28 results about "Nerve function" patented technology

A system for longitudinal assessment of nerve health includes a stimulator to deliver electrical stimuli proximate a target nerve, a sensor to detect muscle responses evoked by the stimuli, a display, and a processor in communication with the stimulator, sensor, and display. The processor controls delivery of the stimuli; determines, from the detected muscle response, one or more nerve-function parameters for the target nerve including at least a stimulation threshold; stores the parameters with a session identifier; retrieves parameters from multiple sessions to compute a longitudinal trend; and controls the display to present the trend together with an indication of the target nerve's status relative to a target range. The system supports objective session-to-session tracking to inform clinical decisions.

The invention, which relates to the technical field of medical training, discloses a multi-sensory feedback fusion stroke rehabilitation exoskeleton robot training system comprising an exoskeleton robot main body, a multi-sensory feedback module, and a motion state monitoring module. By integrating a multi-sensory feedback module, a visual, auditory, tactile and motion state monitoring module and a central control module, multi-dimensional sensory stimulation and real-time data acquisition are realized when a patient is trained, and the central control module adapts parameters in the module according to the real-time motion precision of the patient and personalization. The strength and the type of multi-sensory feedback are dynamically adjusted, meanwhile, motion parameters of an exoskeleton robot body are controlled, a dynamic adjustment mechanism ensures pertinence and effectiveness of training, forward feedback is provided to strengthen a correct motion mode when the motion precision of a patient is high, and correction prompt is provided and assistance or resistance of the robot is adjusted when the motion deviation is large. Therefore, nerve function remodeling and motor ability recovery are effectively promoted.

The invention provides an individualized anesthesia optimization method and system based on transcranial magnetic stimulation-induced electroencephalogram, and relates to the technical field of medical equipment control. According to the technical scheme provided by the invention, the target phase window corresponding to the electroencephalogram rhythm frequency band is predicted by using the autoregression model, and the target stimulation moment is accurately calculated according to the inherent delay of the stimulation equipment, so that closed-loop phase-locked stimulation of the transcranial magnetic pulse is triggered in a specific phase state; and it is ensured that the collected electroencephalogram response signals can accurately reflect cortical function characteristics of an individual in a specific nerve excitation state. Multi-dimensional biological characteristics are extracted from electroencephalogram response signals, an anesthesia reaction prediction model is input to calculate the individualized anesthesia reaction index, individual nerve function differences are fully considered in an anesthesia optimization scheme generated based on the individualized anesthesia reaction index, and compared with a traditional evaluation method of population statistics, the evaluation method has the advantages that the evaluation accuracy is high, and the evaluation efficiency is high. The accuracy of anesthesia response evaluation is remarkably improved, and therefore the accuracy of an anesthesia scheme can be improved.

The invention discloses an intelligent voice rehabilitation training management system. The system comprises an intra-hospital local area server, a preoperative risk assessment module, an intra-operative neural function assessment module, an acoustic assessment module and an individualized rehabilitation training scheme making module. The system is in butt joint with intraoperative nerve monitoring equipment to collect electromyographic signals in real time, and multi-modal fusion analysis is carried out in combination with preoperative / postoperative acoustic parameters and spectrograms. The system utilizes a deep learning model to predict the noise disorder risk and the recovery trajectory at different time points after the operation; three-dimensional training navigation is constructed based on postoperative time, neurological function parameter changes and vocational voice requirements, a rehabilitation path is dynamically optimized by adopting near-end strategy optimization reinforcement learning, and training intensity and content are adjusted in a closed-loop mode through auditory feedback; closed-loop management of preoperative evaluation, intraoperative monitoring, postoperative evaluation, individualized rehabilitation and follow-up visit optimization is achieved, and the accuracy and timeliness of voice function protection and rehabilitation are improved.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

The invention relates to a cranial nerve motor function evaluation system and method based on a terminal with a camera. The system comprises a camera used for collecting a high-definition video sequence of facial actions; the model is used for identifying positioning points of the face according to the high-definition video sequence acquired by the camera; the analysis and evaluation module is used for quantitatively evaluating the cranial nerve motor function state according to the change of the positioning points of the face acquired by the model; the analysis and evaluation module performs analysis and evaluation according to the change quantitative indexes of the positioning points of the face; the camera, the model and the analysis and evaluation module are all deployed at the terminal; and the model and the analysis and evaluation module are deployed in an operating system of the terminal. The evaluation system and method are deployed on a common terminal, and are used for collecting a video sequence of a user completing a standard evaluation action, automatically identifying the movement of a positioning point of a face, and outputting a quantitative score according to a medical standard so as to evaluate human face muscle movement and a cranial nerve function state.

A system and computer-implemented method for intraoperative assessment of nerve health. A processor determines a nerve function parameter from an electrically evoked muscle response to stimulation proximate to a nerve. The processor generates an individualized, predictive target range by accessing a database of historical patient data, identifying a subset of patients with pre-operative characteristics similar to those of the subject, and defining the target range based on intraoperative nerve function measurements associated with successful post-operative outcomes in that subset. A display presents the determined nerve function parameter relative to the individualized target range to provide real-time guidance. The system can integrate intraoperative imaging to concurrently display anatomical and functional information. A predictive model used to generate the target range is refined over time by incorporating outcomes from additional patients, enabling continuous improvement of the assessment.

The utility model discloses a fresh air device capable of providing negative oxygen ions, and relates to the technical field of fresh air devices, the fresh air device comprises a fresh air ventilator case, the front side of the fresh air ventilator case is clamped with a quick release cover plate, and the right side of the fresh air ventilator case is provided with a negative oxygen ion generating mechanism; partition plates are fixedly mounted on the left sides and the right sides of the inner walls of the fresh air ventilation cases correspondingly, and a rhombic heat exchange core is slidably mounted between the opposite faces of the two fresh air ventilation cases. According to the fresh air ventilator, the fresh air ventilator case and the negative oxygen ion generating mechanism are matched with each other, so that the fresh air ventilator can filter and ventilate indoor air and convey negative oxygen ions into a room at the same time, propagation of bacteria and viruses in the air is reduced through the negative oxygen ions, the indoor sanitation level is improved, metabolism of a human body is promoted, and the health of the human body is improved. The immunity is enhanced, and the nerve function is regulated, so that the body fatigue is relieved, the sleep quality is improved, and the ventilation quality of the fresh air ventilator is better.

A transcutaneous magnetic stimulation (tMS) device is provided for modulating nerve function and chronic pain management, and includes a tMS stimulator, a control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module to receive, generate and transmit feedback and control settings relating to a treatment session. The tMS stimulator may be a flexible figure-of-eight coil configured in different sizes and shapes to provide varying pulse and magnetic field strengths for mobile, home, or clinical uses, and also include guidance tools and measurement sensors to aid in positioning and directing the tMS stimulator to a target area for treatment.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The invention relates to the technical field of electrocardiosignal analysis, and discloses an autonomic nerve function evaluation method based on a phase whole sequence signal averaging technology, and the method comprises the steps: selecting a plurality of deceleration anchor points and / or acceleration anchor points from a plurality of sequence values of a heart beat interval sequence of a first to-be-detected object; for each deceleration anchor point / acceleration anchor point, selecting a deceleration sequence segment / acceleration sequence segment corresponding to each deceleration anchor point / acceleration anchor point from the heart beat interval sequence of the first to-be-tested object; averaging values with the same sequence in the plurality of deceleration sequence segments / acceleration sequence segments to obtain a deceleration signal sequence / acceleration signal sequence of the first to-be-detected object; performing power spectral density analysis on the deceleration signal sequence / acceleration signal sequence of the first to-be-detected object to obtain a deceleration index / acceleration index of the first to-be-detected object; and evaluating the autonomic nerve function of the first to-be-tested object according to the deceleration index and / or the acceleration index of the first to-be-tested object. The autonomic nerve function can be evaluated more accurately.

A method of performing bronchial denervation of a bronchus having bronchial nerves along a portion thereof is provided. The method includes providing a cryoablation device having multiple electrodes capable of delivering electrical energy and measuring impedance. At least one bronchial nerve is stimulated with electrical energy. The electrical signals from the at least one bronchial nerve are recorded to provide a first value representative of nerve function. Cryogenic treatment energy is applied to form ice in the bronchus having a thickness to encapsulate the at least one bronchial nerve to cause a reduction in nerve function. The at least one bronchial nerve is restimulated with electrical energy. The electrical signals are recorded from the restimulated at least one bronchial nerve to provide a second value that represents diminished nerve function. The first value and the second value are compared to provide an assessment of the reduction in nerve function.

This invention discloses a functional electrical stimulation rehabilitation aid for stroke, belonging to the field of medical rehabilitation aid technology. It includes an electrical stimulation component, a walking component, a height adjustment component, a body support adjustment component, and a rehabilitation component. This device integrates the electrical stimulation component, the body support adjustment component, and the lower limb rehabilitation training component into one unit, overcoming the limitations of traditional devices that separate head electrical stimulation from limb training. It transmits precise electrical signals to the head's nerve function areas through flexible electrode pads within the helmet, directly promoting the repair and regeneration of damaged nerves. Furthermore, the servo motor-driven linkage mechanism in the rehabilitation component simulates human gait, achieving passive training of lower limb joints and muscles. This eliminates the need for patients to transfer between multiple devices, reducing physical exertion and avoiding safety risks during transfers, making it particularly suitable for acute-phase patients with weak limb mobility.

The application is suitable for the fields of high-end flexible sensing preparation and multi-modal sensing detection technology, and provides a patch type ultrasonic biomarker integrated sensor and a detection method.The sensor comprises a patch type ultrasonic transducer array, which is used for real-time monitoring of muscle and bone diseases, realizes multi-parameter multi-modal data information fusion detection and analysis of muscle and bone structure-function, a microneedle electrode array, which is used for in-situ detection of biomarkers and collection of physiological electrical signals, a flexible electronic circuit, which is used for bearing and connecting the patch type ultrasonic transducer array and the microneedle electrode array, and an acoustic coupling adhesive layer, which is used for skin fitting and acoustic coupling.The application can systematically evaluate the structure, mechanics, metabolic inflammation level and nerve function activity coordination of muscle and bone, provides a new means for early identification, quantitative evaluation and personalized intervention of muscle and bone diseases, and has important clinical and industrial values.

The utility model relates to the technical field of medical instruments, in particular to a multipurpose nerve monitoring drag hook which comprises an embedded fixing part, a handheld part, a connecting part and a U-shaped drag hook body which are sequentially connected and integrally formed. The embedded fixing part, the handheld part, the connecting part and the U-shaped drag hook are hollow, a wire is arranged in the embedded fixing part, the wire is connected with the nerve detector through the wire connecting part, an opening is formed in the front end of the U-shaped drag hook, and the wire is arranged outside the opening. The multi-purpose nerve monitoring drag hook can replace a nerve drag hook to help to pull and dissect a nerve, and meanwhile, the multi-purpose nerve monitoring drag hook has the effect of continuously outputting stimulation current, so that the function of monitoring the nerve function is achieved, functional damage of the nerve in the pulling and dissecting process is prevented, and the operation efficiency is improved.

The application provides a double-oriented composite nerve sheath and a preparation method thereof, and belongs to the field of medical materials. The composite nerve sheath comprises a dense wall layer of collagen fiber axial orientation arrangement and a loose stent layer with an axial orientation interconnecting pore structure. The wall layer is prepared by electrochemical deposition directional guidance of self-assembly of type I collagen protein, the oriented collagen fiber simulates the tissue structure of the nerve epineurium, is beneficial to rapid formation of dense epineurium and other outer layer structures, can guide precise matching of the port nerve bundle, and is beneficial to complete recovery of nerve function. The stent layer provides active sites and proliferation space for cell adhesion, is beneficial to directional and rapid growth of nerve cells, and the oriented interconnecting pore can directionally guide migration of nerve cells, so that directional growth of the nerve axis is guided, and the repair rate and effect are improved.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The application discloses a method and device for predicting nerve function based on imageomics, electronic equipment and storage medium. The method comprises the following steps: acquiring magnetic resonance imaging; constructing a first neural network model using a two-dimensional convolution architecture, a three-dimensional convolution architecture, an encoder and a decoder, and segmenting the magnetic resonance imaging using the first neural network model to obtain an image of a region of interest; extracting features of the image of the region of interest to obtain feature data of the magnetic resonance imaging; screening the feature data by combining a filtering method and an embedding method; constructing a second neural network model using a one-dimensional convolution architecture, a gated recurrent module and a full connection architecture, and predicting nerve function according to the screened feature data using the second neural network model. The application is a brand-new method for predicting nerve function based on imageomics, and realizes the function of predicting the nerve function retention after surgery before surgery.

A method for assessing nerve health during a surgical procedure includes: applying one or more electrical stimuli proximate to the target nerve during the surgical procedure; detecting a muscle response evoked by the one or more electrical stimuli; determining at least one nerve function parameter indicative of the health or function of the target nerve; identifying a target range for the at least one nerve function parameter adapted for the target nerve, the target range being predictive of a desired nerve health status of the target nerve; and outputting an indication of the determined at least one nerve function parameter relative to the identified target range to provide real-time feedback during the surgical procedure involving the target nerve.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The present application relates to a kind of magnetic stimulation coil nerve function detection and regulation method and system, wherein, method includes by control circuit driving capacitor discharges to double-path stimulation coil, generate millisecond-level pulse magnetic field;Utilize the pulse magnetic field and act on nerve tissue, produce including nerve regulation effect of suprathreshold stimulation and subthreshold stimulation;Real-time acquisition is induced by pulse magnetic field stimulation and is produced evoked potential signal;Analysis the evoked potential signal, calculate nerve conduction time and excitation inhibition ratio;According to nerve conduction time and excitation inhibition ratio adjustment double-path stimulation timing and / or capacitor discharge parameter, carry out the detection and coordination regulation of nerve function, to realize the purpose of real-time detection, quantitative evaluation and adaptive accurate regulation to nerve function.

The invention discloses ultrasonic response hydrogel for treating spinal cord injury as well as a preparation method and application of the ultrasonic response hydrogel. The ultrasonic response hydrogel comprises fibroin / polyvinyl alcohol / carboxymethyl cellulose hydrogel and sodium niobate piezoelectric nanoparticles blended in the fibroin / polyvinyl alcohol / carboxymethyl cellulose hydrogel. According to the ultrasonic response hydrogel, synergistic treatment of spinal cord injury in different stages is achieved through a single system, in the acute stage after the spinal cord injury, ultrasonic is applied to activate sodium niobate nanoparticles to catalyze water molecules to generate hydrogen and oxygen in situ, the high-penetrability hydrogen can play a global anti-inflammatory role, and the high-penetrability oxygen can play a role in treating spinal cord injury. Oxygen is used for accurately relieving the anoxic microenvironment of the damaged core area; in the recovery period, a bionic electrical stimulation signal can be efficiently conducted by combining a conductive network formed by the conductive hydrogel with micro-current continuously generated by the piezoelectric nanoparticles under ultrasound, and metabolism and electrical activity of nerve cells can be effectively regulated, so that long-term reconstruction of nerve functions is promoted.

The utility model provides a multi-electrode cell electrical stimulation device which comprises a multi-electrode plate, the multi-electrode plate comprises a flexible substrate and electrodes, the flexible substrate is provided with a first electrode area and a second electrode area, six electrodes are respectively arranged in the first electrode area and the second electrode area, one end of each electrode is provided with a wire connecting end, and the other end of each electrode is provided with a wire connecting end. The wire connecting end is connected with an external wire, the external wire is communicated with the wire connecting end to complete access operation of the electrode operation end, the multi-electrode plate, the resistor and the waveform function generator are sequentially connected in series to form a series electric control circuit, and the two ends of the series electric control circuit are connected with an external power source to form the electrical stimulation device. Two rows of twelve electrode arrays are arranged, multi-path and multi-direction electrical stimulation scheme adjustment is achieved by controlling the electrodes on the two sides to discharge, growth of nerve axons can be promoted, re-myelination of the axons can be promoted, recovery of nerve functions is accelerated, and popularization and application are facilitated.

Relationships between morphological changes to an eye due to intraocular pressure changes and blood perfusion and nerve function changes in the retina are determined by colocalizing retinal perfusion data, optic nerve head (ONH) mechanical deformation data, visual field data and nerve fiber data. Perfusion and nerve function changes from intraocular pressure (IOP) changes are determined by colocalizing retinal perfusion data with ONH mechanical deformation data, visual field data and nerve fiber data. Optical coherence tomography-angiography (OCT-A) can be used to generate retinal perfusion data, mechanical deformation data for an imaged volume, and nerve fiber data. A three-dimensional model (e.g., connectivity map or connectivity model) of the vasculature and nerve fibers can be generated from the OCT-A imaging data and used to predict changes in blood perfusion and nerve function in various areas of the retina due to IOP-induced mechanical deformations.

The application discloses a kind of based on multi-modal fingertip monitor's vascular pressure reflex sensitivity dynamic evaluation method, system and equipment, belong to the technical field of autonomous nerve function assessment of computational physiology.The method relies on monitoring equipment and its specific high-fidelity recording mode that can produce time strictly aligned multi-modal raw data stream in hardware level, relies on synchronous data packet with uniform timestamp that is composed of electrophysiological data sub-packet and optical data sub-packet in data level.The core of method includes: receiving and analyzing the time-aligned data packet, detecting the starting point of skin conductance response event from it, and calculating pulse wave conduction time sequence synchronously;With each skin conductance response event starting point as time reference, analyze the dynamic change characteristics of the pulse wave conduction time sequence in the preset time window after it, and quantify the change characteristics as the evaluation index of vascular pressure reflex sensitivity.The present application makes full use of the accurate timing relationship between skin electrical activity surge event and vascular dynamics instantaneous response provided by high-precision hardware synchronization, solves the problem that traditional pressure reflex sensitivity evaluation method is complex, cannot be continuously monitored, and is difficult to capture instantaneous reflex function.

A system for longitudinal assessment of nerve health includes a stimulator to deliver electrical stimuli proximate a target nerve, a sensor to detect muscle responses evoked by the stimuli, a display, and a processor in communication with the stimulator, sensor, and display. The processor controls delivery of the stimuli, determines, from the detected muscle response, one or more nerve-function parameters for the target nerve including at least a stimulation threshold; stores the parameters with a session identifier; retrieves parameters from multiple sessions to compute a longitudinal trend; and controls the display to present the trend together with an indication of the target nerve's status relative to a target range. The system supports objective session-to-session tracking to inform clinical decisions.

Described herein is a system (100) for assessing and regulating midbrain nerve function The system (100) comprises one or more input devices (102, 104), and a processing device (106) in communication with the one or more input devices (102, 104). The processing device (106) is configured to capture, using the one or more input devices (102, 104), data pertaining to physiological attributes and bioelectrical signals generated across one or more body parts of the user, wherein the physiological attributes comprise at least a stiffness of muscles associated with the one or more body parts of the user, and determine constriction level and health of a plurality of nerves extending through the one or more body parts of the user based on the captured physiological attributes and the bioelectrical signals, wherein the plurality of nerves is associated with a mid-brain of the user.

The disclosure provides a dietary supplement formulation to alleviate sciatica pain, support nerve health, and enhance musculoskeletal health. The formula comprises a synergistic blend of natural ingredients, each selected for its specific properties. The formulation includes a Turmeric Extract (200 mg) for its anti-inflammatory and antioxidant effects, Myo-Inositol Powder (300 mg) for nerve signal transmission, MSM 80 Mesh (300 mg) for reducing inflammation and supporting connective tissue, and Black Currant Extract (250 mg) for its antioxidant properties. Omega 3 Fatty Acid (40 mg) provides anti-inflammatory and neuroprotective benefits, BioPerine (5 mg) enhances ingredient bioavailability, Magnesium (30 mg) supports nerve function and muscle relaxation, Vitamin D3 (10 mcg) is essential for bone health, Vitamin B12 (500 mcg) maintains healthy nerve cells, and Boswellia serrata Extract (100 mg) reduces inflammation.