The invention discloses a road dust suppressant, which is prepared by mixing and blending 0.1-2.0% of water-soluble high molecular polymer, 20-50% of moisture absorption humectant, 1.0-5.0% of preservative, 0.5-5.0% of penetrating agent and the balance water. The road dust suppressant is a dynamic dust-proof and dust-suppressing liquid product which combines functions of wetting, bonding, permeating, adsorbing moisture and the like into a whole and has extremely strong pressurization-resistant function. The road dust suppressant has the advantages of obvious anti-evaporation performance and good water retention hygroscopicity, and dust on the road surface can be coagulated and is unlikely to fly. The road dust suppressant disclosed by the invention not only can be applied to road dust suppressing but also can be simultaneously used for the aspects, such as the mine exploration and transportation environment, storage yards of coal ash, coal and other ores, and the treatments of municipal construction earthwork dust raise.