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Neuroactive steroid compositions and methods of use therefor

Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
Owner:DUKE UNIV

Neuroactive steroid compositions and methods of use therefor

Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Neuroactive steroid compositions and methods of use therefor

Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
Owner:MARX CHRISTINE E +1

Quiz game providing system using user creating quiz game set and method thereof

A quiz game content producing method enables a quiz creator to make, register, and publicize a quiz game set so that other people are able to use the quiz game set in the unit of the quiz game set which comprises one or more quiz steps and game progression material. The present invention also relates to a system and a method for providing a quiz game for a quiz participant who is connected to a quiz channel by enabling a quiz operator to use a publicized quiz game set. In addition, the present invention relates to a system and a method for providing a quiz game using a bidirectional quiz step. The present invention enables a quiz creator to: compose each quiz step by using a unique creative technique in the arrangement of quiz questions or the progression schedule of a quiz game according to selections or difficulties of the overall quiz questions; and develop quiz game content of a quiz game set unit which includes the quiz step. The creation of a quiz game set can be activated by accumulating points or providing a prize for a quiz creator and a quiz operator in a process in which the quiz creator creates the quiz game set and the quiz operator provides a quiz game for quiz participants. The present invention is able to provide a quiz solving game based on the quiz game set by enabling anyone to easily open a quiz channel and invite acquaintances as quiz participants.
Owner:KSEEK CO LTD

Elevator

ActiveUS20160340150A1Reacted to quickly and effectivelyReliability facilitatedElevatorsBuilding liftsDrive wheelEngineering
An elevator includes a first elevator unit vertically movable in a hoistway, and a second elevator unit vertically movable in a hoistway. At least one of said elevator units is an elevator car. One or more belt-shaped hoisting ropes interconnects the first elevator unit and the second elevator unit. A drive wheel is provided for moving said one or more belt-shaped hoisting ropes. Each of the belt-shaped hoisting ropes passes around the drive wheel and includes consecutively a first rope section extending between the drive wheel and the first elevator unit, and a second rope section extending between the drive wheel and the second elevator unit. The elevator further includes non-driven cambered diverting wheels, each said first rope section being arranged to pass around a first cambered diverting wheel, in particular resting against a cambered circumferential surface area thereof, and each the second rope section being arranged to pass around a second cambered diverting wheel, in particular resting against a cambered circumferential surface area thereof. A rope monitoring arrangement is configured to monitor displacement of each of the first rope sections in the axial direction of the wheels away from a predefined zone, and displacement of each of the second rope sections in the axial direction of the wheels away from a predefined zone. The elevator is configured to stop the rotation of the drive wheel when one or more of the first and second rope sections is displaced in the axial direction of the wheels away from a predefined zone.
Owner:KONE CORP

Training device having immediate training effect in water for swimmers

The purpose of the invention was to develop a training device that allows acquiring sense of water immediately after workouts with it.
The possible embodiment comprise an elastic or stretching material with gaseous medium between water and sportsman's palm and (or) forearm, and at least one valve. The embodiment allows to create the artificial gaseous medium at the inner side of human hand and/or forearm in water and to change its pressure and volume. The gaseous medium pressure and volume are set for a sportsman to change his psychosomatic sensations and lead to changes in mechanics and dynamics of the sportsman strokes in water.
The invention with gaseous medium assists swimmer to improve his ability to sense water. If pressure of gaseous medium is properly selected there is an effect of vanishing support during execution of strokes. The effect occurs due to properties of fluent gaseous medium in elastic/stretchy material. Shape of the gaseous medium is very responsive to propulsive forces during underwater part of a stroke. The gaseous medium deformations by water streams/flows cause feedback to swimmer hand, arm, and brain about applied forces. Interactive perception of water through the vanishing gas support assists swimmer to find right mechanics and dynamics of strokes that correspond with the current factors influencing swimming. In other words the device assists in development of human physical qualities required for increase in efficiency of applying hand's (or arm's) force during underwater part of strokes. A sportsman recalls the developed mechanics and dynamics right after workout with the device and its doffing.
Owner:SHAYTAN DMITRY KONSTANTINOVICH +2
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