22results about How to "Reduce activation" patented technology

The invention discloses a preparation method of a composite spray for improving the hemostatic ability of a wound part, the composite spray comprises a liquid A and a liquid B. The liquid B is a sodium alginate aqueous solution, a preparation method of the solution A comprises the following steps: 1, dissolving a lipopeptide conjugate, cholesterol, distearoyl phosphatidylcholine, distearoyl phosphatidylserine and dimethyl sulfoxide in a chloroform-methanol mixed solution to obtain a mixed system; 2, preparing the mixed system into a precursor solution by utilizing a film hydration method; 3, adding calcium chloride into the precursor solution, and reacting in a dark place to obtain a solution A; a precursor solution is designed according to the function of natural platelets, the function of the precursor solution is equivalent to that of nano platelets, the precursor solution is matched with sodium alginate, adverse effects on a blood coagulation system caused by fibrin degradation, platelet activation capability reduction and the like of a wound part due to blood loss can be relieved in a targeted manner, and the preparation has the advantages of rapid hemostasis, good biological activity, no toxic or side effects and the like. And the wound healing is rapid.

The invention belongs to the technical field of biological medicines, and particularly relates to application of asparaginase in preparation of a medicine for treating pancreatic cancer. The asparaginase and the gemcitabine are combined for treating pancreatic cancer, and results show that the combination of the two medicines can promote apoptosis of pancreatic cancer cells, reduce proliferation and reduce activation of pancreatic stellate cells, so that an important scientific basis is provided for improving gemcitabine drug resistance, and meanwhile, a new application is provided for the asparaginase.

The invention belongs to the technical field of phosphorite beneficiation, and particularly discloses a method for improving silicon-calcium collophanite double-reverse flotation froth, which comprises the following steps: adjusting the pH value of phosphorite pulp to be acidic by using oxalic acid, adding a magnesium removal collecting agent for reverse flotation magnesium removal to obtain magnesium-removed concentrate pulp, adding activated carbon into the magnesium-removed concentrate pulp, uniformly mixing, diluting the ore pulp, adjusting the pH value to be 6.5-8, and filtering to obtain the silicon-calcium collophanite double-reverse flotation froth. Adding the foam-inhibiting agent and uniformly mixing; and a cation collecting agent is added for dealumination and desiliconization reverse flotation, and ore pulp obtained after reverse flotation is subjected to solid-liquid separation, so that phosphate concentrate is obtained. According to the method provided by the invention, the pH is adjusted by adopting oxalic acid during reverse flotation magnesium removal, activated carbon is added into ore pulp after magnesium removal to mix an adsorption agent, and a foam inhibition agent is added; the physical and chemical properties of the surface of the foam can be changed, the half-life period of the foam is greatly shortened, and the beneficiation effect is ensured.

The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano drug-loading system as well as a preparation method and application thereof. A polylactic acid-polyglycolic acid copolymer is used as a matrix, polyvinyl alcohol is used as a cross-linking agent, and coated drug-loaded microspheres are formed through cross-linking and grafting of the matrix and the cross-linking agent; and then chitosan is used as a protective agent, chitosan and the coated drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded system is obtained. Through the double-target design, the targeting property to cornea and lacrimal gland is enhanced, the treatment efficiency of the medicine is improved, stable release and continuous release of linarin are realized, and the problem of unstable release of the medicine is solved; in addition, the targeted slow-release nano drug-loading system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.

The invention provides a transmission method and device, a terminal and network equipment. The method comprises the following steps: after a cell activation command, sending a first report to a network; and / or sending first information to a network, the first information being related to the beam; and / or determining a first time, the first time being related to cell activation. By adopting the transmission method provided by the embodiment of the invention, the terminal sends the first report to the network after the cell activation command, and the terminal sends the first information to the network and / or determines the first time, thereby achieving the effect of reducing the activation delay of the secondary cell.

The application belongs to the technical field of biological medicine, and specifically discloses a sprayable double-network hydrogel microsphere adhesive as well as a preparation method and application thereof. The preparation method comprises the following steps: liquid paraffin and sorbitan monooleate, polyoxyethylene sorbitan monolaurate are taken as oil phases to form an emulsion; the emulsion is fully mixed with petroleum ether, centrifugal separation is performed on the gel hydrogel microspheres, and freeze-drying is performed on the gel hydrogel microspheres for storage in the dark; preparation of ropivacaine liposomes; ultrapure water is added into the lipid membrane to obtain a primary liposome suspension, the hydrogel microspheres are used to adsorb the liposomes, and the obtained double-network hydrogel microspheres are collected. The sprayable double-network hydrogel microsphere adhesive as well as the preparation method and application thereof can be used to prepare hydrogel microspheres which can quickly and uniformly cover irregular wounds, and the liposomes carrying ropivacaine can provide sustained analgesic release, so that the problems of maintaining sustained adhesion in a blood-saturated wound and prolonging pain relief are simultaneously solved.

The application discloses application of tamibarotene in preparation of a medicine for preventing and / or treating liver fibrosis, and belongs to the technical field of biological medicine. The application finds that tamibarotene has a significant anti-liver fibrosis effect for the first time. Experimental results show that in two kinds of liver fibrosis animal models induced by CCl4 and TAA, tamibarotene can significantly down-regulate the expression of alpha-SMA and type I collagen, reduce the liver inflammatory response, and improve liver function. In particular, the anti-fibrosis effect of tamibarotene is significantly better than that of RARbeta selective agonist KCL-286 and RARalpha selective agonist Am580, and an unexpected technical effect is achieved. The application provides a new medicine selection for the treatment of liver fibrosis, and has a good clinical application prospect and development value.

The invention relates to the technical field of medical biological detection, provides a new application of FCN2, particularly relates to an application of FCN2 as a target spot in screening or treating Alzheimer's disease, and further provides a kit for performing early screening or curative effect evaluation on Alzheimer's disease by utilizing quantitative detection aiming at FCN2 and a medicine taking the kit as the target spot. The kit and the detection method disclosed by the invention are simple, convenient, reliable, short in period, high in specificity and easy to clinically popularize. The liver-derived plasma protein Ficolin-2 (FCN2) can be used as an early screening target and a drug treatment target of the Alzheimer's disease (AD), is particularly used as a kit and other medical equipment products to be applied, and has important significance on early discovery, precise treatment, curative effect monitoring and the like of high-risk patients.

The present invention relates to 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (i), wherein x, r1, r2, r3, r4, and r5 are as defined in the description. The invention also relates to methods for preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular cancer or diseases with dysregulation of immune responses or other disorders associated with aberrant AHR signals, as monotherapy or in combination with other active ingredients.

The invention discloses an optimal path planning method of a pulse coupling neural network based on double constraints. The method comprises the following steps: mapping a path planning environment to a DC-PCNN network; a DC-PCNN neural network model is constructed, and all neurons are initialized; activating a target neuron, and recording the current neuron as a father node; calculating an exponential decay function of the torque deviation, and multiplying the calculated value as a penalty factor by an update item of the internal activity item; calculating a gravitational function value of the flow field constraint, and using the calculated value to update a current neuron dynamic threshold value; comparing the internal activity item with a dynamic threshold; when gt; if yes, activating the neuron, and recording the current neuron as a father node; repeating the steps S4-S6 until the initial neuron is activated; and backtracking all activated nodes, and planning an optimal path. According to the method, the search efficiency is remarkably improved while the path optimality is ensured.

The invention discloses a modified montmorillonite nanosheet capable of being used as a cfDNA scavenger as well as a preparation method and application of the modified montmorillonite nanosheet. The modified nanosheet is prepared by modifying the surface of a two-dimensional montmorillonite nanosheet with polylysine cations. The modified montmorillonite nanosheet can achieve the effect of inhibiting inflammation by removing cfDNA and adjusting the abundance of intestinal microorganisms, effectively relieves symptoms induced by IBD, has good stability, biocompatibility and biodegradability, and can be used for treating inflammatory bowel diseases.

The invention provides a silicone grease nano-particle loaded with SHAP oligopeptide as well as a preparation method and application of the silicone grease nano-particle. According to the application disclosed by the invention, turbulence stimulation of human umbilical vein endothelial cells is simulated by virtue of treatment of oscillation shearing force, and immunofluorescence, immunoblotting, THP1 adhesion experiments and the like are used for the first time, so that the situation that the SHAP oligopeptide cannot play an obvious role independently is found, while the SHAP oligopeptide can effectively protect the phosphorylation level of MST1 / 2 in HUVECs caused by turbulence stimulation after being loaded in silicon lipid (SLS), so that the SHAP oligopeptide can be used for preparing the HUVECs. Therefore, the activation of endothelial cells is reduced. Furthermore, the invention innovatively discovers and verifies the treatment effect of the silicone grease nanoparticles loaded with the SHAP oligopeptide on the atherosclerosis. In conclusion, the silicone grease nanoparticles loaded with the SHAP oligopeptide, provided by the invention, provide a new thought for relieving and treating the atherosclerosis.

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.

The invention discloses a hollow fiber hemodialysis membrane based on in-situ self-assembly and a preparation method thereof. According to the membrane, PES is used as a matrix, PES, PVP and SF are co-dissolved in a N, N-dimethylacetamide DMAc solvent according to a specific proportion, and dry-wet spinning and an accurate non-solvent induced phase separation regulation technology are adopted, so that the silk fibroin and PVP have a synergistic effect in the phase inversion process, and the membrane is prepared. And multi-stage microphase separation and self-assembly are carried out, so that in-situ and lasting anchoring on the membrane substrate and the surface is realized. The dialysis membrane prepared by the method has excellent long-acting pollution resistance, excellent blood compatibility and a stable three-dimensional gradient structure. The invention further provides an intelligent response type expansion scheme of the membrane, and the membrane can dynamically adjust the performance according to the physiological state of a patient by introducing an environment response component, so that individualized precise dialysis is realized.

The present application relates to the technical field of fluorescent probe, and discloses a fluorescent probe locked by viscosity and glycosidase, and a preparation method and application thereof.The present application provides a compound, the fluorescence emission intensity of which is enhanced with the enhancement of the solution viscosity; meanwhile, after incubation with beta-galactosidase, the fluorescence intensity of the compound at 640nm is enhanced.Therefore, in the early diagnosis imaging of ovarian cancer, the compound can be used as a fluorescent probe locked by viscosity and glycosidase, and is used for accurate imaging of ovarian cancer.The fluorescent probe of the present application greatly improves the selectivity of the probe by using a double activation mechanism, effectively avoids non-specific activation to normal tissues, and is particularly suitable for targeted imaging of specific pathological environments such as tumors.

The invention discloses a non-contact temperature control method and system for a small animal experiment, and belongs to the technical field of experimental animal temperature control. The temperature control method comprises the following steps: S01, fixing an experimental small animal; s02, setting a preset temperature, and carrying out non-contact heating on the target area by adopting a laser heating unit; s03, an infrared temperature measurement unit is adopted to accurately detect the temperature of the target area, the temperature detected in real time is fed back to a control system unit, and the control system unit compares temperature differences; the control system regulates and controls the output power of the laser heating unit; and S04, when the real-time detection temperature of the infrared temperature measurement unit is equal to the preset temperature, non-contact temperature control is completed. According to the invention, non-contact heating of the laser heating unit is adopted; real-time monitoring temperature feedback of the infrared temperature measuring unit is received through the control system unit, accurate heating is performed step by step in a heating mode, accurate control over non-contact temperature control is achieved, and the temperature control accuracy error is within 0.1 DEG C.

The invention belongs to the technical field of biological medicines, discloses an application of a Sema3E inhibitor in preparation of a medicine for preventing, delaying or treating COPD small airway fibrosis, and proposes that the Sema3E inhibitor can be used for treating, preventing or delaying the COPD small airway fibrosis for the first time. The Sema3E inhibitor plays a role by inhibiting the expression of Sema3E. The specific molecular mechanism is as follows: by inhibiting the expression of Sema3E, inhibiting the expression of Wnt5a / b, beta-Catenin, increasing the expression of p-beta-Catenin, inhibiting the activation of a Wnt / beta-Catenin pathway, and inhibiting the activation / proliferation / migration of small airway fibroblasts. Through the mechanism, the effect of preventing, delaying or treating the COPD is achieved, and a new drug intervention target, namely Sema3E, is provided for treatment of the COPD.

The invention relates to an artemisia apiacea-containing penetration enhancing composition with skin cell repairing and relieving effects, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The research finds that the anti-inflammatory effect generated by only inhibiting an upstream anti-inflammatory path of an NF-kappa B channel is limited, and the anti-inflammatory effect can be remarkably enhanced by blocking a downstream conduction chain while inhibiting the NF-kappa B channel. On the basis, through the artemisia apiacea extract and the flos magnoliae extract, an upstream anti-inflammatory path is inhibited, recruitment and infiltration of inflammatory cells are reduced, a downstream conduction chain is blocked, and the anti-inflammatory effect is synergistically improved. Besides, through cooperation of the oat kernel oil, the jasmine flower oil and the squalane, on one hand, the solubility of fat-soluble active matter is improved, on the other hand, the composition can participate in repairing, stabilizing and optimizing the lipid structure of the skin cuticle, synchronously open the skin fat-soluble channel and convey the active matter more efficiently, and therefore the excellent relieving, repairing and stabilizing effects are achieved.

The invention provides a protection effect of costunolide on hypoxic ischemic brain injury (HIBD) of newborn rats, and belongs to the technical field of medicines. It is found for the first time that after HI brain injury, costunolide treatment reduces the cerebral infarction area, neuron loss is reduced, and development of gray matter and white matter of the brain is promoted. In addition, costunolide can inhibit neuronal inflammation, and is represented as reduction of proinflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, IL-18 and the like and reduction of activation of microglial cells and astrocytes. The invention provides a promising candidate drug for clinical treatment of neonatal HIBD in the future.

The invention discloses a three-dimensional surface numerical fitting and series mechanical arm control method based on an RBF (Radial Basis Function), which achieves the purpose of controlling a multi-joint series mechanical arm to realize high-precision polishing on a complex free-form surface through physical modeling and numerical simulation, accurate prediction of a machining surface, planning of a polishing path in a three-dimensional space and establishment of a D-H matrix.

The present application relates to a skin cell soothing and repairing composition containing artemisia and its preparation method and application, and belongs to the technical field of cosmetics. The present application finds that only by inhibiting the upstream anti-inflammatory pathway of the NF-kappa B pathway, the anti-inflammatory effect is limited, while inhibiting the NF-kappa B pathway, the downstream transmission chain is blocked, and the anti-inflammatory effect is significantly enhanced. Based on this, the present application inhibits the upstream anti-inflammatory pathway by artemisia extract and jasminum officinale extract, reduces the recruitment and infiltration of inflammatory cells, blocks the downstream transmission chain, and synergistically improves the anti-inflammatory effect. In addition, the present application cooperates oat kernel oil, jasmine flower oil and squalane, on the one hand, improves the solubility of fat-soluble active substances, on the other hand, participates in the repair, stabilization and optimization of the lipid structure of the skin cuticle, synchronously opens the skin fat-soluble channel, and more efficiently transports active substances, thereby realizing excellent soothing, repairing and stabilizing effects.

The invention discloses a high-strength wear-resistant liquid crystal polymer fiber and a preparation method thereof.The high-strength wear-resistant liquid crystal polymer fiber comprises an inner-layer polymer and an outer-layer cross-linked polymer wrapping the surface of the inner-layer polymer, and the high-strength wear-resistant liquid crystal polymer fiber is obtained through the cross-linking effect between polymer molecules in the direction perpendicular to the fiber axis. The bending resistance and the shearing resistance of the fiber are improved, and the longitudinal layering phenomenon in the machining process is avoided. The high-strength wear-resistant liquid crystal polymer fiber prepared by the invention has excellent mechanical properties, wear resistance and relatively low dielectric constant.