101 results about "Triphenyl phosphonium" patented technology

The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph₃)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.

The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph₃)+XR.Z- where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.

The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph₃)⁺XR.Z⁻ where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.

The invention relates to a fluorescent probe used for conducting linkage detection on superoxide anions (O2.-) and hydrogen polysulfide, in particular to a fluorophore derivative for detecting superoxide anions and hydrogen polysulfide and application thereof. The fluorophore derivative is shown in the general formula I. In the general formula I, R1 represents a C1-22 alkyl group or a halogenated benzyl group or C1-C12 organic acid ester chains; R2 represents hydrogen, a sulfonic group or an amino group or a carboxyl group or a nitro group or halogen; X (a positioning functional group) represents -OH, a butyl triphenyl phosphonium group, an N-propyl morpholino group, a biotin group, a folic acid group, a glycosyl chain group, benzyl chloride or a C1-22 alkyl group; Y1 represents N, O or S; Y2 represents N, O or S. In the presence of the superoxide anions (O2.-) and the hydrogen polysulfide, corresponding fluorescence emission wavelength and intensity change, and the fluorescent probe can be used for detecting the superoxide anions (O2.-) and the hydrogen polysulfide in organisms, interference of external detection conditions can be greatly reduced, the detection signal to noise ratio is high, and sensitivity and selectivity are good. The fluorophore derivative has important significance in biomedicine.

The invention discloses a phosphonium salt modified acrylic fibre antibacterial material and a preparation method thereof, belonging to the field of polyacrylonitrile modified materials. Na type polyacrylonitrile fibre is taken as a carrier, an ion exchange method is adopted, and a part with anion removed of triphenyl phosphonium bromide containing different carbon chain lengths is exchanged to the polyacrylonitrile fibre by adopting an ion exchange method so as to prepare the phosphonium salt modified acrylic fibre antibacterial material. The material combines an antibacterial effect of the phosphonium salt and excellent mechanical and textile performances of the polyacrylonitrile fibre, thus fully taking the advantages of the phosphonium salt and the polyacrylonitrile fibre, and achieving efficient, rapid and permanent antibacterial purposes. The preparation method is simple, convenient to operate and environment-friendly, and can be widely used for development of various antibacterial textiles and sterilization of all kinds of industrial and domestic water.

The invention relates to a method for synthesis of dronedarone. The method comprises the following steps that 1), p-nitrophenol, paraformaldehyde and concentrated hydrochloric acid as raw materials undergo a condensation reaction in the presence of concentrated hydrochloric acid or phosphoric acid as a catalyst to produce 2-chloromethyl-4-nitrophenol; 2), 2-chloromethyl-4-nitrophenol and triphenylphosphine undergo a reflux reaction in the presence of chloroform to produce 2-hydroxy-5-nitrobenzyl-triphenyl-phosphonium chloride, and 3), 2-hydroxy-5-nitrobenzyl-triphenyl-phosphonium chloride and n-valeryl chloride undergo a condensation reaction in a toluene solution in the presence of triethylamine and n-pentanoic acid as catalysts to produce 2-(n-butyl)-5-nitrobenzofuran.

The invention discloses a quaternary phosphonium salt as well as a preparation method and application thereof. The quaternary phosphonium salt is allyl triphenyl phosphonium bromide and has a structural formula I shown in the specification. The preparation method of the quaternary phosphonium salt comprises the following steps of: (1) adding alkenyl halide and trialkyl phosphine which have the mole ratio of 1.13-1.5:1.0 to a solvent, heating to 55-75 DEG C, and reacting for 7-12 hours so as to prepare a crude quaternary phosphonium salt product, wherein reactants need to be continuously stirred in the process; (2) after the crude quaternary phosphonium salt product is cooled to 20-30 DEG C, gathering the crude quaternary phosphonium salt product through a filtering method, and washing and purifying by using the solvent so as to obtain the quaternary phosphonium salt. The preparation method of the quaternary phosphonium salt has the advantages of simpleness, few steps, short time and high product yield; the obtained quaternary phosphonium salt has unsaturated structure, can be used for preparing novel materials by grafting with high-molecular materials, i.e. plastics, rubbers, andthe like, can also be used as an antibacterial agent and a surface active agent and has wide application scope; and in addition, the invention increases the variety of the traditional antibacterial agent.

A method of preparing for 7-amido-3-ethylene cephalosporanic acid considers 7-phenylacetyl amino-3-chloromethyl cephalosporanic acid p-methoxybenzyl ester (GCLE) as a starting material and adopts the Wittig reaction. Ethylene is introduced on position 3 to obtain 7-phenylacetyl amino-3- ethylene-4- cephalosporanic acid p-methoxybenzyl ester, and a product GVNE is obtained. The GVNE is used to prepare for 7-amido-3-7 alkenyl cephalosporanic acid (7-AVCA). The present invention has the main technical characteristic that the triethyl phosphite with quite low price is used to replace triphenyl-phosphonium in the preparation of the GVNE to realize the purpose of introducing the ethylene on the position 3 of GCLE to prepare for the GVNE. The production method is simple; the cost of the main materials is low; the yield is high; the comprehensive benefit efficiency is high; the present invention is applicable to the large scale industrialized preparation of 7-AVCA.

The invention discloses a one alkyl triphenyl substituted group based phosphonium salt preparation method and application. The preparation method includes that a one alkyl triphenyl phosphonium salt halide I is obtained through reaction of several alkyl halides and triphenylphosphine in a DMF (dimethyl formamide) solvent through nucleophilic substitution, and an aqueous solution of a compound I and a sodium tetrafluoroborate aqueous solution are subjected to ion exchange to prepare the phosphonium salt through high yield of recrystallization. The phosphonium salt preparation method and application has the advantages of low cost and easy obtaining of raw materials and low cost, one alkyl triphenyl substituted group containing phosphonium salt II serving as a phase transfer catalyst has the advantages of high catalytic activity, less required dose, long activity time, high thermal stability and low toxicity, high reaction recovery and the like in catalytic fluorine chlorine exchange reaction, and wide commercial application prospect is achieved.

The invention discloses a hydrophilic epoxy resin binder and a preparation method and an application thereof. The hydrophilic epoxy resin binder consists of the following components according to parts by weight: bisphenol A type epoxy resin, a surface active agent Span, a surface active agent Tween and a catalyst, wherein the catalyst can be tetraethyl ammonium chloride, butyl triphenyl phosphonium bromide, benzyl triethyl ammonium bromide, benzyl triethyl ammonium chloride, 2-methyl imidazole or any combination thereof; the bisphenol A type epoxy resin can be bisphenol A type epoxy resin E-44, E-42, E-35, E-31, E-20, E-14, E-12, E-06, E-03 or any combination thereof; the surface active agent Span can be S-20, S-40, S-60, S-80, S-85 or any combination thereof; and the surface active agent Tween can be T-20, T-40, T-60, T-80, T-85 or any combination thereof. The hydrophilic epoxy resin binder is applied in the preparation process of water permeable pavement materials and high-strength cement products.

The invention discloses a double-ligand zinc complex catalyst which is prepared from an active main body zinc halide salt, an active functional ligand L1 and a corrosion-inhibition functional ligand L2, wherein the active functional ligand L1 is tetramethyl ammonium halide, tetraethyl ammonium halide, tetrapropyl ammonium halide, tetraethyl phosphonium halide, tetraphenyl phosphonium halide, methyl tri-tert-butyl phosphonium halide or methyl triphenyl phosphonium halide; and the corrosion-inhibition functional ligand L2 is N-methylimidazole, iminazole, isoquinoline, quinoline, 2-toluquinoline, 4-toluquinoline, biquinoline, pyridine, 3-methylpyridine or 1,10-o-phenanthroline. The invention also discloses application of the catalyst in preparing corresponding cyclic carbonate by CO2-epoxy compound cycloaddition. The catalyst has the advantages of low temperature, high catalytic activity, low corrosivity, easy separation, high stability, favorable recovery performance and the like, can form a homogeneous catalytic system, and has favorable industrial application prospects.

The invention discloses a method for synthesizing triphenyl-phosphonium bromide salt and an intermediate halomethyl benzyl ether compound thereof. The method comprises the following steps that at a temperature of between 10 DEG C below zero and 10 DEG C, hydrogen chloride or hydrogen bromide and benzyl alcohol compound react with paraform to synthesize the halomethyl benzyl ether compound, and then the halomethyl benzyl ether compound reacts with triphenyl-phosphonium bromide in a solvent to obtain the triphenyl-phosphonium bromide salt compound. The method solves the problems that the purity of the halomethyl benzyl ether compound prepared at a temperature of between 20 DEG C and 25 DEG C by the prior method is low, and in the purification process, the intermediate is decomposed, which results in the low yield of the triphenyl-phosphonium bromide salt at the end. The triphenyl-phosphonium bromide salt and the intermediate halomethyl benzyl ether compound which are prepared by the method have the advantages of higher yield and purity without purification, simple process, convenient operation and higher industrial application value, and are easy to be applied to industrial scale production.

The invention discloses an ABS/PLA (acrylonitrile-butadiene-styrene/poly lactic acid) light-emitting composite material for 3D (three-dimensional) printing. The ABS/PLA light-emitting composite material is prepared from the following raw materials in parts by weight: 40 to 50 parts of polylactic acid, 20 to 25 parts of bulk type ABS, 10 to 20 parts of emulsion type ABS, 5 to 10 parts of styrene-acrylonitrile-methacrylic acidglycidyl ester copolymer, 0.01 to 0.05 part of butyl-triphenyl phosphonium bromide, 5 to 10 parts of conductive filler, and 3 to 8 parts of fluorescent powder compound, wherein the fluorescent powder compound is a graphene/SiO2 (silicon dioxide)/fluorescent powder or graphene/SiO2/fluorescent powder/SiO2 composite material. The ABS/PLA light-emitting composite material has the advantages that the mechanical and electrical properties are excellent, the light emitting property is optimum, and the application range of the 3D printing material is widened; the problem of decreasing of light-emitting property due to easy agglomeration of fluorescent powder (especially nano-fluorescent powder) in the composite material in the prior art is solved.

The invention discloses benzyl triphenyl-phosphonium difluoromethane sulfonymide ([BPP]<+>[NTf2]<->)ionic liquid, wherein the structural formula is as follows: (the formula is as shown in the description). The invention further discloses a synthesis method of the ionic liquid as well as application of the ionic liquid as a metal corrosion inhibitor. According to the method, triphenylphosphine andbenzyl chloride are subjected to a combination reaction to synthesize benzyl triphenyl phosphonium chloride, and the [BPP]<+>[NTf2]<-> is obtained through anion exchange reaction. The problem of corrosion of metal magnesium and alloy thereof is solved, and the corrosion prevention efficiency of the ionic liquid is about 91.21 percent. The advantages of simple synthesis process, mild reaction condition, simple after treatment and the like are achieved; the yield of the prepared benzyl triphenyl-phosphonium difluoromethane sulfonymide can reach 92 percent or higher.

Molding compositions particularly useful in coating electronic devices such as integrated circuits are disclosed. The molding compositions include an epoxy resin; a hardener for the epoxy resin, and a quaternary organophosphonium salt for catalyzing a reaction between the epoxy resin and the hardener, such as ethyl triphenyl phosphonium acid acetate. The molding compositions may further include a flame retardant compound such as melamine cyanurate. In a further embodiment, the molding composition may include an additional catalyst, such as 1,8-diazabicyclo[5.4.0]undec-7-ene. Integrated circuits encapsulated with such molding compositions exhibit reduced electrothermally induced parasitic gate leakage.

The invention belongs to the technical field of insect pheromone synthesis, and discloses a new method for synthesizing (5Z,7E)-dodecane-5,7-diene-1-alcohol as well as acetate and propionate thereof.The method takes propynol as an initial raw material to be subjected to coupling with 1-bromobutane to generate 2-heptyne-1-alcohol, triple bond is reduced to be E-type double bond through LiAlH4, 2-heptyne-1-alcohol is oxidized to be olefine aldehyde through PDC, olefine aldehyde reacts with a Wittig reagent (5-ethyoxyl-5-oxopentyl)triphenyl phosphonium bromide to produce (5Z,7E)-dodecane-5,7-dienoic acid ethyl ester which is reduced by LiAlH4 to obtain (5Z,7E)-dodecane-5,7-diene-1-alcohol, (5Z,7E)-dodecane-5,7-diene-1-alcohol reacts with acetyl chloride and propionyl chloride finally to obtain (5Z,7E)-dodecane-5,7-diene-1-alcohol acetate and (5Z,7E)-dodecane-5,7-diene-1-alcohol propionate. The method utilizes LiAlH4 to reduce the triple bond to be the E-type double bond, and utilizes theWittig reaction of the Wittig reagent with the tail end provided with ester group and aldehyde to directly build the Z-type double bond, the synthesis route is simple, convenient and efficient, and the reaction condition is moderate and environmentally friendly.

The invention relates to a synthetic method of p-flurobenzaldehyde, which belongs to the chemical and pharmaceutical field. In the synthetic method, the p-chlorobenzaldehyde and potassium fluoride react under the condition of a solvent and a catalyst at high temperature, wherein, the solvent is one of sulfolane, dimethyl sulfoxide, dimethylformamide, dimethylacetamide, hexamethyl phosphoramide, nitrobenzene and ortho-nitrotoluene; the catalyst is one of or the mixture of two or more than two of benzyl triethyl amine chloride, tetrabutylammonium bromide, hexadecyltrimethylammonium chloride, methyltrioctylammonium chloride, tetraphenylphosphonium bromide, methyltriphenylphosphonium bromide, benzyl triphenyl phosphonium bromide and polyethylene glycol dimethyl ether. Compared with the conventional preparation method, the synthetic method of the invention has the advantages of cheap raw materials, short synthetic route and little 'three wastes' discharge. As the amount of the catalyst used is reduced and the price of the solvent is low, the production cost of the p-flurobenzaldehyde is decreased.

A process for the production of 9-(Z)-retinoic acid is described which comprises reacting an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C₁₅-triphenyl-phosphonium salt. 9-(Z)-retinoic acid is used in the treatment of dermatological diseases.

The invention discloses an alkyl triphenyl phosphonium bis-trifluoromethane sulfimide ion liquid. A preparation method of the liquid comprises the steps that triphenyl phosphine and bromine alkanes with the chain length of 10, 14 and 18 are subjected to an alkylation reaction to synthesize decyl, myristyl and octadecyl triphenyl phosphonium bromide, and then through anion exchange, three target ion liquids, namely, [DTP]+[NTf2]-, [TTP]+[NTf2]- and [OTP]+[NTf2]- are obtained. The ion liquid compound can greatly lower the corrosion rate of magnesium and magnesium alloy of the magnesium and is used for solving the problems of corrosion of magnesium metal and the magnesium alloy of the magnesium metal and the like. The preparation method has the advantages that the synthesizing technology is simple, the reaction raw materials are cheap, the reaction conditions are wild, and the after-treatment is simple, and the yield of the prepared alkyl triphenyl phosphonium bis-trifluoromethane sulfimide ion liquid can reach 90% or above.

The invention relates to a method for preparing 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecatriene, belonging to the technical field of lycopene intermediate synthesis methods. The method comprises the following steps: (1) under the protection of inert gas and in the presence of an organic solvent and alkali, carrying out dissociation reaction on C10 triphenyl phosphonium salt at the temperature of minus 40-30 DEG C; and (2) after the dissociation reaction in the step (1) is completed, adding C4 acetal, carrying out Wittig condensation reaction at the temperature of minus 40-30 DEG C in the presence of the organic solvent and alkali so as to obtain 2,6,10-trimethyl-1,1-dialkoxyl-3,5,9-undecatriene. The method provided by the invention has the advantages of concise process route and easy obtainment of raw materials, low cost and high industrial value.

The invention provides an ethyl triphenyl phosphonium chloride preparation method, which comprises: (1) adding triphenyl phosphine to an organic solvent, adding ethyl chloride in a dropwise manner, heating to a temperature of 120-160 DEG C after the adding, adjusting the reaction pressure to 8-12 kg/cm<2>, and carrying out a thermal insulation reaction for 30-40 h; (2) after completing the thermal insulation reaction, cooling to a room temperature, reducing the pressure to a normal pressure, and carrying out centrifugation on the material obtained after the reaction; and (3) drying the centrifugal precipitate so as to obtain the ethyl triphenyl phosphonium chloride. According to the present invention, with the method, the yield is up to more than 94%, and the purity is up to more than 99%.

The invention provides a synthesizing method for 5E-decene-1-alcohol and acetic acid 5E-decenoate. With acrylaldehyde and acetylene being raw materials, a coupling reaction is carried out under the existence of a palladium catalyst to obtain 5-bromo-4E-pentenal, 5-bromo-4E-pentenal and methoxy methyl-triphenyl phosphonium chloride are subjected to a Wittig reaction to obtain 1E,5E-1-bromo-6-methoxy hexadiene, then 1E,5E-1-bromo-6-methoxy hexadiene and butyl magnesium bromide are subjected to a Kumada coupling reaction to obtain 1E,5E-1-methoxy decadiene, 5E-decenal is obtained through hydrolysis, then 5E-decene-1-alcohol is obtained through reducing, and finally the acetic acid 5E-decenyl acetate is obtained after esterification. The raw materials used for synthesis are low in price and easy to obtain, the synthesizing route is simple, reaction conditions are mild, operation is convenient and safe, industrialized production is easy, the yield is high, and the synthesizing method has important meaning for prevention and treatment of anarsia lineatella.

The invention belongs to the technical field of organic chemistry and particularly relates to a preparation method of ((4-p-fluorophenyl-6-isopropyl-2-(N-methylmethanesulfonamide)-5-pyridyl) methyl) triphenyl phosphonium salt. According to the invention, 4-p-fluorophenyl-6-isopropyl-2-(N-methylmethanesulfonamide) pyrimidine-5-carboxylic acid is reduced in an organic solvent under the existence of hydroboron, alkyl substituted chlorosilane and an auxiliary so as to obtain 4-p-fluorophenyl-5-hydroxymethyl-6-isopropyl-2-(N-methylmethanesulfonamide) pyrimidine (II); the compound II reacts with triphenyl phosphonium salt in the organic solvent to obtain the ((4-p-fluorophenyl-6-isopropyl-2-(N-methylmethanesulfonamide)-5-pyridyl) methyl) triphenyl phosphonium salt. The method disclosed by the invention has mild reaction conditions, is simple and convenient to operate and is suitable for industrial production.

The invention discloses a reverse osmosis membrane scale inhibitor and a preparation method thereof. The scale inhibitor is prepared from polyepoxysuccinic acid, amino trimethylene phosphonic acid, diethylenetriamine pentaacetic acid pentasodium salt, hexadecyl tributyl phosphonium bromide, distilled water, dodecyl triphenyl phosphonium bromide, methoxymethyl triphenyl phosphonium bromide, 1, 2-benzisothiazolin-3-one, hydroxyethylidene-1,1-diphosphonic acid, polyacrylic acid and benzotriazole. The usage amount of the scale inhibitor is less and is only 1 to 5 mg/L; the effect is lasting, i.e., after the scale inhibitor is placed for one month at 60 to 80 DEG C, the scale inhibiting ratio is 96 to 100 percent; the reverse osmosis membrane scale inhibitor has a good sterilizing effect and positive effects in improving calcium scale resistance and iron dispersing property.