146 results about "Benzyl ether" patented technology

The invention mainly relates to a synthesis method of alvimopan. A preparation method of the related alvimopan comprises the following steps of: condensing phenylpropionic acid and substituted oxazolidone; undergoing reaction with chloromethyl benzyl ether under the action of a catalyst to obtain a single configuration; hydrolyzing, and recycling oxazolidone to obtain carboxylic acid; condensing with glycinate; performing deprotection and undergoing reaction with a leaving group donor; butting with (+)-(3R,4R)-4-(3-hydroxy phenyl)-3,4-dimethyl piperidine to obtain alvimopan ester; and hydrolyzing to obtain the alvimopan. The invention also relates to a novel intermediate of the alvimopan and preparation methods of the alvimopan and the novel intermediate of the alvimopan. The technical scheme of the invention has the advantages of simple process, low cost and high product purity, and is suitable for industrial production.

The invention relates to hydroxyphenyl benzyl ether derivative as well as a preparation method and an application thereof. Part of a compound is marked by radionuclide and is used as an Abeta plaque imaging agent, and the hydroxyphenyl benzyl ether derivative is applied to the preparation of a drug for diagnosis and treatment of the allzheimer's disease. The structural formula of the hydroxyphenyl benzyl ether derivative is described in a formula (I). The chemical structure of the class of bran-new hydroxyphenyl benzyl ether derivatives with the high affinity with Abeta plaques inside an AD disease brain is different from a compound disclosed by the prior art, and the hydroxyphenyl benzyl ether derivative belongs a bran-new compound for the diagnosis and the treatment of the allzheimer's disease. The obtained Abeta plaque imaging agent is good in in-vivo stability, low in lipid solubility, and high in brain cleaning speed, does not generate the problem of the radionuclide removed in an in-vivo manner, and has great application values and market values.

The invention discloses a method for continuously recycling high-purity PGMEA from a PGMEA / water solution through extractive rectification. Through addition of ethyl benzyl ether as an extractant, anazeotrope of PGMEA and water is destroyed, the extractant extracts the PGMEA from mixed liquid, mixed liquid of water, the PGMEA and the extractant is obtained at the top of a tower, wastewater is removed from a water phase after phase separation, and an organic phase returns to a temporary extractant storage tank and re-enters an extractive rectification tower; mixed liquid of the PGMEA and the extractant is taken out from a tower kettle of the extractive rectification tower, enters a reduced pressure rectification tower for separation, a PGMEA product is obtained in the tower top of the reduced pressure rectification tower, and an azeotrope agent is recycled in the tower kettle. By the method, the content of organic matters in the discharged wastewater is reduced to very low concentration, the wastewater can be discharged after simple treatment, the treatment amount of the organic matter-containing wastewater is reduced, the concentration of the organic matters in the wastewater is reduced, and the environment pollution is greatly reduced.