The invention relates to a multi-point positioning method for an infrared matrix touch screen. The multi-point positioning method comprises the following steps of: S1, predetermining the number of axes to be scanned and corresponding angles; S2, scanning the axes of different angles in sequence, and generating logic data reflecting axis touch information after processing; S3, combining data intervals obtained in scanning of the X axis and the Y axis to obtain possible touch points; S4, calculating the intersection of the scanning area corresponding to the data interval in a single inclined scanning direction and one touch area generated by S3, and updating the long axis and the short axis in the touch area if the intersection exists; S5, repeating Step S4, calculating intersections of scanning areas corresponding to data intervals in other inclined axial directions and the touch point updated in Step S4, wherein the point does not exist when the intersections of the scanning areas corresponding to all the data intervals in one direction and the touch point updated in Step S4 is 0; otherwise, the point may be a real point; and S6, repeating Step S4 and S5, and calculating other possible touch areas in Step S3.