A fastening device includes a case unit, a spool, a connecting unit, a knob and an engaging unit. The case unit includes a wall forming a receiving space, a partition separates the receiving space into an upper chamber and a lower chamber, a through hole located at the partition, and a base detachably connected to at least one part of the wall. The spool is located at the lower chamber. The knob is connected to the connecting unit. The engaging unit is located at the upper chamber. After the connecting unit is inserted into the spool, the through hole and the engaging unit to couple to the knob, the partition, the spool, the connecting unit, the knob and the engaging unit are connected integrally without being separated from each other while the base is separated from the at least one part of the wall.