5043 results about "Therapeutic effect" patented technology

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, an antidepressant, such as bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, an antidepressant, such as bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

The invention relates to the technical field of medical equipment control, in particular to a control system and a control method of cornea crosslinking equipment. The control system comprises a multi-modal data fusion module which is configured to integrate a preoperative corneal topographic map curvature matrix, OCT layering thickness data and biomechanical parameters to generate a four-channel fusion tensor; the virtual cornea modeling module is configured to input a conditional generative adversarial network to generate a virtual cornea model under the condition of the four-channel fusion tensor; the dynamic energy planning module is configured to generate a thermodynamic diagram of energy distribution based on mechanical response prediction of the virtual cornea model; and an illumination control module configured to perform patterned illumination based on the thermodynamic diagram. According to the method, the virtual cornea model is constructed, the energy distribution thermodynamic diagram is generated, accurate patterning reference can be provided for irradiation treatment, and a better treatment effect is achieved.

The invention relates to the technical field of medical data analysis, in particular to a brain tumor curative effect analysis system which comprises a tumor data sensing layer for collecting multi-department diagnosis and treatment data, tumor image data and patient pathology monitoring data; the tumor feature processing center extracts data features, correlates data and core features before and after treatment through an attention mechanism, and generates a tumor complete-cycle unified feature map; the therapeutic effect dynamic analysis unit evaluates the therapeutic effect in stages, and outputs a therapeutic effect index and a recurrence risk value through a self-supervised model; the dynamic adaptation decision module is used for generating personalized treatment adjustment suggestions based on the dynamic change of the blood brain barrier in combination with the curative effect index, the recurrence risk value and the multi-omics characteristics of the patient; and the AI multi-department consultation unit automatically matches similar cases with field expert suggestions, and formulates a target diagnosis and treatment scheme based on a visual platform and multi-department doctor collaborative consultation in combination with personalized treatment adjustment suggestions. Therefore, the problems of lagging effect evaluation, insufficient diagnosis and treatment suggestions and the like in the prior art are solved.

A compound, as shown in Formula I, is a multi-heterocyclic compound. It has been verified that the compound provided by this invention integrates a novel compound targeting the calcitonin gene-related peptide (CGRP) based on ephedrine. Upon contact with the skin, due to photoactivated cell biological function regulation and the blocking effect of the multi-heterocyclic compound I structure on serotonin receptors, it achieves therapeutic effects on cutaneous vascular malformations and telangiectasia, improves the effectiveness of phototherapy in improving chronic cutaneous vascular diseases, and promotes skin wound healing.

The invention relates to the field of medical information processing and traditional Chinese medicine curative effect evaluation, in particular to a diabetic nephropathy traditional Chinese medicine curative effect evaluation method based on patient report outcome. The method comprises the following steps: searching related symptoms and clinical characterization data of diabetic nephropathy through a medical database, extracting target entries, performing language standardization processing, constructing an initial candidate entry set, calculating the occurrence frequency of each symptom entry, and screening entries meeting a set threshold value to form an entry set; carrying out dimension division on the entry set according to feature attributes to form a preliminary dimension structure set; forming a screening result set through preset logic screening conditions; and carrying out weighted regression fusion on the comprehensive curative effect score and clinical detection data, and outputting a patient curative effect index. In an item weight determination process, dynamic balance between subjective experience and objective statistical information is realized through a mixed weighting model, and the defects of strong subjectivity of expert scoring and large result fluctuation in a traditional method are overcome.

The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).

The present disclosure features useful oligonucleotide compositions and methods related thereto. The present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g. modifications of sugar, base and / or internucleotide linkages) or patterns thereof, can have a significant impact on oligonucleotide properties and activities. The present disclosure also provides methods to treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

The invention discloses a Burkholderia gladioli (Burkholderia gladioli) CT-5 strain and an application of the Burkholderia gladioli CT-5 strain, and relates to the technical field of microorganisms. The strain is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M20242732, and the preservation date is December 05, 2024. The Burkholderia gladioli (Burkholderia gladioli) CT-5 provided by the invention has a remarkable prevention and treatment effect (Plt, Plt) on idesia root rot caused by Fusarium solani (Fusarium solani), and the Burkholderia gladioli (Burkholderia gladioli) CT-5 has a remarkable prevention and treatment effect on idesia root rot caused by Fusarium solani (Busarium solani). The compound has the advantages that the compound can be used for inhibiting pathogenic bacteria of various plants, and the compound can be used for inhibiting pathogenic bacteria of various plants, such as Schizophyllum commune, Diaporthe erens, Colletotrichum acutatum and the like, and has a remarkable inhibiting effect on other various plant pathogenic bacteria such as the Schizophyllum commune, the Diaporthe erens, the Colletotrichum acutatum and the like. In a pot experiment, the biomass, soil nutrients, SOD, POD and CAT enzyme activities of idesia polycarpa seedlings in a CT-5 treatment group are remarkably improved compared with those of a pathogenic bacteria control group (FP) (Plt; 0.05), which indicates that the strain can promote plant growth and activate the activity of defensive enzyme in the body, so that effective control of idesia root rot is realized, and powerful theoretical basis and technical support are provided for sustainable development of idesia.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a targeted liposome as an active component in preparation of a medicine for treating ischemic brain injury. The targeted lipidosome for treating cerebral arterial thrombosis is prepared by fusing the lipidosome and the platelet-neutrophil aggregate membrane, realizes efficient and specific targeting of an ischemic brain region, effectively reduces brain tissue infarction and damage of a new region, relieves brain inflammation through multi-channel regulation and control, and improves the cerebral arterial thrombosis treatment effect. The compound can be used as an active ingredient for preparing a medicine for treating ischemic brain injury. And after the target liposome is further coated with a rutin drug, the synergistic treatment effect is realized. The liposome medicine can be used as an active component and has a good application prospect in treatment of ischemic brain injury diseases.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

The invention discloses a drug-loaded liposome nano-particle, a preparation method thereof and application of the drug-loaded liposome nano-particle in treatment of brain glioma, and belongs to the technical field of biological nano-medicines. The invention provides a novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle and application of the novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle to treatment of brain glioma on the cellular level. The nano-particles are obtained by wrapping copper phthalocyanine derivatives and catalase with lipidosome prepared by a microfluidic method. The co-drug-loaded liposome can catalyze excessive H2O2 in brain glioma to generate oxygen, and O2 is continuously supplied to photodynamic therapy (PDT) to generate active oxygen; meanwhile, Cu < 2 + > can deplete glutathione and improve the oxidative stress level in the glioma, the reduction product Cu < + > can convert H2O2 into hydroxyl radicals with higher toxicity through a Fenton-like reaction, oxidative stress injury is doubly amplified, cascade cooperation of PDT and chemical dynamic therapy (CDT) is achieved, and the treatment effect on the glioma is remarkably enhanced.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

The invention specifically discloses an automatic generation method for a cervical vertebra disease rehabilitation prescription, and the method comprises the steps: constructing a cervical vertebra image feature automatic measurement system based on computer vision and deep learning, so as to monitor the training motion quality of a patient in real time, and obtaining the kinematics parameters of rehabilitation exercise training; acquiring a medical image and clinical data of a patient, and standardizing the medical image to construct a standard space of a multi-modal medical image; performing automatic segmentation and anatomical structure calibration on a vertebral body-intervertebral disc based on the standard space to obtain fusion image features; and constructing a multi-modal hierarchical decision model fusing the image features, the kinematics parameters and the clinical data to carry out quantitative analysis on pathological feature parameters, and outputting a standardized illness state assessment result conforming to international clinical guidelines. The dynamic optimization of the treatment scheme can be realized through a feedback mechanism, and the treatment effect is improved.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

The invention provides a non-invasive intracranial pressure prediction method and system and a storage medium, and the method comprises the following steps: obtaining a multi-modal vital sign original signal from a subject in a non-invasive manner, embedding a timestamp of the multi-modal vital sign original signal, and generating a high-dimensional time sequence feature of each vital sign; based on a preset reference sequence, associating the time sequence features with the original signals by adopting an attention mechanism to obtain alignment features of each vital sign; inputting the alignment features into a gating circulation unit network, and extracting hidden features of each vital sign; and splicing and fusing the hidden vital sign features, sending the fused hidden vital sign features into a classifier, and outputting a judgment result about whether the intracranial pressure of the subject rises or not. The clinical application value of a non-invasive monitoring technology is improved, and then the treatment effect and prognosis quality of a patient are improved.

The invention belongs to the technical field of nerve regulation and control engineering, and provides a cerebrospinal fluid rhythm-based Alzheimer's disease electrical stimulation system, which is characterized in that first frequency band range data and second frequency band range data in brain wave signals are coupled to obtain cerebrospinal fluid rhythm data; then, calculating the phase difference between the first frequency band range data and the cerebrospinal fluid rhythm data; finally, the stimulation frequency is dynamically controlled according to the phase difference, and the stimulation current is dynamically controlled according to the brain tissue water volume fraction. The problem that specific metabolism requirements of non-fast eye movement sleep and fast eye movement sleep cycles cannot be matched by adopting single-frequency-band stimulation is solved, dynamic changes of post-traumatic encephaledema and requirements and influences of cerebrospinal fluid rhythm on current control are considered, the real-time adaptive capacity to the dynamic changes of the post-traumatic encephaledema is improved, and the application prospect is wide. And the treatment effect of the Alzheimer's disease is ensured.

The invention relates to the technical field of medical health management, and discloses an endocrine patient health management system based on big data. According to the system, a multi-source data acquisition module is adopted to acquire heterogeneous health data including physiological monitoring indexes, medication record data, medical image reports and the like, and living habit logs can also be included. The physiological feature noise reduction module is used for extracting steady-state physiological features, the multi-modal fusion module is used for generating a focus dynamic map, and the medication feedback analysis module is used for generating a drug response mode evolution sequence. The data are input into a multi-dimensional decision model, and a health management scheme is output by a personalized scheme generation module. And the living habit analysis module analyzes the living habit logs to generate influence factors, and participates in making a health management scheme. The system realizes multi-source data fusion analysis, can provide a personalized health management scheme for an endocrine patient, improves the disease diagnosis accuracy and treatment effect, and improves the life quality of the patient.

The invention discloses a pain treatment method based on infrared photothermal coupling, and belongs to the technical field of medical engineering. Comprising the following steps: acquiring physiological feature data, pathological feature data and optical feature data of a patient, and acquiring initial equipment parameters of the intelligent infrared photothermal treatment device; the method comprises the following steps: constructing an individualized photo-thermal response prediction model through Monte Carlo photon transmission simulation in combination with finite element heat conduction analysis, predicting a therapeutic effect score and an optimal parameter combination by using a deep neural network model based on a Transform architecture, generating an individualized temperature-time therapeutic curve, and determining initial illumination parameter configuration; controlling the intelligent infrared photothermal treatment device to start a treatment process according to the initial illumination parameter configuration; and according to the comprehensive biomarker score and in combination with a real-time analysis result of the neural network processing module, the output power, the pulse duty ratio and the irradiation mode of the infrared light source are automatically adjusted through the infrared light source control module.

This invention provides a transdermal nanoparticle delivery system for skin anti-inflammation, comprising a protein-blue calyx methyl ether-polymer shell capsule composite structure. The protein has an affinity for the skin, blue calyx methyl ether is loaded within the protein, and the polymer layer coats the surface of the protein. The blue calyx methyl ether nanoparticle transdermal delivery system has a size of 30-80 nm, and the polymer shell thickness is 10-35 nm. The surface properties of the polymer shell can be controlled according to the required transdermal delivery depth, enabling the protein to penetrate the skin barrier and be efficiently delivered deep into the skin, where the blue calyx methyl ether is then slowly released, targeting and alleviating skin inflammation. This addresses the drawback of low therapeutic efficacy of blue calyx methyl ether in treating skin inflammation due to unsatisfactory transdermal effects.

The invention provides a benzofuranone compound as well as a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The benzofuranone compound is a compound as shown in a formula I, a stereoisomer thereof, a tautomer thereof, a crystalline hydrate thereof, a solvate thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof. The benzofuranone compound and the pharmaceutical composition and the pharmaceutical preparation prepared from the benzofuranone compound can prevent or treat organ injury diseases, and have good treatment effects in kidney injury, liver injury, lung injury, brain injury and heart injury.

The present invention relates to the field of pharmaceutical technology, and more particularly to the use of Morinda officinalis polysaccharide in preparing a product for improving renal fibrosis. The preparation method of the Morinda officinalis polysaccharide comprises the following steps: (1) extracting Morinda officinalis from water, filtering, and obtaining a supernatant; (2) subjecting the supernatant to alcohol precipitation to obtain a precipitate; and (3) dialyzing and removing protein from the precipitate. The Morinda officinalis polysaccharide has a significant therapeutic effect in improving renal fibrosis.

The embodiment of the invention provides a drainage tube and a drainage device, and relates to the technical field of medical instruments. The drainage tube comprises a drainage part, a porous loose structure and a granulation blocking structure, the drainage part is provided with a first drainage channel, the drainage part is provided with a first drainage hole, and the first drainage hole is communicated with the first drainage channel; the porous loose structure wraps the drainage part, the granulation blocking structure wraps the porous loose structure, and second drainage holes are formed in the granulation blocking structure; and the second drainage holes, the porous loose structure, the first drainage holes and the first drainage channels are communicated. According to the drainage tube, by arranging the granulation blocking structure, granulation can be blocked from growing into the porous loose structure while negative pressure adsorption is met, so that the condition of granulation tissue bleeding is reduced, and the treatment effect of negative pressure drainage is improved.

The invention provides a gamma delta T cell preparation as well as a preparation method and application thereof, and belongs to the technical field of T cells. The liposome is prepared from the following raw materials in parts by weight: 15-20 parts of modified gamma delta T cell liposome, 1-3 parts of cell stimulating factors and 4-7 parts of culture medium freeze-dried powder, the modified gamma delta T cell lipidosome is prepared by embedding gamma delta T cells through lipidosome, coupling with acetylenic bond modified chitosan, and further mixing with MFAP4 protein and b4GALT1 protein. The culture medium freeze-dried powder is prepared by freeze-drying the culture medium in the engineering culture process of gamma delta T cells, and the cell stimulating factors are resveratrol and quercitrin. According to the gamma delta T cell preparation prepared by the invention, the survival ability and resistance of gamma delta T cells are improved, the anti-tumor activity of the gamma delta T cells is improved, and the gamma delta T cell preparation has relatively good antioxidant and anti-inflammatory effects, reduces the inhibition of inflammation on an immune system and has a very good treatment effect on pancreatic ductal adenocarcinoma.

The invention discloses a method, a system and equipment for evaluating the treatment effect of CGRP on epilepsy or brain injury caused by epilepsy. It is found for the first time that CGRP inhibits expression of P2RX7 by inhibiting a JAK-STAT1 pathway so as to play a role in treating epilepsy or brain injury caused by epilepsy. On the basis, the invention provides a method, a system and equipment for evaluating the treatment effect of the CGRP on the epilepsy or the brain injury caused by the epilepsy for the field, so that a doctor is assisted in evaluating the treatment effect of a patient suffering from the epilepsy or the brain injury caused by the epilepsy, and a clinician is guided to formulate an individualized treatment scheme for the patient.

The invention relates to the field of biological medicine, in particular to IMSFs hydrogel, a ferroptosis induction system, a preparation method and application. The IMSFs hydrogel comprises a hydrogel body, and ferroferric oxide nanoparticles and sorafenib are loaded in the hydrogel body in a wrapping manner. The IMSFs hydrogel can be used as an injectable cascade ferroptosis anti-cancer drug. The preparation method of the IMSFs hydrogel comprises the following steps: firstly, preparing a silk fibroin-hyaluronic acid hydrogel body: dissolving silk hydrogel and hyaluronic acid in a lithium bromide solution; bDDE is added into the dissolved solution, and incubation is carried out; then dialyzing and washing with deionized water to obtain a silk fibroin-hyaluronic acid hydrogel body; and then loading the sorafenib nanoparticles and the ferroferric oxide nanoparticles into the silk fibroin-hyaluronic acid hydrogel body. The IMSFs hydrogel disclosed by the invention integrates magnetic thermal response and drug controlled release, and can be injected to a tumor site, so that the treatment effect on TNBC is remarkably improved.