184results about How to "Reduce oxidative stress" patented technology

The invention discloses a novel nano-drug Res (at) LDH and a preparation method and application thereof.Germanium-doped LDH powder and resveratrol are combined to obtain a nanoscale particle mixed material Res (at) LDH, electron paramagnetic resonance (EPR) tests show that both the germanium-doped LDH and the traditional drug resveratrol show excellent reactive oxygen species (ROS) removal characteristics, and the Res (at) LDH can be used for preparing a novel nano-drug Res (at) LDH. The nano-drug Res (at) LDH formed by combining the two has remarkable synergistic ROS removal efficiency which can reach 90%. Meanwhile, in-vivo biological distribution experiments show that the novel nano-drug Res (at) LDH has excellent blood-brain barrier permeability, enhances accumulation in brain tissues, improves neurological dysfunction, reduces infarct volume, shows strong antioxidant activity, and inhibits release of pro-inflammatory cytokines.

The invention discloses a preparation method of sandwich type immunomagnetic beads with high thermal stability, which comprises the following steps: by taking polystyrene microspheres as a template, introducing oil-phase Fe3O4 nanoparticles into the polystyrene microspheres through a swelling method, and then carrying out hydrolytic condensation reaction on the surface of a microsphere assembly by utilizing n-octyltrimethoxysilane OTMS to obtain the sandwich type immunomagnetic beads with high thermal stability. The preparation method comprises the following steps: carrying out surface amination modification on a silicon dioxide thin layer which is grown by hydrolysis of tetraethoxysilane TEOS to realize coating of an outermost organic shell layer, carrying out surface amination modification, and carrying out cross-linking on 1, 4-butanediol diglycidyl ether and erythritol on the surface to form an epoxy polymer layer so as to obtain the sandwich-type immunomagnetic bead with a cross-linked epoxy polymer layer introduced to the outer layer. According to the epoxy group modification process on the surface of the magnetic bead, a direct cross-linking modification process is adopted, so that the operation steps are simplified, and the obtained epoxy group magnetic bead is ensured to show excellent biocompatibility. In addition, the method omits the tedious process of functional group activation, and allows direct coupling with the antibody, thereby greatly improving the efficiency and convenience of the experiment.

The invention relates to the technical field of health care product preparation, and particularly discloses an oyster peptide enzyme oral liquid capable of enhancing immunity and a preparation method thereof, the oyster peptide enzyme oral liquid comprises the following components: 20 parts of oyster peptide, 50 parts of plant enzyme liquid, 5 parts of honey, 2 parts of fructo-oligosaccharide, 2 parts of lemon juice and 100 parts of purified water; the oyster peptide enzyme oral liquid contains rich natural antioxidant ingredients including oyster peptide and plant enzyme liquid, the oyster peptide contains a large amount of sulfur-containing amino acid, and the ingredients can be used as antioxidants to reduce generation of free radicals and protect cells from oxidative damage; the plant enzyme is rich in natural antioxidant enzyme, can promote synthesis of antioxidant enzyme in vivo and remove free radicals in vivo so as to slow down senescence and diseases, the oyster peptide and the enzyme act together to improve the activity of catalase in vivo, and oxidative stress is reduced by removing superoxide anion free radicals.

The invention relates to antioxidant gel for wound healing as well as a preparation method and application of the antioxidant gel. The antioxidant gel is prepared from the following components in parts by mass: 0.01 to 20 parts of hyaluronic acid, 0.01 to 20 parts of cysteine and 1 to 50 parts of polyethylene glycol carboxyl activated ester. The cysteine modified hyaluronic acid and the polyethylene glycol carboxyl activated ester are cross-linked to form a hydrogel network, the tissue adhesion capacity of the hyaluronic acid gel is remarkably improved, the antioxidant capacity and the anti-inflammatory capacity are further improved, and the hydrogel material is simple in component, good in biocompatibility, stable in cross-linked network and biosafe.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses nano-composite hydrogel based on active oxygen removal as well as a preparation method and application of the nano-composite hydrogel, and relates to the technical field of biomedicine. The nano composite hydrogel based on active oxygen removal comprises a three-dimensional network skeleton structure formed by cross-linking oxidized chondroitin sulfate and carboxymethyl chitosan, and melatonin-loaded mesoporous polydopamine nanoparticles are encapsulated in the three-dimensional network skeleton structure. According to the invention, a nano material is combined with a three-dimensional network skeleton structure of the hydrogel, a novel nano composite hydrogel is developed, and the nano composite hydrogel has self-healing ability, good biocompatibility, good mechanical properties and long-acting drug release ability; meanwhile, the melatonin is loaded into the nano-composite hydrogel to develop a medicine compound, the medicine activity and the treatment effect are better than those of the melatonin, inflammation and oxidative stress can be relieved more effectively, and symptoms can be improved more effectively.

The invention provides a culture method for improving immunity of fishes. The culture method comprises the following steps: S1, selection of culture points; S2, specification and layout of net cages; S3, selection and throwing of fish fries; according to the fry disinfection method disclosed by the invention, the fry are soaked and disinfected by using a compound disinfectant prepared from povidone iodine, polysorbate, citric acid and vitamin C in a specific proportion, so that pathogenic microorganisms on the surfaces and gill parts of fish bodies are effectively killed. According to the breeding management, the immunity of the fish body is comprehensively enhanced by feeding the fish with an immune conditioner composed of campesterol palmitate, immunomodulatory peptide, beta-glucan and astaxanthin in a specific proportion. According to the bottom mud management, the content of harmful substances is reduced by putting a bottom mud modifier composed of sodium molybdate, nitrifying bacteria, photosynthetic bacteria, tetrandrine and sodium alginate in a specific proportion, growth of pathogenic bacteria is inhibited, nutrient substance circulation is promoted, the water quality environment is optimized, and healthy growth of fry is promoted.

The invention belongs to the technical field of biological medicine, and particularly relates to a stem cell preparation based on immunoregulation and a preparation method and application thereof. The stem cell preparation based on immunoregulation is prepared from the following raw materials in parts by weight: 5 to 40 parts of freeze-dried powder, 40 to 120 parts of gastrodia elata polysaccharide and 2 to 6 parts of melatonin, the freeze-dried powder is obtained by mixing and freeze-drying a stem cell culture solution and curcumin lipidosome; the volume ratio of the stem cell culture solution to the curcumin liposome is 1: (10-32); the protein concentration in the stem cell culture solution is 1.2 mg / mL to 1.6 mg / mL. The stem cell preparation provided by the invention can utilize the immune regulation effect of the mesenchymal stem cells to realize the immune repair of adipose tissues.

The invention relates to a bergamot fermented tea beverage, a flavored tea beverage and a preparation method thereof. The preparation method comprises the following steps: S1, brewing shredded bergamot with hot sugar water, and filtering to obtain bergamot tea sugar water; s2, inoculating a kombucha mother solution and a kombucha pellicle into the bergamot tea sugar water obtained in the S1, and then performing primary fermentation to obtain a bergamot fermented tea mother solution and a bergamot fermented tea pellicle; s3, inoculating the bergamot fermented tea mother liquor obtained in the step S2 and bergamot fermented tea mycoderm into the bergamot tea sugar water obtained in the step S1, and then performing secondary fermentation; and S4, centrifuging to remove thallus precipitate, so as to obtain the bergamot fermented tea beverage. Compared with the prior art, the bergamot fermented tea beverage has the advantages that the bergamot tea sugar water is used as the fermentation base solution, the bergamot fermented tea mother solution is formed through the fermentation of the kombucha liquid, and then the secondary fermentation is performed, so that the bergamot fermented tea beverage with the flavor of the bergamot fermented tea and excellent oxidation resistance can be obtained.

The invention relates to the technical field of biological medicines, in particular to a nano-drug for treating idiopathic pulmonary fibrosis as well as a preparation method and application of the nano-drug. The nano-particles are prepared by loading the TGF-beta1 inhibitor and the RSV by using hemoglobin, so that the TGF-beta1 inhibitor and the RSV are cooperated to effectively treat idiopathic pulmonary fibrosis.

The invention discloses a microneedle patch loaded with a sorafenib and copper-doped Prussian blue nano material and application of the microneedle patch in in-situ triple-negative breast cancer treatment. The sorafenib and the copper-doped Prussian blue nano material are loaded in a needle body of the microneedle patch. The microneedle patch can accurately deliver nanoparticles and sorafenib to tumor tissues, the chemical kinetics effect is enhanced through an efficient and mild photothermal therapy, the ferroptosis of triple negative breast cancer cells is enhanced through ferroptosis induced by the nanoparticles and sorafenib in cooperation with drugs, then cell death is induced, and the curative effect is improved. And a brand-new and promising treatment method is provided for in-situ triple-negative breast cancer treatment.

The invention discloses a microneedle patch loaded with vancomycin and a gold / zinc cerium composite nanomaterial and application of the microneedle patch in abscess wound treatment, the microneedle patch comprises a backing layer and a needle body array arranged on the backing layer, the backing layer and the needle body array are formed by an aqueous solution of a degradable polymer, vancomycin and a gold / zinc cerium composite nano material are loaded in an aqueous solution of the degradable polymer for forming the needle body array. According to the microneedle patch disclosed by the invention, based on the photo-thermal synergistic effect of the antibiotics and the gold / zinc-cerium composite nanomaterial, rapid healing of abscess wounds is realized from the aspects of inhibiting growth of bacteria, relieving oxidative stress, promoting angiogenesis and the like.

The invention relates to the technical field of rhinitis medicine preparation, in particular to zirconium-doped cerium oxide nano-enzyme for preparing allergic rhinitis drops and a preparation method of the zirconium-doped cerium oxide nano-enzyme. The preparation method comprises the following steps: step 1, weighing a cerium acetylacetonate (III) hydrate and a zirconium acetylacetonate (IV) hydrate, adding into oleylamine, magnetically stirring and uniformly mixing, and carrying out ultrasonic treatment on the mixture; step 2, putting the mixed solution in the step 1 into a drying oven, heating, preserving heat, and aging to obtain a dark brown colloidal solution; step 3, naturally cooling the colloidal solution to room temperature, adding acetone, centrifuging, discarding supernate, and repeating centrifugal washing for several times; and 4, carrying out vacuum drying on the precipitate obtained in the step 3, and fully grinding to obtain the zirconium-doped cerium oxide nano-enzyme. The prepared zirconium-doped cerium oxide nano-enzyme is applied to preparation of allergic rhinitis drops. The zirconium-doped cerium oxide nano enzyme reduces the inflammatory factor level of the AR mouse and inhibits degranulation of nasal mucosa MCs, so that the pathological state and allergic symptoms of the AR mouse are improved.

The invention discloses a natto peptide sea cucumber polysaccharide liposome for synergistically improving cardiovascular health and a preparation method and application thereof, belongs to the field of active peptide delivery systems, and aims to solve the stability problem of natto oligopeptide in gastrointestinal digestive tracts. The phytosterol and the vitamin E are filled between phospholipid double layers of the liposome to support a gap between the phospholipid double layers, and the ratio of the phytosterol to the vitamin E is (1-3): 1, so that the natto oligopeptide liposome has the effects that the storage of the natto oligopeptide and the stability of the natto oligopeptide in gastrointestinal and digestive tracts can be improved, the bioavailability of the natto oligopeptide liposome is improved, and the bioavailability of the natto oligopeptide liposome is improved. The traditional Chinese medicine composition has synergistic effects in the aspects of anticoagulation, thrombolysis and blood fat reduction, and has a good cardiovascular protection effect.

The invention discloses antioxidant and firming double-layer essence oil and a preparation method thereof, and belongs to the technical field of cosmetics. The double-layer essence oil contains an anti-oxidation and firming composition, the composition comprises the following components: crambe abyssinica seed oil, cynara plantago seed oil, a hop extract and a humulus lupulus extract, and through the synergistic effect of the four components, the double-layer essence oil has good anti-oxidation and skin firming effects; and the double-layer essence oil prepared by the preparation method disclosed by the invention is easier to absorb by skin.

The invention provides a breeding method for improving the production performance of pregnant sows, and the breeding method comprises the following steps: (1) from the 25th-35th day of pregnancy to the 55th-65th day of pregnancy of the sows, adding a first nutritional supplement into a sow feed; (2) from the 55th-65th day of pregnancy of the sows to the 85th-95th day of pregnancy of the sows, adding a second nutritional supplement into the feed of the sows; and (3) adding a third nutritional supplement into the sow feed from the 85th-95th day of pregnancy to delivery of the sows. The breeding method provided by the invention can fully meet the nutritional requirements of the pig fetuses, promote the growth and development of the pig fetuses, avoid intrauterine development retardation, relieve oxidative stress of the sows, shorten the birth process, reduce postpartum inflammation of the sows, promote rapid recovery of the sows, reduce the number of weak piglets, improve the birth weight of the piglets, and further improve the survival rate and health state of the piglets.

The invention relates to the technical field of browning inhibition of fermented rose wine, in particular to a composite browning inhibitor for fermented rose wine and application of the composite browning inhibitor. The composite browning inhibitor provided by the invention is a browning inhibitor especially suitable for the fermented rose wine, can effectively inhibit the browning of the fermented rose wine, and can effectively improve the sensory quality of the fermented rose wine. The composite browning inhibitor is prepared from the following components: calcium chloride, glutathione, EDTA-Na2 (Ethylene Diamine Tetraacetic Acid) and D-sodium erythorbate, wherein the mass ratio of the calcium chloride to the glutathione to the EDTA-Na2 to the D-sodium erythorbate is (1.3 to 2.0) to (0.5 to 1.1) to (0.02 to 0.06) to (0.12 to 0.19).

The invention discloses a composition for improving basic metabolism during low-carbon diet, and belongs to the technical field of food. The composition is prepared from the following components in parts by weight: 0.01 to 0.5 part of opuntia ficus-indica juice powder, 0.01 to 0.5 part of guarana extract, 10 to 50 parts of virgin coconut oil microcapsule powder, 1 to 10 parts of medium chain triglyceride microcapsule powder, 0.1 to 1 part of grape seed extract, 0.01 to 0.1 part of potato extract and 0.1 to 1 part of pomegranate extract. The composition can effectively improve the basal metabolic rate during a low-carbon diet period at a lower dosage. According to the innovative combination mode, the basal metabolic rate is increased, the problem of insufficient energy possibly occurring in the low-carbon diet period is relieved, and side effects and cost increase possibly caused by addition of high-dose plant extracts are avoided.

The invention discloses an application of engineered citrobacter freundii in fermentation synthesis of a stable body. The engineered citrobacter freundii is citrobacter freundii overexpressing a polyphosphate kinase gene Ppk1. The stable body prepared by fermenting the engineered citrobacter freundii is rich in polyphosphates and polyamines, particularly, the content of the polyamines can be up to 21wt%, the polyphosphates in the stable body can store the polyamines in an ionic bond combination mode, the combined polyamines are insoluble in water, a natural anion coating is generated, and the stability of the stable body is improved. And the sustained-release tablet is not easily taken by intestinal epithelial cells, so that the sustained-release tablet has a certain sustained-release effect. The medicine prepared by taking the compound as a main active ingredient shows a remarkable curative effect in ulcerative colitis treatment, has the comprehensive effects of reducing oxidative stress, enhancing the anti-inflammatory ability of a body and regulating immunity, is suitable for patients of all ages, and has outstanding application value and market prospect.

The invention belongs to the technical field of biological pharmacy, and particularly relates to application of D724-0491 in preparation of a product for preventing and treating breast cancer. The D724-0491 inhibits the combination of HBXIP and KEAP1, reduces the nuclear entry level of NRF2, further induces oxidative stress of tumor cells and promotes death of cancer cells, is a novel targeted therapeutic drug for breast cancer, and improves the prognosis survival rate of breast cancer patients.

The invention mainly relates to composite hydrogel of a targeted cartilage end plate as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of biological medicines. The composite hydrogel of the targeting cartilage end plate comprises a cartilage targeting peptide modified drug-loaded exosome, calcium carbonate, chitosan and water, and the cartilage targeting peptide modified drug-loaded exosome comprises an exosome, a cartilage targeting peptide and salvianolic acid A. The composite hydrogel of the targeting cartilage end plate is prepared by the following steps: encapsulating salvianolic acid A by exosome derived from human mesenchymal stem cells, modifying by cartilage targeting peptide to obtain drug-loaded exosome modified by the cartilage targeting peptide, and mixing the drug-loaded exosome with calcium carbonate, chitosan and water. The compound can be used for accurately targeting cartilage endplate cells (CEPCs), remarkably relieving the inflammation of the CEPCs, changing the secretion phenotype of the CEPCs, delaying the senescence of nucleus pulposus cells (NPCs), relieving the inflammation of the NPCs and effectively treating intervertebral disc diseases.

The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano drug-loading system as well as a preparation method and application thereof. A polylactic acid-polyglycolic acid copolymer is used as a matrix, polyvinyl alcohol is used as a cross-linking agent, and coated drug-loaded microspheres are formed through cross-linking and grafting of the matrix and the cross-linking agent; and then chitosan is used as a protective agent, chitosan and the coated drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded system is obtained. Through the double-target design, the targeting property to cornea and lacrimal gland is enhanced, the treatment efficiency of the medicine is improved, stable release and continuous release of linarin are realized, and the problem of unstable release of the medicine is solved; in addition, the targeted slow-release nano drug-loading system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.

The invention discloses a preparation method of a dendrobium loddigesii polysaccharide extract, which comprises the following steps: crushing cleaned dendrobium loddigesii into dendrobium loddigesii powder, extracting with ethanol, filtering, and drying to obtain dendrobium loddigesii powder to be extracted; mixing p-toluenesulfonic acid, n-butyl alcohol and water to obtain an extraction solution; adding to-be-extracted dendrobium loddigesii powder into the extracting solution, heating and extracting, separating, dialyzing to obtain a crude extracting solution, carrying out alcohol precipitation, dialyzing the precipitate, and freeze-drying to obtain the dendrobium loddigesii polysaccharide extract. The mixed solution is used for extracting the dendrobium loddigesii polysaccharide, extraction and separation of the dendrobium loddigesii polysaccharide extract can be achieved, deproteinization treatment is not needed, the purity of the obtained dendrobium loddigesii polysaccharide extract can reach 90% or above, the process is simple and convenient, reproducibility is good, cost is low, and large-scale production is easy. The invention further discloses application of the dendrobium loddigesii polysaccharide extract prepared by the preparation method and the pharmaceutical composition of the dendrobium loddigesii polysaccharide extract in preparation of drugs or health care products for preventing or treating liver injury.

The invention discloses a production method of a product with a crop high-temperature-resistant function, and the method comprises the following steps: S1, screening and identifying antioxidant components in a natural plant extract, S2, producing the antioxidant components by using a microbial fermentation technology, and S3, compounding the antioxidant components with trace elements required by crop growth, s4, packaging the compound based on a thermostable carrier material to protect the biological activity of the antioxidant component, and S5, applying the compound to crops to form a layer of protective film on the surfaces of the crops to improve the antioxidant enzyme activity of the crops and reduce cell damage; the production method of the product with the crop high-temperature-resistant function solves the problem that in the prior art, under long-term high-temperature stress, the activity of antioxidant enzymes in crops can be gradually reduced. And along with the continuous high temperature, the balance of an anti-oxidation system may be destroyed, the free radical scavenging rate is reduced, and cells are damaged.

This invention relates to the field of biomedical technology, and in particular to the application of plateau cattail pollen flavonoids in the preparation of products that improve age-related cognitive dysfunction. This invention provides plateau cattail pollen flavonoids derived from the Lalu Wetland National Nature Reserve in Tibet. These plateau cattail pollen flavonoids can achieve safe and efficient relief of age-related cognitive dysfunction through multi-target synergistic effects, including "regulating gut microbiota to reshape microecological balance, repairing the intestinal barrier to inhibit peripheral inflammation, and crossing the blood-brain barrier to directly inhibit acetylcholinesterase activity." This overcomes the shortcomings of existing technologies, such as the large side effects and poor long-term tolerance of synthetic drugs, and the single target and difficulty in effectively regulating the "microbe-gut-brain axis" of ordinary natural products.

The invention belongs to the technical field of biological medicines, and particularly relates to a thiophenol compound as well as a preparation method and application thereof. The prepared thiophenol compound is applied to human kidney cells HK-2 and living mice, it is found that the compound can remarkably inhibit peroxidation of cell membrane lipid molecules induced by hypoxia-reoxygenation and further induce cell ferroptosis, and the thiophenol compound has a long-term stable inhibition effect. By pretreating the compound, the levels of creatinine and urea nitrogen in serum after kidney injury can be remarkably reduced, which indicates that the compound can relieve acute kidney injury. Besides, the compound prepared by the invention is used for pretreatment, so that kidney external marrow region injury caused by ischemia-reperfusion is remarkably relieved, lesions such as renal tubular epithelial cell necrosis and the like are effectively relieved, and a new treatment strategy is provided for ferroptosis inhibitors when the compound is applied to kidney ischemia-reperfusion injury repair.

The invention provides a method for improving drought resistance of leymus chinensis under an extreme drought condition, and belongs to the technical field of drought-resistant cultivation. The invention provides an application of a salicylic acid solution in drought resistance of leymus chinensis, which proves that salicylic acid can participate in regulating stomatal movement of leymus chinensis, reduce water loss and improve the water utilization efficiency of plants; activation of an anti-oxidation system in plants can be promoted, and oxidative stress reaction caused by drought is relieved. In addition, the application of salicylic acid can also induce leymus chinensis to generate more stress response proteins and enhance the stability of cell walls, so that the survival rate of plants in a drought environment is increased. Therefore, the salicylic acid aqueous solution is applied to drought resistance of leymus chinensis, so that development of a new biotechnological means is facilitated, increasingly severe drought challenges are dealt with, and health and stability of a grassland ecosystem are protected.

The present invention relates to the field of biomedicine technology, and discloses a use of melanin in the preparation of a drug for treating chronic ulcerative colitis and its associated depressive-like behavior. The present invention is the first to discover that melanin has the efficacy of treating chronic ulcerative colitis and its associated depressive-like behavior. MSPI can inhibit the LPS / TLR4 / NLRP3 / ASC / Caspase‑1 inflammatory signaling pathway, reduce oxidative stress, and restore the intestinal barrier, thereby improving UC symptoms. In addition, MSPI can also reduce glial cell activation, brain neuroinflammatory response and neuronal apoptosis, thereby reducing depressive-like behavior.

The invention belongs to the technical field of traditional Chinese medicine and biological medicine, and provides a pharmaceutical composition SGD for improving sepsis acute kidney injury and a preparation method and application thereof, the pharmaceutical composition SGD is prepared from the following raw materials by weight: 25-35 parts of raw white peony root, 8-13 parts of honey-fried licorice root, 10-20 parts of winged euonymus twig, 10-20 parts of caulis sinomenii, 25-35 parts of lalang grass rhizome, 8-13 parts of patrinia and 8-13 parts of sargentgloryvine stem. The SGD is used for treating S-AKI for the first time, on one hand, the SGD reduces oxidative stress and systemic inflammatory response by inhibiting a PI3K-AKT signal channel, on the other hand, the SGD can improve the renal function of S-AKI and the survival rate of mice, and participates in regulating the disease mechanism of S-AKI. The potential protection effect of the SGD on S-AKI, systemic inflammation and oxidative stress is discussed, and the protection mechanism of the SGD is further discussed by paying attention to a PI3K-AKT signaling pathway. And further evidence can be provided for SGD treatment of S-AKI.

This invention belongs to the field of medical technology, specifically relating to the application of mitochondrial transplantation to regulate the immune-metabolic network in the treatment of myocardial dysfunction after cardiac arrest. The mitochondrial transplantation is performed within 0.5-2 hours after the restoration of spontaneous cardiac circulation. This technical solution, through multi-omics integrated analysis, proposes that mitochondrial transplantation exerts a cardioprotective effect by regulating the immune-metabolic-mitochondrial triaxial synergistic network, providing a new research direction for the precision treatment of myocardial dysfunction after cardiac arrest.