15 results about "Nerve excitability" patented technology

The invention relates to the technical field of brain-computer interfaces, and particularly discloses a fusion system combining a brain-computer interface with transcranial electrical stimulation and a feedback stimulation method. The fusion system comprises a main machine part, an auxiliary machine part, a PCB substrate, a terminal integrated receiver and a feedback calculation module. The host part comprises an electroencephalogram signal acquisition device and a transcranial electrical stimulation device which are both installed on a PCB substrate. The auxiliary machine part comprises an MCU and a first wireless device which are both installed on the PCB substrate. The auxiliary machine part further comprises a battery which is connected to the MCU, the electroencephalogram signal collecting device and the transcranial electrical stimulation device. The terminal integrated receiver has a second wireless device. And the terminal integrated receiver is connected to the feedback calculation module. According to the fusion system, the electroencephalogram signal acquisition device and the transcranial electrical stimulation device are combined to acquire brain waves and feed back and adjust transcranial electrical stimulation parameters, so that nervous excitability can be better induced, and an electroencephalogram value is enhanced.

This invention discloses a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its applications, relating to the fields of functional foods and nutritional health technology. The composition includes jujube seed extract, lily extract, poria cocos extract, polygonum multiflorum extract, arborvitae seed extract, clove extract, γ-aminobutyric acid (GABA), theanine, magnesium glycine, and L-glycine. This invention utilizes GABA to reduce nerve excitability; theanine to help improve relaxation; jujube seed extract to enhance sleep stability; glycine to lower core body temperature; and magnesium glycine to stabilize the nervous system. Its improving effects are manifested in: improving NREM sleep quality, enhancing sleep continuity, promoting deep sleep recovery, and reducing drowsiness the following day. It achieves the technical effects of shortening sleep onset time, increasing the proportion of deep sleep, reducing the number of nighttime awakenings, and improving the feeling of sleep recovery.

The invention discloses a system for radiofrequency ablation renal sympathetic nerve removal and nerve excitability measurement, and relates to the technical field of medical instruments. The device comprises a control handle, the end of the control handle is connected with a guide pipe, the free end of the guide pipe is connected with a bent section, and the upper portion of the control handle is rotationally connected with an adjusting handle; the ablation monitoring unit is connected to the tail end of the control handle through a cable and used for monitoring and controlling the ablation temperature; and the nerve excitability monitoring unit is connected to the bottom end of the control handle through a cable and is used for monitoring nerve excitability. By adopting a mode of combining temperature sensor acquisition and nerve excitability monitoring, real-time and visual nerve excitability change feedback and temperature feedback are provided for doctors, the ablation effect is accurately judged in an assisted manner, and the operation flexibility and safety are improved.

The invention provides an umami peptide without nervous excitatory toxicity and a preparation process and application thereof, the umami peptide is extracted from broad bean protein, and the amino acid sequence is shown as SEQ ID NO.1 and / or SEQ ID NO.2. Compared with a traditional umami substance-sodium glutamate (monosodium glutamate MSG), the umami peptide has the characteristics of activating umami receptors TAS1R1 / TAS1R3 without acting on sodium glutamate receptors such as NMDA and the like, and has the advantages that the umami peptide can be used for preparing the umami peptide. No NMDA receptor mediated excitatory neurotoxicity exists; meanwhile, the umami peptide can stimulate intestinal endocrine cells (STC-1) to secrete GLP-1.

The invention provides a duodenum ablation system and method combined with three-dimensional reconstruction. The duodenum ablation system combined with three-dimensional reconstruction comprises a main control unit, a three-dimensional reconstruction module, an intelligent ablation planning module, a neurological function surveying and mapping module, an ablation execution device and a real-time monitoring and feedback control module, through an integrated intracavity electrical stimulation surveying and mapping technology, functional evaluation and mapping can be performed on nerve excitability of a target area before ablation, and a'nerve high-risk area 'is visually marked on a three-dimensional mucous membrane model. When the system performs automatic path planning, the areas can be actively avoided, or verified safe energy parameters are adopted in the areas, so that important intestinal nerve functions are protected to the greatest extent, and the risk of nerve injury related complications is reduced from the source. Therefore, the purposes of intelligent navigation, automatic planning, individualized self-adaptive control and functional nerve protection are achieved.

The invention discloses a composition for improving emotion and sleep and a preparation method, and the composition for improving emotion and sleep comprises the following components in parts by weight: 10-30 parts of a ginseng extract, 100-300 parts of gamma-aminobutyric acid, 50-150 parts of tea leaf theanine, and 50-200 parts of a spina date seed extract. The ginsenoside Rg1 + Rb1 in the ginseng extract is greater than or equal to 3%, the purity of gamma-aminobutyric acid is greater than or equal to 99%, the purity of theanine in tea leaves is greater than or equal to 98%, and the saponin content in the spina date seed extract is greater than or equal to 2%; the composition inhibits secretion of stress hormone through a multi-target synergistic effect, regulates nervous excitability and prolongs a deep sleep period, and is used for relieving mild and moderate anxiety, improving difficulty in falling asleep and improving sleep quality. According to the invention, the problems of single effect, dependence risk, slow effect and the like of the existing product can be solved, and the double effects of emotion regulation and sleep improvement are integrated.

The invention discloses an intelligent nerve regulation and control method based on acoustic-magnetic pairing, and the method comprises the steps: enabling sound stimulation and transcranial magnetic stimulation to form paired stimulation, and introducing real-time motor evoked potential feedback; a closed-loop process from baseline acquisition and TMS intensity parameter determination, paired associated stimulation delay parameter optimization, personalized treatment scheme implementation, and curative effect evaluation and verification of RMT changes is constructed. The nerve excitability is dynamically monitored by using the objective electrophysiological indexes, so that the stimulation parameters are always personalized, the regulation and control precision is remarkably improved, and the traceability and quantification of the curative effect are ensured. According to the intelligent nerve regulation and control method based on acoustic-magnetic pairing provided by the invention, the target nerve pathway can be effectively regulated and controlled by reasonably designing paired association and delay parameters of sound stimulation and TMS stimulation, nerve function reconstruction and rehabilitation treatment are realized, and the method has the advantages of simplicity and convenience in operation, automatic parameter adjustment, safety and reliability.

According to the method, initialization of the pulse neural network is meta-learned by introducing an excitation-suppression balance mechanism constrained by the Deler law, and internal representation widely applicable to many small sample tasks is constructed. In order to ensure that the Thevener's law is strictly obeyed in the synaptic weight updating process, an improved projection gradient descent method is combined with synaptic plasticity, so that the nervous excitability and inhibition characteristics are kept unchanged. According to the invention, an excitation-suppression balance mechanism constrained by the Devener's law is introduced into pulse element learning, and a small sample pulse element learning method based on excitation-suppression balance under the constraint of the Devener's law is provided. In order to enhance the stability and generalization of pulse element learning, a multi-step weighted loss strategy is further developed to guide the element learning of the pulse neural network. The small sample pulse element learning method based on excitation-suppression balance under the constraint of the Devener's law is superior to an early element learning method based on an artificial neural network in some specific tasks, and is completely superior to MAML of a pulse version.

The invention discloses a PFA technology-based dual-channel drive intelligent sleep-aiding pillow, which comprises a pillow, the pillow is provided with a high-voltage and low-frequency generation device and a power supply, the power supply supplies power to the high-voltage and low-frequency generation device, and the high-voltage and low-frequency pulse generation device is used for outputting high-voltage and low-frequency pulse signals. More than two groups of electrode pairs are arranged on the high-voltage low-frequency pulse generating device, are arranged on the surface of the pillow and are positioned at the Fengchi acupoint. Compared with the prior art, more than two groups of electrode pairs are arranged at the position of the Fengchi acupoint of the pillow, each group of electrode pairs corresponds to one Fengchi acupoint, and high-voltage and low-frequency pulsed electric field stimulation is applied to the Fengchi acupoints and peripheral nerves through the high-voltage and low-frequency pulse generator, so that nervous excitability is reduced, sleep is induced, and sleep quality is improved.

The invention belongs to the technical field of medical treatment, and discloses a lumbar muscle degeneration rehabilitation treatment auxiliary device and system, and the device comprises an intelligent infrared light treatment module, a low-frequency electrical stimulation module, a biological feedback monitoring module, and an intelligent control and APP remote management module. Far infrared light (FIR), low-frequency electrical stimulation (EMS) and a biofeedback sensing technology are combined, the system can accurately act on a diseased region, and intelligent and personalized treatment is achieved. Due to the dual effects of infrared light and TENS, inflammatory response and nervous excitability are effectively reduced. Near-infrared light promotes ATP synthesis, the cell repairing capacity is improved, and the rehabilitation time is shortened by about 30%. Muscle functions are improved, relapse is prevented, muscle strength is improved through EMS low-frequency electrical stimulation, muscle atrophy is reduced, and the relapse rate is reduced. And a biological feedback system is intelligently regulated and controlled, so that the treatment accuracy is improved. Remote monitoring is achieved, compliance is improved, a patient can be treated at home and does not need to see a doctor frequently, and medical cost is reduced.

The invention discloses an ultrasonic and electrical stimulation dual-positioning regional anesthesia puncture guiding method and device. The method comprises the following steps: constructing a multi-modal space-time synchronous coordinate system, acquiring sound wave echoes of an ultrasonic transducer array and electrophysiological impedance signals of a conductive tip of a puncture needle, mapping the sound wave echoes and the electrophysiological impedance signals into a data matrix and a response vector, and executing pixel-level space-time registration; inversely calculating a functional effective distance by using a neural excitability model, and generating a virtual space constraint envelope containing a safety retardation and risk early warning area; projecting the envelope to an ultrasonic imaging plane, and overlapping and displaying the visual boundary and the dynamic warning map to generate a fused guide image; the relative position of the needle point track and the envelope is monitored in real time, and when an early warning area is intruded or the distance is out of tolerance, electrical stimulation waveform parameters are automatically adjusted, and the warning state is synchronously updated. The regional anesthesia puncture guiding method solves the technical problems that according to a regional anesthesia puncture guiding method in the prior art, multi-modal data space-time registration is lacked, and functional safety boundary visualization is poor.

The invention discloses marathon energy gel containing a composite electrolyte and high caffeine. According to the main formula (in terms of each part), the capsule comprises 4g of dry gelatin, 0.1 g of gellan gum, 15g of maltodextrin, 7-9g of fructose, 10g of glucose, 300mg of table salt, 150mg of potassium chloride, 25mg of magnesium chloride, 200mg of caffeine, 300mg of taurine, vitamin B as an auxiliary material, and 20mL of water. Through the formula of the composite electrolyte, the requirement of endurance exercise can be met without additionally supplementing salt pills, and the added magnesium element is beneficial to preventing muscle spasm; high-dose caffeine and taurine have a synergistic effect, so that the nervous excitability and the athletic performance are remarkably improved, and the performance of marathon can be averagely improved by about 4 minutes and 50 seconds according to a test; and a gelatin-gellan gum composite colloid system is adopted, so that the beverage has the advantages of good taste and low cost.

This invention belongs to the field of medical technology, specifically relating to the use of a Sigma 1 receptor agonist combined with a GABAAR receptor modulator in the preparation of a pharmaceutical composition for the prevention and / or treatment of tinnitus. This type of pharmaceutical composition exerts an anti-tinnitus effect by synergistically regulating the Sigma 1 and GABAAR receptor pathways, improving imbalances in auditory central nervous system excitability, abnormal neuroplasticity, and related neuroinflammatory responses. In particular, the combination therapy provided by this invention can be used to treat neurodegenerative tinnitus and drug-induced tinnitus.

The invention discloses a stone needle electronic tank therapy instrument for rehabilitation therapy, which belongs to the technical field of electromagnetic physiotherapy and comprises a physiotherapy tank body, the physiotherapy tank body comprises a tank body, a dynamic conversion magnetic seat capable of moving along with air pressure is arranged in a conversion air cavity, and the bottom of the dynamic conversion magnetic seat is connected with an electric stimulation seat through a stand column. The bottom of the electrical stimulation base is provided with an electrical stimulation contact changing current according to pressure change, the side wall of the tank body is provided with an annular air cavity, an annular pneumatic ring is arranged in the annular air cavity, and the bottom of the annular pneumatic ring is provided with an air leakage ring simulating flash tank operation. According to the invention, blood circulation and metabolism are promoted by continuously releasing far infrared rays; ultrasonic waves are generated to conduct micro-vibration stimulation on acupuncture points, the permanent magnets move up and down along with air pressure, a changing magnetic field is generated, local ion flowing is affected, nervous excitability is reduced, pain is relieved, electric stimulation contacts automatically adjust current intensity according to pressure applied to the skin to activate meridians and nerve endings, and the multi-mode synergistic effect is achieved.

The invention discloses application of 40K enriched sylvite in preparation of a medicine for treating diseases related to low nervous excitatory network function, and belongs to the technical field of nuclear medicine and nerve disease treatment crossing. Functional nuclide compensation is taken as a core mechanism, medicinal sylvite with 40K isotope abundance of 0.05%-5% is adopted, the 40K decay frequency in neurons is improved, mild endogenous physical random disturbance is generated, standby neural pathways are activated and strengthened through oral administration in cooperation with low-potassium diet on the premise of safely controlling the radiation dosage and the blood potassium level, and accordingly the effect of preventing and treating the neurons is achieved. The neural network function is remodeled, so that the symptoms of neurodegenerative diseases such as Alzheimer's disease and vascular dementia and neuropsychiatric diseases such as depression and obsessive-compulsive disorder are improved. The invention breaks through the regulation and control limitation of a single neurotransmitter of the existing medicine, has a novel mechanism, is safe and controllable, can be combined with the existing therapy, and provides a brand new treatment scheme for diseases related to low neuroexcitatory network function.