38 results about "Nerve function" patented technology

The invention relates to the technical field of spinal cord injury repair, and discloses a multi-mode nerve regulation electric acupuncture control system for spinal cord injury repair, a patient evaluation module is used for establishing a personalized spinal cord injury model of a patient and evaluating the current nerve function state and rehabilitation potential of the patient to obtain a nerve function evaluation result; the parameter setting module is used for setting multi-modal stimulation parameters in electroacupuncture treatment; the signal processing module is used for collecting local field potential of a spinal cord injury area and electromyographic signals around the injury in real time, preprocessing the collected signals and extracting time-frequency characteristics of the signals. The evaluation module is used for inputting the time-frequency characteristics of the signals into an electro-acupuncture evaluation model, evaluating the neural pathway in real time through the electro-acupuncture evaluation model and outputting an evaluation result; the adjusting module is used for adjusting the frequency, waveform and current intensity parameters of the electroacupuncture needle based on the evaluation result and a Q-learning algorithm, searching an optimal electroacupuncture needle parameter combination and feeding back the optimal electroacupuncture needle parameter combination to the electroacupuncture needle; according to the invention, the pertinence and effectiveness of treatment are improved.

A system for longitudinal assessment of nerve health includes a stimulator to deliver electrical stimuli proximate a target nerve, a sensor to detect muscle responses evoked by the stimuli, a display, and a processor in communication with the stimulator, sensor, and display. The processor controls delivery of the stimuli; determines, from the detected muscle response, one or more nerve-function parameters for the target nerve including at least a stimulation threshold; stores the parameters with a session identifier; retrieves parameters from multiple sessions to compute a longitudinal trend; and controls the display to present the trend together with an indication of the target nerve's status relative to a target range. The system supports objective session-to-session tracking to inform clinical decisions.

The invention, which relates to the technical field of medical training, discloses a multi-sensory feedback fusion stroke rehabilitation exoskeleton robot training system comprising an exoskeleton robot main body, a multi-sensory feedback module, and a motion state monitoring module. By integrating a multi-sensory feedback module, a visual, auditory, tactile and motion state monitoring module and a central control module, multi-dimensional sensory stimulation and real-time data acquisition are realized when a patient is trained, and the central control module adapts parameters in the module according to the real-time motion precision of the patient and personalization. The strength and the type of multi-sensory feedback are dynamically adjusted, meanwhile, motion parameters of an exoskeleton robot body are controlled, a dynamic adjustment mechanism ensures pertinence and effectiveness of training, forward feedback is provided to strengthen a correct motion mode when the motion precision of a patient is high, and correction prompt is provided and assistance or resistance of the robot is adjusted when the motion deviation is large. Therefore, nerve function remodeling and motor ability recovery are effectively promoted.

The invention provides an individualized anesthesia optimization method and system based on transcranial magnetic stimulation-induced electroencephalogram, and relates to the technical field of medical equipment control. According to the technical scheme provided by the invention, the target phase window corresponding to the electroencephalogram rhythm frequency band is predicted by using the autoregression model, and the target stimulation moment is accurately calculated according to the inherent delay of the stimulation equipment, so that closed-loop phase-locked stimulation of the transcranial magnetic pulse is triggered in a specific phase state; and it is ensured that the collected electroencephalogram response signals can accurately reflect cortical function characteristics of an individual in a specific nerve excitation state. Multi-dimensional biological characteristics are extracted from electroencephalogram response signals, an anesthesia reaction prediction model is input to calculate the individualized anesthesia reaction index, individual nerve function differences are fully considered in an anesthesia optimization scheme generated based on the individualized anesthesia reaction index, and compared with a traditional evaluation method of population statistics, the evaluation method has the advantages that the evaluation accuracy is high, and the evaluation efficiency is high. The accuracy of anesthesia response evaluation is remarkably improved, and therefore the accuracy of an anesthesia scheme can be improved.

The invention discloses an intelligent voice rehabilitation training management system. The system comprises an intra-hospital local area server, a preoperative risk assessment module, an intra-operative neural function assessment module, an acoustic assessment module and an individualized rehabilitation training scheme making module. The system is in butt joint with intraoperative nerve monitoring equipment to collect electromyographic signals in real time, and multi-modal fusion analysis is carried out in combination with preoperative / postoperative acoustic parameters and spectrograms. The system utilizes a deep learning model to predict the noise disorder risk and the recovery trajectory at different time points after the operation; three-dimensional training navigation is constructed based on postoperative time, neurological function parameter changes and vocational voice requirements, a rehabilitation path is dynamically optimized by adopting near-end strategy optimization reinforcement learning, and training intensity and content are adjusted in a closed-loop mode through auditory feedback; closed-loop management of preoperative evaluation, intraoperative monitoring, postoperative evaluation, individualized rehabilitation and follow-up visit optimization is achieved, and the accuracy and timeliness of voice function protection and rehabilitation are improved.

The preparation method comprises the following steps: by taking an oriented polylactic acid nanofiber membrane as a raw material, carrying out homogenization treatment to obtain polylactic acid piezoelectric short fibers; gelMA is used as a skeleton matrix, polylactic acid short fibers, LAP and DRG cells are compounded, a 0 / 90-degree alternate grid structure scaffold is constructed through pneumatic extrusion type biological printing, and the dual-network piezoelectric biological scaffold is formed through blue light crosslinking curing. The piezoelectric effect of polylactic acid short fibers is activated through ultrasonic stimulation, mechanical energy is converted into local electric signals, loaded DRG cells are directly driven to secrete CGRP in situ, macrophages are dynamically regulated and controlled to be polarized to M2 anti-inflammatory phenotypes, nerve-immune microenvironment disorder of diabetic bone defects is corrected, vascularization and bone regeneration are promoted, and the diabetic bone defect treatment effect is improved. The problems of short delivery half-life period of traditional cell factors, difficulty in nerve function reconstruction and chronic inflammation caused by non-degradable piezoelectric materials are solved, and non-invasive and degradable precise bone repair is realized.

The invention relates to a cranial nerve motor function evaluation system and method based on a terminal with a camera. The system comprises a camera used for collecting a high-definition video sequence of facial actions; the model is used for identifying positioning points of the face according to the high-definition video sequence acquired by the camera; the analysis and evaluation module is used for quantitatively evaluating the cranial nerve motor function state according to the change of the positioning points of the face acquired by the model; the analysis and evaluation module performs analysis and evaluation according to the change quantitative indexes of the positioning points of the face; the camera, the model and the analysis and evaluation module are all deployed at the terminal; and the model and the analysis and evaluation module are deployed in an operating system of the terminal. The evaluation system and method are deployed on a common terminal, and are used for collecting a video sequence of a user completing a standard evaluation action, automatically identifying the movement of a positioning point of a face, and outputting a quantitative score according to a medical standard so as to evaluate human face muscle movement and a cranial nerve function state.

The present application relates to a fluorescence sensing composite deep electrode, belonging to the field of medical devices, and comprising: a tube body, on the outer part of which several annular electrodes are sequentially arranged along the axial direction, each annular electrode is connected with an electrode wire, and one end of the tube body is a closed end; several optical fiber sensors are also arranged on the tube body, the optical fiber sensors include a detection end and a transmission end, and the detection end is used for detecting the fluorescence generated when a fluorescent indicator acts on metal ions during the neuron activity process; the ends of the electrode wires far away from the annular electrodes and the transmission ends of the optical fiber sensors are led out from the end of the tube body far away from the closed end. The fluorescence sensing composite deep electrode provided by the present application can collect and monitor the electroencephalogram signals, metal ion concentration and distribution in the monitoring area in real time, synchronously and in the same position in the fields of neurosurgery and cerebrospinal nerve function research, and improves the monitoring accuracy of nerve activities and the diagnosis accuracy and efficiency of the lesions of nervous system diseases.

The invention relates to the technical field of neural rehabilitation, in particular to a neural rehabilitation method based on ultrasonic waves, which comprises the following steps: acquiring a real-time rehabilitation effect index when a target neural area excites nerve excitability to the maximum, and performing fusion analysis on the real-time rehabilitation effect index based on a pre-trained rehabilitation evaluation model to obtain a neural rehabilitation result. A neural function recovery degree quantitative score is obtained; and dynamically comparing the quantitative score of the neural function recovery degree with a preset rehabilitation threshold value, and when the quantitative score of the neural function recovery degree does not reach the preset rehabilitation threshold value, automatically triggering an optimization compensation mechanism of the ultrasonic stimulation. By setting the preset rehabilitation threshold value, when the effect does not reach the standard, an optimized compensation mechanism of ultrasonic stimulation is automatically triggered, the need of manual intervention is reduced, and the continuity and effect of treatment are improved.

A system and computer-implemented method for intraoperative assessment of nerve health. A processor determines a nerve function parameter from an electrically evoked muscle response to stimulation proximate to a nerve. The processor generates an individualized, predictive target range by accessing a database of historical patient data, identifying a subset of patients with pre-operative characteristics similar to those of the subject, and defining the target range based on intraoperative nerve function measurements associated with successful post-operative outcomes in that subset. A display presents the determined nerve function parameter relative to the individualized target range to provide real-time guidance. The system can integrate intraoperative imaging to concurrently display anatomical and functional information. A predictive model used to generate the target range is refined over time by incorporating outcomes from additional patients, enabling continuous improvement of the assessment.

The utility model discloses a fresh air device capable of providing negative oxygen ions, and relates to the technical field of fresh air devices, the fresh air device comprises a fresh air ventilator case, the front side of the fresh air ventilator case is clamped with a quick release cover plate, and the right side of the fresh air ventilator case is provided with a negative oxygen ion generating mechanism; partition plates are fixedly mounted on the left sides and the right sides of the inner walls of the fresh air ventilation cases correspondingly, and a rhombic heat exchange core is slidably mounted between the opposite faces of the two fresh air ventilation cases. According to the fresh air ventilator, the fresh air ventilator case and the negative oxygen ion generating mechanism are matched with each other, so that the fresh air ventilator can filter and ventilate indoor air and convey negative oxygen ions into a room at the same time, propagation of bacteria and viruses in the air is reduced through the negative oxygen ions, the indoor sanitation level is improved, metabolism of a human body is promoted, and the health of the human body is improved. The immunity is enhanced, and the nerve function is regulated, so that the body fatigue is relieved, the sleep quality is improved, and the ventilation quality of the fresh air ventilator is better.

A transcutaneous magnetic stimulation (tMS) device is provided for modulating nerve function and chronic pain management, and includes a tMS stimulator, a control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module to receive, generate and transmit feedback and control settings relating to a treatment session. The tMS stimulator may be a flexible figure-of-eight coil configured in different sizes and shapes to provide varying pulse and magnetic field strengths for mobile, home, or clinical uses, and also include guidance tools and measurement sensors to aid in positioning and directing the tMS stimulator to a target area for treatment.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The invention relates to the technical field of electrocardiosignal analysis, and discloses an autonomic nerve function evaluation method based on a phase whole sequence signal averaging technology, and the method comprises the steps: selecting a plurality of deceleration anchor points and / or acceleration anchor points from a plurality of sequence values of a heart beat interval sequence of a first to-be-detected object; for each deceleration anchor point / acceleration anchor point, selecting a deceleration sequence segment / acceleration sequence segment corresponding to each deceleration anchor point / acceleration anchor point from the heart beat interval sequence of the first to-be-tested object; averaging values with the same sequence in the plurality of deceleration sequence segments / acceleration sequence segments to obtain a deceleration signal sequence / acceleration signal sequence of the first to-be-detected object; performing power spectral density analysis on the deceleration signal sequence / acceleration signal sequence of the first to-be-detected object to obtain a deceleration index / acceleration index of the first to-be-detected object; and evaluating the autonomic nerve function of the first to-be-tested object according to the deceleration index and / or the acceleration index of the first to-be-tested object. The autonomic nerve function can be evaluated more accurately.

A method of performing bronchial denervation of a bronchus having bronchial nerves along a portion thereof is provided. The method includes providing a cryoablation device having multiple electrodes capable of delivering electrical energy and measuring impedance. At least one bronchial nerve is stimulated with electrical energy. The electrical signals from the at least one bronchial nerve are recorded to provide a first value representative of nerve function. Cryogenic treatment energy is applied to form ice in the bronchus having a thickness to encapsulate the at least one bronchial nerve to cause a reduction in nerve function. The at least one bronchial nerve is restimulated with electrical energy. The electrical signals are recorded from the restimulated at least one bronchial nerve to provide a second value that represents diminished nerve function. The first value and the second value are compared to provide an assessment of the reduction in nerve function.

1. Name of the design product: Digital vibration perception threshold detector. 2. Use of the design product: Used to detect the vibration perception threshold of the subject and provide objective and accurate values for clinical judgment of sensory nerve function. 3. Design key points of the design product: Lies in the shape. 4. Picture or photo that best shows the design key points: Stereogram.

The invention discloses a three-layer nerve conduit based on cell-loaded near-field direct-writing printing and a preparation method and application thereof, and is characterized in that the inner layer of the three-layer nerve conduit is a cell-loaded ALG / GelMA / PEO hydrogel stent, the middle layer is a PVA / GelMA electrostatic spinning membrane, and the outer layer is a fused near-field direct-writing PCL stent; the preparation method comprises the following steps: preparing an ordered fiber membrane PVA / GelMA from a spinning solution through electrostatic spinning, adding the ordered fiber membrane PVA / GelMA into an acetone / glutaraldehyde solution to obtain a PVA / GelMA electrostatic spinning membrane, and printing a direct-writing PCL support on any single surface of the electrostatic spinning membrane through fusion near-field direct-writing. The preparation method comprises the following steps: preparing an ordered cell-loaded hydrogel scaffold from cell-containing bio-ink through cell-loaded near-field direct writing printing, and finally preparing the three-layer nerve conduit, and the three-layer nerve conduit has the advantages of accelerating axon growth, promoting myelin sheath regeneration and improving nerve function recovery.

This invention discloses a functional electrical stimulation rehabilitation aid for stroke, belonging to the field of medical rehabilitation aid technology. It includes an electrical stimulation component, a walking component, a height adjustment component, a body support adjustment component, and a rehabilitation component. This device integrates the electrical stimulation component, the body support adjustment component, and the lower limb rehabilitation training component into one unit, overcoming the limitations of traditional devices that separate head electrical stimulation from limb training. It transmits precise electrical signals to the head's nerve function areas through flexible electrode pads within the helmet, directly promoting the repair and regeneration of damaged nerves. Furthermore, the servo motor-driven linkage mechanism in the rehabilitation component simulates human gait, achieving passive training of lower limb joints and muscles. This eliminates the need for patients to transfer between multiple devices, reducing physical exertion and avoiding safety risks during transfers, making it particularly suitable for acute-phase patients with weak limb mobility.

The invention discloses an intelligent nerve regulation and control method based on acoustic-magnetic pairing, and the method comprises the steps: enabling sound stimulation and transcranial magnetic stimulation to form paired stimulation, and introducing real-time motor evoked potential feedback; a closed-loop process from baseline acquisition and TMS intensity parameter determination, paired associated stimulation delay parameter optimization, personalized treatment scheme implementation, and curative effect evaluation and verification of RMT changes is constructed. The nerve excitability is dynamically monitored by using the objective electrophysiological indexes, so that the stimulation parameters are always personalized, the regulation and control precision is remarkably improved, and the traceability and quantification of the curative effect are ensured. According to the intelligent nerve regulation and control method based on acoustic-magnetic pairing provided by the invention, the target nerve pathway can be effectively regulated and controlled by reasonably designing paired association and delay parameters of sound stimulation and TMS stimulation, nerve function reconstruction and rehabilitation treatment are realized, and the method has the advantages of simplicity and convenience in operation, automatic parameter adjustment, safety and reliability.

The application is suitable for the fields of high-end flexible sensing preparation and multi-modal sensing detection technology, and provides a patch type ultrasonic biomarker integrated sensor and a detection method.The sensor comprises a patch type ultrasonic transducer array, which is used for real-time monitoring of muscle and bone diseases, realizes multi-parameter multi-modal data information fusion detection and analysis of muscle and bone structure-function, a microneedle electrode array, which is used for in-situ detection of biomarkers and collection of physiological electrical signals, a flexible electronic circuit, which is used for bearing and connecting the patch type ultrasonic transducer array and the microneedle electrode array, and an acoustic coupling adhesive layer, which is used for skin fitting and acoustic coupling.The application can systematically evaluate the structure, mechanics, metabolic inflammation level and nerve function activity coordination of muscle and bone, provides a new means for early identification, quantitative evaluation and personalized intervention of muscle and bone diseases, and has important clinical and industrial values.

The utility model relates to the technical field of medical instruments, in particular to a multipurpose nerve monitoring drag hook which comprises an embedded fixing part, a handheld part, a connecting part and a U-shaped drag hook body which are sequentially connected and integrally formed. The embedded fixing part, the handheld part, the connecting part and the U-shaped drag hook are hollow, a wire is arranged in the embedded fixing part, the wire is connected with the nerve detector through the wire connecting part, an opening is formed in the front end of the U-shaped drag hook, and the wire is arranged outside the opening. The multi-purpose nerve monitoring drag hook can replace a nerve drag hook to help to pull and dissect a nerve, and meanwhile, the multi-purpose nerve monitoring drag hook has the effect of continuously outputting stimulation current, so that the function of monitoring the nerve function is achieved, functional damage of the nerve in the pulling and dissecting process is prevented, and the operation efficiency is improved.

The application provides a double-oriented composite nerve sheath and a preparation method thereof, and belongs to the field of medical materials. The composite nerve sheath comprises a dense wall layer of collagen fiber axial orientation arrangement and a loose stent layer with an axial orientation interconnecting pore structure. The wall layer is prepared by electrochemical deposition directional guidance of self-assembly of type I collagen protein, the oriented collagen fiber simulates the tissue structure of the nerve epineurium, is beneficial to rapid formation of dense epineurium and other outer layer structures, can guide precise matching of the port nerve bundle, and is beneficial to complete recovery of nerve function. The stent layer provides active sites and proliferation space for cell adhesion, is beneficial to directional and rapid growth of nerve cells, and the oriented interconnecting pore can directionally guide migration of nerve cells, so that directional growth of the nerve axis is guided, and the repair rate and effect are improved.

The present application belongs to the field of biomaterial technology, and specifically relates to a nerve repair scaffold and a preparation method thereof. The nerve repair scaffold is a hollow double-shell fiber structure, the outer layer of the double-shell fiber structure is composed of PCL nanofiber filaments, the inner layer of the double-shell fiber structure includes PCL-dECM fiber filaments, and the PCL-dECM fiber filaments are PCL fiber filaments loaded with dECM. The PCL-dECM fiber filaments of the inner layer are arranged along the axial direction of the double-shell fiber structure. After implantation, the nerve repair scaffold can improve the recovery of nerve function and improve biocompatibility.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The application discloses a method and device for predicting nerve function based on imageomics, electronic equipment and storage medium. The method comprises the following steps: acquiring magnetic resonance imaging; constructing a first neural network model using a two-dimensional convolution architecture, a three-dimensional convolution architecture, an encoder and a decoder, and segmenting the magnetic resonance imaging using the first neural network model to obtain an image of a region of interest; extracting features of the image of the region of interest to obtain feature data of the magnetic resonance imaging; screening the feature data by combining a filtering method and an embedding method; constructing a second neural network model using a one-dimensional convolution architecture, a gated recurrent module and a full connection architecture, and predicting nerve function according to the screened feature data using the second neural network model. The application is a brand-new method for predicting nerve function based on imageomics, and realizes the function of predicting the nerve function retention after surgery before surgery.

A method for assessing nerve health during a surgical procedure includes: applying one or more electrical stimuli proximate to the target nerve during the surgical procedure; detecting a muscle response evoked by the one or more electrical stimuli; determining at least one nerve function parameter indicative of the health or function of the target nerve; identifying a target range for the at least one nerve function parameter adapted for the target nerve, the target range being predictive of a desired nerve health status of the target nerve; and outputting an indication of the determined at least one nerve function parameter relative to the identified target range to provide real-time feedback during the surgical procedure involving the target nerve.

The invention relates to the technical field of medical equipment, and discloses a portable acupuncture and massage electromagnetic head therapeutic apparatus which comprises a bottom plate, an adjusting mechanism is fixedly installed on one side of the upper portion of the bottom plate, and the adjusting mechanism comprises a moving assembly and an adjusting assembly and is used for moving and adjusting the device according to the requirements of a user. The output end of the adjusting mechanism is fixedly connected with a head cover, a vibration communication mechanism is arranged outside the head cover, the vibration communication mechanism comprises a vibration assembly and a communication assembly and is used for assisting a user in massage treatment, and a massage mechanism is arranged in the head cover and is used for massaging the user. The massage mechanism comprises a massage heating assembly, a sensing assembly and an electrotherapy assembly. The head condition is monitored in real time through the miniature scanner and the myoelectricity sensor, data are transmitted to the control screen, then the electrode slices correspond to the temples, the effect similar to acupuncture and moxibustion is achieved through electromagnetic signals, the nerve function is adjusted, and multifunctional integration of massage, hot compress and electrotherapy is achieved.

A method for intraoperative guidance during a surgical procedure involving a nerve includes receiving real-time image data from an intraoperative imaging modality, the real-time image data depicting anatomical structures within an intracorporeal treatment area including the nerve; determining at least one nerve function parameter indicative of nerve health; and controlling a display device to concurrently present a visual output comprising both a visual representation derived from the real-time image data and a visual indication of the determined at least one nerve function parameter. The concurrently presented visual output facilitates assessment of the nerve relative to the anatomical structures during the surgical procedure.

The present application relates to a kind of magnetic stimulation coil nerve function detection and regulation method and system, wherein, method includes by control circuit driving capacitor discharges to double-path stimulation coil, generate millisecond-level pulse magnetic field;Utilize the pulse magnetic field and act on nerve tissue, produce including nerve regulation effect of suprathreshold stimulation and subthreshold stimulation;Real-time acquisition is induced by pulse magnetic field stimulation and is produced evoked potential signal;Analysis the evoked potential signal, calculate nerve conduction time and excitation inhibition ratio;According to nerve conduction time and excitation inhibition ratio adjustment double-path stimulation timing and / or capacitor discharge parameter, carry out the detection and coordination regulation of nerve function, to realize the purpose of real-time detection, quantitative evaluation and adaptive accurate regulation to nerve function.

The invention discloses ultrasonic response hydrogel for treating spinal cord injury as well as a preparation method and application of the ultrasonic response hydrogel. The ultrasonic response hydrogel comprises fibroin / polyvinyl alcohol / carboxymethyl cellulose hydrogel and sodium niobate piezoelectric nanoparticles blended in the fibroin / polyvinyl alcohol / carboxymethyl cellulose hydrogel. According to the ultrasonic response hydrogel, synergistic treatment of spinal cord injury in different stages is achieved through a single system, in the acute stage after the spinal cord injury, ultrasonic is applied to activate sodium niobate nanoparticles to catalyze water molecules to generate hydrogen and oxygen in situ, the high-penetrability hydrogen can play a global anti-inflammatory role, and the high-penetrability oxygen can play a role in treating spinal cord injury. Oxygen is used for accurately relieving the anoxic microenvironment of the damaged core area; in the recovery period, a bionic electrical stimulation signal can be efficiently conducted by combining a conductive network formed by the conductive hydrogel with micro-current continuously generated by the piezoelectric nanoparticles under ultrasound, and metabolism and electrical activity of nerve cells can be effectively regulated, so that long-term reconstruction of nerve functions is promoted.