscose staple fiber and oxidized viscose fiber gauze; (4) preparing an oxidized regenerated cellulose sodium solution or an oxidized regenerated cellulose potassium solution; (5) preparing an oxidized regenerated cellulose gauze; and (6) after collagen particles are sprayed, freezing and drying the oxidized regenerated cellulose gauze, so as to finish the preparation of the oxidized regenerated cellulose hemostatic material with the surface nanostructure. The preparation method for the oxidized regenerated cellulose hemostatic material with the surface nanostructure, provided by the invention, is applied to the preparation field of the oxidized regenerated cellulose hemostatic materials.
Owner:WEIGAO HLDG +1
Bionic alginate composite antimicrobial dressing and preparation method thereof
ActiveCN103908693AImprove mechanical propertiesPromote absorptionAbsorbent padsBandagesProcess systemsCross-link
The invention belongs to the field of biomedical materials, and particularly relates to bionic alginate composite antimicrobial dressing and a preparation method thereof. The bionic alginate composite antimicrobial dressing is prepared from the following raw materials: alginate components, chitosan components and silver ion components. The method is characterized by comprising the following steps: adding deionized water to agitate a solvent after mixing the raw materials, so as to obtain mixed water gel; repeatedly thawing, freezing and drying the mixed water gel to obtain a product, wherein the product comprises the following raw materials by weight percent: 60-90% of alginate components, 9.8-39% of chitosan components and 0.2-1% of silver ion components. The process system disclosed by the invention is controllable in temperature and condition, the problems of residues such as a toxic cross-linking agent or an assistant and the like do not exist, the safety risk of clinical application is greatly reduced, and the bionic alginate composite antimicrobial dressing has good product transformation feasibility.
Owner:山东颐诺生物科技有限公司
Preparation method for nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material
InactiveCN107233302AIncrease loadOvercome limitationsTetracycline active ingredientsAerosol deliveryWound healingMedicine
The invention discloses a nanometer cellulose / polydopamine compound intelligent gel drug sustained-release material and a preparation method thereof. The drug sustained-release material comprises nanometer cellulose, polydopamine and a drug loaded on the polydopamine, can be applied to the field of various drug sustained release and is especially suitable for the aspects of wound treatment, tumor postoperative treatment, and the like. The drug sustained-release material disclosed by the invention can load hydrophilic and hydrophobic drugs, is simply prepared, is mild and is capable of saving cost. The nanometer cellulose and the polydopamine both have biocompatibility, can completely degrade, are easy for waste treatment and are beneficial to environmental protection. The drug sustained-release material is especially suitable for wound healing and later treatment of tumor operation.
Owner:QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
Powder absorbable haemostat and its preparation method
InactiveCN102309776AFast hemostasisGood hemostatic effectAbsorbent padsBandagesMicrosphereCross linker
The invention discloses a powder absorbable haemostat and its preparation method, which belongs to the technical field of novel hemostatic material. The main components are chitosan, sodium alginate and hyaluronic acid. The weight ratio of chitosan to sodium alginate to hyaluronic acid is (0.1-10): (0.1-10): 1, The mass fraction of a cross-linking agent calcium chloride solution is 0.5-5 wt%. The invention also discloses a preparation method of the powder absorbable haemostat. According to the invention, the soybean oil is taken as an oil phase, calcium chloride is taken as a cross-linking agent, composite microspheres of chitosan, sodium alginate and hyaluronic acid can be obtained through a simple emulsification crosslinking process, the composite microspheres is dried to obtain the powder absorbable haemostat. According to the invention, the performance advantages of chitosan, sodium alginate and hyaluronic acid are combined by the product, so that the product has a plurality of haemostasis mechanisms which can rapidly suck water and swell, and the powder absorbable haemostat has the good anti-adhesion performance and characteristic of promoting the heal of the wound.
Owner:北京博恩康生物科技有限公司
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