The invention relates to a whole-gasification power generation process with garbage and sludge, wherein a harmless whole-gasification power generation technology is employed and integrates forty-fourhigh and new technologies, comprising: bag breaking, sorting, magnetic sorting, crushing, pulverization, low temperature treatment, medium temperature treatment, high temperature treatment, anaerobictreatment, oxygen-deficient treatment, drying, wall disruption, dehydration, stirring, polymerization, shaping, carbonization, material shaping, evaporation, drying, destructive distillation, pyrolysis, decomposition, splitting, extraction, atomization, liquefaction, evaporation, exchange, catalysis, oxidization, reduction, fusion, vitrification, solidification, gasification, heat preservation, temperature regulation, purification, quenching and tempering, fuel gas production, power generation, circulation and auto-control, in various fields. The process can completely treat garbage and is high in recycling degree of the treated energy resources, and can treat domestic garbage and civil sludge at high efficiency.