16 results about "Benzyl ether" patented technology

The application discloses a near-infrared distinguishing and iron-apoptosis-enhancing functional fluorescent probe and a preparation method and application thereof. The structural formula of the near-infrared distinguishing and iron-apoptosis-enhancing functional fluorescent probe is as follows: firstly, the traditional boronic acid ether trigger unit is improved to be a cyclic diboronic acid ester, N-methyl imidodicarboxylic acid is introduced above the phenylboronic acid to improve the response threshold, and the benzyl ether structure is abandoned and replaced by a phenyl ether structure, which also plays a role in further increasing the oxidation threshold; secondly, the response threshold is adjusted, and in combination with the strong coordination function of the released Fe(III), the cancer environment selectively triggers and releases the functional probe for iron-apoptosis enhancement. The probe disclosed by the application increases the difference in the reaction threshold between the cancer cell environment and the normal cell environment, and through twice adjustment, the fluorescence trigger difference is increased, the iron-apoptosis intermediate is released at the same time of fluorescence triggering, the cancer cells are caused to undergo iron-apoptosis, and the probe is applied to the detection of tumor cells.

The invention relates to the technical field of functional resin, and particularly discloses an acrylic resin coated organic silicon elastomer PA (at) SE prepared through aqueous phase suspension emulsion polymerization and a preparation method and application of the acrylic resin coated organic silicon elastomer PA (at) SE. An inner core of the PA (at) SE is a polyorganosiloxane elastomer ViSE formed by hydrosilylation addition reaction of hydrogen-containing polysiloxane, ethylene polysiloxane and a third functional component, and the third functional component comprises vinyl acetate, allyl acetate, allyl phenyl ether, allyl benzyl ether, cyclohexyl vinyl ether, alpha-C8-18 olefin, 1, 6-hexadiene, 1, 2-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol, 1, 3-propylene glycol and 1, 3-propylene glycol. The additive is one or a mixture of more of 1, 9-decadiene, (poly) ethylene glycol diallyl ether and (poly) propylene glycol diallyl ether. The acrylic resin coated organosilicon elastomer PA (at) SE provided by the invention can be mutually soluble with PC resin and the like, and can also realize toughening and reinforcing effects when being applied to materials such as PC resin and the like.

The application discloses a trifluoromethyl benzyl ether substituted amino acid derivative, a preparation method and application thereof, and belongs to the technical field of organic compound synthesis and medicine. The synthesis method of the trifluoromethyl benzyl ether substituted amino acid derivative is obtained through two-step reaction, that is, first, a photo extension reaction is carried out between a benzyl alcohol compound and hydroxynaphthaldehyde (or hydroxybenzaldehyde), then a Schiff base is formed after an amino acid ester hydrochloride, and then the Schiff base is reduced by sodium cyanoborohydride, and then simple hydrolysis is carried out to obtain the trifluoromethyl benzyl ether substituted amino acid derivative. The preparation method has the characteristics of simple steps, mild reaction conditions and fast reaction, and meets the requirements of green chemistry. The compound prepared according to the method can selectively adjust S1P1 receptors without exciting S1P3 receptors, and is expected to be developed into a new preparation for treating idiopathic pulmonary fibrosis.

This invention provides a photosensitive diamine monomer, a photosensitive polyimide precursor containing the monomer, a method for preparing thin film materials using the photosensitive polyimide precursor, and the application of this material in patterned hydrophilic surfaces and humidity sensor substrates. The photosensitive diamine monomer has a triphenyldiamine backbone, and its side chain contains o-nitrobenzyl ether photosensitive groups. When polyamic acid or polyimide materials prepared from this diamine monomer are irradiated with ultraviolet light, the o-nitrobenzyl ether groups in the side chain undergo a photolysis reaction to generate o-nitrosobenzaldehyde and release phenolic hydroxyl groups. The phenolic hydroxyl groups are covalently fixed on the polymer backbone, which significantly improves the hydrophilicity of the irradiated area. This material can be used to prepare patterned hydrophilic surfaces and has potential application prospects in fields such as the integrated design of humidity sensor substrates and humidity-sensitive materials.

The application discloses a preparation method of a polysubstituted benzyl ether, which comprises the following steps: dissolving a compound III in a polar protic solvent, adding a base, and reacting under the action of an oxidant at a temperature of 15-100 DEG C for 1-48 h to obtain a compound I; the preparation method of the polysubstituted benzyl ether is a green synthesis method, the reaction condition is warm and environment-friendly, the alcohol used can be recycled, the use of expensive metal catalysts is avoided, the cost is low, the reaction steps are few, the yield is high, the discharge of three wastes is reduced, and there is no metal residue, so the method is suitable for industrialized production.

The present application relates to the technical field of functional resin, aiming at the problem that the existing polyorganosiloxane and PC resin are prone to phase separation, and the mechanical properties of the toughened modified PC resin material are obviously reduced, the present application discloses a kind of phenylpropene resin coated organic silicon elastomer SA@SE and its preparation method and application, the SA@SE has shell-core structure, the shell of the SA@SE is linear structure or slightly crosslinked phenylpropene resin, the core of the SA@SE is the polyorganosiloxane elastomer formed by hydrogen-containing polysiloxane, ethylene polysiloxane and third functional component through silicon hydrogenation addition reaction, and the third functional component is selected from styrene, allyl phenyl ether, allyl benzyl ether, cyclohexyl vinyl ether and the like.The SA@SE of the present application is a copolymer grafted and bonded between the inner and outer core-shell through covalent bond, which can realize the mutual solubility with bisphenol A type PC resin and the like, avoid phase separation and delamination, and improve the toughening and impact resistance of the modified PC resin.

The invention relates to the technical field of functional resin, and discloses a styrene-acrylic resin coated organosilicon elastomer SA (at) SE and a preparation method and application thereof in order to solve the problems that existing polysiloxane and PC resin are prone to phase separation, and consequently the mechanical performance of a toughening modified PC resin material is obviously reduced. A shell layer of the SA (at) SE is styrene-acrylic resin of a linear structure or lightly crosslinked, an inner core of the SA (at) SE is a polysiloxane elastomer formed by hydrosilylation addition reaction of hydrogen-containing polysiloxane, ethylene polysiloxane and a third functional component, and the third functional component is selected from styrene, allyl phenyl ether, allyl benzyl ether, cyclohexyl vinyl ether and the like. The SA-SE is a copolymer formed by grafting and bonding an inner core shell and an outer core shell through covalent bonds, mutual dissolution of the SA-SE with bisphenol A type PC resin and the like can be achieved, phase separation and layering are avoided, and the performance effects of toughening, impact resistance and the like of the modified PC resin can be improved.

The present application relates to the chemical industry field, especially to a method for recovering antioxidant 702 from 3,5-di-tert-butyl-4-hydroxybenzyl methyl ether still residue, the method comprising: dissolving the 3,5-benzyl ether still residue in a solvent, converting 3,5-di-tert-butyl-4-hydroxybenzyl methyl ether in the still residue into antioxidant 702 through acid catalysis reaction, after the reaction is completed, neutralizing and washing with water, further carrying out desolventizing, purifying, temperature reducing crystallization, drying and the like to obtain antioxidant 702. The present application can recover by-product antioxidant 702 from 3,5-di-tert-butyl-4-hydroxybenzyl methyl ether still residue, which can not only reduce production cost, save resources, but also reduce waste discharge, protect the environment, and realize economic benefit and environmental benefit.

The application discloses a preparation method of pyraclostrobin and belongs to the technical field of pesticide synthesis. In order to solve the problems of low bromine atom utilization rate and generation of more low-concentration acid-containing wastewater in the production process of pyraclostrobin, the method is provided, which uses sodium bromide as a bromine source, controls the rate of the conversion of the sodium bromide aqueous solution into bromine and sodium chloride, and then realizes bromination in situ. After the reaction is completed, a series of post-treatments are performed to obtain o-nitrobenzyl bromide. Then, etherification and purification treatments are performed to obtain pyrazole benzyl ether (an important intermediate). Finally, reduction, acylation and methylation are performed by using mature technology, and pyraclostrobin is obtained. The sodium bromide can be directly purchased or recycled by simple recovery treatment of the waste liquid formed by the process and directly reused in the process. The method not only provides a new synthesis route for the preparation of pyraclostrobin, but also reduces the raw material cost and improves the bromine atom utilization rate under the premise of realizing the preparation of pyraclostrobin.

This invention relates to the fields of radiopharmaceutical chemistry and clinical nuclear medicine, specifically to an aryl benzyl ether compound with high affinity for monoamine oxidase B (MAO-B) and its applications. This aryl benzyl ether compound has the structure of general formula (I). After radiolabeling, this compound and its derivatives can be used to image MAO-B in the brain, serving as molecular probes for direct targeting of MAO-B and potential surrogate markers for reactive astrocytes.

The application relates to the technical field of functional resin, and particularly discloses an acrylic resin coated silicone elastomer PA@SE prepared through aqueous phase suspension emulsion polymerization as well as a preparation method and application thereof. The PA@SE has a core-shell structure, the shell layer is linear acrylic resin or slightly crosslinked acrylic resin, the inner core of the PA@SE is polyorganosiloxane elastomer ViSE formed through a silicon-hydrogenation addition reaction of hydrogen-containing polysiloxane, ethylene polysiloxane and a third functional component, and the third functional component includes vinyl acetate, allyl acetate, allyl phenyl ether, allyl benzyl ether, cyclohexyl vinyl ether, alpha-C 8‑18 Olefins, 1,6-hexadiene, 1,9-decadiene, (poly)ethylene glycol diallyl ether, (poly)propylene glycol diallyl ether, or a mixture of one or more thereof. The acrylic resin coated silicone elastomer PA@SE provided by the application can not only be mutually soluble with PC resin and the like, but also can realize toughening and reinforcing effects in PC resin and the like.

The invention relates to myristoyl pentapeptide-17 and a preparation method and application thereof.According to the myristoyl pentapeptide-17, low-toxicity and biodegradable NFM and anisole are compounded according to the volume ratio of 1: 1, and the myristoyl pentapeptide-17 has strong polarity and moderate hydrophobicity and can completely replace DMF. According to the mixed solvent, the solubility of Fmoc amino acid monomers, activating reagents and resin is improved, the risk of reproductive toxicity is avoided, and the volatility is reduced compared with that of DMF (Dimethyl Formamide); the process is synergistically enhanced, namely, the mass transfer limitation of the traditional batch-type reaction is overcome through the synergism of the laminar shear effect and the ultrasonic cavitation effect of a continuous flow reaction device, so that the coupling reaction time of the myristoyl pentapeptide-17 is shortened, the occurrence rate of side reaction is reduced, and the universality verifies that the solvent system has excellent performance in the synthesis of the myristoyl pentapeptide-17, and has a wide application prospect in the synthesis of the myristoyl pentapeptide-17. And the coupling efficiency is stable.

The application discloses a trifluoromethyl cyclohexyl benzyl ether substituted nitrogen-containing organic acid derivative, a preparation method and application thereof, and belongs to the technical field of organic compound synthesis and medicine. The synthesis method of the trifluoromethyl cyclohexyl benzyl ether substituted nitrogen-containing organic acid derivative is obtained through two-step reaction, that is, first, a light extension reaction is carried out on a benzyl alcohol compound and hydroxynaphthaldehyde (or hydroxybenzaldehyde), then a Schiff base is generated after the amino acid ester hydrochloride (or amino sulfonic acid, or amino phosphoric acid) is reacted with the benzyl alcohol compound, and sodium cyanoborohydride is used for reduction (or simple hydrolysis is carried out after reduction), so the trifluoromethyl cyclohexyl benzyl ether substituted nitrogen-containing organic acid derivative is obtained. The preparation method has the characteristics of simple steps, mild reaction conditions and fast reaction, and meets the requirements of green chemistry. The compound prepared according to the method can selectively adjust S1P1 receptors without exciting S1P3 receptors, and is expected to be developed into a new preparation for treating inflammatory and immune related diseases such as pulmonary fibrosis, ulcerative colitis and multiple sclerosis.

The application discloses a method for synthesizing benzyl ether compounds by electro-oxidation alkoxylation, and belongs to the technical field of chemical synthesis. The method comprises the following steps: adding a phenol reactant into a mixed solution containing alkali, electrolyte and alcohol solvent, passing current, and generating an electrochemical reaction to obtain benzyl ether compounds. The method does not need chemical oxidants and transition metal catalysts, and is energy-saving and economical. The raw materials used in the reaction are cheap and easy to obtain, and the cost is low. The alkoxylation of the phenol reactant can be directly realized. Compared with the prior art, the method is more green and mild.

The invention discloses a high-performance copolyester elastomer and a preparation method thereof, and belongs to the technical field of copolyester elastomers. The high-performance copolyester elastomer prepared by the invention is prepared from the following raw material components in parts by mass: 60-70 parts of a butylene terephthalate copolymer, 2-4 parts of a flame retardant A, 1-3 parts of a flame retardant B, 30-40 parts of a toughening agent and 0.5-1 part of a compatilizer, wherein the butylene terephthalate copolymer is obtained by reacting and copolymerizing dimethyl terephthalate, dimethyl 2, 5-furandicarboxylate, dimethyl itaconate, dimethyl succinate and butylene glycol and then reacting and terminating with methyl 4-amino-3-nitrobenzoate; the flame retardant A is obtained by reacting cyanuric chloride and 4-benzyloxyaniline and then removing benzyl ether; the flame retardant B is obtained by reacting N-(4-hydroxyphenyl) maleimide with phenyl dichlorophosphate; the high-performance copolyester elastomer prepared by the preparation method disclosed by the invention is relatively good in mechanical property and flame retardance.

The present invention describes a multi-component polyurethane foam composition comprising: (i) a first component, comprising one or more phenolic resins of the benzyl ether type, wherein a) the first component comprises free phenol and free hydroxybenzyl alcohol, wherein at least about 1.2 parts by weight of free hydroxybenzyl alcohol per 1 part by weight of free phenol are comprised in the first component; and / or b) the first component comprises free phenol and free saligenin (o-hydroxybenzyl alcohol), wherein at least about 1.1 parts by weight of free saligenin (o-hydroxybenzyl alcohol) per 1 part by weight of free phenol are comprised in the first component; (ii) a second component, comprising an isocyanate formulation consisting of one or more isocyanate compounds, wherein at least one isocyanate compound has at least 2 isocyanate groups per molecule; and (iii) optionally, a third component, comprising one or more (halogen)hydrocarbon- containing blowing agents and / or water, wherein, if the multi-component polyurethane foam composition does not include a third component, then the first component comprises at least 0.95% by weight, preferably at least 1.0% by weight, and especially preferably at least 2.0% by weight of water.