Intelligent nerve regulation and control method based on acoustic-magnetic pairing

Abstract

The invention discloses an intelligent nerve regulation and control method based on acoustic-magnetic pairing, and the method comprises the steps: enabling sound stimulation and transcranial magnetic stimulation to form paired stimulation, and introducing real-time motor evoked potential feedback; a closed-loop process from baseline acquisition and TMS intensity parameter determination, paired associated stimulation delay parameter optimization, personalized treatment scheme implementation, and curative effect evaluation and verification of RMT changes is constructed. The nerve excitability is dynamically monitored by using the objective electrophysiological indexes, so that the stimulation parameters are always personalized, the regulation and control precision is remarkably improved, and the traceability and quantification of the curative effect are ensured. According to the intelligent nerve regulation and control method based on acoustic-magnetic pairing provided by the invention, the target nerve pathway can be effectively regulated and controlled by reasonably designing paired association and delay parameters of sound stimulation and TMS stimulation, nerve function reconstruction and rehabilitation treatment are realized, and the method has the advantages of simplicity and convenience in operation, automatic parameter adjustment, safety and reliability.

Description

Technical Field

[0001] The present invention belongs to the technical field of neural regulation, and specifically relates to an intelligent neural regulation method based on acoustic-magnetic pairing. Background Art

[0002] In recent years, the application of non-invasive neuromodulation technology in the treatment of brain dysfunction has attracted much attention. With the continuous deepening of our understanding of neural structure and function, various technologies such as magnetic stimulation, electrical stimulation, and ultrasonic stimulation have emerged one after another. However, how to use multimodal stimulation to achieve precise control of brain nerves still faces major challenges. Traditional single stimulation methods have certain limitations in terms of control efficiency, safety, and depth of action. Multimodal paired stimulation methods can enhance the treatment effect by leveraging the synergistic effects between different stimulation modes, while reducing adverse reactions such as muscle fatigue. Because the brain state is characterized by real-time dynamic changes, it is particularly important to design control methods that can automatically detect the brain state and adjust intervention parameters (such as stimulation intensity and delay settings) in real time. In addition, existing technologies also have shortcomings in precisely controlling neural circuits and regulating nerve conduction efficiency. Summary of the Invention

[0003] The present invention is proposed to address the above-mentioned shortcomings, and its purpose is to provide an intelligent neural regulation method based on acoustic-magnetic pairing. This method achieves precise regulation of neural pathways by rationally designing the pairing of sound stimulation and transcranial magnetic stimulation (TMS) and their delay parameters, and automatically adjusts the stimulation parameters according to the neural response.

[0004] In order to achieve the above purpose, the present invention adopts the following scheme: An intelligent neural control method based on acoustic-magnetic pairing includes the following steps: Multiple single-pulse transcranial magnetic stimulations are continuously applied to the target brain area. The intervals between adjacent single-pulse transcranial magnetic stimulations are set within a preset random time range. The intensity of transcranial magnetic stimulation is gradually increased to record motor evoked potentials. The minimum transcranial magnetic stimulation intensity that can produce a preset amplitude motor evoked potential in the target muscle is determined as the resting motor threshold (RMT). Based on the resting motor threshold (RMT), multiple pairs of stimulation consisting of sound stimulation and transcranial magnetic stimulation were administered in groups. In each pair of stimulation, the delay between the sound stimulation and transcranial magnetic stimulation was randomly set according to multiple preset discrete delay parameters. The delivery time, delay parameters, and corresponding motor evoked potentials of each pair of stimulation were synchronously recorded. Compare the changes of motor evoked potential under various preset discrete delay parameters, and select the delay parameter that causes the maximum change of motor evoked potential as the optimal delay parameter; According to the optimal delay parameters and preset stimulation intensity, therapeutic sound stimulation and transcranial magnetic stimulation are paired interventions on the target brain area. During the intervention process, the stimulation parameters and corresponding motor evoked potentials of the therapeutic sound stimulation and transcranial magnetic stimulation paired interventions are monitored and recorded in real time; After completing the paired intervention of therapeutic sound stimulation and transcranial magnetic stimulation, multiple single-pulse transcranial magnetic stimulations were repeatedly applied to obtain the resting motor threshold after the intervention. The resting motor threshold after the intervention was compared with the resting motor threshold before the intervention to evaluate the neuromodulatory effect.

[0005] Furthermore, the specific method of continuously applying multiple single-pulse transcranial magnetic stimulations to the target brain area is: using a transcranial magnetic stimulation device to continuously apply no less than 20 single-pulse transcranial magnetic stimulations to the target brain area, and the interval between two adjacent single-pulse transcranial magnetic stimulations is randomly set within the time range of 10000ms to 12500ms.

[0006] Furthermore, the stimulation intensity of the first single-pulse transcranial magnetic stimulation was set to 30%-35% of the maximum output power of the transcranial magnetic stimulation device, and was increased by no more than 3%-5% of the maximum output power after each subsequent single-pulse transcranial magnetic stimulation until it reached 100% output.

[0007] Furthermore, the minimum transcranial magnetic stimulation intensity required to produce a 50 μV peak-to-peak amplitude motor evoked potential in the target muscle was determined as the resting motor threshold (RMT).

[0008] Furthermore, the paired stimulation consisting of sound stimulation and transcranial magnetic stimulation was divided into several clusters, and a rest interval was set between two adjacent clusters.

[0009] Furthermore, several pairs of paired stimulations consisting of sound stimulation and transcranial magnetic stimulation were continuously performed in each cluster, and the delay parameter between the sound stimulation and transcranial magnetic stimulation in each pair of paired stimulations was randomly set to 25ms, 50ms, 75ms or 100ms.

[0010] Furthermore, a random time interval within the range of 10000ms-12500ms is set between the execution of two adjacent pairs of stimulation consisting of sound stimulation and transcranial magnetic stimulation.

[0011] Furthermore, when performing multiple pairs of paired stimulation consisting of sound stimulation and transcranial magnetic stimulation, the stimulation intensity of transcranial magnetic stimulation was set to 80%-85% of the resting motor threshold.

[0012] Furthermore, according to the optimal delay parameters, when therapeutic sound stimulation and transcranial magnetic stimulation are implemented in pairs on the target brain area, the preset stimulation intensity is 110%-120% of the resting motor threshold.

[0013] Furthermore, the resting motor threshold after intervention was compared with the resting motor threshold before intervention. If the resting motor threshold after several prognoses was reduced by 10%-20% compared with the resting motor threshold before intervention, it was considered to have achieved a therapeutic effect.

[0014] Compared with the prior art, the present invention has the following beneficial effects: First, the intelligent neuromodulation method based on acoustic-magnetic pairing provided by this invention effectively modulates target neural pathways, achieving neurological function reconstruction and rehabilitation therapy through the rational design of paired associations between sound stimulation and TMS stimulation and their timing parameters. This method offers advantages such as ease of operation, automatic parameter adjustment, and safety and reliability, providing a novel and effective technical approach for the clinical treatment of brain dysfunction and the development of personalized neuromodulation programs.

[0015] Secondly, the intelligent neuromodulation method based on acoustic-magnetic pairing provided by this invention pairs sound stimulation with transcranial magnetic stimulation (TMS) and introduces real-time motor evoked potential (MEP) feedback. This establishes a closed-loop process from baseline acquisition and TMS intensity parameter determination, to paired-association stimulation delay parameter optimization, personalized treatment plan implementation, and efficacy evaluation and verification of RMT changes. Dynamic monitoring of neural excitability using objective electrophysiological indicators ensures that stimulation parameters are always personalized, significantly improving control precision and ensuring traceability and quantification of efficacy.

[0016] Third, by delivering no fewer than 20 consecutive single-pulse TMS bursts, with the stimulation intervals randomly set between 10,000 and 12,500 ms, the present invention can collect sufficient samples to obtain statistically reliable resting motor thresholds (RMTs). The larger random intervals avoid short-term cumulative plasticity and muscle fatigue, while also lowering subjects' psychological expectations of the rhythm and minimizing behavioral interference.

[0017] Fourthly, the present invention divides the paired stimulation of sound stimulation and transcranial magnetic stimulation into several clusters, and adds rest segments between the clusters, which can effectively buffer the cortical over-inhibition and muscle fatigue caused by long-term stimulation; at the same time, it leaves a real-time processing window for the system algorithm, making the parameter adaptive adjustment more relaxed and stable.

[0018] Fifth, the present invention randomly selects discrete delays of 25ms, 50ms, 75ms, or 100ms for each pair of sound stimulation and transcranial magnetic stimulation, allowing it to cover critical physiological time windows within a limited number of experiments. The introduction of random order reduces sequence effects, helps quickly identify the optimal synergistic time difference, and improves delay screening efficiency.

[0019] Sixth, the present invention inserts a random interval of 10,000 ms–12,500 ms between two adjacent pairs of paired stimuli, which is consistent with the timing of the single-pulse test, further eliminating the cumulative plasticity interference and ensuring the independence and reliability of each MEP measurement.

[0020] In summary, the present invention is an intelligent neuroregulatory method based on acoustic-magnetic pairing: sound stimulation is paired with transcranial magnetic stimulation (TMS) in a specific way to selectively induce long-term potentiation (LTP) or long-term depression (LTD) effects of synapses, thereby promoting brain neural remodeling and realizing a regulatory method for automated detection, regulation and intervention of various brain dysfunctions; the whole process dynamically adjusts the stimulation strategy through real-time MEP and RMT data to adapt to individual neural state fluctuations and achieve closed-loop self-adaptation; interval randomization, intensity increment and segmented rest design are adopted in many places to significantly reduce the heat accumulation of TMS coil, muscle fatigue of the subjects and the risk of accidental excitement, and ensure safe tolerance; the effect is judged by changes in RMT and MEP to achieve a measurable, comparable and traceable efficacy evaluation method. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 Schematic diagram of optimization of paired stimulation delay parameters in an embodiment of the present invention; Figure 2 Schematic diagram of the timing design of a single stimulation cluster in an embodiment of the present invention. DETAILED DESCRIPTION

[0022] The following describes the implementation of the present invention in detail with reference to the examples, but they do not limit the present invention and are merely examples. At the same time, the advantages of the present invention will become clearer and easier to understand.

[0023] The present invention provides an intelligent neural control method based on acoustic-magnetic pairing, comprising the following steps: Multiple single-pulse transcranial magnetic stimulations are continuously applied to the target brain area. The intervals between adjacent single-pulse transcranial magnetic stimulations are set within a preset random time range. The intensity of transcranial magnetic stimulation is gradually increased to record motor evoked potentials. The minimum transcranial magnetic stimulation intensity that can produce a preset amplitude motor evoked potential in the target muscle is determined as the resting motor threshold (RMT). Based on the resting motor threshold (RMT), multiple pairs of stimulation consisting of sound stimulation and transcranial magnetic stimulation were performed in groups. In each pair of stimulation, the delay between the sound stimulation and transcranial magnetic stimulation was randomly set according to multiple preset discrete delay parameters, and the delivery time, delay parameters, and corresponding motor evoked potentials of each pair of stimulation were synchronously recorded. Compare the changes of motor evoked potential under various preset discrete delay parameters, and select the delay parameter that causes the maximum change of motor evoked potential as the optimal delay parameter; According to the optimal delay parameters and preset stimulation intensity, therapeutic sound stimulation and transcranial magnetic stimulation are paired interventions on the target brain area. During the intervention process, the stimulation parameters and corresponding motor evoked potentials of the therapeutic sound stimulation and transcranial magnetic stimulation paired interventions are monitored and recorded in real time; After completing the paired intervention of therapeutic sound stimulation and transcranial magnetic stimulation, multiple single-pulse transcranial magnetic stimulations were repeatedly applied to obtain the resting motor threshold after the intervention. The resting motor threshold after the intervention was compared with the resting motor threshold before the intervention to evaluate the neuromodulatory effect.

[0024] In the above technical solution, the specific method of continuously applying multiple single-pulse transcranial magnetic stimulations to the target brain area is: using a transcranial magnetic stimulation device to continuously apply no less than 20 single-pulse transcranial magnetic stimulations to the target brain area, and the interval between two adjacent single-pulse transcranial magnetic stimulations is randomly set within the time range of 10000ms to 12500ms.

[0025] In the above technical solution, the stimulation intensity of the first single-pulse transcranial magnetic stimulation is set to 30%-35% of the maximum output power of the transcranial magnetic stimulation device, and after each subsequent single-pulse transcranial magnetic stimulation, it is increased by no more than 3%-5% of the maximum output power until it reaches 100% output.

[0026] In the above technical solution, the minimum transcranial magnetic stimulation intensity required to produce a 50 μV peak-to-peak amplitude motor evoked potential in the target muscle is determined as the resting motor threshold.

[0027] In the above technical solution, the paired stimulation consisting of sound stimulation and transcranial magnetic stimulation is divided into several clusters, and a rest interval is set between two adjacent clusters.

[0028] In the above technical solution, several pairs of paired stimulations consisting of sound stimulation and transcranial magnetic stimulation are continuously executed in each cluster, and the delay parameters between the sound stimulation and transcranial magnetic stimulation in each pair of paired stimulations are randomly set to 25ms, 50ms, 75ms or 100ms.

[0029] In the above technical solution, a random time interval within the range of 10000ms-12500ms is set between the execution of two adjacent pairs of stimulations consisting of sound stimulation and transcranial magnetic stimulation.

[0030] In the above technical solution, when performing delay parameter screening of multiple pairs of paired stimulations consisting of sound stimulation and transcranial magnetic stimulation, the stimulation intensity of transcranial magnetic stimulation is set to 80%-85% of the resting motor threshold.

[0031] In the above technical solution, according to the optimal delay parameters, when therapeutic sound stimulation and transcranial magnetic stimulation are implemented in pairs on the target brain area, the preset stimulation intensity is 110%-120% of the resting motor threshold.

[0032] In the above technical solution, the resting motor threshold after intervention is compared with the resting motor threshold before intervention. If the resting motor threshold after a certain prognosis is reduced by 10%-20% compared with the resting motor threshold before intervention, it is considered that the treatment effect has been achieved.

[0033] Example: The intelligent neural control method based on acoustic-magnetic pairing of this embodiment specifically includes the following steps: (1) Phase 1: Baseline acquisition and TMS intensity parameter determination Twenty single-pulse stimulations were delivered using a TMS device, with the interstimulus interval randomly controlled between 10,000 and 12,500 ms. Initial stimulation intensity was 30% of the stimulator's maximum output, and after each stimulation, the intensity was increased by 3% of maximum output until it reached 100%. Motor evoked potentials (MEPs) were recorded via surface electromyography (sEMG) with each TMS stimulation. After completing 20 stimulations, the system adjusted the TMS output to the minimum intensity required to produce an MEP with a peak-to-peak amplitude of 50 μV in the patient's target muscle, which determines the resting motor threshold (RMT). After the stimulation ended, the system automatically entered the next phase after a 10,000 ms wait.

[0034] (2) The second stage: Optimization of the delay parameters of paired-association stimulation Stimulation was divided into four clusters, with 20 pairs of paired associative stimulation within each cluster (80 pairs total), with a 20-second interval between clusters to prevent muscle fatigue. Each pair consisted of a sound stimulus (500 Hz, 110 dB, 50 ms) and a TMS stimulus (set to 80% of the RMT intensity). The delay between the sound and TMS stimuli was randomly selected from one of four options: 25 ms, 50 ms, 75 ms, or 100 ms. Each delay was administered 20 times. The interval between each pair of stimulations was randomly controlled between 10,000 ms and 12,500 ms. The system automatically recorded the duration, type, and delay parameters of each stimulation to facilitate subsequent efficacy evaluation and mechanism studies. Based on these randomly selected delay parameter pairs, the motor cortex on one side was stimulated with different delays. The delay parameter that resulted in the highest motor evoked potential amplitude in the target muscle was selected as the optimal delay parameter and used to adjust the parameters for subsequent interventions in the target brain region.

[0035] The control system automatically records the timing of each stimulation, the type of stimulation (sound or TMS), and the distribution of different delay pairings. This data provides a detailed basis for subsequent efficacy evaluation and mechanism studies. By pairing sound and TMS stimulation and precisely controlling the optimal delay between them, precise control of target brain regions is achieved, maximizing the synergistic effect of the two stimulation modalities. The randomized time interval design and stimulation cluster grouping strategy effectively prevent psychological and muscle fatigue caused by continuous stimulation, ensuring patient safety and comfort. The entire process is controlled by a microcomputer or single-chip microcomputer, using TTL level triggering and a built-in random function to generate random delays. The system also records the type and absolute timing of each stimulation, providing reliable data support for subsequent statistical analysis and efficacy evaluation. The system automatically records and analyzes the motor evoked potential amplitudes obtained for each pairing parameter across the four stimulation clusters. The delay parameter that elicits the greatest motor evoked potential change is determined as the optimal delay parameter for the patient's personalized delay combination of acoustic-magnetic paired intervention.

[0036] Phase 3: Implementation of personalized treatment plan Based on the results of the first two phases of testing, the optimal stimulation intensity (set to 120% of RMT) and optimal delay parameters were determined. Then, 100 pairs of paired-association stimulation interventions were implemented. During the stimulation process, the system monitored the patient's status and MEP changes in real time and automatically recorded all data for subsequent effect evaluation.

[0037] Phase IV: Efficacy evaluation to verify RMT changes Repeat the single-pulse TMS stimulation process from the first phase, re-measure the TMS intensity required to achieve RMT after the intervention, and collect MEP data again. Statistically compare the changes in RMT and MEP amplitude before and after the intervention to verify the effectiveness of this method in neuromodulation and neural remodeling. Compare the resting motor threshold after the intervention with the resting motor threshold before the intervention. A therapeutic effect is considered achieved if the resting motor threshold after several prognoses is reduced by 10%-20% compared to the pre-intervention resting motor threshold. If a therapeutic effect is not achieved, adjust the delay parameters again.

[0038] The intelligent neuromodulation method based on acoustic-magnetic pairing, provided by this invention, effectively modulates target neural pathways through the rational design of paired associations between sound stimulation and TMS stimulation, as well as their timing parameters, achieving neurological function reconstruction and rehabilitation therapy. This method offers advantages such as ease of use, automatic parameter adjustment, and safety and reliability, providing a novel and effective technical approach for the clinical treatment of brain dysfunction and the development of personalized neuromodulation programs.

[0039] The above is only a specific embodiment of the present invention. It should be pointed out that any changes or substitutions that can be easily thought of by any technician familiar with the field within the technical scope disclosed by the present invention should be covered by the protection scope of the present invention. The rest not described in detail are prior art.

Claims

1. An intelligent neural control method based on acoustic-magnetic pairing, characterized by: The steps include: Multiple single-pulse transcranial magnetic stimulations are continuously applied to the target brain area. The intervals between adjacent single-pulse transcranial magnetic stimulations are set within a preset random time range. The intensity of transcranial magnetic stimulation is gradually increased to record motor evoked potentials. The minimum transcranial magnetic stimulation intensity that can produce a preset amplitude motor evoked potential in the target muscle is determined as the resting motor threshold (RMT). Based on the resting motor threshold (RMT), multiple pairs of stimulation consisting of sound stimulation and transcranial magnetic stimulation were performed in groups. In each pair of stimulation, the delay between the sound stimulation and transcranial magnetic stimulation was randomly set according to multiple preset discrete delay parameters, and the delivery time, delay parameters, and corresponding motor evoked potentials of each pair of stimulation were synchronously recorded. Compare the changes of motor evoked potential under various preset discrete delay parameters, and select the delay parameter that causes the maximum change of motor evoked potential as the optimal delay parameter; According to the optimal delay parameters and preset stimulation intensity, therapeutic sound stimulation and transcranial magnetic stimulation are paired interventions on the target brain area. During the intervention process, the stimulation parameters and corresponding motor evoked potentials of the therapeutic sound stimulation and transcranial magnetic stimulation paired interventions are monitored and recorded in real time; After completing the paired intervention of therapeutic sound stimulation and transcranial magnetic stimulation, multiple single-pulse transcranial magnetic stimulations were repeatedly applied to obtain the resting motor threshold after the intervention. The resting motor threshold after the intervention was compared with the resting motor threshold before the intervention to evaluate the neuromodulatory effect.

2. The intelligent neural control method based on acoustic-magnetic pairing according to claim 1, characterized in that: The specific method of continuously applying multiple single-pulse transcranial magnetic stimulations to the target brain area is: using a transcranial magnetic stimulation device to continuously apply no less than 20 single-pulse transcranial magnetic stimulations to the target brain area, and the interval between two adjacent single-pulse transcranial magnetic stimulations is randomly set within a time range of 10,000 ms to 12,500 ms.

3. The intelligent neural control method based on acoustic-magnetic pairing according to claim 2, characterized in that: The stimulation intensity of the first single-pulse transcranial magnetic stimulation was set to 30%-35% of the maximum output power of the transcranial magnetic stimulation device, and increased by no more than 3%-5% of the maximum output power after each subsequent single-pulse transcranial magnetic stimulation until it reached 100% output.

4. The intelligent neural control method based on acoustic-magnetic pairing according to claim 3, characterized in that: The minimum transcranial magnetic stimulation intensity required to produce a 50 μV peak-to-peak amplitude motor evoked potential in the target muscle was determined as the resting motor threshold.

5. The intelligent neural control method based on acoustic-magnetic pairing according to any one of claims 1 to 4, characterized in that: The paired stimulation consisting of sound stimulation and transcranial magnetic stimulation was divided into several clusters, and a rest interval was set between two adjacent clusters.

6. The intelligent neural control method based on acoustic-magnetic pairing according to claim 5, characterized in that: Several pairs of sound stimulation and transcranial magnetic stimulation were performed continuously in each cluster, and the delay parameters between sound stimulation and transcranial magnetic stimulation in each pair of stimulation were randomly set to 25ms, 50ms, 75ms or 100ms.

7. The intelligent neural control method based on acoustic-magnetic pairing according to claim 6, characterized in that: A random time interval between two adjacent pairs of sound stimulation and transcranial magnetic stimulation was set within the range of 10,000 ms to 12,500 ms.

8. The intelligent neural control method based on acoustic-magnetic pairing according to claim 7, characterized in that: When performing multiple pairs of stimulation consisting of sound stimulation and transcranial magnetic stimulation, the stimulation intensity of transcranial magnetic stimulation was set to 80%-85% of the resting motor threshold.

9. The intelligent neural control method based on acoustic-magnetic pairing according to claim 8, characterized in that: According to the optimal delay parameters, when therapeutic sound stimulation and transcranial magnetic stimulation are implemented in paired intervention on the target brain area, the preset stimulation intensity is 110%-120% of the resting motor threshold.

10. The intelligent neural control method based on acoustic-magnetic pairing according to claim 9, characterized in that: The resting motor threshold after intervention was compared with the resting motor threshold before intervention. If the resting motor threshold after intervention was reduced by 10%-20% compared with the resting motor threshold before intervention, it was considered to have achieved therapeutic effect.

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