18 results about "GABA receptor" patented technology

Provided are compositions and method for prophylaxis and / or therapy of hearing loss or related dysfunctions, including but not limited to tinnitus, that could be ameliorated by restoring central nervous system inhibitory synapses. The compositions include polynucleotides and viral vectors that are used to express at least one GABA receptor component which may be a GABAA receptor alpha 1 subunit or GABAR receptor Ib subunit. Expression of the GABA receptor may be under control of a CaMKII promoter.

In some embodiments, a composition comprising Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus plantarum, and Streptococcus thermophilus is provided. In some embodiments, provided is the use of a composition of any of the examples herein for preventing or alleviating anxiety and / or sensory hypersensitivity, preventing or treating autism spectrum disorder (ASD), anxiety disorder and / or gastrointestinal (GI) disorder or condition, enhancing attention and / or concentration, or stimulating a GABA receptor in a subject. In some embodiments, methods and kits are provided for preventing or alleviating anxiety and / or sensory hypersensitivity, preventing or treating autism spectrum disorders, anxiety disorders, and / or gastrointestinal disorders or conditions, enhancing attention and / or concentration, or stimulating GABA receptors in a subject. In certain embodiments, the compositions are safe to use and effective to prevent or alleviate anxiety and / or sensory hypersensitivity in subjects, particularly children subjects.

The present invention relates to a synergistic composition for the treatment of disorders related to central nervous system (CNS) excitability. The synergistic composition comprises combination of GABA receptor agonists and synaptic plasticity enhancer or salts thereof along with pharmaceutically acceptable excipients. The GABA receptor agonists are selected from the group consisting of 4-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanamido]butanoic acid, 4- (Pyridine-3-carbonylamino)butanoic acid and 4-(hexadecanoylamino)butanoic acid or salts thereof. The synaptic plasticity enhancer are selected from magnesium 2- acetamidoethanesulfonate, magnesium bis (2-aminoethane-1-sulfonate), magnesium;(2S,3R)- 2,3,4-trihydroxybutanoate, N-(2-Hydroxyethyl)hexadecanamide, 1-(4-aminobutyl)guanidine and 5'-inosinic acid or salts thereof.

The invention discloses a dampness-clearing sleep-aiding Tibetan foot bathing tablet and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations, the dampness-clearing sleep-aiding Tibetan foot bathing tablet is composed of a monarch drug group, a ministerial drug group, an adjuvant drug group, a conductant drug group and an auxiliary material group, and the preparation method comprises the following steps: step 1, crushing; step 2, weighing; step 3, extracting active ingredients; step 4, drying and powdering; step 5, total mixing; step 6, tabletting; step 7, inner packaging; and step 8, external packaging. Through the compatibility of monarch, minister, assistant and guide, the synergistic effect of dampness clearing and sleep aiding is realized, the monarch drug group and the adjuvant drug group synergistically regulate a dampness clearing pathway (AQP4 aquaporin + TRPV1 ion channel), the minister drug group and the guide drug group synergistically enhance the sleep aiding effect (GABA receptor activation + glutamic acid inhibition), and clinical experiments show that after the traditional Chinese medicine composition is used for 4 weeks, the effective rate of improving the dampness symptom reaches 80%, and the curative effect is good. And the sleep quality improvement rate reaches 82%.

The present application provides a propofol analogue, a preparation method thereof and application thereof in non-narcotic field. The propofol analogue has a structure as shown in general formula (G). The propofol analogue of the present application can greatly reduce or eliminate the affinity to GABA receptor, i.e. weaken or eliminate the narcotic property. It targets specific targets and shows effects in improving sleep, regulating blood pressure, relieving vomiting, resisting depression, protecting heart and brain, etc. (G).

The present invention belongs to the field of biotechnology and mainly relates to a LAMP detection primer and method for the mutation of the GABA receptor of the codling moth. The primers include a forward outer primer F3, a reverse outer primer B3, a forward inner primer FIP, a reverse inner primer BIP, a forward loop primer Loop-F, and a reverse loop primer Loop-B. Using the detection primers provided by the present invention, a rapid detection method for the A302S mutation of the GABA receptor of the codling moth can be established, and further determine whether the codling moth is resistant to abamectin. The LAMP detection primer set can be used for the detection of the mutation of the GABA receptor of the codling moth, with high sensitivity, a large detection range, and accurate and reliable results; the detection method is simple to operate, does not require nucleic acid extraction of the oriental fruit moth, has a short detection time, and the detection results are visualizable. The present invention can provide technical support for the resistance monitoring and early warning of the codling moth in the field, and also provide theoretical support for the integrated control of the oriental fruit moth.

The invention discloses an essential oil composition as well as a preparation method and application thereof. The composition comprises jasmine essential oil, torreya grandis essential oil and basil essential oil. The essential oil composition disclosed by the invention can induce the expression of sleep-related genes Gabra1 and Htr1a and promote sleep by improving the expression of a 5-HT receptor and a GABA receptor.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to a Jin medicine compound calming ointment that prolongs deep sleep and is non-addictive, as well as its preparation method. This invention is the first to use prolonging deep sleep duration as the core therapeutic target. The combined use of various herbs in this invention nourishes blood and calms the mind, nourishes yin and clears heat, and harmonizes the heart and kidneys, effectively treating insomnia caused by deficiency of heart and liver blood, disharmony between heart and kidneys, and yin deficiency with excessive fire. Furthermore, this invention, through the synergistic effect of multiple components, can effectively regulate the neurotransmitter GABA receptors, targeting and prolonging deep sleep, reducing the number of nighttime awakenings, fundamentally optimizing sleep structure, and also inhibiting excessive activation of the HPA axis, reducing abnormally elevated cortisol levels, thereby alleviating anxiety, breaking the vicious cycle of anxiety-insomnia, and effectively treating anxiety-related insomnia. Simultaneously, it has antioxidant effects, protects nerve cells, improves cerebral microcirculation, provides sufficient oxygen and nutrients to the brain, and creates a favorable physiological environment for the restoration of normal sleep rhythms.

The invention relates to the technical field of food, and particularly discloses a composition for promoting auditory sense system development and application. The composition is prepared from the following components in parts by mass: 0.1 part of IGF-1 and 1 to 1500 parts of structural triglyceride. A specific amount of IGF-1 is compounded with structural triglyceride, so that the movement speed and average movement distance of the zebrafish after auditory stimulation can be increased, the content of 5-hydroxytryptamine and acetylcholin esterase in the zebrafish is increased, the expression of GABA receptor genes is promoted, and the yield of the zebrafish is increased. By adding important neurotransmitters in an auditory sense system, auditory sense neuron survival, differentiation and synaptic formation are supported, so that the excitability of an auditory sense nerve pathway is adjusted, and the development of the auditory sense system is promoted. The composition can be used for preparing food such as infant formula milk powder, child formula milk powder, liquid milk, infant complementary food, supplements or dietary supplements.

The invention belongs to the technical field of biological medicines, and relates to a pharmaceutical composition and application thereof in preparation of medicines for preventing and / or treating erectile dysfunction. A novel brain-gonad axis regulation target medicine for treating obstructive sleep apnea related low testosterone is researched and explored, and through combined medication of a glutamate receptor activator and a GABA receptor inhibitor, signal transmission of olfactory sensory neurons-olfactory bulb GnRH neurons-hypothalamic GnRH neurons-anterior pituitary can be activated, so that the low-testosterone brain-gonad axis regulation target medicine for treating obstructive sleep apnea related low testosterone can be used for treating obstructive sleep apnea related low testosterone. Therefore, the ED symptom is improved, and the treatment of the ED is further realized.

The invention discloses application of 2-hydroxy-4-(2-hydroxy-3, 5-dichlorobenzyl) aminobenzoic acid 2-borneol ester in treatment of mental diseases, belongs to the field of pharmacy, and provides a novel medicine for treating mental diseases. Excitation / inhibition unbalance of a nerve circuit can be adjusted through mechanisms such as nNOS-PSD95 uncoupling and alpha2GABAA receptor agonistic action, and an obvious inhibition effect on immune inflammation which has an important position in occurrence and development of mental diseases is achieved. In consideration of complex causes of mental diseases and difficulty in good treatment effect of single-target mechanism medicines, the novel medicine provided by the invention further inhibits central inflammation on the basis of regulating excitation / inhibition imbalance of a central nervous circuit, comprehensively aims at various etiological mechanisms of the mental diseases, is remarkably different from an existing treatment medicine mechanism, and has a good application prospect. The traditional Chinese medicine has the advantages of remarkable treatment effect, quick response, small side effect, no response to the existing medicine and the like.

The application discloses a woodfordioid toxic alkane type sesquiterpene CNA, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. The woodfordioid toxic alkane type sesquiterpene CNA compound of formula I is obtained by cold soaking, silica gel and gel column chromatography from Artocarpus styracifolius. The CNA compound has a new cis-hydrogenated indene core structure, contains nine continuous chiral centers and a highly crowded polycyclic skeleton feature, and has good biological activity. Cell experiments show that the woodfordioid toxic alkane type sesquiterpene CNA has signal transmission to endogenous and exogenous system GABA B receptor and can be used for preparing drugs for treating or preventing nervous system related diseases, and opens up a new direction for developing a new GABA B receptor antagonist or modulator and exploring a GABA receptor related treatment target and developing a nervous system disease drug.

The invention relates to the technical field of sleep-aiding capsules, and particularly discloses ergothioneine sleep-aiding nutritional capsules and a process thereof. The capsule is prepared from the following components in parts by mass: 80 to 120 mg of gamma-aminobutyric acid (GABA), 130 to 170 mg of a magnesium citrate compound, 20 to 28 mg of magnesium, 25 to 35 mg of nano ergothioneine, 180 to 220 mg of a South African drunken solanum extract, 15 to 25 mg of pyrroloquinoline quinone (PQQ), 8 to 12 mg of spermidine, 45 to 55 mg of jujuboside A and 1.8 to 2.2 mg of melatonin sustained-release microspheres. The prepared capsule can be used for adjusting nerve excitability and enhancing the function of a GABA receptor; the traditional Chinese medicine composition has the effects of resisting oxidation and inflammation, improving brain microenvironment, providing energy support for sleep and adjusting sleep rhythm, is more comprehensive and remarkable in effect, high in safety and small in side effect compared with a single-component product, and has a remarkable effect compared with a chemically synthesized hypnotic. The traditional Chinese medicine composition has no drug dependence and tolerance, reduces the burden on the body, and is suitable for long-term administration.

The invention discloses a compound essential oil composition containing sandalwood and capable of soothing nerves and helping sleep as well as a preparation method and application of the compound essential oil composition. The compound essential oil composition provided by the invention comprises the following components in parts by weight: 1-11 parts of sweet almond essential oil, 1-5 parts of sandalwood essential oil, 1-8 parts of rhizoma acori graminei essential oil, 1-6 parts of freesia essential oil, 1-4 parts of bitter orange leaf essential oil and 1-5 parts of purslane essential oil. The compound essential oil composition is obtained by compounding specific essential oil components, the components have an obvious synergistic effect, and the compound essential oil composition has the effects of inhibiting gamma-aminobutyric acid (GABA) lytic enzyme activity, promoting activation of a GABA receptor, increasing expression of olfactory dopamine receptor subunit D3, regulating a glutamic acid system, reducing the level of inflammatory factors and the like; the traditional Chinese medicine composition has a mechanism that multiple molecules synergistically act on multiple targets, can play a role in different emotion and physiological states due to the dual regulation effect on part of mechanisms, helps to recover the balance of a nervous system, and has remarkable effects of soothing the nerves and helping sleep.

The invention belongs to the technical field of medical artificial intelligence, and particularly relates to a method for searching a target spot of a drug for treating diseases through network pharmacology and computer-aided drug design and application of the target spot. Epidemiological studies show that the treatment of depression is mainly psychological guidance and drug therapy, however, different patients have different reactions to drugs, and unexpected adverse reactions are generated. Through network pharmacology, molecular docking and Mendel randomization technologies, the application of lamotrigine in preparation of the anti-depression medicine through acting on one or more target spots in GABRA1, GABRB2, GABRA6, GABRD, GABRG2, GABRG1, GABRA5, GABRA4, GABRB3 and GABRA2 is found and verified. The lamotrigine provides new dawn for safely, economically and effectively improving clinical treatment of depression patients based on the safe and economical'old medicine 'characteristics and the potential effective targeting activation effect of the lamotrigine on GABA receptors.

The invention relates to acanthopanax, schisandra chinensis and poria cocos paste for treating insomnia and a preparation method of the acanthopanax, schisandra chinensis and poria cocos paste. The acanthopanax, schisandra chinensis and poria cocos paste is prepared from the following raw materials in parts by weight: 150-250 parts of an acanthopanax extract, 100-180 parts of a schisandra chinensis extract, 180-220 parts of a poria cocos extract, 80-120 parts of a spina date seed extract, 50-80 parts of a polygala tenuifolia extract, 60-100 parts of a tuber fleeceflower stem polysaccharide extract, 00-300 parts of xylitol and 10-20 parts of sodium carboxymethyl cellulose. The traditional Chinese medicine composition has the beneficial effects that through GABA receptor alpha2 subunit expression and 5-HT1A double-target synergistic effect, the limitation of a single medicine on the tranquilizing effect is broken through, and slow-wave sleep is synergistically prolonged; the traditional Chinese medicine is used for treating insomnia, especially for heart-spleen deficiency and liver-kidney deficiency syndromes. A synergistic sedative mechanism of tenuigenin and iridoid of tuber fleeceflower stem is introduced, so that the problem of poor effect of a traditional ointment formula on phlegm-heat disturbing heart type insomnia is solved; the pachymaran and the tenuigenin reduce the level of cortisol at night and reduce the awakening frequency by inhibiting excessive activation of an HPA axis.

A pharmaceutical composition is provided and includes at least one orthosteric GABA receptor ligand that directly binds to at least one GABA-A receptor or at least one GABA-B receptor at the endogenous GABA binding site, and at least one non-orthosteric GABA receptor ligand that binds a site distinct from the endogenous GABA binding site on at least one GABA receptor type. This ensures the orthosteric and non-orthosteric ligands for each receptor type are co-present. The orthosteric and non-orthosteric ligands may be co-formulated for concurrent availability, such that the presence of the orthosteric ligand enables or enhances the therapeutic effect of the non-orthosteric ligand.

A pharmaceutical composition is provided and includes at least one orthosteric GABA receptor ligand that directly binds to at least one GABA-A receptor or at least one GABA-B receptor at the endogenous GABA binding site, and at least one non-orthosteric GABA receptor ligand that binds a site distinct from the endogenous GABA binding site on at least one GABA receptor type. This ensures the orthosteric and non-orthosteric ligands for each receptor type are co-present. The orthosteric and non-orthosteric ligands may be co-formulated for concurrent availability, such that the presence of the orthosteric ligand enables or enhances the therapeutic effect of the non-orthosteric ligand.