60 results about "Protic solvent" patented technology

The application discloses a method for purifying functionalized perfluoropolyether by complex extraction, comprising the following steps: dissolving a mixture containing non-functionalized perfluoropolyether and functionalized perfluoropolyether in a fluorine-containing organic solvent to obtain a raw material solution; contacting the raw material solution with a complex extraction agent; after extraction equilibrium, collecting a fluorine-containing organic solvent phase and concentrating to obtain non-functionalized perfluoropolyether; collecting a complex extraction agent phase and concentrating to obtain functionalized perfluoropolyether; at least one end group of the functionalized perfluoropolyether is -COOH, -CH2OH, -CH2SH or -NH2; the complex extraction agent is a mixed solution of an amine compound and a strong polar protic solvent, or a mixed solution of at least one of a carboxylic acid compound and a sulfonic acid compound and a strong polar protic solvent; and the strong polar protic solvent is one or more of methanol, ethanol, ethylene glycol, isopropanol, n-butanol and water.

This invention relates to a novel bio-based esteramide mixture and its use as a solvent, and more particularly as a polar aprotic solvent, for example, for dissolving agricultural surfactants in agricultural formulations.

The present application relates to the technical field of synthesis of nitrogen-containing heterocyclic compounds, and particularly relates to a continuous flow synthesis method of nitrogen-containing heterocyclic acetic acid; specifically, nitrogen-containing heterocyclic compounds, halogenated acetic acid ester and inorganic acid binding agent are mixed in an aprotic solvent, and then are introduced into a microchannel of an ultrasonic microchannel continuous flow reactor to perform a substitution reaction under ultrasonic cavitation; after the reaction, the reaction liquid is collected and post-treated to obtain a nitrogen-containing heterocyclic acetic acid ester intermediate; the nitrogen-containing heterocyclic acetic acid ester intermediate is introduced into a second microreactor using an inorganic lye to perform a hydrolysis reaction, and after the reaction, the reaction liquid is collected and post-treated to obtain the nitrogen-containing heterocyclic acetic acid; the present application realizes continuous flow reaction of a heterogeneous system by using emulsification and ultrasonic technology, and can be used for the next step of continuous flow hydrolysis reaction after simple filtration and separation; the present application has high yield of two-step reaction, simple separation, short reaction time, and is suitable for large-scale industrial production.

The present application relates to the technical fields of organic metal compound synthesis, and discloses a production process method for synthesizing ferrocene based on one-pot method, which takes sodium, anhydrous ferrous chloride and dicyclopentadiene as raw materials, and completes the whole process of dicyclopentadiene depolymerization, sodium cyclopentadiene generation and ferrocene coordination synthesis in a non-protic solvent through gradient temperature control in one-pot method.The present application discards the disadvantages of multi-step reaction in traditional process, and does not need to prepare cyclopentadiene by pre-depolymerizing dicyclopentadiene, thus greatly simplifying the production process, reducing energy consumption and raw material loss, and achieving the product conversion rate of up to 85%, the purity of up to 99%, simple and controllable operation, adaptation to industrialized continuous production, and good economic and environmental benefits.

This invention belongs to the field of organic electrochemical synthesis and microchemical technology, and relates to a method for preparing 2-chlorobenzoic acid by electrochemical reduction debromination in a continuous flow microreactor. The method includes: dissolving 3-bromo-2-chlorobenzoic acid, a supporting electrolyte, and a proton source in a polar aprotic solvent to prepare a cathode reaction solution; continuously feeding this solution into the cathode channel of a microchannel electrochemical reactor using a metering pump, while simultaneously pumping the anolyte into the anode channel; connecting a DC power supply and conducting a selective electrochemical debromination reaction under set current density, reaction temperature, and material residence time conditions; and obtaining high-purity 2-chlorobenzoic acid from the outlet material through gas-liquid separation, neutralization, extraction, and recrystallization. This invention combines a continuous flow microreactor with electrochemical debromination technology, significantly enhancing mass and heat transfer, resulting in a shorter reaction time, higher conversion and yield, and the addition of a reducing agent, ease of scale-up, and intrinsic safety, demonstrating promising industrial application prospects.

This invention discloses a novel class of β-carboline quaternary ammonium salt derivatives, their preparation methods, and applications. The derivatives have the structure shown in Formula I, where R1, R2, and R3 are various substituents, and X... ‑ It is a halide ion. Its preparation method uses substituted indole-2-methylamine and substituted α-haloacetophenone as starting materials, and constructs them through a one-step cyclization reaction in an aprotic solvent mediated by a catalytic protic acid (such as p-toluenesulfonic acid). This method is mild, simple to operate, requires no metal catalyst, eliminates the risk of metal residue, and has good functional group compatibility. Activity tests of the obtained series of compounds showed that they have significant inhibitory activity against the proliferation of non-small cell lung cancer cell lines (such as A549 and H1299), with some compounds exhibiting activity superior to the positive control drug cisplatin. Therefore, this compound has important application value in the preparation of antitumor drugs, especially anti-lung cancer drugs.

The application relates to the technical field of phosphazene flame retardants, and particularly discloses a high-performance low-cost phosphazene flame retardant and a preparation method thereof. The method comprises the following steps: first, purifying an industrial by-product mixed sodium phenate to obtain anhydrous mixed sodium phenate; then, under the action of a nucleophilic substitution promoter composed of an alkaline compound and a polar aprotic solvent, step-by-step nucleophilic substitution reaction is carried out by controlling feeding sequence, reaction temperature and other conditions; after the reaction is completed, high-purity phosphazene flame retardant products are obtained through vacuum concentration and water washing precipitation; meanwhile, unreacted sodium phenate and solvents are recycled and reused; and a complete green closed-loop production process is constructed. Through the unique promoter system and process design, the application effectively coordinates the reaction activities of different components in the mixed sodium phenate, inhibits side reactions, significantly reduces the cost of raw materials, ensures excellent thermal stability and flame retardant efficiency of the products, realizes near-zero emission and maximization of resource utilization, and has an outstanding industrial application prospect.

This invention provides a method for preparing sulfated polysaccharides suitable for the production of microcapsules. [Solution] The present invention relates to a method for preparing sulfated polysaccharides. A mixture comprising at least one polysaccharide and at least one polar aprotic solvent is prepared in this method. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, and the mixture is then subjected to a temperature treatment so that at least one polysaccharide is converted to at least one sulfated acetate polysaccharide. At least one sulfated acetate polysaccharide is separated from the mixture and converted to a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and methods for producing microcapsules.

Provided herein is a method of sequentially isolating DNA and RNA from a sample, the method comprising: contacting the sample with a solid support comprising surface silanol groups in the presence of an aqueous nucleic acid purification buffer to provide a DNA-bound solid support; removing the DNA-bound solid support from the sample; contacting the sample with a solid support comprising surface carboxyl groups in the presence of the aqueous nucleic acid purification buffer to provide an RNA-bound solid support; and removing the RNA-bound solid support from the fluid sample, wherein the aqueous nucleic acid purification buffer comprises a polar aprotic solvent. Also provided are kits comprising the purification buffer and solid support, use of the kits in an automated nucleic acid analysis platform, and a nucleic acid analysis apparatus comprising an automated nucleic acid analysis platform and the above kits.

This application relates to the field of PET plastics technology, and more particularly to a UV absorber and PET plastic. The UV absorber is prepared by the following method: under a protective gas atmosphere, alkyl α-cyano-4-hydroxy-3-alkoxycinnamic acid, an inorganic base, and an epoxy chain extender are dissolved in a polar aprotic solvent, and the mixture is stirred and reacted at 100°C~120°C for 2~8 hours. After the reaction, acidification, filtration, washing, and drying are performed sequentially. The solution provided in this application can effectively improve the dispersion stability of the UV absorber in the PET matrix, reduce the risk of migration and precipitation, and maintain the advantage of high material transparency.

The application provides a preparation method of pentaerythritol phosphate, which uses pentaerythritol and phosphoric acid as reaction raw materials, and esterifies under the action of a polar aprotic solvent and a nano TiO2 / WO3 composite material to generate pentaerythritol phosphate. The purity of the pentaerythritol phosphate is greater than or equal to 99.0%, the yield is greater than or equal to 95%, the nano TiO2 / WO3 composite material is easy to recover, and the nano TiO2 / WO3 composite material can be reused more than three times. The preparation method in the application has mild reaction conditions, low energy consumption, and the solvent can be partially recovered, is green and environment-friendly, has high product purity, and does not need a complex purification step.

The present invention relates to a method for manufacturing an ink comprising n-type conducting polymer, said method comprising the steps of: a) providing a catalyst or a catalyst precursor: b) oxidizing said catalyst precursor by means of an oxidizing promoter thus obtaining said catalyst: c) adding a monomer to a solvent system comprising a polar aprotic solvent in the presence of said catalyst, thus providing a reaction solution: d) allowing the monomer to polymerize in said reaction solution thus obtaining an ink comprising n-type conducting polymer, wherein said catalyst is a quinone comprising at least one branched side chain comprising at least one chiral centre.

This application relates to the field of medicinal chemistry, specifically disclosing an antitumor molecular gel compound and its preparation method. It is prepared from the following raw materials: phthalic anhydride or its substituted derivative, a 2-amino-6-substituted benzothiazole derivative, a condensing agent, an organic base, and a polar aprotic solvent. The preparation method is as follows: S1, dissolving the 2-amino-6-substituted benzothiazole derivative and the organic base in a solvent; S2, dissolving the phthalic anhydride or its substituted derivative in the solvent and adding it dropwise to a first mixture to obtain a second mixture; S3, adding the condensing agent to the second mixture; S4, quenching the reaction solution in ice water and extracting with ethyl acetate; S5, separating and purifying the crude product by column chromatography. The compound of this application can be used to develop novel antitumor drugs that target and degrade tumor-related proteins, possessing advantages such as molecular conformational stability, optimized physicochemical properties, hydrophobicity regulation, and enhanced binding affinity.

The application belongs to the technical field of thermoplastic polyurethane elastomers, and particularly relates to a photo-induced deformation TPU material and a preparation method and application thereof. The photo-induced deformation TPU material comprises the following raw materials in parts by weight: 30-38 parts of diisocyanate; 5-10 parts of modified black phosphorus nanosheet; 40-50 parts of polycarbonate diol; 9-12 parts of chain extender; and 0.5-1 part of catalyst. The preparation method of the modified black phosphorus nanosheet comprises the following steps: performing ice-water bath ultrasonic treatment on black phosphorus crystals and an amino compound in a polar aprotic solvent to obtain amino-functionalized black phosphorus nanosheet; and dispersing the amino-functionalized black phosphorus nanosheet in an aromatic solvent to make it react with diphenylmethane diisocyanate to obtain the modified black phosphorus nanosheet. The photo-induced deformation TPU material prepared by using the modified black phosphorus nanosheet as a light response filler has excellent photo-induced deformation performance, good mechanical performance and cycle stability.

This invention provides a method for preparing apraxitentan, the method comprising the following steps: (1) reacting compound D with compound X in a polar aprotic solvent to obtain intermediate E; (2) reacting intermediate E with ethylene glycol in an organic solvent in the presence of a base to obtain intermediate F; (3) reacting intermediate F with 2-chloro-5-bromopyrimidine in the presence of a base to obtain intermediate G; (4) finally removing the protecting group from intermediate G to obtain apraxitentan; wherein, R is selected from Li, Na or K.

The invention provides a polyimide film and a preparation method thereof. The preparation method of the polyimide film comprises the following steps: mixing cyclodextrin, an inorganic nano material and water, stirring for a certain time to form an inclusion compound, removing water, and adding a polar aprotic solvent to form an inclusion compound solution I; mixing a polar aprotic solvent containing a diamine monomer with the inclusion compound solution I to obtain an inclusion compound solution II; mixing the inclusion compound solution II with a dianhydride monomer to obtain a reaction system; carrying out polymerization reaction on the reaction system to obtain a polyamide acid solution; and preparing the polyimide film by using the polyamide acid solution. On the basis of ensuring the appearance and mechanical properties of the polyimide film, the thermal expansion coefficient of the polyimide film is reduced, and the thermal stability of the polyimide film is improved.

The present disclosure provides surfactant-based compositions, methods, kits, and systems for use in cell permeabilization, analytical and diagnostic assays, polypeptide stabilization, viral inactivation, and bioprocess workflows. In certain aspects, permeabilization buffers comprising defined concentrations of nonionic surfactants in polar protic solvents permeabilize diverse cell types while preserving intracellular targets and compatibility with downstream detection chemistry and nucleic acid amplification. Related compositions include loading, blocking, running, and mountant buffers, as well as polypeptide stabilization and viral inactivation solutions formulated with the surfactants. In additional aspects, the surfactants are used in lateral flow devices, bead-based assays, and lipid nanoparticle workflows, including determination of encapsulation efficiency. The disclosure further provides methods and systems in which data generated from surfactant-containing workflows are analyzed by machine-learning processes to determine attributes of buffer performance and recommend protocol parameters.

The present application relates to galvanized surface treatment technical field, disclose a kind of for electroplating zinc surface treatment agent's self-crosslinking waterborne polyurethane and its preparation method.The self-crosslinking waterborne polyurethane includes 30%-80% hydrophobic polycarbodiimide modified waterborne polyurethane emulsion and 20%-70% carboxylate type waterborne polyurethane emulsion.The preparation of hydrophobic polycarbodiimide modified waterborne polyurethane emulsion includes the following steps: water-soluble aprotic solvent, isocyanate-terminated polycarbodiimide oligomer, hydrophobic long carbon chain alcohol and polyurethane catalyst are reacted at 50-120 ℃ for 2-5 hours, then hydrophilic polyurethane prepolymer and quantitative deionized water are added, fully dispersed, then slowly add the aqueous solution of polyamine, continue to disperse for 0.5-4 hours.Compared with prior art, the present application has the characteristics of single-component stable storage, and has the performance close to double-component waterborne polyurethane.

The application discloses a preparation method of o-carboxybenzaldehyde, which comprises the following steps: S1, reacting a phthalide with a potassium hydrogen peroxysulfate complex salt and an alkali in a polar protic solvent to prepare an intermediate; S2, hydrolyzing the intermediate obtained in the step S1 by using a strong protic acid aqueous solution to obtain a product o-carboxybenzaldehyde; and S3, adjusting the pH of the product obtained in the step S2 to 3-4 by using a sodium hydroxide aqueous solution, quenching excessive potassium hydrogen peroxysulfate complex salt by using a saturated sodium sulfite solution, cooling, recrystallizing, filtering and vacuum drying to obtain a final product o-carboxybenzaldehyde. The preparation method of the o-carboxybenzaldehyde can effectively reduce the synthesis cost, avoids the use of dangerous and toxic reagents, effectively reduces the generation of industrial three wastes, and is simple in process, convenient in operation, low in raw material cost, high in yield and beneficial to large-scale industrial production.

This invention discloses a highly efficient composite solubilizer for the hydration of butene to sec-butanol, belonging to the field of chemical process technology. Its composition includes: 0-60 parts of a polyether-based polymeric surfactant, 15-35 parts of a highly polar aprotic solvent, and 10-20 parts of a co-catalyst. The main solubilizing component of this invention disperses oily butene into extremely small droplets, allowing it to mix uniformly in water, thereby increasing the surface area for the reaction. The co-solvent, as the main component, provides a stable environment, ensuring that this highly mixed state is maintained for a certain period. The added additives, possessing both water and oil solubility, facilitate smoother dissolution of the mixture and help the reactants quickly contact the active sites of the catalyst. This accelerates the reaction rate of butene and water, significantly improving the efficiency of the one-time conversion to sec-butanol and greatly saving the large amount of energy required for material recycling.

The application discloses a preparation method of a low-thermal-expansion-coefficient polyimide film, and comprises the following steps: S1, configuring diamine, dianhydride and polar aprotic solvent, the molar ratio of the diamine and the dianhydride being 1:(0.95-1.05); adding the diamine into the polar aprotic solvent under nitrogen protection; S2, sequentially adding the dianhydride and a capping agent into the diamine solution, controlling the temperature and carrying out polycondensation reaction, controlling the viscosity of the reaction system to be 150-220 mPa.s, and filtering to obtain a polyamic acid solution; and S3, scraping the polyamic acid solution on a substrate, carrying out imidization treatment and drying to form a film, and obtaining a low-thermal-expansion-coefficient polyimide film product; the main component of the diamine is p-phenylenediamine and diaminobenzanilide, and the main component of the dianhydride is pyromellitic dianhydride. The obtained film has a thermal expansion coefficient similar to that of a copper foil and high tensile property. The application further discloses a polyimide film and a copper-clad plate comprising the polyimide film.

This invention belongs to the field of pharmaceutical synthesis, specifically relating to a method for preparing a chiral intermediate of betasine besylate. The method uses a mixed solution of protic and non-protic solvents in a specific ratio as the solvent for system resolution and purification. The reaction steps are simple, the product yield and optical purity are high, and the material utilization rate is high with low production costs.

The present invention is also directed to a new process for making bis-polyisobutenyl amine by reacting polyisobutylene epoxide with a polyamine, optionally in the presence of a catalyst, protic solvent initiator, and / or diluent. In addition, the present invention is also directed to a number of uses of bis-polyisobutenyl amine, including but not limited to the use of bis-polyisobutenyl amine in lubricants, surfactants, emulsifiers, resins, and the like.

This invention provides a method for synthesizing 3-(4-azidofurazan-3-oxomethyl)-3-azidomethyloxetane, its structural formula is shown below: The method includes the following steps: Step 1, 3-nitro-4-hydroxyfurazan, 3,3-dibromomethyloxetane, a basic donor and a phase transfer catalyst are added to a polar aprotic solvent, and the mixture is stirred at 45-85°C for 0.5-2 hours. Then, the mixture is extracted, washed with water, dried, filtered, the solvent is evaporated, and recrystallized to obtain 3-(4-azidofurazan-3-oxomethyl)-3-azidomethyloxetane. 3-(4-nitrofurazan-3-oxomethyl)-3-bromomethyloxetane; the 3-(4-nitrofurazan-3-oxomethyl)-3-bromomethyloxetane obtained in steps 2 and 1 and the azidating agent are added to a polar aprotic solvent and stirred at room temperature for 0.5-1.5 h. Then, the mixture is extracted, washed with water, dried, filtered, and the solvent is evaporated to obtain the final product. The 3-(4-azidofurazan-3-oxomethyl)-3-azidomethyloxetane prepared by this invention can be used as an energetic binder or an energetic initiator.

The present invention provides a polyarylethersulfone and a preparation method therefor. The preparation method comprises: mixing a polar aprotic solvent, a bisphenol monomer, and an alkaline substance, heating the mixture, dehydrating same, then cooling same to T1, adding a dihalodiphenylsulfone monomer, and maintaining the temperature at T1 for a first-stage polymerization reaction; and adding a low-polarity solvent, and then heating to T2 for a second-stage polymerization reaction, so as to obtain a polyarylethersulfone. The present invention allows for reduction or partial inhibition of the production of cyclic oligomers during a reaction, so as to obtain a polyarylethersulfone having a narrow molecular weight distribution and a low amount of cyclic polymers.

The present application relates to the technical field of fine chemical industry, in particular to a kind of perfluoro-2-alkyloxy propionyl fluoride and preparation method thereof, in the presence of polar aprotic solvent, using metal fluoride supported on support agent to catalyze acyl fluoride and hexafluoroepoxy propane reaction, perfluoro-2-alkyloxy propionyl fluoride is obtained.The present application utilizes the loading performance of support agent, metal ion in metal fluoride is fixed, it is beneficial to fluorine ion to be free, increase oligomerization reactivity, without adding phase transfer catalyst, the high yield, high efficiency preparation of perfluoro-2-alkyloxy propionyl fluoride can be realized.

The present invention relates to either the compound of formula (I) or a pharmaceutically acceptable salt thereof. The present invention further relates to a synthesis method for producing either the compound of formula (I) or a pharmaceutically acceptable salt thereof, comprising, at least, the compound of formula (II) in a non-protic solvent, without a solvent, or in a protic solvent, and the amine of formula (IV) in a molar ratio of 1 to 20 equivalents relative to the compound of formula (II), for example, NHR 5 R 6 This invention relates to a synthesis method that includes a step of reacting with [a specific substance]. JPEG2026521175000180.jpg44170

The application discloses a kind of electrostatic spinning porous polyimide micro-nanofiber membrane and its dynamic preparation method, the method is that binary organic amine is completely dissolved in polar aprotic solvent, according to the set adding proportion, batch addition binary organic anhydride solution, polyamide acid solution is prepared by heating and stirring and carrying out polycondensation reaction;Polyamide acid solution is chemically imidized using gradient heating method, and polyimide solution is prepared;Polar aprotic solvent and high volatility non-benign solvent are added in polyimide solution to dilute and stir, and polyimide spinning solution is prepared;Polyimide spinning solution is placed in controlled humidity environment to carry out electrospinning, and electrostatic spinning porous polyimide micro-nanofiber is obtained, and further electrostatic spinning porous polyimide micro-nanofiber membrane is obtained.The application realizes the continuous, controllable preparation of porous polyimide micro-nanofiber membrane, and provides a feasible technical path for its heat insulation protection, heat management and air filtration in extreme environment.