166 results about "Nerve function" patented technology

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

Compostions of GLA and / or other EFAs with TA or related compounds, and their use in therapy or nutrition or in preparation of composition for therapy or nutrition, especially to improve cell membrane EFA concentration and / or (particularly in diabetic complications) impaired nerve function and blood flow.

A system for determining proximity of a surgical device relative to nerve structure includes at least one surgical device having a sensor assembly operably coupled to a processing unit and configured to transmit at least one electrical signal generated by the processing unit through nerve structure to elicit a measurable response there from. The processing unit is configured to calculate a signature property value of nerve structure based on the measurable response and to determine proximity of the nerve structure to the surgical device based on the measurable response. The processing unit is further configured to test the nerve function after completing the surgical procedure.

The invention discloses a heart rate variability analyzing method based on an amplitude spectrum and instruments. The method comprises the following steps that a human body autonomic nervous function monitor is installed, after amplification, filtering and analog-digital conversion are carried out on electrocardio signals collected by an electrocardio electrode slice, an RR interval time sequence is built, the QRS waveform of the electrocardio signals has the features of large amplitude, short time limit, steep waveform and easy recognition, the key for obtaining HRV signals is that the R wave of an electrocardiogram is accurately calibrated, and according to the morphological characteristic of an R wave picture, the wave crest of the R wave is the maximum positive value in a single signal period; the instruments included in the method comprise a preamplifier module used for amplifying the electrocardio signals, a filter module, an A / D conversion module, an R crest positioning module, a signal pseudo crest pseudo differential eliminating module, an RR sequence forming module, an interpolation module and a display module which are sequentially connected, the preamplifier module is connected with the electrocardio electrode slice through a guide line, and the electrode slice is arranged on the surface of the human body skin and used for collecting the electrocardio signals of the human body.

Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

The invention discloses a method for acquiring the imaging data of a neuro navigation system, which comprises the following steps of: acquiring scanned images in a functional magnetic resonance imaging mode, wherein the functional magnetic resonance imaging mode comprises BOLD scan cortex functional imaging and DTI scan alba functional imaging; transmitting the scanned images according to DICOM and classifying and converting the scanned images; and according to category, and carrying out the registration and fusion of the neuro navigation structural images and the converted scanned images, wherein the registration and fusion comprises the registration mapping of BOLD activation maps and the fusion of DTI maps. Therefore, the neuro functional images are registered and fused in neuro navigation, cerebral white matter fiber tracks is carried out and used as image data of the neuro navigation system so as to provide a powerful tool for making surgical plan before a surgery and protecting normal brain functions in the surgery and to provide a platform for brain function research.

A non-invasion system for measuring the blood pressure and waveform of arteria radialis on wrist of hand is disclosed. It can be used to monitor blood pressure, variation of cardiac rhythm, automatic nerve function, the waveform and frequency of respiration, cough, sneeze, etc and recognize the identity of person.

The invention discloses a pure idea nerve muscle electrical stimulation control and nerve function evaluation system which comprises a signal collecting module, a signal processing module and an instruction control module. The signal collecting module is used for collecting input electroencephalogram signals and other physiological signals in real time; the signal processing module is used for reading the electroencephalogram signals, carrying out feature extracting through a cospace model algorithm, and carrying out mode recognition on feature data through a support vector machine to obtain a decision value; according to the decision value and the decision value threshold vale range, an idea imagination mode is judged and transmitted to the instruction control module; the instruction control module is used for converting the idea imagination mode into a trigger nerve muscle electrical stimulator switch so that nerve muscle electrical stimulation can be carried out on the limb part of a user. The system has the advantages of high stability and adaptation, and lays the foundation for the large-scale application stage of an idea control system, and it is hopeful to obtain considerable social benefits and economic benefits.

The present invention discloses method and apparatus of detecting, exciting and regenerating sensation, motor and internal organ signals of vertebrate including human, and is especially one kind microelectronic system aided nerve channel function recovering method and apparatus. The nerve channel function recovering apparatus includes two parts, one part for the function reconstruction of the ascending nerve channel and the other part for the function reconstruction of the descending nerve channel. The weak electric signal of the damaged nerve tract or nerve fiber is detected with detecting electrodes, amplified, recognized and extracted to generate controlled electric exciting signal for exciting the damaged nerve tract or nerve fiber to regenerate corresponding nerve signal and restore the function of the damaged nerve tract or nerve fiber micro electronically.

The invention belongs to the technical field of medicine and relates to purple perilla seed oil fat emulsion injecta being rich in omega-3 fatty acid and a preparation method thereof. The purple perilla seed oil fat emulsion injecta comprises 5 to 30 percent of refined purple perilla seed oil, 0.5 to 7.5 percent of an emulsifying agent, 1.4 to 3.6 percent of glycerin, 0 to 0.5 percent of EDTA-2Na, 0 to 0.5 percent of an antioxidant, 0.1 percent of hydrochloric acid or sodium hydroxide with the pH being 6.0 to 8.5 and the residual amount of water for injection. The purple perilla seed oil fat emulsion injecta has good stability and can avoid side effect caused by the metabolism of fat emulsion which is rich in omega-3 fatty acid. The injecta of the invention is the fat emulsion injecta with natural refined purple perilla seed oil, which can be sent for high-temperature sterilization and provide human bodies with energy to keep the factors needed by brain and nerve functions. The injecta has the functions of anti-thrombus and antiatheroscloresis, canceration prevention, inhabitation of tumour cells transfer and inhabitation of abnormalism symptoms.

The invention discloses a hand five-finger rehabilitation training and correction device and relates to the technical field of rehabilitation devices. An upper box body and a lower box body are connected in a matched mode, a containing cavity is formed in the inside, a hand training mechanism is fixed to the upper box body, prime mover mechanisms are arranged in the containing cavity and transfer power to the hand training mechanism through a transmission mechanism, the hands are driven to perform rehabilitation training. The hand five-finger rehabilitation training and correction device is provided with two different prime mover mechanisms, adopts hand-cranking and motor hybrid drive and provides active, passive and cooperated training modes, the designed hand-cranking drive is used for healthy limb training and promoting rehabilitation of a hand nerve function and a double-side cooperated function, a more simplified parallel six-rod mechanism is adopted, and the actual holding rule of the hands is greatly recovered. Quick and convenient dismounting of a drive rod and adjustment of a drive rod installing position are achieved through exercise and limiting of a secondary slide block, thus the exercise angles of knuckles are adjusted in a certain range, and the hand five-finger rehabilitation training and correction device achieves the purposes of meeting different rehabilitation training demands and achieving personalized training.

A method for cryo-induced renal neuromodulation includes applying cryoenergy to neural fibers that contribute to renal function, or to vascular structures that contact, feed or perfuse the neural fibers. In one embodiment, cryoenergy is applied via a distal energy-delivering section of a flexible catheter. The distal section may include a plurality of microtubes for transporting a cryogen to the distal tip. The energy-delivering section contacts and extracts heat from the wall of the renal artery. In one embodiment, the distal energy-delivering section is radially expandable. The renal nerve is cooled to a degree such that nerve function is disrupted.

Disclosed are an EEG and ERPs based brain cognitive nerve function assessment system and method. The brain cognitive nerve function assessment system includes a behavioral data acquisition subsystem,an electrocephalogram signal acquisition subsystem and a data analysis report subsystem. The behavioral data acquisition subsystem outputs behavior codes to the electrocephalogram signal acquisition subsystem. The electrocephalogram signal acquisition subsystem outputs the behavior codes and electrocephalogram signals to the analysis subsystem. The behavioral data acquisition subsystem includes test scheme of stimulus presentation software. The test scheme includes an early screening / diagnosis scheme for clinical brain diseases and a test scheme for testing multi-domain cognitive ability of ahuman brain. The assessment method of the EEG and ERPs based brain cognitive nerve function assessment system includes the following steps: debugging of software and hardware equipment before testing;sequential completion of all test links; and data analysis and analysis report outputting. The EEG and ERPs based brain cognitive nerve function assessment system and method realize a major breakthrough in the field of EEG and ERPs based brain cognition, enter a clinical application stage, and expand the application from single brain disease to the whole society.

A device based on a liquid metal and used for repairing a defective peripheral nerve function comprises a concentric sleeve structure formed by an outer pipe and an inner pie, wherein a nerve growth promotion substance is filled in the inner pipe, a liquid metal material is filled in a channel between the outer wall of the inner pipe and the inner wall of the outer pipe, and conductive nanometer materials are placed in two ends; or the device comprises a multichannel catheter which is provided with a plurality of axial channels, wherein the bore diameter of an inner side channel of the multichannel catheter is larger than that of the outer side channel, the nerve growth promotion substance is filled in the inner side channel, the liquid metal material is filled in the middle of the outer side channel, and the conductive nanometer materials are placed in two ends; or the device comprises a hollow sheet structure body, wherein one side of the structure body is coated with the nerve growth promotion substance, the liquid metal material is filled in the middle of a hollow part, the conductive nanometer materials are placed in two ends, and the liquid metal material is gallium, a gallium indium alloy or a gallium indium and tin alloy. The device is used for repairing the defective peripheral nerve function, can promote nerve growth, and maintains a signal transmission function of a never regeneration process.

The invention relates to a Chinese medicament health product for supplementing female hormone for women during menopause. The Chinese medicament health product comprises the oral medication raw materials of epimedium herb, radix paeoniae alba, raspberry, motherwort, angelica sinensis, fructus corni, yerbadetajo herb, polygala, wolfberry fruit, placenta hominis, fructus ligustri lucidi, radix polygoni multiflori, dodder, broomrape, semen boitae, rhizoma anemarrhenae, mulberries, rhizoma curculiginis, prepared rhizome of rehmannia, semen zizyphi spinosae, rhizoma cyperi, fructus tritici levis, tuckahoe, Chinese dage and flos albiziae, and external-use raw materials of common cnidium fruit, rhizoma ligustici wallichii, epimedium herb, caulis spatholobi, cortex albiziae, phellodendron bark, red sage root, tuber fleeceflower stem, mother-of-pearl, red raspberry and herba leonuri. The Chinese medicament health product can stimulate adrenal hyperblastosis, improve the level of female hormone, obviously adjust the vegetative nerve function, reduce endocrine disequilibrium, improve psychataxia and maintain homergy, and all the medicaments are compatible with one another to achieve effects of warming the kidney, benefiting yin, and regulating and tonifying yin and yang.

The invention relates to a rat leg motion reconstruction test method based on spinal nerve function electrical stimulation. Corresponded three-dimensional coordinates based on spinal segments are established while rat spinal cord is focused, a tester can find out an electrode implanting position rapidly and accurately, and the success rate of tests is increased; excitation pulses are transmitted to two electrodes inserted into the rat spinal cord alternately, coherent stretching motions of the rat leg can be implemented, and the tester can grasp the process of rat spinal cord electrical stimulation more directly; meanwhile, the electromyographic signals of rat leg muscles can be collected through an electromyographic monitor and are used for comparison and analysis. By the aid of test method, the rat leg stretching motion reconstruction based on the spinal nerve function electrical stimulation can be completed, and important significance is provided for the fields of scientific research and teach; the operating ability of the tester is improved, the tester can grasp complex spinal cord stimulation tests which are difficult to grasp more easily, and the further academic research of the tester can be benefited.

The present invention is one kind of Chinese medicine composition for treating cerebral hemorrhage and is preparation process. The Chinese medicine composition consists of effective components from motherwort, giant knotweed, leech, gentian, and buffalo horn or rhinoceros horn; and may be prepared into medicine powder, tincture, capsule, tablet, micro pill and other forms. The Chinese medicine composition has the function of promoting blood circulation to disperse blood clots, and can alleviate hemorrhagic apoplexy cerebral edema, promote the absorption of hematoma and disease focus repair, improve the ischemic and anoxic state of nerve tissue around hematoma, protect damaged brain cell and promote restoring of the nerve function.

The present invention relates to a device for examining nerve function. In order to examine the function of a nerve of the human body, the device for examining nerve function of the present invention includes: at least one stimulator for stimulating the human body; and a stimulator-fixing member having a form corresponding to the hands or feet of the human body, wherein the stimulator is located at one side of the simulator-fixing member so as to fix the stimulator to the hands or feet of the human body. The device for examining nerve function of the present invention further includes at least one blood-circulation detection sensor fixed at the stimulator-fixing member. According to the present invention, since the degree of hypoesthesia is examined through the stimulation of the stimulator, test accuracy and reliability may be greatly improved and it is possible to systematically and actively determine a diagnosis and course of treatment for a patient having diabetes or spinal nerve damage, e.g. hypoesthesia.

The invention relates to the field of medicine, and discloses a novel application of stilbene compounds in preparation of drugs for curing ischemia stroke in the acute phase. The effective time windows of rhubarb stilbene glucoside and piceatannol can last for 6 hours; the rhubarb stilbene glucoside and piceatannol can decrease the water content in the rat brain tissues during the cerebral ischemia process of a rat, and improve the rat nerve function scores. The mechanism is that rhubarb stilbene glucoside and piceatannol have strong functions of oxidation resistance and clearance of oxygen free radicals, and have a brain protection function. The piceatannol has stronger functions of oxidation resistance and clearance of oxygen free radicals than those of the rhubarb stilbene glucoside in vitro. So the invention provides applications of rhubarb stilbene glucoside and piceatannol in preparation of drugs for curing ischemia stroke in the acute phase.

A composition having autonomic nerve function regulating action, comprising sesamin and / or episesamin as an active ingredient, is provided.

The invention discloses a medicine compound for curing rheumatism rheumatoid arthritis and a preparation method thereof. The medicine compound contains more than 50 kinds of traditional Chinese medicine, such as radix angelicae tuhuo, ramulus mori, Gentiana macrophylla, asarum, Clematis chinensis, Caulis Trachelospermi, wild aconite root, radix aconiti lateralis preparata, earthworm, attacus altisima, scorpion, and the like. The medicine compound of the invention is mainly used for thrombolysis, depressurization, relieving rheumatic pains, nourishing vitality and relaxing vein, relaxing the muscles, stimulating the blood circulation, and adjusting the immunity of human body. The medicine compound has unique effect in curing anemofrigid-damp arthralgia, arthralgia and myalgia, deficiency of the kidney, female blood-insufficiency, hemiplegia, lumbar vertebra and cervical vertebra. Besides the medicine compound has the effect of recovering the nerve function which the other medicines cannot reach. The medicine compound of the invention has obvious effect on curing rheumatism rheumatoid arthritis and paralysis caused by rheumatism, is free from toxic side effect, takes effect quickly and is convenient to use without boiling.

The present invention discloses a thrombolysis oligopeptide-imidazolidine binary conjugate, a preparation method and uses thereof. According to the present invention, L-Lys is adopted as a linking arm to link 1,3-dioxy-2-[(4-oxyacetic acid)phenyl]-4,4,5,5-tetramethylimidazoline, ARPAK having a thrombolysis effect, GRPAK, RPAK or PAK to obtain the thrombolysis oligopeptide-imidazolidine binary conjugate represented by a formula I or II, wherein the thrombolysis oligopeptide-imidazolidine binary conjugate integrally has characteristics of nanometer structure, BBB crossing, thrombolysis and NO removing. The thrombolysis oligopeptide-imidazolidine binary conjugate has high NO free radical clearance activity, excellent thrombolysis activity and excellent antithrombosis activity. In vivo anti-stroke activity test results show that: with the thrombolysis oligopeptide-imidazolidine binary conjugate, nerve functions of stroke rats can be effectively protected, brain infarct volume of the stroke rats can be reduced, excellent anti-stroke activity is provided, and the thrombolysis oligopeptide-imidazolidine binary conjugate can be prepared into a clinical drug for brain infarction treatment.

The present invention relates to novel peptide derivatives, which are recognized as ligands to G-coupled protein receptor proteins. The peptide of the present invention can be used in (1) development of a receptor binding assay system using the expression system of the recombinant receptor protein and screening of candidates for pharmaceutical compounds, and (2) development of pharmaceutical preparations such as a neutral nerve function regulator, a circulatory function regulator, a cardiac function regulator, an immune function regulator, a digestive organ function regulator, a metabolic function regulator, a generative organ regulator or the like.

The present invention belongs to a Chinese traditional medicine preparation in medical preparation product for curing sequela of cerebral paralysis; the preparation is made of the following raw materials of Chinese traditional medicines with corresponding weight portions of 6 portion to 12 portion of zhinanxing, 6 portion to 12 portion of pinellia tuber, 4 portion to 8 portion of giant typhonium tuber, 10 portion to 20 portion of chuanxiong rhizome, 6 portion to 12 portion of body of Buthus martensii, 15 portion to 25 portion of earthworm, 10 portion to 20 portion of tall gastrodia tuber, 15 portion to 25 portion of clematis, 10 portion to 20 portion of white caltrop, 40 portion to 60 portion of milk vetch roots, 10 portion to 20 portion of magnolia officinalis, 15 portion to 25 portion of trifoliate orange fruit, 15 portion to 25 portion of roots of red salvia, 10 portion to 20 portion of flagleaf, 15 portion to 25 portion of Tuckahoe, 15 portion to 25 portion of milkwort roots, 15 portion to 25 portion of codonopsis pilosula, 5 portion to 7 portion of safflowers, 10 portion to 20 portion of ledeboruiella root, 10 portion to 20 portion of myrrh, 7 portion to 11 portion of gynura segetum and 15 portion to 20 portion of sapanwood. The present invention of the preparation contains active components which can stimulate the impaired brain cells and recover the function of the cells through blood-brain barrier; at the same time, the preparation can repair the impaired nerves and recover the impaired blood-brain barrier to protect the brain tissue and improve the nerve function of patients; the preparation can promote the absorption of encephalic hematoma and reduce the disability rate; in this way, people can recover normal living and working capability and the present invention is a good medicine for curing sequela of cerebral paralysis.

The present technology relates generally to the field of electrophysiology and specifically to automated devices, components, systems, and related methods for monitoring potential injury to the nervous system using evoked potentials during intraoperative neurophysiologic monitoring.

The invention belonging to the cell biology and pharmacology technical field relates to the purpose of a Chinese traditional medicine monomeric compound, in particularly to the new purpose of a protocatechuic acid in the aspect of promoting the external proliferation and induction-differentiation of a nerve stem cell. The invention is characterized in the application of producing medicine to treat the neurodegenerative diseases by nerve stem cell transplantation, in the application of producing neurenergen and cell differential agent for restoring damaged nerve tissues and reconstructing nerve functions, and in the application of constructing high efficient medical screening model to initially screen and appraise the efficacy of medicine. The invention confirms the new phamacoloic activity of the protocatechuic acid, providing material basis with regard to prevention effect of the Chinese traditional medicine, and providing reference for the development of new medicine with independent intellectual property rights.