54 results about "Antiepileptic Agents" patented technology

The present invention relates to the use of cannabidiol (CBD) in the treatment of patients with childhood-onset epilepsy who are concurrently taking one or more antiepileptic drugs that works via GABA receptor agonism. Preferably the AED is stiripentol. Preferably the CBD used is in the form of a highly purified extract of cannabis such that the CBD is present at greater than 98% of the total extract (w/w) and the other components of the extract are characterised. In particular the cannabinoid tetrahydrocannabinol (THC) has been substantially removed, to a level of not more than 0.15% (w/w) and the propyl analogue of CBD, cannabidivarin, (CBDV) is present in amounts of up to 1%. Alternatively, the CBD may be a synthetically produced CBD.

The invention discloses a detection kit for antiepileptic drugs in serum and application thereof, and belongs to the technical field of drug analysis. The kit disclosed by the invention adopts an LC-MS/MS method; ten common antiepileptic drugs can be detected at one time; the kit is simple in pretreatment process, low in cost, high in sensitivity and high in specificity; separation and detection of the antiepileptic drugs are completed within 6 min, the accuracy and precision basically meet the requirements, the kit can be used for quantitative analysis of the clinical antiepileptic drugs, anda reliable detection method is provided for monitoring the treatment concentration of the clinical antiepileptic drugs.

The invention provides application of a panaxadiol saponins fraction in preparing a medicine for preventing epilepsia. The component comprises the following main constituents: ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rc and ginsenoside Rd, and the medicine is prepared from active constituents in the single panaxadiol saponins fraction or from the active constituents in the single panaxadiol saponins fraction and other medicines. By taking one of five panaxadiol saponins: ginseng, American ginseng rhizome medicinal materials, ginseng stems and leaves, American ginseng stem and leaf medicinal materials and total extractives or total saponins of the ginseng, the American ginseng rhizome medicinal materials, the ginseng stems and leaves and American ginseng stem and leaf medicinal materials as a starting raw material independently or taking a mixture which consists of two or more than two different raw materials as the starting raw material comprehensively, the medicine is prepared by establishing the chromatographic separation and purification technology. According to the medicine prepared from the panaxadiol saponins fraction provided by the invention, an anti-epileptic effect can be greatly improved, and moreover, the toxic and side effects, especially dermatitis and intelligence toxicity, of traditional anti-epileptic medicines can be resisted, therefore, long-standing defects that the anti-epileptic medicines are not enough in curative effect and low in safety are overcome. The structural formula of the panaxadiol saponin is shown in specification.

The invention provides a method for simultaneously determining the content of various antiepileptic drugs in blood and application of the method, and belongs to the technical field of medicine detection. According to the method of the invention, a protein precipitation method is combined with HPLC-MS/MS to determine the content of the nine antiepileptic drugs in the plasma. The determination method of the nine antiepileptic drugs in the plasma is fully verified from the aspects of specificity, linearity, sensitivity, accuracy, precision, matrix effect, recovery rate, stability and the like; finally, the method is applied to animal pharmacokinetic research of oral medication, can calculate pharmacokinetic parameters through a non-atrioventricular model, can give the real level of the real concentration of the medicine for treating epilepsy in the body of a patient and can guide doctors to reasonably formulate a drug administration scheme, and therefore, the patient can reasonably take the medicine, side effects can be reduced; and the method has important significance on achieving the optimal curative effect of the patient.

The invention discloses a cynanchum otophyllum saponin composition. The cynanchum otophyllum saponin composition comprises cynanchum otophyllum saponin M1 and cynanchum otophyllum saponin M2, and the cynanchum otophyllum saponin M1 and the cynanchum otophyllum saponin M2 are combined at a mass ratio of 1:1. Tests show that the cynanchum otophyllum saponin composition can be taken orally and absorbed, can be used together with phenobarbital sodium, can be used for enhancing the antiepileptic effect of phenobarbital sodium, is superior to the single cynanchum otophyllum saponin M1 and the single cynanchum otophyllum saponin M2 in effect and can be prepared into an antiepileptic medicine.

The present invention refers to a pharmaceutical composition comprising racetam and carnitine. Said pharmaceutical composition may further comprise coenzyme Q10 and/or agent associated with mitochondrial and/or metabolic disturbance, such as hypocholesterolemic agent of the statins group, a hypoglycemic agent, or an antiepileptic agent. The invention also includes a method of treatment for mitochondrial disturbances comprising administration of the pharmaceutical composition of the invention.

The invention provides a quality control material and/or a calibration material for simultaneously monitoring 78 neuropsychiatric drugs as well as a preparation method and application of the quality control material and/or the calibration material. The quality control material and/or the calibration material comprises the 78 neuropsychiatric drugs, a matrix and an antioxidant, the antioxidant is a combination of ascorbic acid, butylated hydroxytoluene and ethylenediamine tetraacetic acid; the mass content of the antioxidant in the quality control product and/or the calibration product is 0.2-0.5%; the 78 kinds of neuropsychiatric drugs comprise 15 kinds of antiepileptic drugs, 23 kinds of antipsychotic drugs and 40 kinds of antidepressant drugs. The quality control product and/or the calibration product prepared by adding the antioxidant in a specific combination have high stability, effectively eliminate the matrix effect generated in the process of mass spectrometric detection of the neuropsychiatric drugs of the serum sample, and significantly improve the accuracy and indoor precision of mass spectrometric detection; the technical bottleneck is solved for the industrialization and wide application of the technology for detecting the psychotherapy drugs by mass spectrometry.

The invention relates to the field of antiepileptic drug preparations, in particular to a topiramate sustained-release capsule and a preparation method thereof. The topiramate sustained-release capsule comprises a drug-containing sustained-release pill core, an enteric coating layer and an immediate-release layer. The weight ratio of pharmaceutical active ingredient topiramate to the drug-containing sustained-release pill core is 40%-80%, and the weight ratio of the topiramate to the immediate-release layer is 20%-60%. According to the opiramate sustained-release capsule, a part of the pharmaceutical active ingredient topiramate is distributed in the drug immediate-release layer, when the topiramate sustained-release capsule enters the gastrointestinal tract, the drug immediate-release layer begins to disintegrate, the topiramate is dissolved, and the effective blood concentration can be quickly reached, at the moment, the sustained-release part of the drug is not dissolved under the protection of enteric coating, when the drug enters the intestine, the topiramate is released in a sustained mode under the action of the sustained-release coating, and effective and stable blood drugconcentration can be continuously maintained.

The invention belongs to the technical field of detection of drugs and metabolites thereof and particularly relates to a method for detecting antiepileptic drugs and metabolites thereof in hair by liquid chromatography-mass spectrometry. The invention provides a system which is used for judging whether the dosage of an anti-epileptic drug is excessive or insufficient by detecting or inputting the content of the anti-epileptic drug or metabolites thereof in hair. The detection method comprises the following steps of (1) pretreating a hair sample to obtain a solution to be detected; and (2) detecting the concentration of the anti-epileptic drug in the hair by adopting a liquid chromatography-mass spectrometry method. The detection method is simple, convenient and sensitive, the long-term medication condition of a subject can be reflected by detecting the anti-epileptic medicine in the hair, the hair sample is simple and convenient to take, the storage requirement is low, and the method is suitable for clinical large-scale popularization.

The invention provides a lactate dehydrogenase inhibitor that makes it possible to suppress refractory epilepsy in which conventional antiepileptic drugs are ineffective, and an antiepileptic drug containing said inhibitor. The lactate dehydrogenase inhibitor of the invention contains a compound represented by formula (III); i.e., isosafrole or a compound having isosafrole as a scaffold, and the antiepileptic drug of the invention has these compounds as an active ingredient.

The invention relates to a 5-substituted phenoxy-1, 2, 4-triazole [4, 3-a] pyridine compound used for antiepileptic medicament, and medical salt of the compound. The invention provides the new 5-substituted phenoxy-1, 2, 4-triazole [4, 3-a] pyridine compound which has comparatively low toxic and side effects and shows the valuable pharmacological properties as anticonvulsant, and addition salt of pharmaceutically acceptable acid of the compound. The formula I shows the compound and the addition salt of the pharmaceutically acceptable acid of the compound, wherein R is selected from all bromoalkanes. The compound is high in anticonvulsion activity, comparatively low in toxic and side effects and high in safety index, thus laying the foundation for the research and application of the antiepileptic medicament.

The invention discloses an epilepsy drug treatment outcome prediction method and device. The epilepsy drug treatment outcome prediction method comprises the following steps: acquiring a multi-modal magnetic resonance image of a TSC patient before anti-epilepsy drug treatment; randomly dividing the TSC patients into a training set and a test set according to a proportion; performing region segmentation on each modal magnetic resonance image based on a U-net + + network to obtain a region of interest; performing feature extraction on each region of interest to obtain high-dimensional image omics features; analyzing and screening the high-dimensional image omics features to obtain target image omics features; training a prediction model for the target radiomics characteristics in the training set by using a machine learning algorithm, constructing and obtaining an epilepsy drug treatment outcome prediction model, and verifying the model; and predicting target radiomics characteristics of a patient to be treated by using the constructed epilepsy drug treatment outcome prediction model to obtain a predicted epilepsy drug treatment outcome. According to the method, the drug treatment outcome of the epilepsy patient can be quickly and effectively predicted, and a doctor is assisted in formulating a better treatment scheme.

The invention provides a biomarker, a detection method thereof and application of the biomarker in epilepsy pathology research and anti-epilepsy drug screening, the biomarker is related to zebra fish epilepsy pathology characteristics, and the biomarker is a nerve excitation cluster; the nerve excitation cluster is a set of adjacent nerve excitation clusters in time and space obtained when MATLAB analysis is performed on image data obtained by performing GCaMP fluorescent dynamic imaging on zebra fish; and the nerve excitation cluster is a set of at least three connected excitation state pixel points in a single-frame image. According to the invention, a GCaMP dynamic imaging technology and a zebra fish hereditary epilepsy model are combined, data are subjected to visualization and quantitative analysis by adopting an image data processing pipeline based on MATLAB, a local nerve excitation cluster is used as an epilepsy biomarker, efficient judgment of the epilepsy pathology condition of a nervous system is realized, and the biomarker has the advantages of rapidness, objectivity, accuracy and the like and can be used for screening high-throughput antiepileptic drugs.