331 results about "Protic solvent" patented technology

The invention belongs to the technical field of liquid chromatography-mass spectrometry detection pretreatment, and particularly relates to a pretreatment method for liquid chromatography-tandem mass spectrometry analysis of pesticide and veterinary drug residues in serum, which comprises the following steps: (S1) carrying out heating reaction on Sc (III) salt, Cu (II) salt and 1H-pyrazole-4-formic acid (H2PyC) in a polar aprotic solvent, and cooling to obtain a green crystal, namely MOF-919; the chemical formula of the MOF-919 is [Sc < 3 > (mu3-O) (OH) < 3 >] [Cu3 (mu3-O) (mu-PyC) < 3 > (H2O) < 6 >] < 2 >; (S2) mixing the serum sample with an acetonitrile solution containing formic acid, carrying out ultrasonic treatment, vortex oscillation and centrifugation, taking supernate, and diluting the supernate with an aqueous solution containing formic acid to obtain a to-be-purified solution; and (S3) adding MOF-919 into the to-be-purified liquid, mixing, performing ultrasonic treatment, performing vortex oscillation, centrifuging, and taking supernate, thereby completing the pretreatment of the to-be-purified liquid. According to the method, the MOF-919 is used for adsorbing chemical pollutant residues in serum, especially phospholipids, so that the purpose of removing the chemical pollutant residues in blood is achieved. The method is simple and convenient to operate, small in organic solvent consumption and good in purification effect, and can be widely applied to residue analysis of chemical pollutants in serum.

Disclosed herein is an aqueous nucleic acid purification buffer comprising a polar aprotic solvent. Also provided herein are using such purification buffers to precipitate nucleic acids from a solution onto a solid support, thereby providing a solid support that binds to nucleic acids. Also provided herein is a method for treating a nucleic acid comprising exposing a sample comprising the nucleic acid to an aqueous medium comprising a polar aprotic solvent in the presence of a solid support; and precipitating the nucleic acid onto the solid support, thereby providing a solid support that binds to the nucleic acid. Further provided herein are kits and compositions comprising such aqueous nucleic acid purification buffers, as well as related nucleic acid analysis devices, and uses of the kits.

The invention belongs to the technical field of polymer electrolyte membrane materials, and particularly relates to a high-ionic-conductivity polymer electrolyte membrane and a preparation method thereof.The preparation method comprises the steps that 1, PEO and lithium salt are added into a polar aprotic solvent, and the mixture is rapidly and violently stirred to be completely dissolved; (2) adding a cross-linking agent and a photoinitiator into the mixed solution, and violently stirring to obtain a mixed solution; and (3) coating the mixed solution in a polytetrafluoroethylene template, heating to remove the solvent, and performing ultraviolet radiation. According to the invention, a three-dimensional cross-linked network is formed by photocuring of an acrylate group of the cross-linking agent, PEO chain segment crystallization is inhibited, and lithium salt anions (such as TFSI-) are physically embedded. A benzene ring structure in a cross-linked network endows the electrolyte membrane with flexibility, mechanical property deterioration caused by a plasticizer or a diluent is avoided, the compact structure of the electrolyte membrane can inhibit lithium dendrite growth, the ionic conductivity reaches 1.7 * 10 <-4 > S / cm, and the electrochemical window reaches 4.9 V. The method is simple in process and suitable for large-scale preparation of the high-energy-density solid-state lithium battery.

A pattern formation method may use a resist composition. The resist composition may include an organometallic compound represented by any one of Formulae 1-1 to 1-4, an additive represented by Formula 2, and a solvent. The solvent may include a non-polar solvent, a polar aprotic solvent, or a combination thereof.Refer to the specification for the descriptions of M11, L11 to L14, a11 to a14, R11 to R14, b11 to b14, Y11 to Y13, X11 to X13, Y21, Y22, L21, and a21 in Formulae 1-1 to 1-4 and 2.

The invention relates to a synthesis method of milobalin or acid salt thereof, and belongs to the technical field of medicine synthesis. In order to solve the problem that chiral resolution needs to be adopted in the prior art, the invention provides a synthesis method of miloabalin or an acid salt thereof, which comprises the following steps: under the action of an organic strong base, carrying out Michael addition reaction on a compound shown as a formula III and acetonitrile in a non-polar organic solvent at a low temperature of-50 DEG C or below to obtain an intermediate product; under the alkaline condition, the intermediate product is subjected to an oxidation reaction and a hydrolysis reaction under the action of an oxidizing agent, after the reaction is finished, an intermediate product is obtained through acidification, and the intermediate product is subjected to a high-temperature decarboxylation reaction in an aprotic solvent to obtain a compound of a formula VI; and carrying out Hofmann degradation reaction on the compound of formula VI to obtain the compound of formula I miloabalin or miloabalin acid salt. The method has the advantages of high stereoselectivity, no need of chiral resolution operation, avoidance of the problem of large material loss caused by resolution, high chiral purity and high yield.

The invention relates to a preparation method of a lithium difluoro-bis (oxalate) phosphate concentrated solution, the lithium difluoro-bis (oxalate) phosphate concentrated solution is composed of lithium difluoro-bis (oxalate) phosphate and an aprotic solvent, the aprotic solvent comprises any one or a combination of at least two of diethyl carbonate, ethyl methyl carbonate, ethylene carbonate or propylene carbonate, the concentration of the lithium difluoro-bis (oxalate) phosphate in the lithium difluoro-bis (oxalate) phosphate concentrated solution is 10-35 wt%. The lithium difluoro bis (oxalate) phosphate concentrate provided by the invention exists in a non-proton electrolyte state, so that an evaporative crystallization process is omitted, and the production cost is reduced; the product transportation cost can be reduced through pipeline transportation; and compared with a lithium phosphate solid difluoro bis (oxalate), the process of re-dissolution during use is omitted, the risk of impurity introduction is avoided, and the use cost is reduced.

The invention discloses a ketoazine-based polymer, an anion exchange membrane and a preparation method and application of the ketoazine-based polymer and the anion exchange membrane. A first linking group and a second linking group are mixed and then mixed with an aryl monomer A in an aprotic solvent of halogen atoms; slowly adding a super acid mixture; performing polymerization reaction in an environment of-5 to 3 DEG C to obtain a reaction solution; pouring the reaction liquid into a first mixed solvent to obtain PAAz; carrying out primary quaternization reaction on PAAz through carbonate, bicarbonate or hydroxide salt of alkali metal, and adding an organic base catalyst to assist the primary quaternization reaction; in the first quaternization reaction, a quaternization reagent is added; and pouring into a second mixed solvent, and precipitating to obtain purified PAAz. Under the condition of super acid catalysis, two or more alicyclic amine derivatives containing ketone groups react with one or more aromatic fused rings to generate a polymer containing secondary or tertiary amine. And carrying out quaternization treatment to finally form the cationic polymer.

The invention relates to a polyisobutylene polyether alcohol amine compounds and compositions thereof. The invention also is directed to a new process for making the polyisobutylene polyether alcohol amine compound(s) by reacting a polyisobutylene epoxide with a specific polyetheramine, a protic solvent, a diluent, and optionally a catalyst. In addition, the invention further relates to the many uses of the polyisobutylene polyether alcohol amine compound(s) and composition(s) including but not limited to its use in lubricants, surfactants, emulsifiers, adhesives, resins, and the like.

The present invention is directed to a method for preparing a cell penetrating peptide-cargo formulation, said method comprising providing the cell penetrating peptide in ethanol without an aprotic solvent, associating the cell penetrating peptide with a nucleic acid cargo in an association buffer comprising 30-90% sucrose (in particular 50-90% sucrose) at a ratio of 3:1 to the cell penetrating peptide in ethanol, and storing the cell penetrating peptide-cargo formulation at -70°C or below, wherein associating is performed in a volume between 0.5x and 0.1x the final volume at which the formulation is prepared for administration. The formulation may also be lyophilised. Also provided are cell penetrating peptide-cargo formulations obtainable and / or obtained by the method herein, pharmaceutical compositions comprising the formulations, and said formulations and pharmaceutical compositions for use in the transport of the cargo across a lipid membrane and delivery of the cargo into a cell or for use in raising an immune response in a subject.

The invention discloses a preparation and purification method of high-purity tris (dimethylamino) silane. The preparation and purification method comprises the steps of reactive distillation, crude product separation, product purification, desolvation recovery and neutralization recovery. Through aprotic solvent solubility and hydrodynamic design, the problem of blockage is radically solved; the T3 tower high vacuum is adopted to guarantee the purity of a thermosensitive substance, and the T4 high vacuum is adopted to realize near zero loss of a solvent; by adopting triple material circulation, the raw material utilization rate is greater than or equal to 98%, the solvent recovery rate is greater than or equal to 99.8%, and the industrial cost can be reduced by 32%.

The invention relates to the technical field of p-fluorobenzaldehyde production, and particularly discloses a production process of high-purity p-fluorobenzaldehyde. The invention relates to a production process of high-purity p-fluorobenzaldehyde. The production process comprises the following steps: S1, carrying out a chlorination reaction by taking p-fluorotoluene and chlorine as raw materials to prepare a mixed chlorination solution of p-fluoromethyl benzyl monochloride, p-fluoromethyl benzyl dichloride and p-fluoromethyl benzyl trichloride; s2, adding an organic complexing agent, which is a water-soluble aprotic solvent, into the mixed chlorinated liquid prepared in the step S1, and then performing vacuum rectification to obtain distillate and residual liquid; rectifying by taking the residual liquid as a raw material to obtain kettle liquid and rectified liquid; and S3, carrying out hydrolysis reaction by taking the rectification liquid and water as raw materials, separating, and drying to obtain the product. The production process of the high-purity p-fluorobenzaldehyde has the advantages of high raw material conversion rate, high product purity and few three-waste products.

The present application relates to the technical field of chemical medicine preparation, and particularly relates to a preparation method of tetrabromophenol tetrahalosulfonophthalein, which is prepared from 3,4,5,6-tetrahalophenol sulfonophthalein as raw material, organic carboxylic acid in aqueous solution, liquid bromine, oxidation by hydrogen peroxide to obtain tetrabromophenol tetrahalosulfonophthalein crude product, then salification with alkali salt in an aprotic solvent to obtain tetrabromophenol tetrahalosulfonophthalein salt; and then acid conversion with organic carboxylic acid in aqueous solution, recrystallization to obtain tetrabromophenol tetrahalosulfonophthalein pure product; the present application provides a preparation method of tetrabromophenol tetrahalosulfonophthalein, which is low in cost, high in yield and purity, simple in method, mild in condition, high in yield and purity, and beneficial to mass production.

The invention relates to polyethersulfones which can be used as engineering thermoplastics and also as polymers suitable for use in membrane technologies. A method for producing a polyethersulfone includes carrying out a nucleophilic polycondensation between 4,4'dioxydiphenyl sulfone and 4,4'dichlorodiphenyl sulfone in the presence of potassium carbonate in an aprotic solvent environment in two steps of: a) obtaining a dipotassium salt of 4,4'dioxydiphenyl sulfone and b) adding 4,4'dichlorodiphenyl sulfone to the salt obtained in the first step, then holding the resulting mixture while controlling the viscosity thereof to provide a mixture containing a polyethersulfone in a dissolved form in which the mass fraction of the polymer is from 50.5 to 53.3%, isolating the polyethersulfone and drying same. The invention makes it possible to produce a high-molecular-weight polyethersulfone having a controlled set mass-average molecular mass of from 85340 to 104300 g / mol, rendering the polymer suitable for use in the production of finished articles.

The invention relates to a preparation method of suvorexant, which comprises the following steps: (1) dissolving a compound VIII (R)-4-(5-chlorobenzo [d] oxazole-2-yl)-7-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester in a reaction solvent, adding an acidic reagent at the temperature of 5-15 DEG C, and reacting at the temperature of 25-35 DEG C to prepare a compound IX (R)-5-chloro-2-(5-methyl-1, 4-diazacycloheptane-1-carboxylic acid tert-butyl ester; 2, 4-diazacycloheptane-1-yl) benzo [d] oxazole is used as a raw material; and (2) in an alkaline environment and an aprotic solvent, carrying out acylation nucleophilic reaction on the compound IX and 5-methyl-2-(2H-1, 2, 3-triazole-2-yl) benzoic acid to obtain the suvorexant. According to the preparation method, the obtained product is high in yield, the purity reaches 99.9% or above, and the intermediate product is good in character, few in impurity and suitable for industrial production.

The invention relates to a process for the production of a mixture of 5-hydroxymethylfurfural and glucose from a feedstock containing fructose in the presence of at least one polar aprotic solvent and of at least one dehydration catalyst, in which process the reaction temperature is less than 90° C.

An improved solvent system for the formulation and application of N-alkyl thiophosphoric triamide urease inhibitors. These formulations provide safety and performance benefits relative to existing alternatives and enable storage, transport and subsequent coating or blending with urea based or organic based fertilizers. These formulations are comprised primarily of environmentally friendly aprotic and protic solvents (particularly dimethyl sulfoxide and alcohols / polyols) to stabilize the urease inhibitor.

The invention discloses a preparation method and application of a porous para-aramid nanofiber membrane. The preparation method of the para-aramid nanofiber membrane comprises the following steps: placing a substrate coated with an aramid nanofiber solution in an aprotic solvent to obtain an aramid nanofiber membrane containing the aprotic solvent; and immersing the aramid nanofiber membrane containing the aprotic solvent into a protic solvent, replacing the aprotic solvent in the nanofiber membrane with the protic solvent, and heating and drying to obtain the para-aramid nanofiber membrane. The para-aramid nanofiber membrane prepared by the preparation method of the para-aramid nanofiber membrane has highly adjustable porosity and pore structure, and has a huge application prospect in the fields of battery diaphragm and membrane separation and the like, and the preparation method is simple and suitable for large-scale industrial application.

The application discloses a method for purifying functionalized perfluoropolyether by complex extraction, comprising the following steps: dissolving a mixture containing non-functionalized perfluoropolyether and functionalized perfluoropolyether in a fluorine-containing organic solvent to obtain a raw material solution; contacting the raw material solution with a complex extraction agent; after extraction equilibrium, collecting a fluorine-containing organic solvent phase and concentrating to obtain non-functionalized perfluoropolyether; collecting a complex extraction agent phase and concentrating to obtain functionalized perfluoropolyether; at least one end group of the functionalized perfluoropolyether is -COOH, -CH2OH, -CH2SH or -NH2; the complex extraction agent is a mixed solution of an amine compound and a strong polar protic solvent, or a mixed solution of at least one of a carboxylic acid compound and a sulfonic acid compound and a strong polar protic solvent; and the strong polar protic solvent is one or more of methanol, ethanol, ethylene glycol, isopropanol, n-butanol and water.

The invention discloses an application of a cyclochalcone cationic compound as a fluorescent dye in the field of pressing discoloration and detection of trace water or protonic solvents in solvents, the structural formula of the cyclochalcone cationic compound is shown in formula I. The monitoring of the trace water or protonic solvents in the solvents can be realized in the'opening 'process of a fluorescent signal of the dye; the dye fluorescence signal'closing 'phenomenon can be observed through grinding, and the process can be applied to the fields of stress detection, ink-free writing, anti-counterfeiting and the like. The dye can be prepared into test paper, developing powder and other test carriers for portable application, has the advantages of simplicity in operation, low cost, real-time detection and the like, and has the potential of large-scale popularization and application.

The disclosed recycling method of waste polyester depolymerization and mild selective depolymerization of blended textiles is to use waste polyester and blended textiles as raw materials, under the action of alkaline catalyst, or use mixed solvents composed of alcohol compounds and aprotic solvents as reaction solvents, or use alcohol compounds or mixed solvents composed of alcohol compounds and aprotic solvents as reaction solvents, so that the polyester in waste polyester and blended textiles undergoes hydrolysis, selective hydrolysis, alcoholysis or selective alcoholysis, and then depolymerizes to generate small molecule degradation products, while other non-polyester components do not undergo chemical changes. The alkaline catalyst and reaction solvent selected by the application not only can reduce the reaction temperature, but also can efficiently catalyze the depolymerization of polyester without causing chemical changes in non-polyester components, so that the energy consumption and reaction time can be greatly reduced, the recycling efficiency can be improved, the purity and yield of polyester depolymerization products can be greatly improved, and the recycling and utilization of all components in textiles can be realized.

The invention discloses a preparation method of trifluoromethyl sulfide, which comprises the step of reacting a trifluoromethyl reagent with sulfur in a polar aprotic solvent in the presence of fluoride to obtain the trifluoromethyl sulfide. The reaction conditions are mild, and trifluoromethyl sulfide can be prepared through one-step reaction.

A salt-philic solvent-phobic (SP2) polymer coating on a lithium anode, sodium anode, or a silicon anode selectively transports salt over solvent and is configured to promote salt-derived SEI formation on the anode. The SP2 coating can include a polymer backbone, a first side chain comprising a first moiety having salt affinity, and a second side chain comprising a second moiety immiscible with polar aprotic solvents.

The invention belongs to the technical field of high polymer materials, and particularly relates to polyamide acid resin, a polyimide film and a preparation method thereof, and the polyamide acid resin is obtained by condensation polymerization of a diamine monomer and a dianhydride monomer in a molar ratio of 1: (0.8-1.2) in a polar aprotic solvent; the diamine monomer and the dianhydride monomer comprise a first type of diamine compound with a hydrophobic group and / or a first type of dianhydride compound with a rigid ester ring structure, and a second type of diamine compound and a second type of dianhydride compound. The low-grade and low-water-absorption special monomer is introduced into the formula, the molecular chain structure is changed, the dielectric constant is reduced, and therefore the short-time ghost phenomenon is reduced.

The invention provides polyimide and a preparation method thereof. The preparation method comprises the following steps: adding a sodium hydroxide aqueous solution into a monomer solution containing a dianhydride monomer and an aprotic solvent, mixing, adding diisocyanate, carrying out a polymerization reaction to obtain a reaction product system, and precipitating from the reaction product system to obtain polyimide, wherein the feeding time of the diisocyanate is 4 to 5 hours; in the monomer solution, the molar concentration of the dianhydride monomer is 0.5-0.6 mol / L; the obtained polyimide has the advantages of high specific concentration viscosity, high molecular weight and excellent high temperature resistance.

The invention discloses a pretreatment method and application of a mirabegron resin compound, and relates to the pretreatment method of the mirabegron resin compound, which comprises the following steps: extracting the mirabegron resin compound by an extraction solvent to obtain a sample to be detected for detection; wherein the extraction solvent comprises an aprotic solvent, an ionized solvent and a counter-ion solvent. According to the method, a multi-factor synergistic strategy is adopted, the extraction time of mirabegron in the mirabegron resin compound is remarkably shortened, the medicine extraction efficiency is remarkably improved, the extraction method is high in recovery rate, meanwhile, comprehensive optimization of quality is ensured, a foundation is laid for accurate determination of the medicine content, the consistency of the medicine effect is ensured, and the method is suitable for large-scale popularization and application. The requirements of links such as drug research and development, production and quality control are met.

The invention relates to the technical field of polyimide composite materials, and particularly discloses a covalently-bonded high-thermal-conductivity insulating polyimide composite material and a preparation method thereof. The preparation method comprises the following steps: 1, preparation and surface functionalization of a hybrid filler; 2, preparation of polyamide acid composite slurry: carrying out in-situ polymerization on the hybrid filler, a diamine monomer and a dianhydride monomer in a polar aprotic solvent; and 3, chemical imidization and molding: adding an end-capping reagent into the polyamide acid composite slurry obtained in the step 2, and then carrying out chemical imidization treatment to obtain the high-thermal-conductivity polyimide composite material. According to the composite material disclosed by the invention, the hybrid filler is added, and the hybrid filler is utilized to influence the form and interface thermal resistance of a three-dimensional heat-conducting network, so that the comprehensive performance of the whole composite material is further influenced; the larger the total mass fraction of the hybrid filler in the composite material is, the larger the heat conductivity coefficient, the tensile strength and the volume resistivity of a sample are.

The application discloses a composite catalyst for chemical flow casting preparation of a polyimide film and a method for preparing the polyimide film. After a polyamide acid composition is flow cast on a support to form a gel film, the polyimide film is prepared through high-temperature curing. The polyamide acid composition is uniformly mixed at normal temperature from a polyamide acid solution, a polar aprotic solvent, an imidization composite catalyst, a thermal latent catalytic type blocking agent and a dehydrating agent. The imidization composite catalyst is compounded from two types of imidization catalysts with high activity and low activity respectively. The application develops a normal-temperature (16 DEG C to 35 DEG C) chemical flow casting preparation method of a PI film by adopting the imidization catalysts with high catalytic activity and low activity to prepare the composite catalyst. Compared with a traditional low-temperature chemical flow casting method, the manufacturing energy consumption and manufacturing cost are greatly reduced.

A process for upcycling a polymeric waste material containing a polyarylethersulfone (PAES polymer) having less than 20 mol% reactive end groups, comprising depolymerizing the PAES polymer in the presence of a phenolic nucleophile and an alkali salt-forming carbonate agent in a polar aprotic solvent to obtain a PAES reactive macromer of lower molecular weight which is recovered. A composite comprising a resin matrix, reinforcing fibers and the PAES reactive macromer. An article made from a self-crosslinking PAES reactive macromer. Such a PAES reactive macromer contains more than 60 mol% of reactive end group(s) Ref, at most 20 mol% halide end group(s) X, and at most 20 mol% of unreactive end group(s) Ne, based on the total amount of moles of end groups. Preferably, Ref contains at least one group selected from –OH, -NH2, -COOH, –C≡CH, –C≡C–Ar, and / or an OH group connected to –Ara--W-Ara-, wherein Ar is an aryl group, Ara is an allyl-substituted aryl group, and W is a single bond, –C(CH3)2– and / or –SO2–. Preferably, Ne is an alkoxy group, such as methoxy, and X is Cl.

The invention provides polyether sulphone and a preparation method thereof. The preparation method comprises the following steps: mixing a polar aprotic solvent, a bisphenol monomer and an alkaline substance, introducing protective gas, heating, dehydrating, cooling to T1, adding a diphenyl sulfone monomer, and carrying out heat preservation at T1 to carry out a first-stage polymerization reaction; adding a low-polarity solvent, heating to T2, and carrying out second-stage polymerization reaction to obtain polyether sulfone; wherein the low-polarity solvent is selected from one or a combination of more than two of normal hexane, cyclohexane, methylbenzene, ethylbenzene, biphenyl and diphenyl ether. By reducing or partially inhibiting the generation of the cyclic oligomer in the reaction process, the polyarylether sulfone with narrow molecular weight distribution and low content of the cyclic polymer is obtained. The method provided by the invention is simple and easy to implement, is convenient to control, avoids complex product purification and separation processes, and is beneficial to industrial implementation.