Analgesic tramadol hydrochloride oral disintegrating tablet and preparing method thereof

Abstract

The present invention relates to an analgesic tramadol hydrochloride oral disintegrant tablet. It is made up by using main medicine tramadol hydrochloride and auxiliary material gelatin and / or mannitol and / or aspartame and / or glucose and / or microcrystal cellulose and / or crosslinked povidone and essence, etc. and adopting freeze-drying or coating, granulating and pressing processes. When it is taken in, it has no need of drinking water, it can be quickly disintegrated in oral cavity, and can be used for curing acute and chronic pain, moderate and light pain due to cancer, pain due to fracture and pain after various operations and toothache, and can obtain good therapeutic effect.

Description

technical field

[0001] The invention relates to medicines, in particular to an orally disintegrating tablet of analgesic tramadol hydrochloride and a preparation method thereof. Background technique

[0002] Tramadol hydrochloride is a 4-phenylpiperidine analgesic, which is widely used in clinic because of its strong analgesic effect, low addiction, low tolerance and low dependence. This product is a non-opioid central analgesic. Although it can also bind to opioid receptors, its affinity is very weak. The affinity for μ receptors is equivalent to 1 / 6000 of morphine, and the affinity for κ and δ receptors is only 1 / 6000. 1 / 25 of mu receptors. Tramadol hydrochloride is a racemate, its (+) enantiomer acts on opioid receptors, while the (-) enantiomer inhibits the reuptake of norepinephrine by neuronal protrusions and increases extraneuronal 5- The concentration of serotonin can affect the transmission of pain and produce analgesic effect, the strength of which is 1 / 8~1 / 10 of...