4 results about "GABA receptor" patented technology

The present invention relates to a synergistic composition for the treatment of disorders related to central nervous system (CNS) excitability. The synergistic composition comprises combination of GABA receptor agonists and synaptic plasticity enhancer or salts thereof along with pharmaceutically acceptable excipients. The GABA receptor agonists are selected from the group consisting of 4-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanamido]butanoic acid, 4- (Pyridine-3-carbonylamino)butanoic acid and 4-(hexadecanoylamino)butanoic acid or salts thereof. The synaptic plasticity enhancer are selected from magnesium 2- acetamidoethanesulfonate, magnesium bis (2-aminoethane-1-sulfonate), magnesium;(2S,3R)- 2,3,4-trihydroxybutanoate, N-(2-Hydroxyethyl)hexadecanamide, 1-(4-aminobutyl)guanidine and 5'-inosinic acid or salts thereof.

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

This invention relates to the field of traditional Chinese medicine technology, and more particularly to a Jin medicine compound calming ointment that prolongs deep sleep and is non-addictive, as well as its preparation method. This invention is the first to use prolonging deep sleep duration as the core therapeutic target. The combined use of various herbs in this invention nourishes blood and calms the mind, nourishes yin and clears heat, and harmonizes the heart and kidneys, effectively treating insomnia caused by deficiency of heart and liver blood, disharmony between heart and kidneys, and yin deficiency with excessive fire. Furthermore, this invention, through the synergistic effect of multiple components, can effectively regulate the neurotransmitter GABA receptors, targeting and prolonging deep sleep, reducing the number of nighttime awakenings, fundamentally optimizing sleep structure, and also inhibiting excessive activation of the HPA axis, reducing abnormally elevated cortisol levels, thereby alleviating anxiety, breaking the vicious cycle of anxiety-insomnia, and effectively treating anxiety-related insomnia. Simultaneously, it has antioxidant effects, protects nerve cells, improves cerebral microcirculation, provides sufficient oxygen and nutrients to the brain, and creates a favorable physiological environment for the restoration of normal sleep rhythms.

The application discloses a woodfordioid toxic alkane type sesquiterpene CNA, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. The woodfordioid toxic alkane type sesquiterpene CNA compound of formula I is obtained by cold soaking, silica gel and gel column chromatography from Artocarpus styracifolius. The CNA compound has a new cis-hydrogenated indene core structure, contains nine continuous chiral centers and a highly crowded polycyclic skeleton feature, and has good biological activity. Cell experiments show that the woodfordioid toxic alkane type sesquiterpene CNA has signal transmission to endogenous and exogenous system GABA B receptor and can be used for preparing drugs for treating or preventing nervous system related diseases, and opens up a new direction for developing a new GABA B receptor antagonist or modulator and exploring a GABA receptor related treatment target and developing a nervous system disease drug.