The invention belongs to a detection system (01) for a noninvasive ventilation interface and particularly relates to a detection system for evaluating the air leakage and the comfortableness of interfaces such as a nasal mask, a mouth-nose mask and a full-face mask (08) for noninvasive ventilation by combining three-dimensional structure characteristics of human heads. The detection system comprises a detection air source (02), a human head three-dimensional model (03), a simulation trachea (05), a lung model (04) and a micro processing unit (07), wherein the detection air source (02) can be used for generating a designated ventilation waveform; the human head three-dimensional model (03) can be used for detecting the surface stress; the simulation trachea (05) and the lung model (04) are connected with the human head three-dimensional model and allow sensors (06) to be placed; and the micro processing unit (07) can be used for evaluating the air leakage and the comfortableness of the head and the face. The air leakage is detected by comparing the preset ventilation waveform of the air source with the actually-detected waveform of the trachea model, and the stresses of the mask worn at different positions of the head are measured by a plurality of pressure sensors arranged on the head model and are compared with a human tolerance threshold, and thus the comfortableness of the mask is judged.